International psychogeriatrics最新文献

{"title":"Transitions of loneliness and lonely life expectancy: A longitudinal study across 24 countries.","authors":"Jingjie Zhu, Zeyu Huang, Shitong Yang, Junjia Jiang, Huazhen You, Junling Gao","doi":"10.1016/j.inpsyc.2025.100134","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100134","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore individual- and country-level factors associated with loneliness' transitions and estimate total life expectancy (TLE) and lonely life expectancy (LLE) at age 60 across 24 countries.</p><p><strong>Design: </strong>This is a longitudinal study.</p><p><strong>Setting: </strong>Data were drawn from five harmonized multinational cohorts.</p><p><strong>Participants: </strong>This study included 61,511 older adults aged 60 and above MEASUREMENTS: A multistate Markov model was used to estimate the life expectancy of older adults in states of loneliness and non-loneliness, and factors associated with the state transition probabilities.</p><p><strong>Results: </strong>Female, low education, multimorbidity, and psychological disorders were associated with higher risk of transitioning from \"Not lonely\" to \"Lonely\", while physical activity was linked to recovery. Beyond individual-level factors, high GDP, civil society participation, and accessible public transport were linked to lower loneliness risk. However, civil society participation and transport access had limited effects on mortality. TLE for older adults aged 60 was 23.14 years, with a LLE of 4.31 years. Older adults in high-GDP countries had a 1.25-year longer TLE and a 2.40-year shorter LLE. Greater civil society participation was linked to a 0.75-year increase in TLE and a 2.78-year reduction in LLE. In contrast, higher urbanization was associated with a slightly longer TLE but a higher LLE. Public transport accessibility correlated with a significantly reduced LLE by 1.97 years.</p><p><strong>Conclusions: </strong>This study highlights the longitudinal associations between individual behaviors, socioeconomic factors and loneliness, offering valuable insights for promoting healthy aging globally.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100134"},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for management and future investigation of psychosis in neurodegenerative disease: Findings from the International Psychogeriatric Association (IPA) working group.","authors":"Andrew A Namasivayam, Corinne E Fischer, Victor Abler, Byron Creese, Maria Paula Gastiazoro, Adriana P Hermida, Manabu Ikeda, Zahinoor Ismail, Dilip V Jeste, Joanne McDermid, Kathryn Mills, Sanjeev Pathak, Susan Peschin, Anne Margriet Pot, Jacobo Mintzer, Mary Sano, Jeffrey Cummings, Clive Ballard","doi":"10.1016/j.inpsyc.2025.100133","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100133","url":null,"abstract":"<p><strong>Introduction: </strong>Psychosis is frequently observed in patients with neurodegenerative disease and may precede onset of cognitive symptoms. Additionally, the presence of psychosis in neurodegenerative disease is often associated with adverse effects including increased progression of cognitive decline and conversion to dementia, increased caregiver burden, and increased rates of placement in long-term care. Moreover, existing pharmacological treatments, which consist principally of off-label antipsychotic medications, may be associated with increased risk of harm, making management of symptoms challenging.</p><p><strong>Objective: </strong>We review recent advances in the field of psychosis in neurodegenerative disease, including advances in clinical criteria, biomarkers (neuroimaging, pathology, and genomic and epigenomics), and treatments.</p><p><strong>Method: </strong>Under the direction of the International Psychogeriatric Association (IPA), a task force comprised of experts in the field of psychosis in neurodegenerative disease was convened. An in-person meeting was organized in September 2024, coincident with the annual IPA Congress. The task force undertook a review of the literature in the areas of clinical care, biomarkers, and treatment, from which key recommendations for the management and future investigation of psychosis in neurodegenerative disease were derived.</p><p><strong>Results: </strong>It was concluded that psychosis in neurodegenerative disease has a characteristic phenomenology that despite sharing some features with schizophrenia spectrum psychotic disorders, may differ in other clinically meaningful aspects. Etiopathogenesis based on biomarker, genomic, and treatment studies may differ to some extent among neurodegenerative diseases. There is emerging evidence supporting the use of prescriptive non-pharmacological (WHELD intervention) and novel pharmacological (pimavanserin, muscarinic agonists) approaches in the treatment of psychosis in neurodegenerative disease.