International psychogeriatrics最新文献

{"title":"The impact of the first COVID-19 lockdown on presentations with depressive symptoms in older people - an electronic health records study.","authors":"Latha Velayudhan, Wai Yan Cheung, Gayan Perera, Robert Stewart, Christoph Mueller","doi":"10.1017/S104161022200062X","DOIUrl":"10.1017/S104161022200062X","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1076-1078"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.","authors":"D C Steffens, M E Garrett, K L Soldano, D R McQuoid, A E Ashley-Koch, G G Potter","doi":"10.1017/S1041610220001143","DOIUrl":"10.1017/S1041610220001143","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression.</p><p><strong>Design: </strong>A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study.</p><p><strong>Setting: </strong>Longitudinal, naturalistic follow-up study.</p><p><strong>Participants: </strong>Older depressed adults, both outpatients and inpatients, receiving care at an academic medical center.</p><p><strong>Measurements: </strong>The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was administered to the study participants at baseline and a minimum of twice within a subsequent 3-year period in order to measure cognitive decline. A GWAS analysis was conducted to identify genetic variation that is associated with baseline and change in the CERAD Total Score (CERAD-TS) in NCODE.</p><p><strong>Results: </strong>The GWAS of baseline CERAD-TS revealed a significant association with an intergenic single-nucleotide polymorphism (SNP) on chromosome 6, rs17662598, that surpassed adjustment for multiple testing (<i>p</i> = 3.7 × 10^-7; false discovery rate <i>q</i> = 0.0371). For each additional G allele, average baseline CERAD-TS decreased by 8.656 points. The most significant SNP that lies within a gene was rs11666579 in <i>SLC27A1</i> (<i>p</i> = 1.1 × 10^-5). Each additional copy of the G allele was associated with an average decrease of baseline CERAD-TS of 4.829 points. <i>SLC27A1</i> is involved with processing docosahexaenoic acid (DHA), an endogenous neuroprotective compound in the brain. Decreased levels of DHA have been associated with the development of Alzheimer's disease. The most significant SNP associated with CERAD-TS decline over time was rs73240021 in <i>GRXCR1</i> (<i>p</i> = 1.1 × 10^-6), a gene previously linked with deafness. However, none of the associations within genes survived adjustment for multiple testing.</p><p><strong>Conclusions: </strong>Our GWAS of cognitive function and decline among individuals with late-life depression (LLD) has identified promising candidate genes that, upon replication in other cohorts of LLD, may be potential biomarkers for cognitive decline and suggests DHA supplementation as a possible therapy of interest.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1021-1029"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794099/pdf/nihms-1601798.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38139095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological correlates of early grief in bereaved older adults.","authors":"Brianna M Hoffmann, Nutta-On P Blair, Timothy L McAuliffe, Gyujoon Hwang, Eric Larson, Stacy A Claesges, Abigail Webber, Charles F Reynolds, Joseph S Goveas","doi":"10.1017/S1041610224000048","DOIUrl":"10.1017/S1041610224000048","url":null,"abstract":"<p><p>Prolonged grief disorder (PGD) is associated with impairments in cognitive functioning, but the neuropsychological correlates of early grief in older adults are poorly understood. This preliminary study cross-sectionally examined neuropsychological functioning in bereaved adults with high and low grief symptoms and a non-bereaved comparison sample and further explored the relationship between multidomain cognitive measures and grief severity. A total of ninety-three nondemented older adults (high grief: <i>n</i> = 44; low grief: <i>n</i> = 49) within 12 months post-bereavement and non-bereaved comparison participants (<i>n</i> = 43) completed neuropsychological battery including global and multiple domain-specific cognitive functioning. Linear regression models were used to analyze differences in multidomain cognitive measures between the groups and specifically examine the associations between cognitive performance and grief severity in the bereaved, after covariate adjustment, including depressive symptoms. Bereaved older adults with higher grief symptoms performed worse than those with lower symptoms and non-bereaved participants on executive functioning and attention and processing speed measures. In the bereaved, poorer executive functioning, attention and processing speed correlated with higher grief severity. Attention/processing speed-grief severity correlation was seen in those with time since loss ≤ 6 months, but not > 6 months. Intense early grief is characterised by poorer executive functioning, attention, and processing speed, resembling findings in PGD. The putative role of poorer cognitive functioning during early grief on the transition to integrated grief or the development of PGD remains to be elucidated.