Comparative analysis of regressive and non-regressive autism: a study of clinical patterns and environmental risk factors in Turkey.

IF 2.7 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI:10.1080/13651501.2025.2519522

Nagihan Cevher Binici, Ayşe Kutlu, Çisel Yazan Songür, Hande Emine Sabah Barış

{"title":"Comparative analysis of regressive and non-regressive autism: a study of clinical patterns and environmental risk factors in Turkey.","authors":"Nagihan Cevher Binici, Ayşe Kutlu, Çisel Yazan Songür, Hande Emine Sabah Barış","doi":"10.1080/13651501.2025.2519522","DOIUrl":null,"url":null,"abstract":"Objective: This study compared clinical features, symptom severity, and prenatal/perinatal risk factors in children with regressive (ASD-R) and non-regressive autism spectrum disorder (ASD-NR) in a Turkish paediatric sample.Method: A retrospective cross-sectional study was conducted with 143 children aged 2-6 years diagnosed with ASD, grouped as ASD-R (n = 29) or ASD-NR (n = 114). Symptom severity was assessed using the CARS, AuBC, and ABC. Data on prenatal and perinatal factors, epilepsy, and parental age were collected.Results: No significant differences were found in CARS, AuBC, or total ABC scores, except for higher lethargy/social withdrawal scores in the ASD-NR group. Prenatal and perinatal risk factors and epilepsy prevalence were similar. However, parental ages at birth were significantly higher in the ASD-R group. Logistic regression did not yield significant predictors of regression.Conclusion: The findings suggest that prenatal and perinatal factors may influence developmental regression in ASD when interacting with genetic vulnerability. Longitudinal studies are needed to clarify the role of early environmental exposures and epigenetic mechanisms in regression patterns.","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"136-143"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychiatry in Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13651501.2025.2519522","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: This study compared clinical features, symptom severity, and prenatal/perinatal risk factors in children with regressive (ASD-R) and non-regressive autism spectrum disorder (ASD-NR) in a Turkish paediatric sample.

Method: A retrospective cross-sectional study was conducted with 143 children aged 2-6 years diagnosed with ASD, grouped as ASD-R (n = 29) or ASD-NR (n = 114). Symptom severity was assessed using the CARS, AuBC, and ABC. Data on prenatal and perinatal factors, epilepsy, and parental age were collected.

Results: No significant differences were found in CARS, AuBC, or total ABC scores, except for higher lethargy/social withdrawal scores in the ASD-NR group. Prenatal and perinatal risk factors and epilepsy prevalence were similar. However, parental ages at birth were significantly higher in the ASD-R group. Logistic regression did not yield significant predictors of regression.

Conclusion: The findings suggest that prenatal and perinatal factors may influence developmental regression in ASD when interacting with genetic vulnerability. Longitudinal studies are needed to clarify the role of early environmental exposures and epigenetic mechanisms in regression patterns.

查看原文本刊更多论文

退行性和非退行性自闭症的比较分析：土耳其临床模式和环境风险因素的研究。

目的：本研究比较了土耳其儿童样本中退行性（ASD-R）和非退行性自闭症谱系障碍（ASD-NR）患儿的临床特征、症状严重程度和产前/围产期危险因素。方法：对143例2-6岁诊断为ASD的儿童进行回顾性横断面研究，分为ASD- r组（ = 29）和ASD- nr组（ = 114）。使用CARS、AuBC和ABC评估症状严重程度。收集了产前和围产期因素、癫痫和父母年龄的数据。结果：除了ASD-NR组嗜睡/社交退缩得分较高外，CARS、AuBC或总ABC得分均无显著差异。产前和围产期危险因素与癫痫患病率相似。然而，ASD-R组的父母出生时年龄明显更高。逻辑回归没有产生显著的回归预测因子。结论：产前和围产期因素可能与遗传易感性相互作用，影响ASD的发育倒退。需要纵向研究来阐明早期环境暴露和表观遗传机制在回归模式中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.