International psychogeriatrics最新文献

{"title":"Recommendations for management and future investigation of psychosis in neurodegenerative disease: Findings from the International Psychogeriatric Association (IPA) working group.","authors":"Andrew A Namasivayam, Corinne E Fischer, Victor Abler, Byron Creese, Maria Paula Gastiazoro, Adriana P Hermida, Manabu Ikeda, Zahinoor Ismail, Dilip V Jeste, Joanne McDermid, Kathryn Mills, Sanjeev Pathak, Susan Peschin, Anne Margriet Pot, Jacobo Mintzer, Mary Sano, Jeffrey Cummings, Clive Ballard","doi":"10.1016/j.inpsyc.2025.100133","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100133","url":null,"abstract":"<p><strong>Introduction: </strong>Psychosis is frequently observed in patients with neurodegenerative disease and may precede onset of cognitive symptoms. Additionally, the presence of psychosis in neurodegenerative disease is often associated with adverse effects including increased progression of cognitive decline and conversion to dementia, increased caregiver burden, and increased rates of placement in long-term care. Moreover, existing pharmacological treatments, which consist principally of off-label antipsychotic medications, may be associated with increased risk of harm, making management of symptoms challenging.</p><p><strong>Objective: </strong>We review recent advances in the field of psychosis in neurodegenerative disease, including advances in clinical criteria, biomarkers (neuroimaging, pathology, and genomic and epigenomics), and treatments.</p><p><strong>Method: </strong>Under the direction of the International Psychogeriatric Association (IPA), a task force comprised of experts in the field of psychosis in neurodegenerative disease was convened. An in-person meeting was organized in September 2024, coincident with the annual IPA Congress. The task force undertook a review of the literature in the areas of clinical care, biomarkers, and treatment, from which key recommendations for the management and future investigation of psychosis in neurodegenerative disease were derived.</p><p><strong>Results: </strong>It was concluded that psychosis in neurodegenerative disease has a characteristic phenomenology that despite sharing some features with schizophrenia spectrum psychotic disorders, may differ in other clinically meaningful aspects. Etiopathogenesis based on biomarker, genomic, and treatment studies may differ to some extent among neurodegenerative diseases. There is emerging evidence supporting the use of prescriptive non-pharmacological (WHELD intervention) and novel pharmacological (pimavanserin, muscarinic agonists) approaches in the treatment of psychosis in neurodegenerative disease.</p><p><strong>Conclusion: </strong>Future directions include the need for the implementation of evidence-based nonpharmacological treatments consistent with the aims of precision medicine, further investigation into novel pharmacological agents, mapping specific psychotic symptoms to specific biomarkers, and further exploration of the link between psychosis in neurodegenerative disease and other late-life psychoses.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100133"},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferring amyloid pathologies among patients with mild cognitive impairment using phase‒amplitude coupling of electroencephalography: A case‒control study.","authors":"Yuki Miyazaki, Masahiro Hata, Shun Takahashi, Ryohei Fukuma, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Hideki Kanemoto, Kenji Yoshiyama, Keiko Matsunaga, Kayako Isohashi, Haruhiko Kishima, Manabu Ikeda, Takufumi Yanagisawa","doi":"10.1016/j.inpsyc.2025.100132","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100132","url":null,"abstract":"<p><strong>Background: </strong>Early detection of Alzheimer's disease (AD) is crucial in the era of disease-modifying therapies (DMTs). While amyloid positron emission tomography (PET) is an important approach for detecting amyloid pathologies, the high cost and limited availability of this method have led to challenges in community-wide screening. Electroencephalography (EEG) is a low-cost, noninvasive method that may help to bridge this gap. Previous studies have suggested that certain EEG features, including phaseamplitude coupling (PAC), could reflect AD-related network abnormalities; however, it remains unclear whether PAC can serve as a reliable predictor of amyloid pathology.</p><p><strong>Methods: </strong>We analyzed resting-state EEGs from 61 participants with mild cognitive impairment (MCI) who underwent amyloid PET scans: 28 were PET-positive, and 33 were PET-negative. We examined PAC (synchronization indices) between low-frequency (delta, theta, alpha, beta) and high-gamma (70-100 Hz) activities. A naïve Bayes classifier with a stratified 10-fold cross-validation was used to predictor amyloid PET status.