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1064-1069"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical restraint in older people: an opinion from the Early Career Network of the International Psychogeriatric Association.","authors":"Mustafa Atee, Claire V Burley, Victor Adekola Ojo, Agboola Jamiu Adigun, Hayoung Lee, Daniel Jake Hoyle, Olufisayo Elugbadebo, Tomas Leon","doi":"10.1017/S1041610223000728","DOIUrl":"10.1017/S1041610223000728","url":null,"abstract":"<p><p>The International Psychogeriatric Association (IPA) has expressed significant concerns over the use of physical restraints in older people across diverse aged care settings. Following an extensive analysis of the available literature, the IPA's Early Career Network (ECN) has formulated a collection of evidence-based recommendations aimed at guiding the use of physical restraints within various care contexts and demographic groups. Physical restraints not only infringe upon human rights but also raise significant safety concerns that adversely impact the physical, psychological, social, and functional well-being of older adults. Furthermore, their effectiveness in geriatric settings remains inadequate. Given these considerations, the IPA and its ECN firmly assert that the use of physical restraints should only be considered as a final recourse in the care of older people.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"995-1006"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On prospective resilience methods and precision medicine approaches.","authors":"Theodore D Cosco, John R Best, Shawna Hopper","doi":"10.1017/S1041610223000972","DOIUrl":"10.1017/S1041610223000972","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"986-987"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are superagers super rare?","authors":"Yuta Katsumi, Alexandra Touroutoglou","doi":"10.1017/S1041610224000024","DOIUrl":"10.1017/S1041610224000024","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"853-856"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purpose in life and cognitive health: a 28-year prospective study.","authors":"Angelina R Sutin, Martina Luchetti, Yannick Stephan, Antonio Terracciano","doi":"10.1017/S1041610224000383","DOIUrl":"10.1017/S1041610224000383","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the prospective association between purpose in life measured at three points across middle and older adulthood and cognitive outcomes assessed 8-28 years later.</p><p><strong>Design: </strong>Prospective Study.</p><p><strong>Setting: </strong>Wisconsin Longitudinal Study of Aging (WLS).</p><p><strong>Participants: </strong>WLS participants who reported on their purpose in life at Round 4 (1992-1994; <i>M</i>_age = 52.58), Round 5 (2003-2007; <i>M</i>_age = 63.74), and/or Round 6 (2010-2012; <i>M</i>_age = 70.25) and were administered a cognitive battery at Round 7 (2020; <i>M</i>_age = 79.94) were included in the analysis (<i>N</i> = 4,632).</p><p><strong>Measurements: </strong>Participants completed the Ryff measure of purpose in life and were administered the telephone interview for cognitive status and measures of verbal fluency, digit ordering, and numeric reasoning.</p><p><strong>Results: </strong>Purpose in life measured at age 52 was related to better global cognitive function and verbal fluency but unrelated to dementia at age 80. In contrast, purpose in life at ages 63-70 was associated with lower likelihood of dementia, as well as better global cognitive function and verbal fluency at age 80. The effect sizes were modest (median Beta coefficient = .05; median odds ratio = .85). A slightly steeper decline in purpose in life between ages 52 and 70 was found for individuals with dementia at age 80.</p><p><strong>Conclusions: </strong>Purpose in life is associated with healthier cognitive function measured up to 28 years later. Individuals with lower purpose, especially in their 60s or older, and with steeper declines in purpose, are more likely to have dementia at age 80.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"956-964"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of cognitive \"super-aging\" in three Australian samples using different diagnostic criteria.","authors":"Alice Powell, Ben C P Lam, David Foxe, Jacqueline C T Close, Perminder S Sachdev, Henry Brodaty","doi":"10.1017/S1041610223000935","DOIUrl":"10.1017/S1041610223000935","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the frequency of exceptional cognition (cognitive super-aging) in Australian older adults using different published definitions, agreement between definitions, and the relationship of super-aging status with function, brain imaging markers, and incident dementia.