International psychogeriatrics最新文献

{"title":"Social health and prevention of dementia: Integration of human and mice studies.","authors":"Myrra Vernooij-Dassen, Isabelle F van der Velpen, Suzanne D Lanooij, Eddy A van der Zee, M Arfan Ikram, Wilhelmus H I M Drinkenburg, Andrea Costanzo, Meike W Vernooij, Ulrich L M Eisel, René Melis, Martien J H Kas, Marieke Perry","doi":"10.1016/j.inpsyc.2025.100054","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100054","url":null,"abstract":"<p><strong>Objectives: </strong>Prevention of dementia is considered a healthcare priority. We aimed to identify potentially modifiable risk factors and mechanisms within the social health domain to find novel avenues to prevent cognitive decline and dementia.</p><p><strong>Design: </strong>We integrated the results of eight sub-studies of the Social Health in Mice and Men (SHiMMy) project that were separately published in specialized journals, but not yet jointly considered. We followed the integrative methodology of Whittemore and Knafl, using the conceptual framework for social health to structure and integrate the results of human epidemiological and qualitative studies and experimental mice studies. This is a novel multi-method approach.</p><p><strong>Participants: </strong>Participants of the population-based longitudinal cohort Rotterdam study were included in the epidemiolocal studies (ranging from N = 1259 to N = 3.720) and in the qualitative study (n = 17). Mice intervention studies were performed using a transgenic mouse model for Alzheimer's pathology and matched controls, under group and single housed conditions.</p><p><strong>Measurements: </strong>Epidemiological studies include social health markers (loneliness, perceived social support, marital status) and magnetic resonance imaging of the brain. The semi-structured qualitative study used an interview guide. The mice study assessed behavioral and histological markers.</p><p><strong>Results: </strong>In human and mice studies, we identified several similar potentially modifiable risk (e.g. marital status, social group size) and protective (e.g. perceived social support, behavioral responses) factors. This alignment of findings showing that social health may impact brain health lend further support to our social health hypothesis.</p><p><strong>Conclusion: </strong>These results allow us to propose evidence-based social health targets for preventive interventions.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100054"},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of enhanced group cognitive behaviour therapy for older adults (CBT-OA) with depression and anxiety: A replication study.","authors":"Anna Skosireva, Linda Gobessi, Gail Eskes, Keri-Leigh Cassidy","doi":"10.1016/j.inpsyc.2024.100013","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100013","url":null,"abstract":"<p><strong>Objectives: </strong>Enhanced cognitive behavioural therapy for older adults (CBT-OA) modifies standard CBT to better address the needs of older adults, considering age-related impacts on learning. This study evaluated the effectiveness of Cassidy's manualized CBT-OA protocol (Cassidy, 2016a, 2016b) for late-life depression or anxiety in a larger sample at a different center.</p><p><strong>Design: </strong>This retrospective observational study used a within-subject pre-/post-data design to evaluate the CBT-OA group for seniors with depression or anxiety. Outcome measure were compared before and after the CBT-OA intervention. A post-hoc analysis examined differential effects of age ('young-old' versus 'old-old').</p><p><strong>Setting: </strong>CBT-OA groups were held in an urban, community-based geriatric psychiatry outpatient setting from 2015-2019.</p><p><strong>Participants: </strong>The analysis included forty community-dwelling outpatients over 65 years old with symptoms of late-life depression and/or anxiety.</p><p><strong>Intervention: </strong>Cassidy's manualized CBT-OA protocol for late-life depression or anxiety was used. Five CBT-OA series were held, each lasting 7-9 weeks (average of 8 weeks) with 2-h weekly sessions, involving 6-9 participants per series.</p><p><strong>Measurements: </strong>Outcome measures included the self-reported Beck Depression Inventory-II, Beck Anxiety Inventory, and Perceived Quality of Life Questionnaire.</p><p><strong>Results: </strong>CBT-OA significantly improved mood, anxiety, and perceived quality of life, with the greatest gains in 'young-old' participants.</p><p><strong>Conclusion: </strong>This first replication study of Cassidy's CBT-OA protocol for late-life depression or anxiety showed similar positive findings. Future research should use a randomized-controlled design to examine CBT-OA's efficacy, considering different age groups, longer-term follow-up, and well-being measures aligned with positive psychiatry.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100013"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, loneliness, mild cognitive impairment and dementia in older adults.","authors":"Tomoyuki Kawada","doi":"10.1016/j.inpsyc.2025.100055","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100055","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100055"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between loneliness, social isolation and dementia - What does it mean?","authors":"Jiska Cohen-Mansfield","doi":"10.1016/j.inpsyc.2024.100003","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100003","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100003"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failure to recover from proactive semantic interference predicts trajectory of decline in everyday function among older adults with amnestic mild cognitive impairment.","authors":"D Diane Zheng, Rosie E Curiel Cid, Alexandra Ortega, Elizabeth A Crocco, David Vaillancourt, Melissa J Armstrong, Breton Asken, Steven T DeKosky, Malek Adjouadi, Glenn Smith, Ranjan Duara, Michael Marsiske, Monica Rosselli, Warren W Barker, David A Loewenstein","doi":"10.1016/j.inpsyc.2024.100005","DOIUrl":"10.1016/j.inpsyc.2024.100005","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the predictive utility of proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) deficits on the longitudinal everyday functional decline on the Clinical Dementia Rating Sum of Boxes (CDR-SOB) among older adults with amnestic mild cognitive impairment (aMCI).