</p><p><strong>Results: </strong>Theta-high gamma PAC was lower in the PET-positive group, particularly at the posterior (P3) and occipital (O2) electrodes (p < 0.05). The classifier trained on the theta-high gamma PAC achieved a mean balanced accuracy of 64.6 % (95 % confidence interval = 0.599-0.693), which was significantly greater than chance, whereas the other bands were not predictive.</p><p><strong>Conclusions: </strong>Theta-high gamma PAC in resting-state EEG can distinguish amyloid PET-positive patients with MCI from PET-negative patients, thereby providing a feasible, noninvasive biomarker for AD pathology. Integrating PAC analysis into routine EEG could improve the early identification of individuals who qualify for DMTs, thereby facilitating timely intervention.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100132"},"PeriodicalIF":4.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI).","authors":"Nora Molina-Torres, Carlos Platero, Oscar Pérez-Berasategui, Pol Andrés-Benito, Mónica Povedano, Pilar Mesa-Lampré, María Abadía-Morales, Ana-Cristina Calvo, Antonio Lobo, Concepción De La Cámara-Izquierdo, Rosario Osta","doi":"10.1016/j.inpsyc.2025.100129","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100129","url":null,"abstract":"<p><strong>Background: </strong>This study intends to assess to what extent instruments commonly used in clinical practice, as well as plasma p-tau-181, can predict the progression from MCI to dementia. The usefulness of a disease progression model (DPM) is also explored.</p><p><strong>Methods: </strong>A longitudinal, prospective nested case-control study was conducted with patients from the Geriatrics outpatient clinics who met the MCI International Working Group criteria. The patients had a first clinical interview and two follow-ups after 12 and 24 months. Validated Spanish instruments were used for assessment, including the Mini-Mental State Examination (MMSE), the clock test, verbal fluency, the EURO-D depression scale, Barthel's Index, and Lawton's Index. P-tau-181 analysis was performed with SIMOA (Single MOlecule Array). A robust parametric disease progression model (RPDPM) was developed.</p><p><strong>Results: </strong>Fifty-nine patients fulfilled the inclusion criteria. The median age was 82.7 + /-8.7 years, 93 % had amnestic MCI and 45.8 % progressed to dementia (ICD-11 criteria) in two years. P-tau-181 was not prognostic. An RPDPM with the MMSE, clock test, and Lawton's Index could predict progression to dementia with an AUC of 0.945.</p><p><strong>Conclusion: </strong>A combination of the MMSE, clock test, and Lawton's Index in a DPM model predicted progression from MCI to dementia best. P-tau and other blood biomarkers did not predict progression. Our results highlight the strength of clinical variables to predict the progression of MCI.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100129"},"PeriodicalIF":4.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for neurocognitive disorders-From clinical trials to practical implementation.","authors":"Huali Wang","doi":"10.1016/j.inpsyc.2025.100131","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100131","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100131"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the vascular depression hypothesis: The role of intracranial atherosclerosis in post-CABG depression (NOAHS study results).","authors":"Mark A Oldham, Patrick Walsh, Joy J Choi, Hochang B Lee","doi":"10.1016/j.inpsyc.2025.100130","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100130","url":null,"abstract":"<p><strong>Background: </strong>Depression after coronary artery bypass graft (CABG) surgery is common and associated with worse outcomes. The Neuropsychiatric Outcomes After Heart Surgery (NOAHS) study evaluates the vascular depression hypothesis, which implicates cerebrovascular disease as a contributor to late-life depression, as applied to a CABG surgery cohort.</p><p><strong>Methods: </strong>We evaluate whether right or left middle cerebral artery (MCA) stenosis or its severity is associated with a greater risk of post-CABG depression. NOAHS was a prospective study of non-demented patients 40 years of age or older having CABG surgery. Depression was evaluated at baseline and monthly after surgery to 12 months. Transcranial Doppler (TCD) assessed intracranial atherosclerosis at baseline. We examined whether MCA stenosis predicted new-onset depression, adjusting for baseline characteristics.