International Journal of Psychiatry in Clinical Practice最新文献

Investigating psychiatric morbidity, hopelessness and suicide risk in patients with 22q11.2 deletion syndrome: a case-control study. 调查 22q11.2 缺失综合征患者的精神病发病率、绝望感和自杀风险：一项病例对照研究。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-11-18 DOI: 10.1080/13651501.2024.2427624

Isabella Berardelli, Mariarosaria Cifrodelli, Salvatore Sarubbi, Carlotta Giuliani, Giulia Antonelli, Fabrizio Schirripa, Carolina Putotto, Federica Pulvirenti, Marco Innamorati, Maurizio Pompili

{"title":"Investigating psychiatric morbidity, hopelessness and suicide risk in patients with 22q11.2 deletion syndrome: a case-control study.","authors":"Isabella Berardelli, Mariarosaria Cifrodelli, Salvatore Sarubbi, Carlotta Giuliani, Giulia Antonelli, Fabrizio Schirripa, Carolina Putotto, Federica Pulvirenti, Marco Innamorati, Maurizio Pompili","doi":"10.1080/13651501.2024.2427624","DOIUrl":"https://doi.org/10.1080/13651501.2024.2427624","url":null,"abstract":"Background: The psychiatric phenotype of the 22q11.2 deletion syndrome (22q11DS) has been largely described.Objectives: With a case-control study design, we now compared a sample of 22q11DS patients with a psychiatric diagnosis with a sample of psychiatric patients without 22q11DS to investigate possible differences between groups for depression severity, hopelessness, and suicide. Patients with 22q11DS were divided into two groups according to the levels of hopelessness to evaluate the relationship between hopelessness and the severity of the 22q11DS, the level of disability, functional impairment, physical frailty, and autonomy level.Results: Results showed that suicide risk evaluated with the C-SSRS was similar in the two groups of patients and that a diagnosis of 22q11DS does not appear to be a risk factor for suicide; however, 22q11DS patients had more severe hopelessness. Patients with a more severe clinical presentation and worse overall functioning have higher levels of depressive symptoms and hopelessness.Conclusions: The results suggest the need to assess and monitor psychiatric symptoms in patients with 22q11DS.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid variability in drug-naïve individuals affected with Major Depressive Disorder: a systematic review and meta-analysis. 重度抑郁症患者的血脂变异性：系统综述和荟萃分析。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-11-15 DOI: 10.1080/13651501.2024.2427617

Behzad Ensan, Zeinab Sadat Hosseini, Mohammad Mirzaei, Hakime Ghadiri Hakim, Nima Zafari, Tannaz Jamialahmdi, Amirhossein Sahebkar

{"title":"Lipid variability in drug-naïve individuals affected with Major Depressive Disorder: a systematic review and meta-analysis.","authors":"Behzad Ensan, Zeinab Sadat Hosseini, Mohammad Mirzaei, Hakime Ghadiri Hakim, Nima Zafari, Tannaz Jamialahmdi, Amirhossein Sahebkar","doi":"10.1080/13651501.2024.2427617","DOIUrl":"https://doi.org/10.1080/13651501.2024.2427617","url":null,"abstract":"Background: This study aimed to provide a comprehensive synthesis of the evidence examining lipid profiles in drug-naïve MDD patients.Materials and methods: We searched PubMed, Scopus, and ISI Web of Science up to August 2023 for total cholesterol, HDL-C, LDL-C, and triglyceride levels in drug-naïve MDD patients.Results: A total of 17 articles comprising 2174 individuals including drug-naïve MDD subjects and controls were included. Our results showed that concentrations of total cholesterol were lower in drug-naïve MDD patients compared with healthy controls (SMD -0.49, 95% CI -0.881 to -0.105; p = 0.015; I2 = 90.6%). However, comparison of other lipid levels between MDD patients and healthy controls demonstrated no significant difference. The results revealed that the association of total cholesterol levels with MDD is more prominent in male-dominant studies (SMD -1.20, 95% CI -2.23 to -0.18, I2 = 87.9%) than in female-dominant studies (SMD -0.25, 95% CI -0.63-0.13, I2 = 89.0%). In meta-regression, none of the factors including year of publication, Newcastle-Ottawa Scale score, sample size, BMI, and mean age of participants had a significant influence on the association between cholesterol levels and MDD.Conclusions: Lower levels of total cholesterol, especially in males, are associated with MDD, so early lipid monitoring and targeted interventions are necessary.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complex clinical and cognitive phenotype of adult patients with attention deficit hyperactivity disorder (ADHD) and comorbid hoarding disorder. 注意缺陷多动障碍（ADHD）合并囤积症成年患者复杂的临床和认知表型。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-11-15 DOI: 10.1080/13651501.2024.2427615

