International Journal of Preventive Medicine最新文献_第3页

Preventive Role of Simvastatin against Infertility: Potential Role of PGC-α/PPARβ/UCPs and NF-κβ Signaling Pathways. 辛伐他汀对不孕症的预防作用：PGC-α/PPARβ/UCPs和NF-κβ信号通路的潜在作用

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_175_24

Ozra Motaghinejad, Mina Gholami, A Wallace Hayes, Majid Motaghinejad, Mojgan Javedani Masroor, Arash Mohazzab

{"title":"Preventive Role of Simvastatin against Infertility: Potential Role of PGC-α/PPARβ/UCPs and NF-κβ Signaling Pathways.","authors":"Ozra Motaghinejad, Mina Gholami, A Wallace Hayes, Majid Motaghinejad, Mojgan Javedani Masroor, Arash Mohazzab","doi":"10.4103/ijpvm.ijpvm_175_24","DOIUrl":"10.4103/ijpvm.ijpvm_175_24","url":null,"abstract":"Several inflammatory-related signaling pathways are involved in infertility. A common feature involves activating inflammatory cascades in the mitochondrial respiratory chain. Oxidative stress triggers mitochondrial dysfunction and initiates intrinsic apoptosis pathways, leading to cell damage/death in germ cells. Disruption of the mitochondrial respiratory chain is a leading cause of degenerative disorders of germ cells. However, the signaling pathways responsible for disrupting the mitochondrial respiratory chain function are unclear and require further studies. Among the signaling pathways potentially involved, the PGC-α/PPARβ/UCPs pathway has been reported to modulate mitochondrial function in germ cells. Although the role of the cell death cascades on germ cell-induced damage has not been unwoven, apoptosis, necrosis, autophagy, and their related signaling cascades play roles in infertility. Thus, therapeutic agents, such as simvastatin, with anti-cell death properties should be considered as possible new therapeutic approaches for managing infertility.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"88"},"PeriodicalIF":1.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community Health Workers Intervention in Artificial Intelligence-Integrated Personalized Medicine: A Holistic Approach to Polycystic Ovary Syndrome Management. 社区卫生工作者干预人工智能集成个性化医疗：多囊卵巢综合征管理的整体方法。

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_155_25

Nidhi Aggarwal, Sahjid Mukhida

引用次数: 0

Association of Vitamin B12 and Vitamin D Levels with Glycemic Control in Patients with Type 2 Diabetes Mellitus. 维生素B12和维生素D水平与2型糖尿病患者血糖控制的关系

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_188_25

Umesh P Singh, Dheerendra K Mishra, Pooja Gangwar, Pramod Kushwaha

{"title":"Association of Vitamin B12 and Vitamin D Levels with Glycemic Control in Patients with Type 2 Diabetes Mellitus.","authors":"Umesh P Singh, Dheerendra K Mishra, Pooja Gangwar, Pramod Kushwaha","doi":"10.4103/ijpvm.ijpvm_188_25","DOIUrl":"10.4103/ijpvm.ijpvm_188_25","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is a growing global health concern, especially in low- and middle-income countries like India. Optimal glycemic control remains a cornerstone of diabetes management in primary care. Emerging evidence suggests that micronutrient deficiencies, particularly vitamin B12 and vitamin D, may adversely affect glucose metabolism and insulin sensitivity, yet their routine assessment is often overlooked in clinical practice.Objectives: To evaluate the association between serum vitamin B12 and vitamin D levels with glycemic control in patients with T2DM and to explore their potential as modifiable risk factors in primary care-based diabetes management.Methods: This cross-sectional study enrolled 500 patients with T2DM attending the outpatient clinic of Shyam Shah Medical College, Rewa, in 2024. Data collected included demographics, BMI, HbA1c, fasting and postprandial glucose, vitamin B12, 25-hydroxyvitamin D, lipid profile, and renal function tests. Patients were categorized based on glycemic control (Group A: HbA1c < 7%, Group B: HbA1c ≥ 7%). Statistical analyses included t-tests, Pearson correlation, and multivariate regression.Results: Group A had significantly higher vitamin B12 (674.2 ± 609.5 pg/mL) and vitamin D levels (31.20 ± 13.80 ng/mL) compared to Group B (457.76 ± 463.6 pg/mL and 26.76 ± 20.63 ng/mL, respectively; P < 0.01). HbA1c showed inverse correlations with both vitamins. Multivariate analysis confirmed both as independent predictors of glycemic control.Conclusions: Vitamin B12 and D deficiencies are significantly associated with poor glycemic control and may serve as modifiable targets in diabetes care, warranting routine screening in primary care settings.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"84"},"PeriodicalIF":1.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Hidden Dangers of Vaping and the Need for Community Action: An Indian Perspective. 电子烟的隐患和社区行动的必要性：印度人的视角。

