International Journal of Preventive Medicine最新文献

{"title":"Validation of the Persian Version of Child-to-Parent Aggression Questionnaire and the Prevalence of Child to Parent Aggression in North West of Iran.","authors":"Maryam Mohammadzadeh, Fariba Heidari, Mohammad Zakaria Pezeshki, Sanaz Norouzi","doi":"10.4103/ijpvm.ijpvm_124_25","DOIUrl":"10.4103/ijpvm.ijpvm_124_25","url":null,"abstract":"<p><strong>Background: </strong>Child-to-parent aggression is a public health issue in the communities. The aim of this study was to validation of 10-item questionnaire of child-to-parent aggression (CPA).</p><p><strong>Methods: </strong>The standard guideline of World Health Organization was applied for validation of the original CPA questionnaire (CPAQ). The face validity index (FVI), content validity index (CVI), and content validity ratio (CVR) were assessed. We applied confirmatory factor analysis (CFA) using Lisrel 8.80. To evaluate the reliability, Cronbach's alpha and internal consistency coefficient (ICC) were calculated. In total, 258 adolescents of 12-18 years, filled out the Persian CPAQ, and their parents filled out Persian socioeconomic status (SES) questionnaire. The regression analysis via SPSS 16.0 was conducted.</p><p><strong>Results: </strong>Cronbach's alpha was 0.83. The ICC was 0.812 and 0.879 for aggression questionnaire against fathers and mothers, respectively. The prevalence of psychological violence against mother or father was 77.1% and was 13.2% for physical violence in all participants. The rates of severe psychological and physical violence were 15.5% and 3.9%, respectively. In regression analysis, boys were 89% more likely to perpetrate severe physical aggression toward at least one of parents than girls (95%CI: 0.14-0.89). Daughters committed meaningfully more psychological (<i>P</i> = 0.004) and physical violence (<i>P</i> = 0.041) against mothers than fathers. SES was significantly related to psychological violence toward both parents (<i>P</i> = 0.025).</p><p><strong>Conclusions: </strong>The Persian version of CPA tool had acceptable validity and reliability and can be used for screening. The high prevalence of children's and adolescent's aggression against their parents calls for action to plan for educational consulting interventions.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"59"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The Prevalence of Vitamin B12, Hemoglobin, and Ferritin Deficiency in Patients with Morbid Obesity and Changes in their Blood Levels after Bariatric Surgery\".","authors":"Laiba Saher","doi":"10.4103/ijpvm.ijpvm_242_25","DOIUrl":"10.4103/ijpvm.ijpvm_242_25","url":null,"abstract":"","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"64"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost Effectiveness of Diagnosis and Screening Methods in Nonalcoholic Fatty Liver Disease: A Systematic Review.","authors":"Ali Sarabi Asiyabar, Nasrin Abolhasanbeigi Gallehzan, Mahmood Zamandi, Aziz Rezapour, Aghdas Souresrafil, Marziye Hadian, Elaheh Mazaheri, Majid Khosravi","doi":"10.4103/ijpvm.ijpvm_369_24","DOIUrl":"10.4103/ijpvm.ijpvm_369_24","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that is emerging and spreading worldwide. This condition manifests as a hepatic component of the metabolic syndrome, and its occurrence is closely associated with risk factors such as insulin resistance and abdominal obesity. This study aims to review and analyze the cost-effectiveness of diagnostic and screening methods for NAFLD through a systematic review.</p><p><strong>Methods: </strong>Searches were conducted in Web of science, Scopus, Pubmed, Embase, National Health Services Economic Evaluation Database, Cochrane Database of Systematic Reviews; DAHTA-Database. NHS Health Technology assessment (Centre for review and. DISSEMMINATION Library-CRD), Cost Effectiveness Analysis Registry. The search covered articles published between January 1990 and December 2023. Studies that were written in English and Persian and examined the cost-utility and cost-effectiveness of diagnosis and screening methods in NAFLD were included in our review. Data extraction was guided by the Consolidated Health Economic Evaluation Reporting Standards checklist, and the quality of economic evaluations was assessed using the Criteria for Health Economic Quality Evaluation tool. All costs were converted to 2024 U.S. dollars using Purchasing Power Parity.