International Journal of Psychiatry in Clinical Practice最新文献

The D-stress scale: a measure of stress based on a new approach. d -应力量表：一种基于新方法的应力测量。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-30 DOI: 10.1080/13651501.2025.2560350

Jean-Luc Ducher, Damien Fouques, Stéphane Locret, Lucia Romo

{"title":"The D-stress scale: a measure of stress based on a new approach.","authors":"Jean-Luc Ducher, Damien Fouques, Stéphane Locret, Lucia Romo","doi":"10.1080/13651501.2025.2560350","DOIUrl":"https://doi.org/10.1080/13651501.2025.2560350","url":null,"abstract":"Background: The perceived stress scale (PSS-10) assumes that stress results from perceived situational demands exceeding the perceived coping resources. However, today's hectic lifestyles may lead to stress even when demands can be met. We aimed to assess a new measure of stress, the D-Stress scale, which focuses on feelings of relentless pressure, irrespective of the coping resources.Methods: We administered our 10-item questionnaire to 1099 French-speaking adults (455 men, 642 women), aged 18-29 years, using an online platform (May-July 2022). Participants also completed the PSS-10 and measures of depression (PHQ-9) and anxiety (GAD-7). Exploratory and confirmatory factor analyses and correlations were run.Results: The D-Stress scores correlated highly with the PSS-10 perceived helplessness subscale (r = 0.714; 95% CI [0.684-0.742]), thus supporting the construct validity. The exploratory factor analysis revealed three underlying factors: one that related to experiencing external pressures (subscale 1), another that related to putting pressure on oneself (subscale 2), and a third that related to exhaustion (subscale 3). Subscale 1 was most strongly linked to depression/anxiety; the other two subscales were more strongly linked to demographic characteristics.Conclusion: The D-Stress scale can rapidly assess stress and could identify underlying sources to help target interventions.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of patients starting treatment with second-generation antipsychotics: insights from a European retrospective real-world analysis. 开始使用第二代抗精神病药物治疗的患者的管理：来自欧洲回顾性现实世界分析的见解。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-29 DOI: 10.1080/13651501.2025.2564789

Giancarlo Cerveri, Claudio Mencacci, Alessandro Ruggieri, Valeria Pegoraro, Riccardo Cipelli, Clara Bagatin, Simona Barzaghi, Alessandro Lovera, Irene Gabarda Inat, Alessandro Comandini, Agnese Cattaneo

{"title":"Management of patients starting treatment with second-generation antipsychotics: insights from a European retrospective real-world analysis.","authors":"Giancarlo Cerveri, Claudio Mencacci, Alessandro Ruggieri, Valeria Pegoraro, Riccardo Cipelli, Clara Bagatin, Simona Barzaghi, Alessandro Lovera, Irene Gabarda Inat, Alessandro Comandini, Agnese Cattaneo","doi":"10.1080/13651501.2025.2564789","DOIUrl":"https://doi.org/10.1080/13651501.2025.2564789","url":null,"abstract":"Objectives: Understanding real-life management of mental health disorders is crucial for enabling effective social and healthcare interventions. This retrospective real-world study investigated differences in the management of young adults (<30 years) and adults (≥30 years) starting treatment with second-generation antipsychotics (SGAs) in Italy, Spain and Poland.Methods: Patients' characteristics, treatment and safety profile and healthcare resource utilisation were analysed from general practitioners' and psychiatrists' electronic medical records and from pharmacy prescription records. The main analysis was stratified by age, but stratification by SGA molecule and a focus on subjects with schizophrenia were also provided.Results: A total of 530,587 subjects started treatment with SGAs. Throughout data sources, young adults accounted for from 17.8% to 30.2%; women were more represented among adults, who also had higher proportions of comorbid conditions. Young adults showed higher frequencies of switches (from 4.7% to 11.0% for young adults and from 2.9% to 8.6% for adults) and add-ons (from 2.5% to 5.6% for young adults and from 1.7% to 5.0% for adults) and exhibited slightly better adherence/persistence with the initial SGA.Conclusions: Distinct management behaviours were identified depending on age. A nuanced approach integrating tailored therapeutic strategies is needed to optimise long-term outcomes for patients requiring treatment with SGAs.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between the Montgomery-Åsberg Depression Rating Scale and Sheehan Disability Scale in patients with bipolar depressive episodes. Montgomery-Åsberg抑郁评定量表与Sheehan残疾评定量表在双相抑郁发作患者中的关系。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-22 DOI: 10.1080/13651501.2025.2560353

Hidehiro Oshibuchi, Hiroshi Nakamura, Kazumasa Yoshida, Jun Ishigooka, Katsuji Nishimura