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_154_25

Nidhi Aggarwal, Sahjid Mukhida

引用次数: 0

Selegiline Improved Oxidative and Inflammatory Stress Factors in Gentamicin-Induced Nephrotoxicity in Human Renal Tubular Epithelial Cells. 斯来吉兰改善庆大霉素诱导的人肾小管上皮细胞肾毒性中的氧化和炎症应激因子。

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_361_24

Khojasteh Hoseinynejad, Mahsa Poursangbor, Maryam Radan, Fereshteh Nejaddehbashi

{"title":"Selegiline Improved Oxidative and Inflammatory Stress Factors in Gentamicin-Induced Nephrotoxicity in Human Renal Tubular Epithelial Cells.","authors":"Khojasteh Hoseinynejad, Mahsa Poursangbor, Maryam Radan, Fereshteh Nejaddehbashi","doi":"10.4103/ijpvm.ijpvm_361_24","DOIUrl":"10.4103/ijpvm.ijpvm_361_24","url":null,"abstract":"Background: Gentamicin, an effective antibiotic, can lead to kidney damage through increased oxidative stress and inflammation. As a monoamine oxidase inhibitor, selegiline has antioxidant and anti-inflammatory properties that may reduce the negative effects of gentamicin.Method: This study was conducted on human kidney tubular cells (HEK) and divided into five groups, control, group of cells exposed to gentamicin, group of cells exposed to gentamicin+ 20 μmol selegiline treatment, group of cells exposed to gentamicin + treatment of cells with selegiline 30 μmol, and group of cells exposed to gentamicin + treatment of cells with selegiline 40 μmol were placed, and in all groups, the amount of gentamicin was 3 μmol.Results: This research showed that selegiline increases cell viability, total antioxidant capacity, and interleukin 10 as well as decreases the amount of reactive oxygen species, malondialdehyde, and interleukin 6 against the effects of gentamicin-induced nephrotoxicity.Conclusions: These findings show that selegiline can have protective effects on kidney damage caused by gentamicin and by reducing oxidative stress and inflammation, it can be proposed as a promising treatment option to reduce the side effects of gentamicin.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"87"},"PeriodicalIF":1.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Prenatal Testing (NIPT): A Paradigm Shift in Prenatal Care. 无创产前检测（NIPT）：在产前护理范式转变。

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-12-31 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_266_25

