International psychogeriatrics最新文献

{"title":"Failure to recover from proactive semantic interference predicts trajectory of decline in everyday function among older adults with amnestic mild cognitive impairment.","authors":"D Diane Zheng, Rosie E Curiel Cid, Alexandra Ortega, Elizabeth A Crocco, David Vaillancourt, Melissa J Armstrong, Breton Asken, Steven T DeKosky, Malek Adjouadi, Glenn Smith, Ranjan Duara, Michael Marsiske, Monica Rosselli, Warren W Barker, David A Loewenstein","doi":"10.1016/j.inpsyc.2024.100005","DOIUrl":"10.1016/j.inpsyc.2024.100005","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the predictive utility of proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) deficits on the longitudinal everyday functional decline on the Clinical Dementia Rating Sum of Boxes (CDR-SOB) among older adults with amnestic mild cognitive impairment (aMCI).</p><p><strong>Design: </strong>Longitudinal prospective cohort study.</p><p><strong>Setting: </strong>1Florida Alzheimer's Disease Research Center (1FLADRC).</p><p><strong>Participants: </strong>97 older adults aged 54 to 98 years who were diagnosed with aMCI following a baseline evaluation. The average age was 71.9 years, 51 % male, average education 15.7 years, and 56 % Hispanic. The mean MMSE score was 28.0. Participants were followed annually for 3 to 4 visits with a mean follow-up time of 38.9 months (range 22.7 to 70.3 months).</p><p><strong>Measurements: </strong>CDR-SOB were obtained at each visit and the latent growth curve trajectory of CDR-SOB was estimated. The associations between PSI and frPSI and the growth curve trajectory of CDR-SOB were examined.</p><p><strong>Results: </strong>The growth curve model that best fits the CDR-SOB trajectory was a linear form and included the fixed and random effect of intercept and slope of time. After adjusting for age, sex, education, Hispanic background, Hopkins Verbal Learning Test (HVLT) immediate and delayed recall, and amyloid positivity, frPSI (β = -0.134, se=0.04, p < 0.01) remained statistically significant in predicting a steeper slope on the trajectory of decline in CDR-SOB.</p><p><strong>Conclusions: </strong>frPSI at baseline predicted the rate of everyday functional decline over time among participants with aMCI regardless of amyloid status and demonstrated its utility of longitudinal prediction of change in CDR-SOB.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100005"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive remediation for patients with late-life schizophrenia: A follow-up pilot study.","authors":"Angela C Golas, Bishoy M Elgallab, Petal S Abdool, Christopher R Bowie, Tarek K Rajji","doi":"10.1016/j.inpsyc.2024.100006","DOIUrl":"10.1016/j.inpsyc.2024.100006","url":null,"abstract":"<p><strong>Objectives: </strong>The number of older adults with schizophrenia (\"late-life schizophrenia\" (LLS)) is growing with the aging of the general population. Cognitive impairment in adults with LLS predicts functioning. Cognitive remediation (CR) improves cognition in schizophrenia, however literature in LLS is sparse. Anticholinergic burden (ACB) impacts CR effects. We previously showed that CR is feasible in LLS but did not produce a promising cognitive effect. This study examined the feasibility, tolerability, and effect of an intensive, prolonged and flexible CR on overall and specific cognitive functions in LLS. We also assessed ACB impact on CR effect on global cognition.</p><p><strong>Design: </strong>Pre-post intervention SETTING PARTICIPANTS: Tertiary care outpatients with LLS INTERVENTION: We adapted the CR protocol from our previous pilot study, providing CR over 24, twice-weekly, therapist-guided group sessions that combined computerized drill-and-practice exercises with skills transference strategies, with additional time allocated for exercise practice.</p><p><strong>Measurements: </strong>We assessed participants at baseline and at study completion using clinical and cognitive measures.</p><p><strong>Results: </strong>Thirty-four participants (mean (SD) age = 65.8 (5.7)) attended at least one CR session, 25 participants completed baseline and follow-up assessments, and 20 participants completed at least 75 % of the CR sessions. There was no time effect on global cognition, although there was an interaction with ACB. There was also a pattern of improvement in executive function across several cognitive tests.</p><p><strong>Conclusions: </strong>An intensive, prolonged and flexible CR was feasible and well-tolerated, showing promise in improving executive function of patients with LLS. Larger and randomized controlled trials are needed in this population.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100006"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between changes in apathy and cognition in Alzheimer's disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).","authors":"Krushnaa Sankhe, Shankar Tumati, Jamie Perin, Luc Rivet, Danielle Vieira, Paul B Rosenberg, Nathan Herrmann, David Shade, Alan J Lerner, Prasad R Padala, Olga Brawman-Mintzer, Christopher H van Dyck, Anton P Porsteinsson, Suzanne Craft, Allan I Levey, Jacobo Mintzer, Krista L Lanctôt","doi":"10.1016/j.inpsyc.2024.100012","DOIUrl":"10.1016/j.inpsyc.2024.100012","url":null,"abstract":"<p><strong>Background: </strong>Previous trials have shown improvements in both apathy and cognition with methylphenidate (MPH).