Giacomo Grassi, Corinna Moradei, Chiara Cecchelli, Michael van Ameringen

{"title":"The complex clinical and cognitive phenotype of adult patients with attention deficit hyperactivity disorder (ADHD) and comorbid hoarding disorder.","authors":"Giacomo Grassi, Corinna Moradei, Chiara Cecchelli, Michael van Ameringen","doi":"10.1080/13651501.2024.2427615","DOIUrl":"10.1080/13651501.2024.2427615","url":null,"abstract":"Objectives: Several studies consistently showed that patients with attention deficit hyperactivity disorder (ADHD) have high rates of hoarding disorder (HD) comorbidity. The aim of the present study was to compare the clinical and cognitive features of adult ADHD patients with and without hoarding comorbidity according to a self-report measure, and a sample of healthy controls.Methods: Fifty-seven consecutive adult outpatients with a primary diagnosis of ADHD with comorbid hoarding disorder (ADHD+HD), 57 matched ADHD patients without hoarding disorder comorbidity (ADHD-HD), and a control group of 47 healthy controls (HCs) were enrolled. All subjects undergone a comprehensive clinical assessment and a neurocognitive assessment focused on attention, memory, and executive functions.Results: The ADHD groups differed on most of the clinical and cognitive measures compared to HCs. ADHD+HD patients showed similar ADHD symptoms but greater subjective impulsivity, mood and anxiety symptoms, and a greater functional impairment compared to ADHD-HD patients as well as greater attentional and executive functioning impairments.Conclusions: ADHD patients with comorbid hoarding disorder present a more complex clinical and neuropsychological phenotype correlated to a greater functional impairment compared to ADHD patients without this comorbidity. These results further highlight the relevance of assessing and treating hoarding behaviours in adults with ADHD.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Borderline personality disorder is an innate empathy anomaly: a scoping and narrative review. 边缘型人格障碍是与生俱来的移情异常：范围界定和叙述性综述。

IF 4.6 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-10-29 DOI: 10.1080/13651501.2024.2420662

David Hayward, Donald MacIntyre, Douglas Steele

{"title":"Borderline personality disorder is an innate empathy anomaly: a scoping and narrative review.","authors":"David Hayward, Donald MacIntyre, Douglas Steele","doi":"10.1080/13651501.2024.2420662","DOIUrl":"10.1080/13651501.2024.2420662","url":null,"abstract":"Background: Studying empathy in borderline personality disorder (BPD) is essential because difficulties with interpersonal functioning are integral.Objectives: This scoping and narrative review explores the aetiological theory that BPD is an innate anomaly of cognitive empathy, with a normal or heightened emotional empathy.Eligibility criteria and sources of evidence: Ovid MEDLINE(R) ALL was searched using the terms empathy; theory of mind; mentalisation or mentalising; borderline empathy; emotion recognition and BPD. For inclusion in the scoping review, articles needed to empirically assess an empathic skill in people with BPD, or self-reported empathy in a BPD group compared to controls, or empathic skill as a 'borderline feature' in a nonclinical sample.Charting method: The results of empirical studies were categorised as per their methodological approach, with results in the BPD group reported as comparable, enhanced or reduced compared to controls.Results: 320 articles were returned, with 38 eligible. The majority affirmed that people with BPD have an anomalous empathetic ability, especially a deficient cognitive empathy. Furthermore, this is trait, evident early in development, correlates with syndrome severity, and is mediated by atypical neural networks.Conclusions: This substantiates the theory that BPD is, at least in major part, an innate empathy anomaly.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-15"},"PeriodicalIF":4.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between coping strategies and change in symptom severity in contamination-focused OCD patients during the COVID-19: a one-year follow-up. 在 COVID-19 测试中，以污染为重点的强迫症患者的应对策略与症状严重程度变化之间的关系：一年随访。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-10-25 DOI: 10.1080/13651501.2024.2420641