</p><p><strong>Results: </strong>The search yielded 1649 studies, and 11 studies were eligible for inclusion. The studies were mainly based on a European setting and then Asian and American alike. Most of the studies used different decision analysis models such as decision tree and Markov to evaluate the cost-effectiveness. The lowest and highest numerical values of outcome measures were 0.021 and 14.46 quality-adjusted life years, respectively. Furthermore, the lowest and highest numerical value of the cost of diagnosis and screening methods in NAFLD were $101, and $123,706, respectively.</p><p><strong>Conclusions: </strong>Policymakers, decision-makers, and healthcare professionals should consider not only the acceptability, accuracy, sensitivity, accessibility, and feasibility of NAFLD screening and diagnostic strategies but also their cost-effectiveness and affordability, taking into account the financial burden of the disease and local and national cost-effectiveness data.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"79"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innate Immune Profile in Diabetes Mellitus Rat Treated with Acalypha Indica Extract: Focus on TLR-2, TLR-4, <i>Nos2, Arg1</i>, and Liver Inflammation.","authors":"Tri Handayani, Ani R Prijanti, Desak G B Krisnamurti, Adisti Dwijayanti, Wilzar Fachri, Rani W Hakim","doi":"10.4103/ijpvm.ijpvm_334_24","DOIUrl":"10.4103/ijpvm.ijpvm_334_24","url":null,"abstract":"<p><strong>Background: </strong><i>Acalypha indica</i> (Ai) is an herb that is known to have anti-inflammatory and anti-diabetic effects. This research was carried out with the aim of determining the effect of Ai extract on the inflammatory process as part of the innate immune response that occurs in type 2 diabetes mellitus.</p><p><strong>Methods: </strong>Twenty-five Sprague-Dawley rats were divided into five groups: the normal group, high fructose and cholesterol (HFC) group, HFC + Ai 250 mg/kgBW group, HFC + Ai 400 mg/kgBW group and HFC + pioglitazone (Pgz) group. After 12 weeks, the rats were sacrificed. The liver tissue was taken to measure the levels of TLR2 and TLR4 using the ELISA method. The expression of the <i>Nos2</i> and <i>Arg1</i> genes in the liver was measured using PCR. Hematoxylin eosin (HE) slides were made to count the inflammatory cells.</p><p><strong>Results: </strong>Ai extract at a dose of 400 mg/kgBW could reduce random blood glucose (RBG) levels (<i>P</i> = 0.005) with mean ± SEM, respectively (82 ± 5.73), (199.9 ± 27.55), (260.6 ± 67.29), (147.2 ± 12.18), and (148.8 ± 29.4). Ai extract at a dose of 400 mg/kgBW can also reduce fasting blood glucose (FBG) levels (<i>P</i> = 0.02) with mean ± SEM, respectively (76.65 ± 2.612), (144.7 ± 13.03), (193.0 ± 46.17), (117.0 ± 2.629), and (130.5 ± 8.890). In addition, administration of Ai extract showed an increasing effect on TLR4 levels (<i>P</i> = 0.03) with mean ± SEM, respectively (1.967 ± 0.149), (2.632 ± 0.146), (2.687 ± 0.134), (2.902 ± 0.136), and (2.513 ± 0.334). Administration of Ai extract also showed an increase in the number of inflammatory cells in the liver (<i>P</i> = 0.0001) with mean ± SEM, respectively (25.92 ± 2.03), (46.76 ± 3.43), (44.28 ± 3.69), (46.32 ± 3.13), and (30.72). ± 2.94). Administration of Ai extract did not show significant differences in TLR2 levels and <i>Nos2</i> and <i>Arg1</i> gene expression. The confidence level used was 95%.</p><p><strong>Conclusions: </strong>Ai extract can reduce RBG and FBG but cannot reduce inflammation in the liver.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"74"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating World Health Organization Package of Essential Noncommunicable Disease Interventions at Primary Health Care - An Impact Evaluation Study from a Mountainous State of India.","authors":"Anupam Parashar, Guman S Negi, Rajeev Marwaha, Prem Lal, Anmol K Gupta","doi":"10.4103/ijpvm.ijpvm_326_25","DOIUrl":"10.4103/ijpvm.ijpvm_326_25","url":null,"abstract":"<p><strong>Background: </strong>Noncommunicable diseases are the leading cause of death globally. This single-arm interventional (pretest-posttest) study was conducted in one rural and one tribal district of Himachal Pradesh. Persons with NCDs (cardiovascular disease, chronic obstructive pulmonary disease, diabetes mellitus) reporting to outpatient departments were enrolled. Components of the World Health Organization Package of Essential Noncommunicable Disease (WHO-PEN) protocols 1 and 2 were used. Nonphysician health workers managed NCD patients, providing individualized counseling on behavioral risk factors of major NCDs. The counselling was conducted at baseline, three months, and six months from enrolment, using brief interventions based on the \"5As\" and \"5Rs\" models. Follow-up was done at baseline, three months, six months, and 12 months postenrollment to assess outcomes.