International Journal of Preventive Medicine最新文献

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Examining the Effectiveness of Japanese Local and National Government Information Sources on COVID-19 Vaccine Uptake. 检验日本地方和国家政府信息来源在COVID-19疫苗摄取方面的有效性。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-07-30 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_344_24
Marina Richey, Satoko Yasuno
{"title":"Examining the Effectiveness of Japanese Local and National Government Information Sources on COVID-19 Vaccine Uptake.","authors":"Marina Richey, Satoko Yasuno","doi":"10.4103/ijpvm.ijpvm_344_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_344_24","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of different levels of government in generating compliance with public health initiatives during pandemics is not currently known. As public health is administered at both local and national levels, this study aimed to determine which government level is most effective in motivating the public so that resources can be efficiently allocated.</p><p><strong>Methods: </strong>The usage rates and subsequent vaccine uptake of the Japanese national government's main COVID-19 vaccination website, \"Vaccine Navi,\" were compared to Japanese local governments' websites and mailed paper flyers. Data were collected through an online survey of 1088 participants matched to national demographic data asking about their experience with Vaccine Navi and local resources in receiving information about the COVID-19 vaccine. T-tests and ordinary least squares regression modeling were used for statistical analysis.</p><p><strong>Results: </strong>The information resources created by local Japanese governments to aid in vaccine rollout were used significantly more than the national government's Vaccine Navi. There was no statistically significant difference in the number of vaccines received after a local and national information source was used.</p><p><strong>Conclusions: </strong>Local health resources are beneficial to distributing information during health crises, and utilizing local public health offices is advantageous for public health guidance during pandemics.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"53"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do the Modified Mediterranean and Dietary Approaches to Stop Hypertension Dietary Patterns Interact with Psychological Disorders to Affect Sleep Quality and Quantity? Yazd Health Study-Taghzieh Mardom-e-Yazd Study. 改良的地中海和饮食方法是否能阻止高血压饮食模式与心理障碍相互作用影响睡眠质量和数量?亚兹德健康研究- taghzieh Mardom-e-Yazd研究。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-07-30 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_130_24
Saeed Sherafatmanesh, Farzan Madadizadeh, Mahdieh Hosseinzadeh, Mohammad Mohammadi, Masoud Mirzaei, Hossein Khosravi-Boroujeni, Amin Salehi-Abargouei
{"title":"Do the Modified Mediterranean and Dietary Approaches to Stop Hypertension Dietary Patterns Interact with Psychological Disorders to Affect Sleep Quality and Quantity? Yazd Health Study-Taghzieh Mardom-e-Yazd Study.","authors":"Saeed Sherafatmanesh, Farzan Madadizadeh, Mahdieh Hosseinzadeh, Mohammad Mohammadi, Masoud Mirzaei, Hossein Khosravi-Boroujeni, Amin Salehi-Abargouei","doi":"10.4103/ijpvm.ijpvm_130_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_130_24","url":null,"abstract":"<p><strong>Background: </strong>The separate relationship between dietary food intake and psychiatric illnesses on individuals' sleep has been discovered in previous investigations. However, it is yet unknown how these variables combine to affect the quantity and quality of sleep. Therefore, the purpose of the present cross-sectional study was to assess the possible interaction between Dietary Approaches to Stop Hypertension (DASH) and modified Mediterranean (mMED) dietary patterns (DPs) and psychological ailments (PAs) on sleep quality and duration among Iranian adults, Yazd, Iran.</p><p><strong>Materials and methods: </strong>Baseline data from a large Iranian cohort study (Yazd Health Study (YaHS)-Taghzieh Mardom-e-Yazd (TAMYZ)) were used in the current investigation. A validated food frequency questionnaire was utilized to obtain participants' dietary consumption. The adherence level of the study DPs was calculated according to the earlier scientific literature. The depression, anxiety, and stress scale-21 questionnaire was employed to assess PAs. Additionally, gathering information regarding the individuals' sleep quality and duration was done via a validated nocturnal sleep questionnaire and a short version of the Pittsburgh questionnaire. Finally, the multivariable adjusted binary logistic regression test was used to examine the interaction between DPs and PAs on sleep quality and duration.