Emine Cengiz Cavusoglu, Arda Kazim Demirkan

{"title":"Relationship between coping strategies and change in symptom severity in contamination-focused OCD patients during the COVID-19: a one-year follow-up.","authors":"Emine Cengiz Cavusoglu, Arda Kazim Demirkan","doi":"10.1080/13651501.2024.2420641","DOIUrl":"https://doi.org/10.1080/13651501.2024.2420641","url":null,"abstract":"Objective: To examine the relationship between coping strategies and the change in symptom severity in contamination-focused OCD patients during the COVID-19 pandemic over a one-year follow-up.Methods: In March 2020, a one-year follow-up study was initiated with 56 contamination-focused OCD patients in Turkey. Coping strategies were evaluated using the COPE scale. OCD symptom severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) at the beginning and end of the year. The Fear of COVID-19 Scale was administered mid-year.Results: One year post the onset of COVID-19, 68% of patients showed increased OCD symptom severity, while 32% displayed a decrease. Higher scores on the fear of COVID-19 scale and lower acceptance scores from COPE subscales were correlated with increased OCD symptom severity.Conclusions: The COVID-19 pandemic has intensified OCD symptoms in a substantial proportion of patients, particularly those with heightened fears related to the pandemic, and reduced acceptance-based coping strategies. Tailored interventions emphasising adaptive coping mechanisms may benefit OCD patients in managing their symptoms during external stressors like pandemics.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unexpected improvement in nicotine consumption after low-frequency repetitive magnetic stimulation. 低频重复磁刺激后尼古丁消耗量的意外改善

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-10-17 DOI: 10.1080/13651501.2024.2417651

Ismail Rammouz, Omar El Oumary, Rachid Aalouane, Zouhayr Souirti, Said Boujraf

{"title":"Unexpected improvement in nicotine consumption after low-frequency repetitive magnetic stimulation.","authors":"Ismail Rammouz, Omar El Oumary, Rachid Aalouane, Zouhayr Souirti, Said Boujraf","doi":"10.1080/13651501.2024.2417651","DOIUrl":"https://doi.org/10.1080/13651501.2024.2417651","url":null,"abstract":"Background: We report a case on the efficiency of low-frequency repetitive transcranial magnetic stimulation (rTMS) on cigarette consumption cessation.The patient was 29 years old, He received intensive psychiatric treatments along with ten years of history of depressive and obsessive-compulsive disorders.The first four years of treatment were marked by good outcomes. However, the last 6 years were marked by persisting depressive symptoms associating with psychotic features and sexual obsessions.Methods: The patient received 20 sessions of rTMS over two weeks, 10 times per week at 1 Hz frequency, each session lasted 20 min with 200 pulses and 100% of motor threshold. In the meanwhile, the patient continued his full drug-based treatment according to the reported prescription.Results and conclusion: After 20 sessions, the patient reported a decreased severity of his depressive symptoms with a BDI (Beck Depression Inventory) score of 6 but without significant improvement of OCD with a YBOCS score of 32. However, the patient reported great improvement in his tobacco craving and a diminishing number of consumed cigarettes in the second week of the rTMS protocol of treatment. This ended with tobacco cessation within a month. However, this occurred without any medication or psychological support for treating tobacco dependence.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-3"},"PeriodicalIF":2.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can simple biomarkers of inflammation guide the diagnosis of psychiatric disorders? 简单的炎症生物标志物能否指导精神疾病的诊断？

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-10-07 DOI: 10.1080/13651501.2024.2412641