</p><p><strong>Methods: </strong>Change of 10-year risk of developing cardiovascular disease (CVD) using the WHO/International Society of Hypertension risk-assessment charts for SEAR and changes in behavioral and biological risk factors were compared to the baseline after one year of behavioral change intervention.</p><p><strong>Results: </strong>The 10-year CVD risk ≥20% decreased significantly from 17.9% at enrolment to 5.4% after one year of behavioral interventions. Significant improvements were seen in blood pressure, blood sugar control, and behavioral risk factors.</p><p><strong>Conclusions: </strong>Implementing the WHO-PEN protocols is feasible for managing NCDs at the primary healthcare level. Involving a health worker or counselor is essential for initiating and sustaining healthy behaviors and ensuring the individual's treatment compliance.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"73"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Scientometric Analysis of Research on Bisphenol and Other Endocrine-Disrupting Chemicals in Cardiovascular Disease; Trends, Collaboration Networks, and Thematic Shift.","authors":"Fran Espinoza-Carhuancho, Miguel Cabanillas-Lazo, Ivan Calderon, Cesar Mauricio-Vilchez, Lucia Quispe-Tasayco, Frank Mayta-Tovalino","doi":"10.4103/ijpvm.ijpvm_271_25","DOIUrl":"10.4103/ijpvm.ijpvm_271_25","url":null,"abstract":"<p><strong>Background: </strong>To map the global scientific production on bisphenol and cardiovascular disease between 2019 and 2024, based on the publication volume, network of collaboration, citation trends, and theme evolution in order to provide an overview of research dynamics, principal contributors, and emerging areas in this field.</p><p><strong>Methods: </strong>This was a descriptive scientometric study. The criteria for selection were that the article must have been published between January 2019 and December 2024, and that the terms \"bisphenol\" be in the title or abstract. Scopus literature was then searched on December 24, 2024, via a large search algorithm. 640 documents were flagged and studied using SciVal and Bibliometrix in R Studio 4.5.1, to calculate for a variety of bibliometric indicators, and to perform some advanced bibliometric analysis.</p><p><strong>Results: </strong>Between 2019 and 2024, scientific production worldwide on bisphenol and cardiovascular disease comprised 640 documents published in 402 sources, with an annual growth rate of 6.1%. A total of 3519 authors collaborated, with an average of 6.7 coauthors per document and 18.1% of documents with international coauthorship. Most of overall documents were articles (525), followed by reviews (75), book chapters (16), and conference papers (12). Authors were led by Elisa Cairrao (University of Beira Interior, Portugal) and institutions such as Nanjing Medical University, China. The journal with the highest scholarly output was \"Environmental Pollution,\" with 15 published. Per Bradford's Law, the bulk of publications are in a few journals. Lotka's Law shows that most authors wrote only a single document, and thematic evolution shows trends such, for instance, the stability of \"antioxidant activity\" and the evolution of \"bisphenol A\" into themes like \"atherosclerosis,\" and \"cardiovascular disease.\"</p><p><strong>Conclusions: </strong>The results showed that the studies were concentrated in some journals, and that specific authors and institutions have contributing significantly to this research topic. Understanding these patterns could help inform new research efforts and policy decisions towards a better management of the effects of bisphenol on health related to cardiovascular diseases.