</p><p><strong>Design: </strong>Longitudinal prospective cohort study.</p><p><strong>Setting: </strong>1Florida Alzheimer's Disease Research Center (1FLADRC).</p><p><strong>Participants: </strong>97 older adults aged 54 to 98 years who were diagnosed with aMCI following a baseline evaluation. The average age was 71.9 years, 51 % male, average education 15.7 years, and 56 % Hispanic. The mean MMSE score was 28.0. Participants were followed annually for 3 to 4 visits with a mean follow-up time of 38.9 months (range 22.7 to 70.3 months).</p><p><strong>Measurements: </strong>CDR-SOB were obtained at each visit and the latent growth curve trajectory of CDR-SOB was estimated. The associations between PSI and frPSI and the growth curve trajectory of CDR-SOB were examined.</p><p><strong>Results: </strong>The growth curve model that best fits the CDR-SOB trajectory was a linear form and included the fixed and random effect of intercept and slope of time. After adjusting for age, sex, education, Hispanic background, Hopkins Verbal Learning Test (HVLT) immediate and delayed recall, and amyloid positivity, frPSI (β = -0.134, se=0.04, p < 0.01) remained statistically significant in predicting a steeper slope on the trajectory of decline in CDR-SOB.</p><p><strong>Conclusions: </strong>frPSI at baseline predicted the rate of everyday functional decline over time among participants with aMCI regardless of amyloid status and demonstrated its utility of longitudinal prediction of change in CDR-SOB.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100005"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive remediation for patients with late-life schizophrenia: A follow-up pilot study.","authors":"Angela C Golas, Bishoy M Elgallab, Petal S Abdool, Christopher R Bowie, Tarek K Rajji","doi":"10.1016/j.inpsyc.2024.100006","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100006","url":null,"abstract":"<p><strong>Objectives: </strong>The number of older adults with schizophrenia (\"late-life schizophrenia\" (LLS)) is growing with the aging of the general population. Cognitive impairment in adults with LLS predicts functioning. Cognitive remediation (CR) improves cognition in schizophrenia, however literature in LLS is sparse. Anticholinergic burden (ACB) impacts CR effects. We previously showed that CR is feasible in LLS but did not produce a promising cognitive effect. This study examined the feasibility, tolerability, and effect of an intensive, prolonged and flexible CR on overall and specific cognitive functions in LLS. We also assessed ACB impact on CR effect on global cognition.</p><p><strong>Design: </strong>Pre-post intervention SETTING PARTICIPANTS: Tertiary care outpatients with LLS INTERVENTION: We adapted the CR protocol from our previous pilot study, providing CR over 24, twice-weekly, therapist-guided group sessions that combined computerized drill-and-practice exercises with skills transference strategies, with additional time allocated for exercise practice.</p><p><strong>Measurements: </strong>We assessed participants at baseline and at study completion using clinical and cognitive measures.</p><p><strong>Results: </strong>Thirty-four participants (mean (SD) age = 65.8 (5.7)) attended at least one CR session, 25 participants completed baseline and follow-up assessments, and 20 participants completed at least 75 % of the CR sessions. There was no time effect on global cognition, although there was an interaction with ACB. There was also a pattern of improvement in executive function across several cognitive tests.</p><p><strong>Conclusions: </strong>An intensive, prolonged and flexible CR was feasible and well-tolerated, showing promise in improving executive function of patients with LLS. Larger and randomized controlled trials are needed in this population.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100006"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between changes in apathy and cognition in Alzheimer's disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).","authors":"Krushnaa Sankhe, Shankar Tumati, Jamie Perin, Luc Rivet, Danielle Vieira, Paul B Rosenberg, Nathan Herrmann, David Shade, Alan J Lerner, Prasad R Padala, Olga Brawman-Mintzer, Christopher H van Dyck, Anton P Porsteinsson, Suzanne Craft, Allan I Levey, Jacobo Mintzer, Krista L Lanctôt","doi":"10.1016/j.inpsyc.2024.100012","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100012","url":null,"abstract":"<p><strong>Background: </strong>Previous trials have shown improvements in both apathy and cognition with methylphenidate (MPH).</p><p><strong>Objectives: </strong>To assess whether changes in apathy correlated with changes in cognition in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).</p><p><strong>Participants: </strong>Mild to moderate AD patients with clinically significant apathy randomized to MPH (20 mg/day) or placebo for 6 months.