Ram K Garg, Yogesh Kumar, Ram Niwas, Jitendra Singh

{"title":"Non-Invasive Prenatal Testing (NIPT): A Paradigm Shift in Prenatal Care.","authors":"Ram K Garg, Yogesh Kumar, Ram Niwas, Jitendra Singh","doi":"10.4103/ijpvm.ijpvm_266_25","DOIUrl":"10.4103/ijpvm.ijpvm_266_25","url":null,"abstract":"Prenatal screening has undergone a profound transformation with the emergence of Non-Invasive Prenatal Testing (NIPT), a technology that analyzes cell-free fetal DNA (cffDNA) in maternal blood to detect common chromosomal abnormalities. Compared to traditional biochemical and ultrasound-based screening, NIPT offers markedly higher accuracy, earlier detection, and reduced procedural risk, representing a true paradigm shift in prenatal care. This narrative review synthesizes current evidence on the clinical performance, technological evolution, and ethical implications of NIPT within modern obstetric practice. Findings indicate that NIPT demonstrates exceptional sensitivity and specificity for trisomy 21, with strong performance for trisomy's 18 and 13 and promising application to sex chromosome aneuploidies. Its adoption has led to a significant reduction in invasive diagnostic procedures such as amniocentesis, thereby enhancing maternal safety and psychological comfort. Recent advancements-including SNP-based and fragmentomics-enhanced sequencing, artificial intelligence integration, and combined screening approaches-have further expanded NIPT's precision and potential scope. However, challenges persist regarding test accessibility, cost-effectiveness, and the interpretation of complex results from expanded panels. Beyond its clinical and technological merits, the review underscores the importance of addressing ethical, legal, and social concerns such as informed consent, privacy protection, and equitable access, particularly as direct-to-consumer models emerge. Ultimately, NIPT stands as a transformative innovation in reproductive medicine, offering a safer and more individualized approach to prenatal screening. Its continued success will depend on the establishment of robust ethical frameworks and equitable implementation strategies to ensure that advances in genetic technology translate into meaningful and responsible improvements in maternal-fetal care.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"86"},"PeriodicalIF":1.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty Acid Profile and Hazard Index of Ready-to-Eat Foods Available in the Market: A Risk Survey. 市售即食食品的脂肪酸分布及危害指数：一项风险调查。

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-11-27 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_118_24

Masoumeh Moslemi, Abdol-Samad Abedi, Narges Shahbazpour, Ghazaleh Bahramian, Roholla Ferdousi, Seyed Ehsan Beladian Behbahan

{"title":"Fatty Acid Profile and Hazard Index of Ready-to-Eat Foods Available in the Market: A Risk Survey.","authors":"Masoumeh Moslemi, Abdol-Samad Abedi, Narges Shahbazpour, Ghazaleh Bahramian, Roholla Ferdousi, Seyed Ehsan Beladian Behbahan","doi":"10.4103/ijpvm.ijpvm_118_24","DOIUrl":"10.4103/ijpvm.ijpvm_118_24","url":null,"abstract":"Background: Dietary fat is of necessary macronutrients for body health. According to the guidelines, up to 10% of calories can be supplied by saturated fat. Moreover, intake of trans fats should be reduced up to zero, if possible. Owing to the increasing share of ready-to-eat foods in the daily basket, we aimed to analyze these types of foods to determine their fatty acid profile, and the hazard indices of atherogenicity and thrombogenicity.Methods: Four types of industrial and seven types of retail ready-to-eat foods were purchased from local markets. The fatty acid profile was determined using a gas chromatograph-flame ionization detector.Results: According to our results, trans fats were found at very low levels in the products. The amount of saturated and trans fats increased by increasing the concentration of meat. In comparison, the most concentration of unsaturated fatty acids was observed in the products prepared with vegetable oils and/or nonmeat ingredients, including sausage, salami, falafel, and samosa. Among the fatty acids, palmitic, oleic, and linoleic acids were predominant in both industrial and retail foods. Evaluation of hazard indices in the foods revealed that both atherogenicity (0.2-0.85) and thrombogenicity (0.46-1.51) indexes were within the normal ranges, except for industrially packed hamburger with a thrombogenicity index of 3.7 due to its high stearic acid.Conclusions: Considering the low atherogenicity and thrombogenicity indexes, we concluded that the ready-to-eat foods did not compromise the health of the consumers. It was approved by the low ratio of SFA/USFA in almost all the products.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"66"},"PeriodicalIF":1.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why Type 2 Diabetes Risk Factors Are Concerningly High in Slum Areas? 为什么贫民窟地区2型糖尿病风险因素高？