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"75"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet during Pregnancy and Allergy Onset in the Childhood: A Systematic Literature Review and Meta-Analysis.","authors":"Lini Anisfatus Sholihah, Irvan Adhin Cholilie, Desty Muzarofatus Sholikhah, Fista Utami","doi":"10.4103/ijpvm.ijpvm_393_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_393_24","url":null,"abstract":"<p><strong>Background: </strong>Maternal diet during pregnancy may influence childhood allergy risk. Our objective is to study the relationship between maternal diet during pregnancy and childhood's allergy onset.</p><p><strong>Methods: </strong>We systematically search SCOPUS and PubMed (2014 to 2024) for randomized controlled trials (RCTs), case control, and cohorts investigating maternal diet during pregnancy and childhood allergy outcomes. The study protocol was registered in the PROSPERO (CRD42024570531). The evidence was critically appraised using Newcastle Ottawa Scale for case-control and cohort studies and Revised Cochrane risk of bias for cluster randomized trials (RoB2) tool for RCTs by two independent reviewers. Random-effects meta-analyses were performed to pool effect estimates, and heterogeneity was assessed using the I² statistic.</p><p><strong>Results: </strong>A total of 41 studies (37 cohorts, 1 case-control, and 3 RCTs) were analyzed. Meta-analyses suggest that maternal egg intake during pregnancy has a protective role on childhood eczema (OR: 0.51; 95% CI: 0.32, 0.80) and food allergy (OR: 0.60, 95% CI: 0.38, 0.96), and vitamin D has a negative association with childhood rhinitis (OR: 0.86; 95% CI: 0.76, 0.97). No significant association was found between maternal vitamin D intake on childhood asthma and fish oil supplementation on childhood hay fever and asthma. Variability in methodology, dietary assessment methods, and follow-up duration contributed to heterogeneity and becomes the limitation in our study.</p><p><strong>Conclusions: </strong>specific maternal diet patterns, such as egg and vitamin D consumption during pregnancy, may have help preventing childhood eczema, food allergy, and rhinitis. Further RCTs are needed to explore the effects of other dietary components on allergy outcomes.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"49"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of C-Reactive Protein and Nitric Oxide Serum Levels in Hypertensive Incidence of Aceh Population, Indonesia.","authors":"Desiana Desiana, Khairi Suhud, Zainal A Muchlisin, Basri A Gani, Azhari Gani","doi":"10.4103/ijpvm.ijpvm_180_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_180_24","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a prevalent health issue in Aceh, with inflammatory markers like C-reactive protein (CRP) and endothelial function indicators such as nitric oxide (NO) playing potentially pivotal roles in its pathophysiology. This study evaluates the relationship between CRP and NO serum levels and their association with hypertension in the Aceh population.</p><p><strong>Methods: </strong>This cross-sectional study involved 120 hypertensive patients from various communities in Aceh. Serum levels of examination of CRP levels using latex agglutination and NO were principles by immunosorbent assay and the Griess reaction, respectively. Data on blood pressure and other clinical parameters were also collected.</p><p><strong>Results: </strong>Female subjects reported more (51%) than men (49%). The highest average CRP levels were found in Ras Gayo (5165 (mg/L), Ras Aneuk Jamee (7270 mg/L), and Aceh (6128 mg/L), but the three tribes had no significant difference (<i>P</i> > 0.05). The highest average NO level was found in Ras Gayo (51.79 (μmol/L), Ras Aneuk Jamee (44.27 μmol/L), and Ras Aceh (31.87 μmol/L), and there was a significant difference (<i>P</i> < 0.05). Correlation analysis showed that the incidence of hypertension was associated with infection markers CRP titers and NO levels (r = 0.81).</p><p><strong>Conclusions: </strong>There is a significant difference in the quantity of NO levels from the Gayo tribe, Aneuk Jamee, and Aceh from hypertensive patients. Besides that, there is no difference in the quantity of CRP levels between the Gayo tribe, Aneuk Jamee, and Aceh. Hypertension experienced by subjects is related to markers of infection (CRP) and NO in the blood serum of hypertension patients from the Acehnese tribe, stronger than the Gayo and Aneuk Jamee tribes.