</p><p><strong>Results: </strong>In our sample (n = 148, average age 66.1, 75.7 % male), 11 % had baseline depression and 26 % had mild cognitive impairment (MCI). Perceived psychosocial support was high, with a mean score of 82.7 of 100 on the Medical Outcomes Study social support survey. Excluding those with baseline depression, 13 (16 %) developed new-onset depression. New-onset depression was associated with younger age, greater baseline functional impairment, lower perceived psychosocial support, MCI status, and prior depression. MCA stenosis and its severity was not associated with new-onset depression in any model; however, lower perceived psychosocial support did predict new-onset depression.</p><p><strong>Conclusions: </strong>We did not find an association between baseline MCA stenosis and new-onset depression after CABG. Instead, well established risk factors including lower perceived social support were more strongly associated with post-CABG depression.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100130"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor titled: \"Revisiting dementia findings in Nigeria's oldest old: A critical appraisal of long-term survivorship data\" by Brijesh Sathian, Javed Iqbal, Israel Nascimento and Hanadi Al Hamad.","authors":"Olusegun Baiyewu, Sujan Gao, Michael L Cuccaro, Olufisayo Elugbadebo, Margaret A Pericak-Vance","doi":"10.1016/j.inpsyc.2025.100111","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100111","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100111"},"PeriodicalIF":4.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response for: Possible errors in \"Electroconvulsive therapy in individuals with dementia/major NCD presenting with behavioral symptoms: A systematic review\" [Int Psychogeriatr 36 (2024) 864-879].","authors":"Anil K Bachu, Vijaya Padma Kotapati, Tejasvi Kainth, Rikinkumar Patel, Nagy A Youssef, Rajesh R Tampi","doi":"10.1016/j.inpsyc.2025.100084","DOIUrl":"10.1016/j.inpsyc.2025.100084","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100084"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences contribute to increased risk of health in middle and late life: The longitudinal mediating effect of activities of daily living and chronic diseases.","authors":"Yijun Liu, Zhe Zhao, Shiyin Tian, Shaojie Yu, Juanfang Zhu, Yuanyuan Yang, Qinqin Jiang, Jinhai Sun, Shengjun Wang, Lei Yuan","doi":"10.1016/j.inpsyc.2025.100117","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100117","url":null,"abstract":"<p><strong>Background: </strong>Adverse Childhood Experiences (ACEs) have long-term effects on health, but the mechanisms remain unclear.</p><p><strong>Objective: </strong>To investigate the association between ACEs and health status, exploring the potential mediating roles of activities of daily living (ADL) and chronic diseases.</p><p><strong>Participants and setting: </strong>9575 middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).</p><p><strong>Methods: </strong>Longitudinal analysis of 4 waves (2013-2018) data. ACEs were derived from 2014 self-report life history survey. Latent growth curve modeling assessed the mediating effect of ADL and chronic diseases on the relationship between ACEs and self-rated health (SRH).</p><p><strong>Results: </strong>Among the 9575 individuals (mean [standard deviation, SD] age, 58.12 [8.73] years; 5174 [54.04 %] were females), the average ACEs score was 2.27 (SD = 1.75). Individuals with higher ACEs reported lower baseline SRH (β = -0.156, P < .001) and greater decline over time (β = -0.075, P < .001). Mediation analysis indicated that both baseline and longitudinal changes in ADL and chronic diseases (intercept and slope) partially mediated the association between ACE and the intercept of SRH, while ADL (intercept and slope) and chronic diseases (slope) fully mediated the association between ACE and the slope of SRH.</p><p><strong>Conclusions: </strong>ACEs were associated with poorer health status and accelerated decline, partially mediated by impaired ADL and increased chronic diseases. Interventions targeting ACE reduction, enhancing ADL, and managing chronic diseases could effectively improve the health of middle-aged and older adults.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100117"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, loneliness, mild cognitive impairment and dementia in older adults.","authors":"Tomoyuki Kawada","doi":"10.1016/j.inpsyc.2025.100055","DOIUrl":"10.1016/j.inpsyc.2025.100055","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100055"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible errors in \"Electroconvulsive therapy in individuals with dementia/major NCD presenting with behavioral symptoms: A systematic review\" [Int Psychogeriatr 36 (2024) 864-879].","authors":"Eivind Aakhus","doi":"10.1016/j.inpsyc.2025.100060","DOIUrl":"10.1016/j.inpsyc.2025.100060","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100060"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}