{"title":"Relationship between the Montgomery-Åsberg Depression Rating Scale and Sheehan Disability Scale in patients with bipolar depressive episodes.","authors":"Hidehiro Oshibuchi, Hiroshi Nakamura, Kazumasa Yoshida, Jun Ishigooka, Katsuji Nishimura","doi":"10.1080/13651501.2025.2560353","DOIUrl":"https://doi.org/10.1080/13651501.2025.2560353","url":null,"abstract":"Objective: To examine the relationship between depressive symptoms and daily functioning among patients with bipolar depression using the Montgomery-Åsberg Depression Rating Scale (MADRS) and Sheehan Disability Scale (SDS).Methods: A post-hoc analysis was conducted using data from a placebo-controlled study of lurasidone involving 399 patients with bipolar depression. Pearson's correlation coefficient was used to analyse the correlation between the MADRS and SDS total scores. Receiver operating characteristic (ROC) analysis determined the MADRS cut-off score for adequate functional improvement, defined as all SDS subscale scores ≤2.Results: The MADRS and SDS scores were positively correlated (r = 0.764). The ROC analysis yielded a MADRS cut-off score of 15.5 for adequate functional improvement with 86.9% sensitivity and 75.9% specificity. The wide distribution of the relationship observed between symptoms and functioning indicated diversity in treatment responsiveness in bipolar depression.Conclusions: Depressive symptoms and daily functioning are correlated; however, this relationship is not straightforward, highlighting the need for evaluating symptoms and functioning separately. Importantly, direct application of the statistical MADRS threshold in clinical practice may be inappropriate for estimating SDS-based functioning. Further research is needed to establish norms linking levels of symptoms and functioning in bipolar depression.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asenapine for aggressive behaviours in psychiatric disorders: a systematic review of efficacy and real-world effectiveness. 阿塞那平治疗精神疾病中的攻击行为：疗效和现实世界有效性的系统综述。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-18 DOI: 10.1080/13651501.2025.2560357

Mauro Scala, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti

{"title":"Asenapine for aggressive behaviours in psychiatric disorders: a systematic review of efficacy and real-world effectiveness.","authors":"Mauro Scala, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti","doi":"10.1080/13651501.2025.2560357","DOIUrl":"https://doi.org/10.1080/13651501.2025.2560357","url":null,"abstract":"Background: Clinical decision-making for the pharmacological treatment of aggressive behaviour in psychiatry remains challenging. Asenapine, a second-generation antipsychotic with a higher affinity for dopamine D4 than for D2 receptors, may become a treatment option, although this remains to be demonstrated.Methods: A systematic search was conducted across biomedical databases according to PRISMA Reporting Items for Systematic Review. We aimed to examine the efficacy and effectiveness of asenapine in the management of aggressive behaviours including psychomotor agitation, hostility, irritability, anger, impulsivity, self-harm, behavioural disinhibition, as well as physical and verbal aggression, across psychiatric disorders.Results: Of the 12 studies included, four reported asenapine's efficacy in aggressive behaviours compared to placebo, and five described the effectiveness in uncontrolled settings. Three studies found no advantages over olanzapine. Major evidence supports asenapine's efficacy in reducing psychomotor agitation and hostility, with benefits independent of its anti-manic and antipsychotic effects.Conclusion: Asenapine may be a viable option for the treatment of psychomotor agitation and hostility, although more head-to-head trials are needed to clarify its efficacy relative to other antipsychotics. Since the evidence of efficacy in other aggressive domains and diagnoses is still limited, clinicians should primarily consider the tolerability profile to guide their prescription.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin usage in the treatment of risperidone induced hyperprolactinemia in an adolescent patient with bipolar disorder type 1: a case report. 二甲双胍用于治疗利培酮诱导的1型青少年双相情感障碍患者的高泌乳素血症：1例报告。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-17 DOI: 10.1080/13651501.2025.2563341