</p><p><strong>Design: </strong>Three longitudinal cohort studies.</p><p><strong>Setting: </strong>Participants recruited from the electoral roll, Australian Twins Registry, and community advertisements.</p><p><strong>Participants: </strong>Older adults (aged 65-106) without dementia from the Sydney Memory and Ageing Study (<i>n</i> = 1037; median age 78), Older Australian Twins Study (<i>n</i> = 361; median age 68), and Sydney Centenarian Study (<i>n</i> = 217; median age 97).</p><p><strong>Measurements: </strong>Frequency of super-aging was assessed using nine super-aging definitions based on performance on neuropsychological testing. Levels of agreement between definitions were calculated, and associations between super-aging status for each definition and functioning (Bayer ADL score), structural brain imaging measures, and incident dementia were explored.</p><p><strong>Results: </strong>Frequency of super-aging varied between 2.9 and 43.4 percent with more stringent definitions associated with lower frequency. Agreement between different criteria varied from poor (K = 0.04, AC1 = .24) to very good (K = 0.83, AC1 = .91) with better agreement between definitions using similar tests and cutoffs. Super-aging was associated with better functional performance (4.7-11%) and lower rates of incident dementia (hazard ratios 0.08-0.48) for most definitions. Super-aging status was associated with a lower burden of white matter hyperintensities (3.8-33.2%) for all definitions.</p><p><strong>Conclusions: </strong>The frequency of super-aging is strongly affected by the demographic and neuropsychological testing parameters used. Greater consistency in defining super-aging would enable better characterization of this exceptional minority.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"939-955"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting and promoting resilience in later life.","authors":"Lauren R Miller-Lewis","doi":"10.1017/S1041610223000820","DOIUrl":"10.1017/S1041610223000820","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"849-852"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention for sleep problems in nursing home residents with dementia: a cluster-randomized study.","authors":"Martin Nikolaus Dichter, Jonas Dörner, Denise Wilfling, Almuth Berg, Thomas Klatt, Ralph Möhler, Burkhard Haastert, Gabriele Meyer, Margareta Halek, Sascha Köpke","doi":"10.1017/S1041610223004489","DOIUrl":"10.1017/S1041610223004489","url":null,"abstract":"<p><strong>Objective: </strong>To reduce sleep problems in people living with dementia using a multi-component intervention.</p><p><strong>Design: </strong>Cluster-randomized controlled study with two parallel groups and a follow-up of 16 weeks.</p><p><strong>Setting: </strong>Using external concealed randomization, 24 nursing homes (NH) were allocated either to the intervention group (IG, 12 clusters, 126 participants) or the control group (12 clusters, 116 participants).</p><p><strong>Participants: </strong>Participants were eligible if they had dementia or severe cognitive impairment, at least two sleep problems, and residence of at least two weeks in a NH.</p><p><strong>Intervention: </strong>The 16-week intervention consists of six components: (1) assessment of sleep-promoting activities and environmental factors in NHs, (2) implementation of two \"sleep nurses,\" (3) basic education, (4) advanced education for staff, (5) workshops to develop sleep-promoting concepts, and (6) written information and education materials. The control group (CG) received standard care.</p><p><strong>Measurements: </strong>Primary outcome was ≥ two sleep problems after 16 weeks assessed with the Sleep Disorders Inventory (SDI).</p><p><strong>Results: </strong>Twenty-two clusters (IG = 10, CG = 12) with 191 participants completed the study. At baseline, 90% of people living with dementia in the IG and 93% in the CG had at least two sleep problems. After 16 weeks, rates were 59.3% (IG) vs 83.8% (CG), respectively, a difference of -24.5% (95% CI, -46.3% - -2.7%; cluster-adjusted odds ratio 0.281; 95% CI 0.087-0.909). Secondary outcomes showed a significant difference only for SDI scores after eight and 16 weeks.</p><p><strong>Conclusions: </strong>The MoNoPol-Sleep intervention reduced sleep problems of people living with dementia in NH compared to standard care.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"965-978"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}