Ozgur Ozkalayci, Nihal Tastekin

{"title":"Can simple biomarkers of inflammation guide the diagnosis of psychiatric disorders?","authors":"Ozgur Ozkalayci, Nihal Tastekin","doi":"10.1080/13651501.2024.2412641","DOIUrl":"https://doi.org/10.1080/13651501.2024.2412641","url":null,"abstract":"Objective: In this study, we wanted to investigate the usability of routine blood samples taken at the beginning of hospitalisation in inpatients to predict the presence of psychotic symptoms in patients.Methods: We divided the hospitalised patients into two groups those with and without psychotic symptoms according to their ICD-10 diagnosis codes. Then, we compared the complete blood count, c-reactive protein (CRP), and fasting glucose levels, which can be used as simple markers of inflammation.Results: In this retrospective study, which included 349 patients, we found that blood leukocytes, neutrophils, CRP, and fasting glucose levels were higher in patients with psychotic symptoms than in patients without psychotic symptoms (p = 0.015; p = 0.013; p = 0.002; and p = 0.001, respectively). According to regression analysis, patients with high glucose levels were 4.9 times more likely to have psychotic symptoms than those with low glucose levels. In addition, according to the ROC analysis results; when we used 87 mg/dl as the cut-off value for fasting glucose, it was observed that it predicted psychotic symptoms with approximately 69% sensitivity and 71% specificity.Conclusion: Although our results still have some limitations, they are promising for the future use of simple biomarkers of inflammation for the differential diagnosis of psychiatric disorders.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mirtazapine blood levels and antidepressant response. 米氮平的血药浓度和抗抑郁反应。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-09-28 DOI: 10.1080/13651501.2024.2409654

Domenico De Donatis, Marco Verrastro, Giuseppe Fanelli, Chiara Fabbri, Ignazio Maniscalco, Xenia Hart, Georgios Schoretsanitis, Laura Mercolini, Raffaele Ferri, Bartolo Lanuzza, Alessandro Serretti, Andreas Conca, Vincenzo Florio

{"title":"Mirtazapine blood levels and antidepressant response.","authors":"Domenico De Donatis, Marco Verrastro, Giuseppe Fanelli, Chiara Fabbri, Ignazio Maniscalco, Xenia Hart, Georgios Schoretsanitis, Laura Mercolini, Raffaele Ferri, Bartolo Lanuzza, Alessandro Serretti, Andreas Conca, Vincenzo Florio","doi":"10.1080/13651501.2024.2409654","DOIUrl":"https://doi.org/10.1080/13651501.2024.2409654","url":null,"abstract":"Objective: Therapeutic drug monitoring (TDM) is an important tool for treatment optimisation. Its usefulness has recently been demonstrated for some first-line antidepressants; however, few studies have been reported on the relationship between blood levels of mirtazapine and its antidepressant effects. The aim of this study was to investigate the association between blood concentration of mirtazapine and antidepressant response.Methods: 59 outpatients treated with mirtazapine for depression were recruited and followed up for three months in a naturalistic setting. Hamilton Depression Rating Scale-21 (HAMD-21) was administered at baseline, month 1, and month 3 to assess antidepressant response. Mirtazapine serum concentration was measured at steady state. Linear regression analysis and nonlinear least-squares regression were used to estimate association between serum concentration of mirtazapine and antidepressant response.Results: Our results showed no overall association between serum concentration of mirtazapine and symptom improvement at month 1 and month 3. A marginally significantly higher serum concentration of mirtazapine was found in responders vs non-responders at month 3.Conclusions: The study suggests that serum concentration of mirtazapine is not strongly associated with the antidepressant efficacy of mirtazapine. This is probably attributed to its pharmacodynamic profile, even though higher blood levels seem to be marginally more effective.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring real-world prescribing patterns for maintenance treatment in bipolar disorders: a focus on antidepressants and benzodiazepines. 探索现实世界中双相情感障碍维持治疗的处方模式：关注抗抑郁药和苯二氮卓类药物。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-09-04 DOI: 10.1080/13651501.2024.2398796

Sanja Andric Petrovic, Dusan Jankovic, Nina Kaurin, Vanja Mandic Maravic, Danilo Pesic, Ivan Ristic, Nadja P Maric