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-11-27 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_335_24

Angely Margaretha Eriady, Bryany Titi Santi, Laurentius Aswin Pramono, Sandy Vitria Kurniawan

{"title":"Why Type 2 Diabetes Risk Factors Are Concerningly High in Slum Areas?","authors":"Angely Margaretha Eriady, Bryany Titi Santi, Laurentius Aswin Pramono, Sandy Vitria Kurniawan","doi":"10.4103/ijpvm.ijpvm_335_24","DOIUrl":"10.4103/ijpvm.ijpvm_335_24","url":null,"abstract":"Background: Indonesia ranks fifth among the most diabetic countries in the world, with a prevalence of 1.5%. This figure can also increase in community groups in slum areas because they are a group that is limited in accessing good quality health services. Hence, preventing complications from type 2 diabetes mellitus (T2DM) is a concern in slum areas.Objective: This study aims to determine the prevalence and factors related to T2DM, description of physical activity, smoking status, central obesity, and sociodemographic features in the community in a slum area of Penjaringan, North Jakarta.Methods: Cross-sectional research in the slum area Penjaringan Jakarta Utara was conducted from July 2022 to November 2022. We conducted a total sampling method and obtained 3314 respondents. Data analysis was done using Chi-square and Mann-Whitney tests for bivariate analysis. Multivariate analysis used logistic regression analysis with a significance level of P < 0.05.Results: The study showed the prevalence of T2DM in slum area communities in Penjaringan North Jakarta was 9.6%. Age (OR = 0.62, 95% CI 0.44-0.86, P < 0.05) and central obesity (OR = 1.02, 95% CI 1.01-1.03, P < 0.05) had a significant relationship with T2DM. While physical inactivity (OR = 1.00, 95% CI 1.00-1.00, P < 0.05) and gender (OR = 1.20, 95% CI 0.94-1.53, P < 0.05) had no association with T2DM.Conclusions: The prevalence of T2DM in people in slum areas is greater than the prevalence of diabetes in Jakarta. Central obesity and age are the variables that have a significant correlation with T2DM.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"79"},"PeriodicalIF":1.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence of Polymorphism in Vitamin D Receptor Genes and its Correlation with Susceptibility to Pulmonary Tuberculosis in the Global Population (2010-2023): A Systematic Review and Meta-Analysis. 全球人群维生素D受体基因多态性患病率及其与肺结核易感性的相关性（2010-2023）：一项系统综述和荟萃分析

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-11-27 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_322_24

Alireza Firouzjahai, Mahdie Taheri, Siamak Sabaghi, Radmehr Nozari, Samaneh Rouhi, Mohammad Ranaee, Zahra Ahmadnia, Sara Babazadeh, Somayeh Ahmadi Goorji, Afra Hosseinpanahi