</p><p><strong>Results: </strong>Participants with the greatest adherence to the mMED DP and with severe depression had significantly lower odds of \"low sleep quality\" than those without depression signs and with the lowest adherence to the diet (<i>P</i> for interaction: 0.039).</p><p><strong>Conclusion: </strong>A mMED DP might help those with severe depression by improving sleep quality. Prospective investigations are needed to confirm this finding.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"54"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Inflammatory Index and Coronary Artery Disease Risk and Mortality: A Nonlinear Dose-Response Systematic Review and Meta-Analysis. 饮食炎症指数与冠状动脉疾病风险和死亡率:非线性剂量反应系统评价和荟萃分析。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-07-30 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_358_24
Ebrahim Benam, Mahdi Keshani, Mohammad Amin Mohammadi, Hasan Shemirani, Masoumeh Sadeghi
{"title":"Dietary Inflammatory Index and Coronary Artery Disease Risk and Mortality: A Nonlinear Dose-Response Systematic Review and Meta-Analysis.","authors":"Ebrahim Benam, Mahdi Keshani, Mohammad Amin Mohammadi, Hasan Shemirani, Masoumeh Sadeghi","doi":"10.4103/ijpvm.ijpvm_358_24","DOIUrl":"https://doi.org/10.4103/ijpvm.ijpvm_358_24","url":null,"abstract":"<p><strong>Background: </strong>This systematic review and meta-analysis study aims to investigate the association between dietary inflammatory index (DII) and coronary artery disease (CAD) risk and mortality.</p><p><strong>Methods: </strong>A comprehensive search in PubMed, Web of Science, Embase, and Scopus was implemented for relevant observational studies investigating the relation between DII and risk of CAD and CAD mortality published up to May 2024. Articles that reported the relative risk, odd ratio (OR), or hazard ratio for the highest score of DII versus the lowest score of DII were retrieved. For quantitative analyses, categorical analysis, linear and nonlinear analyses, and subgroup analysis are performed.</p><p><strong>Results: </strong>Finally, 18 studies [CAD (n = 13) and CAD mortality (n = 5)] were included. Individuals with the highest score of DII versus the lowest ones have 38% (1.38; 95% CI: 1.22 to 1.56) and 40% (1.40; 95% CI: 1.13 to 1.75) more risk to CAD and CAD mortality, respectively. The linear analysis declared that the summary OR for CAD is 1.16 (95% CI: 1.08 to 1.24) and for CAD mortality 1.09 (95% CI: 1.03 to 1.14) per each 1-point increase in DII. There was also evidence of nonlinear relationship between the DII and CAD as the relation became even more significant when the DII were more than 2 points (<i>P</i> < 0.001). A positive association was revealed in the DII score (proinflammatory diet) and risk of CAD and CAD mortality.</p><p><strong>Conclusions: </strong>However, due to the large heterogeneity and some aforementioned limitations, more high-quality prospective studies can validate our results.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"56"},"PeriodicalIF":1.8,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Television (TV) Food Commercials Target Children: A Content Analysis of TV Food Advertisements in Iran. 针对儿童的电视食品广告:伊朗电视食品广告的内容分析。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_274_24
Maryam Amini, Mehrnoosh Shafaatdoost, Delaram Ghodsi, Mohadese Borazjani, Maryam Aghayan, Nastaran Shariatzadeh
{"title":"Television (TV) Food Commercials Target Children: A Content Analysis of TV Food Advertisements in Iran.","authors":"Maryam Amini, Mehrnoosh Shafaatdoost, Delaram Ghodsi, Mohadese Borazjani, Maryam Aghayan, Nastaran Shariatzadeh","doi":"10.4103/ijpvm.ijpvm_274_24","DOIUrl":"10.4103/ijpvm.ijpvm_274_24","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze the content of Iran's television (TV) food advertisements directed at children in 2020.</p><p><strong>Methods: </strong>All the programs broadcast on Channel II TV were downloaded for one week; however, only children's programs were analyzed. The validated protocol was used to analyze the content of the advertisements. In addition, compliance of food advertisements with Iran's, World Health Organization Eastern Mediterranean Region (WHO EMR), and International Network for Food and Obesity/Non-communicable Diseases (NCDs) Research Monitoring and Action Support (INFORMAS) standards was assessed.