{"title":"Exploring real-world prescribing patterns for maintenance treatment in bipolar disorders: a focus on antidepressants and benzodiazepines.","authors":"Sanja Andric Petrovic, Dusan Jankovic, Nina Kaurin, Vanja Mandic Maravic, Danilo Pesic, Ivan Ristic, Nadja P Maric","doi":"10.1080/13651501.2024.2398796","DOIUrl":"https://doi.org/10.1080/13651501.2024.2398796","url":null,"abstract":"Objective: Bipolar disorders (BD) are characterized by highly recurrent nature, necessitating adequate maintenance treatment for long-term disorder control. This study aimed to investigate real-world prescribing patterns among outpatients with BD, focusing on the utilisation of antidepressants (AD) and benzodiazepines (BDZ).Methods: We analysed prescription patterns of the five main groups of psychotropic medications (antipsychotics, mood stabilizers, AD, BDZ, and anticholinergic medications) and their relationships with basic socio-demographic and clinical data in a sample of 107 clinically stable BD outpatients (75.7% female, age 44.8 ± 11.7).Results: Maintenance therapy predominantly involved polypharmacy (92.5%), with mood stabilizers (87.9%) and antipsychotics (80.4%, predominantly second-generation) being the most commonly prescribed. Our findings highlight a high percentage of patients prescribed AD (50.5%) and BDZ (54.2%). BDZ patients, compared to the non-BDZ group in maintenance treatment, were significantly older with longer psychiatric history and a decreased likelihood of comorbid personality disorder diagnoses.Conclusions: This study offers insights into prescribing practices within a university psychiatric clinic in the Western Balkans. The prevalent use of polypharmacy in real-world clinical settings, along with high percentage of patients prescribed AD and BDZ, suggests a gap between guideline recommendations and clinical practice, indicating a lack of consensus or standardized approaches in clinical practice.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world demographic and clinical profiles of patients with treatment-resistant depression initiated on esketamine nasal spray. 开始使用艾司氯胺酮鼻喷雾剂的难治性抑郁症患者的真实人口统计学和临床概况。

IF 2.9 4区医学

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-09-02 DOI: 10.1080/13651501.2024.2398788

Ludovic Samalin, Lila Mekaoui, Pierre De Maricourt, Anne Sauvaget, Marie-Alix Codet, Émeline Gaudré-Wattinne, Clotilde Wicart, Maud Rothärmel

{"title":"Real-world demographic and clinical profiles of patients with treatment-resistant depression initiated on esketamine nasal spray.","authors":"Ludovic Samalin, Lila Mekaoui, Pierre De Maricourt, Anne Sauvaget, Marie-Alix Codet, Émeline Gaudré-Wattinne, Clotilde Wicart, Maud Rothärmel","doi":"10.1080/13651501.2024.2398788","DOIUrl":"https://doi.org/10.1080/13651501.2024.2398788","url":null,"abstract":"Objective: ESKALE is a French, multicentre, observational study of adults with treatment-resistant depression (TRD) treated with esketamine. This interim analysis describes baseline demographic and clinical characteristic evolution in patients included and treated from early access program to post-marketing launch.Methods: Data were collected from medical records and included patient characteristics, disease history at esketamine initiation, use of neurostimulation, the patient's care pathway, and the number of antidepressant treatment lines prescribed prior to esketamine initiation. Descriptive statistics were used for each cohort: the early access program 'Temporary Authorisation for Use' (ATU), post-ATU, and post-launch cohorts.Results: The overall ESKALE cohort (N = 160 included; n = 157 treated with esketamine; average age 49.0 years; 66.2% female) demonstrated moderate-to-severe depression according to clinical assessment and a mean Montgomery-Åsberg Depression Rating Scale score of 32.6 (8.0); however, severity, subtype, and comorbidities were heterogeneous across the cohorts. Earlier use of esketamine and prior to alternative treatments occurred during the later cohorts.Conclusion: These findings demonstrated a high burden of TRD in these patients and that esketamine is used in TRD treatment regardless of their disease severity, subtype, or existing comorbidities. These results also suggest that esketamine is potentially a clinically useful alternative treatment, particularly with healthcare professionals gaining greater familiarity with and easier access to esketamine.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0