</p><p><strong>Objectives: </strong>To assess whether changes in apathy correlated with changes in cognition in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).</p><p><strong>Participants: </strong>Mild to moderate AD patients with clinically significant apathy randomized to MPH (20 mg/day) or placebo for 6 months.</p><p><strong>Measurements: </strong>Apathy was measured with the Neuropsychiatric Inventory-apathy (NPI-A) domain. Cognition was measured using the Mini-Mental State Exam (MMSE), Hopkins Verbal Learning (immediate [HVLT-I], delayed [HVLT-D] recall), Digit Span (Forward [DF], Backward [DB]), Trail Making (TMT-A, TMT-B), Action Verbal Fluency (AV), Category Fluency (CF), and the Short Boston Naming Test (BNT).</p><p><strong>Design: </strong>Linear mixed models included cognitive change scores as dependent variables and time, treatment, change in NPI-A and the interaction between treatment and change in NPI-A as independent variables, which were additionally adjusted for baseline NPI-A and cognitive scores, age, sex, level of education and presence of diabetes.</p><p><strong>Results: </strong>199 participants (66 % male) were included (98-MPH, 101-placebo). Among all participants, worsening CF was associated with worsening apathy (-0.15 (0.05), p = .003). In addition, change in HVLT-I was associated with the interaction between changes in apathy and treatment (-0.31 (0.07), p = 0.0000158).</p><p><strong>Conclusion: </strong>Changes in apathy are mostly independent of cognitive changes and apathy response to MPH may be independent from cognition. These results are consistent with the view that apathy as a syndrome is related to but distinct from cognition.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100012"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic influence of mood on subjective cognitive complaints in mild cognitive impairment: A time series network analysis approach.","authors":"Varsha D Badal, Laura M Campbell, Colin A Depp, Emma M Parrish, Robert A Ackerman, Raeanne C Moore, Philip D Harvey, Amy E Pinkham","doi":"10.1016/j.inpsyc.2024.100007","DOIUrl":"10.1016/j.inpsyc.2024.100007","url":null,"abstract":"<p><strong>Objectives: </strong>Subjective cognitive complaints (SCC) are common and clinically relevant in mild cognitive impairment (MCI) but are intertwined with mood states. Using Ecological Momentary Assessment (EMA) of SCC and network analyses we sought to uncover the links between mood and SCC and how these links may vary by the presence or absence of MCI.</p><p><strong>Design: </strong>We used EMA to collect intensive longitudinal data. In addition to analyzing the data at an aggregate level to estimate between-person associations of affect and SCC variables, we used time series analyses to estimate contemporaneous and time-lagged relations between the variables.</p><p><strong>Setting: </strong>EMA survey and mobile cognitive testing in subjects' natural environments.</p><p><strong>Participants: </strong>The sample included 100 participants, 48 with Normal Cognition (NC), and 52 with MCI.</p><p><strong>Measurements: </strong>Participants completed 30-day EMA protocols in which surveys sampling SCC and moods were delivered 3 times per day.</p><p><strong>Results: </strong>The association between SCC (as measured by EMA) and standard in-lab measures of SCC was significant in MCI, but not in NC. Despite no average level differences in severity of SCC, there was a strong association between negative affect (as measured by EMA) with SCC in NCs compared to MCI.</p><p><strong>Conclusions: </strong>EMA maybe a useful and valid approach to measuring SCCs in MCI. Network analyses indicated that negative affect was linked with later SCCs. This finding was strong in persons with NC than in persons with MCI. The basis of the attenuated association between negative affect and SCCs in MCI deserves further study.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100007"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding to \"The effect of study partner characteristics on the reporting of neuropsychiatric symptoms across the neurocognitive spectrum\".","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.1016/j.inpsyc.2024.100028","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100028","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100028"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with loneliness in a national study among persons 80 years and older in India in 2017-2018.","authors":"Supa Pengpid, Karl Peltzer, André Hajek, Razak M Gyasi","doi":"10.1016/j.inpsyc.2024.100019","DOIUrl":"10.1016/j.inpsyc.2024.100019","url":null,"abstract":"<p><strong>Objectives: </strong>This study's objective was to determine the variables linked to loneliness in Indian adults 80 years of age and above (as well as stratified by sex).</p><p><strong>Design: </strong>Cross-sectional survey of the 2017-2018 Longitudinal Ageing Study in India (LASI) SETTING: Community-dwelling nationally representative population in India.</p><p><strong>Participants: </strong>The analytic sample included 3163 community-dwelling individuals ≥ 80 years (excluding proxy interviews).</p><p><strong>Measurements: </strong>A single item was used to measure loneliness. We employed multiple linear regressions (with social, health, and demographic variables as explanatory variables).