</p><p><strong>Conclusion: </strong>Future directions include the need for the implementation of evidence-based nonpharmacological treatments consistent with the aims of precision medicine, further investigation into novel pharmacological agents, mapping specific psychotic symptoms to specific biomarkers, and further exploration of the link between psychosis in neurodegenerative disease and other late-life psychoses.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100133"},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI).","authors":"Nora Molina-Torres, Carlos Platero, Oscar Pérez-Berasategui, Pol Andrés-Benito, Mónica Povedano, Pilar Mesa-Lampré, María Abadía-Morales, Ana-Cristina Calvo, Antonio Lobo, Concepción De La Cámara-Izquierdo, Rosario Osta","doi":"10.1016/j.inpsyc.2025.100129","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100129","url":null,"abstract":"<p><strong>Background: </strong>This study intends to assess to what extent instruments commonly used in clinical practice, as well as plasma p-tau-181, can predict the progression from MCI to dementia. The usefulness of a disease progression model (DPM) is also explored.</p><p><strong>Methods: </strong>A longitudinal, prospective nested case-control study was conducted with patients from the Geriatrics outpatient clinics who met the MCI International Working Group criteria. The patients had a first clinical interview and two follow-ups after 12 and 24 months. Validated Spanish instruments were used for assessment, including the Mini-Mental State Examination (MMSE), the clock test, verbal fluency, the EURO-D depression scale, Barthel's Index, and Lawton's Index. P-tau-181 analysis was performed with SIMOA (Single MOlecule Array). A robust parametric disease progression model (RPDPM) was developed.</p><p><strong>Results: </strong>Fifty-nine patients fulfilled the inclusion criteria. The median age was 82.7 + /-8.7 years, 93 % had amnestic MCI and 45.8 % progressed to dementia (ICD-11 criteria) in two years. P-tau-181 was not prognostic. An RPDPM with the MMSE, clock test, and Lawton's Index could predict progression to dementia with an AUC of 0.945.</p><p><strong>Conclusion: </strong>A combination of the MMSE, clock test, and Lawton's Index in a DPM model predicted progression from MCI to dementia best. P-tau and other blood biomarkers did not predict progression. Our results highlight the strength of clinical variables to predict the progression of MCI.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100129"},"PeriodicalIF":4.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for neurocognitive disorders-From clinical trials to practical implementation.","authors":"Huali Wang","doi":"10.1016/j.inpsyc.2025.100131","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100131","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100131"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor titled: \"Revisiting dementia findings in Nigeria's oldest old: A critical appraisal of long-term survivorship data\" by Brijesh Sathian, Javed Iqbal, Israel Nascimento and Hanadi Al Hamad.","authors":"Olusegun Baiyewu, Sujan Gao, Michael L Cuccaro, Olufisayo Elugbadebo, Margaret A Pericak-Vance","doi":"10.1016/j.inpsyc.2025.100111","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100111","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100111"},"PeriodicalIF":4.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response for: Possible errors in \"Electroconvulsive therapy in individuals with dementia/major NCD presenting with behavioral symptoms: A systematic review\" [Int Psychogeriatr 36 (2024) 864-879].","authors":"Anil K Bachu, Vijaya Padma Kotapati, Tejasvi Kainth, Rikinkumar Patel, Nagy A Youssef, Rajesh R Tampi","doi":"10.1016/j.inpsyc.2025.100084","DOIUrl":"10.1016/j.inpsyc.2025.100084","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100084"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences contribute to increased risk of health in middle and late life: The longitudinal mediating effect of activities of daily living and chronic diseases.","authors":"Yijun Liu, Zhe Zhao, Shiyin Tian, Shaojie Yu, Juanfang Zhu, Yuanyuan Yang, Qinqin Jiang, Jinhai Sun, Shengjun Wang, Lei Yuan","doi":"10.1016/j.inpsyc.2025.100117","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100117","url":null,"abstract":"<p><strong>Background: </strong>Adverse Childhood Experiences (ACEs) have long-term effects on health, but the mechanisms remain unclear.</p><p><strong>Objective: </strong>To investigate the association between ACEs and health status, exploring the potential mediating roles of activities of daily living (ADL) and chronic diseases.