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"44"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepato-renal Protective Effect of Glutamine in Oxidative Stress Rat Model by Elevating the Glutamine-Glutathione Axis.","authors":"Behruz H Khaliphani, Sina Mahdavifard, Mohammad Mazani","doi":"10.4103/ijpvm.ijpvm_362_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_362_24","url":null,"abstract":"<p><strong>Background: </strong>Toxic compounds such as carbon tetra chloride (CCl4) can cause acute hepato-renal injury by producing free radicals and inflammatory mediators. Therefore, we examined the impact of glutamine (Gln) on oxidative stress and inflammatory markers in blood and tissue homogenates, as well as hepato-renal dysfunction markers and histopathological parameters in an oxidative stress rat model induced by CCl₄.</p><p><strong>Methods: </strong>The study included four groups, each comprising nine rats: control (C), oxidative stress rat model (OSRM), and those treated with Gln (1,000 mg/L in drinking water for 2 weeks). Oxidative stress was induced by administering CCl₄ (1 ml/kg) on the 15^th day. The hepatic NF-kβ expression was analyzed, and markers of oxidative stress and inflammation were assessed. Additionally, biochemical markers of hepatic and renal functions were measured, and histopathological changes in the liver and kidney tissues were examined.</p><p><strong>Results: </strong>The findings indicated that Gln treatment significantly reduced liver and kidney histopathological changes caused by oxidative stress induction. The treatment lowered hepatic NF-kβ expression, liver and renal dysfunction parameters, and markers of oxidative stress and inflammation. Moreover, it notably improved systemic, renal, and hepatic antioxidant potential (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>The hepato-renoprotective effects of Gln included the prevention of liver necrosis and renal tubule disturbance. Gln enhanced liver and kidney functions by reducing NF-kβ signaling and boosting systemic, hepatic, and renal antioxidant potential through elevating the glutathione (GSH)/GSSG ratio and antioxidant enzyme activities. It is likely that the enhancement of the glutamine-glutathione axis is the primary mechanism behind its hepato-renoprotective effects.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"48"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of Psyllium with Weight Loss Diet in Preventing Liver Dysfunction in Overweight or Obese Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).","authors":"Zahra Akbarzadeh, Mojgan Nourian, Gholamreza Askari, Mohammad R Maracy, Reza Amani","doi":"10.4103/ijpvm.ijpvm_254_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_254_24","url":null,"abstract":"<p><strong>Introduction: </strong>MASLD is the revised nomenclature of nonalcoholic fatty liver disease (NAFLD) which is the most common chronic liver disease worldwide and it significantly impacts the burden of the disease. Individuals who are overweight or obese have three times higher risk of developing MASLD. Losing body weight is, therefore, recommended to manage MASLD. This study was performed to assess the effect of psyllium on liver function in overweight or obese adults with (MASLD).</p><p><strong>Methods: </strong>We assessed 80 overweight or obese MASLD patients diagnosed by elastography. They were divided into intervention and placebo groups through randomized block design. Intervention group was given 10 grams of psyllium and the control group was given 10 grams of ground wheat as supplement. Weight loss diet and physical activity (PA) recommendations were followed by both groups for 10 weeks. Serum liver enzymes, liver function (measured by fibroscan), PA, and dietary intake were assessed pre- and post-intervention.</p><p><strong>Results: </strong>Totally, 78 participants finished the RCT. After controlling confounding variables, intake of calorie (<i>P</i> = 0.02), carbohydrate (<i>P</i> = 0.01), alanine aminotransferase (<i>P</i> = 0.006), waist circumference (<i>P</i> = 0.006), BMI (<i>P</i> = 0.006), and liver fibrosis score (0.001) were lowered in the intervention group compared with the controls. However, serum aspartate aminotransferase reduction was not significant (<i>P</i> = 0.98).</p><p><strong>Conclusions: </strong>Psyllium can be introduced as a dietary supplement that exerts beneficial role in gut health, weight loss, and preventing MASLD.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"46"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}