Ece Topkaya, Oğuz Bilal Karakuş

{"title":"Metformin usage in the treatment of risperidone induced hyperprolactinemia in an adolescent patient with bipolar disorder type 1: a case report.","authors":"Ece Topkaya, Oğuz Bilal Karakuş","doi":"10.1080/13651501.2025.2563341","DOIUrl":"https://doi.org/10.1080/13651501.2025.2563341","url":null,"abstract":"Antipsychotic drugs are used in the treatment of many mental disorders, especially psychotic disorders, bipolar disorders and neurodevelopmental disorders in children and adolescents. Antipsychotics, along with their effectiveness in treatment, have also been associated with a number of adverse effects. One of these is hyperprolactinaemia (hyperPRL) that occurs with antipsychotics. This situation is thought to be due to dopamine blockade in the tuberoinfundibular pathway, which has an effect on prolactin release. Hereby, we present a 15 year old female adolescent bipolar disorder type 1 case who developed hyperprolactinaemia with risperidone treatment which was ameliorated with metformin use (850-2000 mg/day). Although there are studies showing that metformin can be used in the treatment of hyperprolactinaemia, as far as we know, there are not enough studies on the use of metformin in adolescents. Future studies are needed to elucidate the risk factors, aetiological mechanism and treatment alternatives of this adverse effect, which occurs due to antipsychotics and may negatively affect medication compliance.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-3"},"PeriodicalIF":2.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of IL-1β, IL-6, and inflammatory markers during exacerbation and after antipsychotic treatment in drug-free schizophrenia patients. 无药精神分裂症患者病情加重期间和抗精神病治疗后IL-1β、IL-6和炎症标志物的评估

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-16 DOI: 10.1080/13651501.2025.2560349

Salih Kalyoncu, Hasan Mervan Aytac, Oya Guclu

{"title":"Evaluation of IL-1β, IL-6, and inflammatory markers during exacerbation and after antipsychotic treatment in drug-free schizophrenia patients.","authors":"Salih Kalyoncu, Hasan Mervan Aytac, Oya Guclu","doi":"10.1080/13651501.2025.2560349","DOIUrl":"https://doi.org/10.1080/13651501.2025.2560349","url":null,"abstract":"Objective: This study aimed to compare interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and inflammatory markers from the complete blood count in drug-free male schizophrenia (SCZ) patients during acute exacerbation with healthy controls and to evaluate changes after treatment.Method: Sixty-one drug-free male SCZ patients hospitalised in an inpatient clinic and 61 healthy controls were included. Sociodemographic data, body measurements, and some scale scores were collected. Blood samples were drawn after 10-12 h of fasting to measure inflammatory parameters in patients (pre- and post-treatment) and controls.Results: Compared to the control group, patients exhibited significantly higher neutrophil counts (5.13 vs. 4.51 × 10³/μL), neutrophil-to-lymphocyte ratio (2.43 vs. 1.85), C-reactive protein (CRP) (3.18 vs. 1.63 mg/L), and erythrocyte sedimentation rate (ESR) (5.57 vs. 3.20 mm/hr), while eosinophil levels (0.17 vs. 0.25 × 10³/μL) were significantly lower. Logistic regression indicated that eosinophil, CRP, and ESR predicted SCZ diagnosis. In the post-treatment period, IL-1β (2.65 to 1.61 ng/L) and IL-6 levels (1.42 to 0.92 ng/L) were significantly lower, while eosinophil levels (0.17 to 0.29 × 10³/μL) were significantly higher compared to the pre-treatment period.Conclusion: Reductions in IL-1β and IL-6 after antipsychotic treatment support inflammatory processes in SCZ. Eosinophil, CRP, and ESR may serve as peripheral biomarkers .","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical validation of a Chinese translation of the parent tic questionnaire. 父母抽噎问卷中文翻译的临床验证。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-11 DOI: 10.1080/13651501.2025.2553313

Qinyu Li, Yingying Cai, Rong Chen, Duan Lin, Jiqiang Xie, Yanting Lu, Yajun Tang, Xiumei Liu

{"title":"Clinical validation of a Chinese translation of the parent tic questionnaire.","authors":"Qinyu Li, Yingying Cai, Rong Chen, Duan Lin, Jiqiang Xie, Yanting Lu, Yajun Tang, Xiumei Liu","doi":"10.1080/13651501.2025.2553313","DOIUrl":"https://doi.org/10.1080/13651501.2025.2553313","url":null,"abstract":"Background: The Yale Global Tic Severity Scale (YGTSS), although extensively utilised in China for evaluating tic disorders (TD), relies exclusively on clinician-administered assessments. At present, no parent-report instruments validated in the Chinese context are available for assessing tics. The Parent Tic Questionnaire (PTQ), originally developed as the first parent-rated tool for TD symptom evaluation, has yet to undergo validation in any Asian language.Methods: A total of 414 children and adolescents aged 2-16 years with a TD diagnosis were recruited. The PTQ, YGTSS, Conners' Parent Rating Scale (CPRS-48) and Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) were administered to examine the psychometric characteristics of the PTQ.Results: Cronbach's alpha coefficients for the PTQ motor, vocal and total tic subscales were 0.789, 0.821 and 0.849, indicating satisfactory internal consistency. Strong correlations were observed between PTQ total scores and YGTSS scores. A cut-off score of 14 on the PTQ emerged as the most appropriate threshold for differentiating between mild and moderate TD. The content validity index further demonstrated high validity for the Chinese PTQ.Conclusions: The validated Chinese version of the PTQ exhibits robust psychometric properties and provides clinically informative metrics for tic severity stratification, establishing a foundation for score standardisation in routine assessments.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment effectiveness for comorbid anorexia nervosa and obsessive-compulsive disorder: a systematic review. 神经性厌食症合并强迫症的治疗效果：系统综述。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1080/13651501.2025.2537660