</p><p><strong>Results: </strong>Regressions found that higher food insecurity, higher perceived discrimination, higher functional disability, female sex, and lower life satisfaction increased the odds of higher loneliness among the oldest-old. The sex-stratified analysis found similar results.</p><p><strong>Conclusions: </strong>Several demographic, health, and social-related factors were identified as being associated with higher loneliness. These factors can be targeted in addressing the onset and progression of loneliness in later life, particularly among the oldest old.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100019"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients.","authors":"Dickson Olusegun Adedeji, Jasper Holleman, Lena Johansson, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Ulrika Akenine, Marieclaire Overton, Alina Solomon, Miia Kivipelto, Shireen Sindi, Simona F Sacuiu","doi":"10.1016/j.inpsyc.2024.100009","DOIUrl":"10.1016/j.inpsyc.2024.100009","url":null,"abstract":"<p><strong>Objective: </strong>Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.</p><p><strong>Design: </strong>Longitudinal observational study.</p><p><strong>Setting: </strong>Memory clinic, Karolinska University Hospital, Stockholm, Sweden.</p><p><strong>Participants: </strong>Consecutive patients (n = 162) who agreed to take part in the Cortisol and Stress in AD (Co-STAR) study during 2014-2017 and had data available for variables of interest.</p><p><strong>Measurements: </strong>Participants rated their depressive symptoms using the Geriatric Depression Scale (GDS) and collected diurnal salivary cortisol samples at home. Cognitive performance was assessed by standardized cognitive tests in the following domains: memory, working memory, processing speed, perceptual reasoning, and general cognitive function. Dementia, mild cognitive impairment (MCI), and subjective cognitive decline (SCD) were diagnosed as part of the clinical work-up. We determined the associations between GDS and cognitive domain scores using linear regressions, including cortisol levels as covariates. We also tested if cerebrospinal fluid (CSF) AD biomarkers amyloid β42 (Aβ42) and tau proteins modified these associations.</p><p><strong>Results: </strong>The GDS score was negatively associated with performance in working memory and processing speed, independently of cortisol levels. These associations were no longer significant after introducing AD biomarkers as covariates. Baseline GDS score was not associated with change in memory or processing speed at follow-up.</p><p><strong>Conclusions: </strong>The underlying amyloid pathology may affect the association between depressive symptoms and cognitive performance in memory clinic patients.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100009"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computerized functional skills training and the importance of early errors during training.","authors":"Dylan J Jester, Jeonghyun Shin","doi":"10.1016/j.inpsyc.2024.100024","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2024.100024","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100024"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans.","authors":"Joan M Cook, Michelle J Bovin, Mia Maria Günak, Karen A Lawrence, Robert H Pietrzak","doi":"10.1016/j.inpsyc.2024.100027","DOIUrl":"10.1016/j.inpsyc.2024.100027","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the psychometric properties of an assessment measure for posttraumatic stress disorder (PTSD) that corresponds with the current version of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) in older adults.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Nationally representative web-based survey (National Health and Resilience in Veterans Study; NHRVS) between November 18, 2019 and March 8, 2020.</p><p><strong>Participants: </strong>A total of 3001 veterans aged 60 years and older (mean age=73.2 years) MEASUREMENTS: PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5).</p><p><strong>Results: </strong>PCL-5 scores demonstrated excellent internal consistency, and strong convergent and discriminant validity. Veterans who met criteria for probable PTSD and subthreshold PTSD had higher rates of childhood and adult trauma exposure than those who did not meet criteria for either of these groups. A recently proposed 8-factor model provided the best fit to item-level PCL-5 data, with dysphoric (i.e., anhedonia, dysphoric arousal) symptoms having the strongest most consistent associations with measures of functioning.</p><p><strong>Conclusions: </strong>This is the first known study to examine the psychometric properties of the PCL-5 among older veterans. Results indicate that the PCL-5 is a reliable and valid instrument for use with community-dwelling older veterans. The finding that dysphoric symptoms of PTSD were most consistently linked to measures of functioning underscores the importance of targeting these symptoms as part of prevention, assessment, and treatment efforts in this population.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 2","pages":"100027"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of neurocognitive functioning with behavioral pathology in older adults.","authors":"Dilip V Jeste","doi":"10.1016/j.inpsyc.2025.100047","DOIUrl":"10.1016/j.inpsyc.2025.100047","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100047"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}