</p><p><strong>Participants and setting: </strong>9575 middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).</p><p><strong>Methods: </strong>Longitudinal analysis of 4 waves (2013-2018) data. ACEs were derived from 2014 self-report life history survey. Latent growth curve modeling assessed the mediating effect of ADL and chronic diseases on the relationship between ACEs and self-rated health (SRH).</p><p><strong>Results: </strong>Among the 9575 individuals (mean [standard deviation, SD] age, 58.12 [8.73] years; 5174 [54.04 %] were females), the average ACEs score was 2.27 (SD = 1.75). Individuals with higher ACEs reported lower baseline SRH (β = -0.156, P < .001) and greater decline over time (β = -0.075, P < .001). Mediation analysis indicated that both baseline and longitudinal changes in ADL and chronic diseases (intercept and slope) partially mediated the association between ACE and the intercept of SRH, while ADL (intercept and slope) and chronic diseases (slope) fully mediated the association between ACE and the slope of SRH.</p><p><strong>Conclusions: </strong>ACEs were associated with poorer health status and accelerated decline, partially mediated by impaired ADL and increased chronic diseases. Interventions targeting ACE reduction, enhancing ADL, and managing chronic diseases could effectively improve the health of middle-aged and older adults.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100117"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter regarding \"The effect of study partner characteristics on the reporting of neuropsychiatric symptoms across the neurocognitive spectrum\".","authors":"Dylan X Guan, Zahinoor Ismail","doi":"10.1016/j.inpsyc.2024.100030","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100030","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 4","pages":"100030"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal support to the sociocultural stress and coping model. A 4-year follow-up of family caregivers of people with dementia.","authors":"Andrés Losada-Baltar, María Márquez-González, Brent T Mausbach, Lucía Jiménez-Gonzalo, José A Fernandes-Pires, Javier Olazarán, Laura García-García, Laura Gallego-Alberto, Isabel Cabrera","doi":"10.1016/j.inpsyc.2025.100079","DOIUrl":"10.1016/j.inpsyc.2025.100079","url":null,"abstract":"<p><strong>Objectives: </strong>According to the sociocultural stress-and-coping model for family caregivers, caregiving stressors contribute directly to caregivers' distress. In addition, there is another path to explain this distress, as several cultural (e.g., familism) and cognitive variables (e.g., dysfunctional thoughts) have important intermediate roles in the pathway from stress to distress. In particular, coping variables appear to play important intermediary roles in this pathway. The aim of this study was to provide longitudinal support to this two-paths stress and coping model.</p><p><strong>Methods: </strong>Participants were 304 dementia family caregivers who were interviewed yearly during a 4-year period (5 assessment points). Sociodemographic variables, stressors, familism, dysfunctional thoughts about caregiving, cognitive fusion, leisure engagement, ambivalence, guilt and depressive symptoms were measured. The paths established by the sociocultural stress and coping model were tested.</p><p><strong>Results: </strong>Greater cognitive fusion, greater reaction to BPSD, increased ambivalence, increased guilt, and reduced engagement in leisure activities were associated with greater experience of depressive symptoms. However, cultural and cognitive variables (i.e., familism and dysfunctional thoughts) did not show a direct association with depressive symptoms but were associated with increased cognitive fusion and reduced engagement in leisure activities. Overall, the stress-and-coping model explained 52.45 % of the variance in depressive symptoms through the 4-year study period.</p><p><strong>Discussion: </strong>This study provides longitudinal support to the two-paths proposed by the sociocultural stress and coping model. Specifically, cultural and cognitive factors are more distally related to caregiver outcomes via their association with coping variables, which in turn appear proximally related to caregiver distress (i.e., depressive symptoms).</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100079"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, loneliness, mild cognitive impairment and dementia in older adults.","authors":"Tomoyuki Kawada","doi":"10.1016/j.inpsyc.2025.100055","DOIUrl":"10.1016/j.inpsyc.2025.100055","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100055"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}