Molly Fennig Steinhoff, Madison Massmann, Kirsten Gilbert

{"title":"Treatment effectiveness for comorbid anorexia nervosa and obsessive-compulsive disorder: a systematic review.","authors":"Molly Fennig Steinhoff, Madison Massmann, Kirsten Gilbert","doi":"10.1080/13651501.2025.2537660","DOIUrl":"10.1080/13651501.2025.2537660","url":null,"abstract":"Objective: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are severe, commonly co-occurring disorders. AN and OCD comorbidity is associated with worsened prognosis and treatment responses, so better understanding treatment efficacy across both disorders could improve outcomes. We conducted the first known systematic review of non-pharmacological treatment efficacy for comorbid AN and OCD.Methods: A systematic review of PubMed, PsycNet, Scopus, ProQuest and Google Scholar, up to and including January 2024, yielded 14 studies. PRISMA methodology was used. The study was preregistered (PROSPERO CRD42024507762).Results: AN symptoms tended to improve while OCD symptoms did not. Most studies looked at treatments developed for AN. Studies examined a range of treatment types (e.g., deep brain stimulation and family-based therapy), study types (e.g., case study, single-arm and randomised controlled trial) and spanned all levels of care. Participants were mostly patients with AN, and many also had OCD symptoms. Risk-of-bias was variable.Conclusion: Current treatments may be effective for AN but not for comorbid OCD symptoms. More research is needed examining comorbid AN and OCD treatment, particularly with more severe OCD. Future efforts should investigate transdiagnostic treatments, utilisation of OCD treatments for AN and longitudinal designs to examine relapse in addition to remission.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"97-109"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perimenopausal depression: etiology, clinical characteristics, and the role of traditional Chinese medicine. 围绝经期抑郁症：病因、临床特点及中药的作用。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-01 Epub Date: 2025-06-14 DOI: 10.1080/13651501.2025.2501250

Ling Wang, Yunyun Liu, Xiaoying Qi, Hong Luo

引用次数: 0

Further evidence of depressive symptomatology profile predicting treatment outcome. 抑郁症症状分析预测治疗结果的进一步证据。

IF 2.7 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-01 Epub Date: 2025-06-25 DOI: 10.1080/13651501.2025.2519530

Maria Luca, Antonina Luca, Alessandro Serretti

{"title":"Further evidence of depressive symptomatology profile predicting treatment outcome.","authors":"Maria Luca, Antonina Luca, Alessandro Serretti","doi":"10.1080/13651501.2025.2519530","DOIUrl":"10.1080/13651501.2025.2519530","url":null,"abstract":"Background: Non-response to treatment is a major problem in Major Depressive Disorder. The identification of predictors of poor outcome could improve treatment strategies. Overall baseline severity is one of the strongest predictors, but the specific symptoms profile is poorly investigated.Methods: Baseline symptoms scores of 1533 depressed patients were assessed through the 30-item Inventory for Depressive Symptomatology, Clinician-rated (IDS-C30), as part of the Sequenced treatment alternatives to relieve depression (STAR*D) trial. Treatment outcomes were assessed after treatment with citalopram. We tested IDS-C30 individual items associated with non-response in the whole sample and sex-stratified subgroups.Results: Sadness, sleep disturbances and lassitude were predictors of outcome in the whole sample. Females showed higher scores at many somatic domains (i.e., aches and pain), the latter relating to poor outcome. Anhedonic features, albeit with sex-specific differences, were associated with poor outcome across all study groups, along with depression severity and suicidal thoughts.Conclusions: Our findings further refine the observation that specific baseline symptomatology profiles are related to poor response in depressed individuals. This finding may inform at a clinical level for personalised treatment. The sex-specific differences suggest a thorough assessment of depressive features at the very first approach with the depressed patient.Keypoints: Sadness, sleep disturbances and reduced energy are strong predictors of poor outcome in depressed individualsSomatic complaints may be stronger predictors among females compared to malesAnhedonic features relate to non-response.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"144-151"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0