</p><p><strong>Measurements: </strong>Apathy was measured with the Neuropsychiatric Inventory-apathy (NPI-A) domain. Cognition was measured using the Mini-Mental State Exam (MMSE), Hopkins Verbal Learning (immediate [HVLT-I], delayed [HVLT-D] recall), Digit Span (Forward [DF], Backward [DB]), Trail Making (TMT-A, TMT-B), Action Verbal Fluency (AV), Category Fluency (CF), and the Short Boston Naming Test (BNT).</p><p><strong>Design: </strong>Linear mixed models included cognitive change scores as dependent variables and time, treatment, change in NPI-A and the interaction between treatment and change in NPI-A as independent variables, which were additionally adjusted for baseline NPI-A and cognitive scores, age, sex, level of education and presence of diabetes.</p><p><strong>Results: </strong>199 participants (66 % male) were included (98-MPH, 101-placebo). Among all participants, worsening CF was associated with worsening apathy (-0.15 (0.05), p = .003). In addition, change in HVLT-I was associated with the interaction between changes in apathy and treatment (-0.31 (0.07), p = 0.0000158).</p><p><strong>Conclusion: </strong>Changes in apathy are mostly independent of cognitive changes and apathy response to MPH may be independent from cognition. These results are consistent with the view that apathy as a syndrome is related to but distinct from cognition.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100012"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic influence of mood on subjective cognitive complaints in mild cognitive impairment: A time series network analysis approach.","authors":"Varsha D Badal, Laura M Campbell, Colin A Depp, Emma M Parrish, Robert A Ackerman, Raeanne C Moore, Philip D Harvey, Amy E Pinkham","doi":"10.1016/j.inpsyc.2024.100007","DOIUrl":"10.1016/j.inpsyc.2024.100007","url":null,"abstract":"<p><strong>Objectives: </strong>Subjective cognitive complaints (SCC) are common and clinically relevant in mild cognitive impairment (MCI) but are intertwined with mood states. Using Ecological Momentary Assessment (EMA) of SCC and network analyses we sought to uncover the links between mood and SCC and how these links may vary by the presence or absence of MCI.</p><p><strong>Design: </strong>We used EMA to collect intensive longitudinal data. In addition to analyzing the data at an aggregate level to estimate between-person associations of affect and SCC variables, we used time series analyses to estimate contemporaneous and time-lagged relations between the variables.</p><p><strong>Setting: </strong>EMA survey and mobile cognitive testing in subjects' natural environments.</p><p><strong>Participants: </strong>The sample included 100 participants, 48 with Normal Cognition (NC), and 52 with MCI.</p><p><strong>Measurements: </strong>Participants completed 30-day EMA protocols in which surveys sampling SCC and moods were delivered 3 times per day.</p><p><strong>Results: </strong>The association between SCC (as measured by EMA) and standard in-lab measures of SCC was significant in MCI, but not in NC. Despite no average level differences in severity of SCC, there was a strong association between negative affect (as measured by EMA) with SCC in NCs compared to MCI.</p><p><strong>Conclusions: </strong>EMA maybe a useful and valid approach to measuring SCCs in MCI. Network analyses indicated that negative affect was linked with later SCCs. This finding was strong in persons with NC than in persons with MCI. The basis of the attenuated association between negative affect and SCCs in MCI deserves further study.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100007"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with loneliness in a national study among persons 80 years and older in India in 2017-2018.","authors":"Supa Pengpid, Karl Peltzer, André Hajek, Razak M Gyasi","doi":"10.1016/j.inpsyc.2024.100019","DOIUrl":"10.1016/j.inpsyc.2024.100019","url":null,"abstract":"<p><strong>Objectives: </strong>This study's objective was to determine the variables linked to loneliness in Indian adults 80 years of age and above (as well as stratified by sex).</p><p><strong>Design: </strong>Cross-sectional survey of the 2017-2018 Longitudinal Ageing Study in India (LASI) SETTING: Community-dwelling nationally representative population in India.</p><p><strong>Participants: </strong>The analytic sample included 3163 community-dwelling individuals ≥ 80 years (excluding proxy interviews).</p><p><strong>Measurements: </strong>A single item was used to measure loneliness. We employed multiple linear regressions (with social, health, and demographic variables as explanatory variables).</p><p><strong>Results: </strong>Regressions found that higher food insecurity, higher perceived discrimination, higher functional disability, female sex, and lower life satisfaction increased the odds of higher loneliness among the oldest-old. The sex-stratified analysis found similar results.</p><p><strong>Conclusions: </strong>Several demographic, health, and social-related factors were identified as being associated with higher loneliness. These factors can be targeted in addressing the onset and progression of loneliness in later life, particularly among the oldest old.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100019"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding to \"The effect of study partner characteristics on the reporting of neuropsychiatric symptoms across the neurocognitive spectrum\".","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.1016/j.inpsyc.2024.100028","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100028","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100028"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}