{"title":"The Prevalence of Polymorphism in Vitamin D Receptor Genes and its Correlation with Susceptibility to Pulmonary Tuberculosis in the Global Population (2010-2023): A Systematic Review and Meta-Analysis.","authors":"Alireza Firouzjahai, Mahdie Taheri, Siamak Sabaghi, Radmehr Nozari, Samaneh Rouhi, Mohammad Ranaee, Zahra Ahmadnia, Sara Babazadeh, Somayeh Ahmadi Goorji, Afra Hosseinpanahi","doi":"10.4103/ijpvm.ijpvm_322_24","DOIUrl":"10.4103/ijpvm.ijpvm_322_24","url":null,"abstract":"Background: Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene play a significant role in the susceptibility to pulmonary tuberculosis (TB). Recognition of these polymorphisms is a crucial aspect of TB treatment. This study aims to investigate the effects of VDR gene polymorphisms on TB susceptibility.Methods: This research encompassed studies from 2010 to 2023. The synthesis and integration of data, along with meta-analysis and qualitative heterogeneity investigation, were conducted using a documentation table. STATA 14 software was employed for meta-analysis, utilizing both the fixed and random effects models. To assess data heterogeneity, the Q test (p < 0.10) with the chi-square χ2 distribution at the 95% confidence level was employed. Two-sided statistical tests were conducted with α = 0.05.Results: The highest pooled OR of genotype polymorphism of the VDR gene was associated with the FF (OR: 1.165, 95% CI; 0.953- 1.424), TT (OR: 1.163, 95% CI; 1.018- 1.329), Tt (95% CI: 0.768-1.095) and tt (95% CI: 0.594-1.416) each one OR: 0.917, Ff (OR: 0.888, 95% CI; 0.699- 1.130, weight: 100.00) and ff (OR: 0.648, 95% CI; 0.418- 1.006, weight: 100.00), respectively. The statistical difference between case and control groups was found to be significant in terms of TT genotype (P = 0.026). A statistically significant difference was observed between individuals (Along with the polymorphism of VDR genes) with and without pulmonary TB.Conclusions: The FF and TT genotypes exhibited the highest prevalence of polymorphism.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"68"},"PeriodicalIF":1.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Fat Diet Exacerbates Neuroinflammation and Disease Severity in a Rat Model of Multiple Sclerosis. 高脂肪饮食加重多发性硬化症大鼠模型的神经炎症和疾病严重程度

IF 1.5

International Journal of Preventive Medicine Pub Date : 2025-11-27 eCollection Date: 2025-01-01 DOI: 10.4103/ijpvm.ijpvm_152_24

Shahsanam Gheibi, Masood YahyaZadeh, Mojtaba Karimipour, Ahad Ghazavi, Khosrow Kashfi

{"title":"High-Fat Diet Exacerbates Neuroinflammation and Disease Severity in a Rat Model of Multiple Sclerosis.","authors":"Shahsanam Gheibi, Masood YahyaZadeh, Mojtaba Karimipour, Ahad Ghazavi, Khosrow Kashfi","doi":"10.4103/ijpvm.ijpvm_152_24","DOIUrl":"10.4103/ijpvm.ijpvm_152_24","url":null,"abstract":"Background: Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system. The use of high-fat diet is a modifiable risk factor for a variety of inflammatory diseases. Thus, the aim of this study was to investigate the effects of a high-fat diet on the progression of MS in a validated animal model.Methods: Adult Wistar rats (N = 10/group) were randomly divided into four groups: (1) standard diet, (2) high-fat diet, (3) and (4) standard and high-fat diet for 45 days, followed by induction of experimental encephalomyelitis. Animals were evaluated for clinical symptoms of MS and biochemical tests, including total cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein-cholesterol (LDL-C and HDL-C), fibrinogen, interferon-gamma (IFN-γ), and interleukin-17 (IL-17). Tissue samples were subjected to neuropathological evaluation. The analysis was performed by one-way analysis of variance (ANOVA).Results: The high-fat diet increased the progression of experimental autoimmune encephalomyelitis (EAE) disease, INF-γ (approximately 1.5 folds), IL-17 levels (approximately 3 folds), lymphocyte proliferation, TG (approximately 40 folds), TC (approximately 80 folds), LDL-C (approximately 14 folds), and fibrinogen levels (approximately 100 folds), but HDL-C (approximately 40 folds) was decreased (P < 0.05) in the affected MS group compared to standard diet.Conclusions: This study demonstrates that a high-fat diet significantly worsens clinical and immunological outcomes in an animal model of MS. The elevation of pro-inflammatory cytokines, particularly IFN-γ and IL-17, suggests that dietary fat may promote an inflammatory environment that accelerates disease progression. These findings highlight the need for further research to elucidate the underlying mechanisms.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"72"},"PeriodicalIF":1.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0