</p><p><strong>Results: </strong>A total of 761 TV advertisements targeted children on channel II. \"Food products\" were the most frequent advertisements (41.7%). \"Desserts and sweets\" were the most advertised food products (46%), followed by \"condiments\" and \"dairy products\" (20.5% and 11.7%, respectively). \"Stimulation of appetite\" and \"high quality/careful preparation\" were the most frequent appeals for advertisements directed at children. \"Animation/Company-owned character(s)\" was the most frequent advertising strategy. Most food advertisements adhered to Iran's regulations; however, according to the WHO EMR and INFORMAS, most food advertisements have not met advertising standards. Present research revealed that food products were a prominent part of other advertisements on children's TV.</p><p><strong>Conclusions: </strong>Children were predominantly exposed to foods high in fat, salt, and sugar, and the share of unhealthy food advertisements, such as desserts, sweets, fast foods, fats, and sugared drinks, was significant. Regarding the high violation rate of the advertising regulations, a more careful audit of commercials targeting children is highly recommended.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"40"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Anchor in the Storm: A Healthcare Professional's Guide to Preventing and Managing Collective Trauma. 风暴中的锚:医疗保健专业人员预防和管理集体创伤的指南。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_437_25
Nader Aghakhani, Béatrice Marianne Ewalds Kvist, Aniroda Broomand
{"title":"The Anchor in the Storm: A Healthcare Professional's Guide to Preventing and Managing Collective Trauma.","authors":"Nader Aghakhani, Béatrice Marianne Ewalds Kvist, Aniroda Broomand","doi":"10.4103/ijpvm.ijpvm_437_25","DOIUrl":"10.4103/ijpvm.ijpvm_437_25","url":null,"abstract":"","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"43"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effectiveness of Topical Gel Containing Arginine-Releasing Chitosan Nanofibers on the Healing of Diabetic Foot Ulcers: A Randomized Controlled Clinical Trial. 含有精氨酸释放壳聚糖纳米纤维的局部凝胶对糖尿病足溃疡愈合的有效性:一项随机对照临床试验。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_41_24
Razieh Ramazani, Rasool Soltani, Farzin Khorvash, Azade Taheri, Mehdi Shahbazi Azad
{"title":"The Effectiveness of Topical Gel Containing Arginine-Releasing Chitosan Nanofibers on the Healing of Diabetic Foot Ulcers: A Randomized Controlled Clinical Trial.","authors":"Razieh Ramazani, Rasool Soltani, Farzin Khorvash, Azade Taheri, Mehdi Shahbazi Azad","doi":"10.4103/ijpvm.ijpvm_41_24","DOIUrl":"10.4103/ijpvm.ijpvm_41_24","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcer (DFU) is one of serious consequences of diabetes mellitus leading to many complications. Chitosan is a natural polymer used in wound dressings and is effective on healing. Also, arginine is the most important amino acid in wound healing. In this study, the clinical effects of a topical gel containing arginine-releasing chitosan nanofibers on the healing of DFUs was evaluated.</p><p><strong>Methods: </strong>In this randomized controlled clinical trial, patients with grades 1 or 2 DFU were divided to two groups of drug (<i>n</i> = 25) and control (<i>n</i> = 31). For drug and control groups, arginine-releasing chitosan nanofibers gel and a type of novel dressing (Sorbact<sup>®</sup> gel dressing) were applied every other day for 14 days. The percentage of change in wound size as well as the rate of complete healing of the ulcer (>90% reduction in the size) at the 7<sup>th</sup> and 14<sup>th</sup> days of the intervention was recorded and compared between the groups.</p><p><strong>Results: </strong>There was significant decrease in the wound size in both groups at the end of weeks 1 and 2 compared to the baseline. However, there was no significant difference between the groups regarding the percentage of decrease in the size. There was no significant difference between the groups in terms of the rate of complete wound healing at the end of the study (9 cases [36%] vs. 7 cases [22.58%], respectively; <i>P</i> = 0.269).</p><p><strong>Conclusions: </strong>Topical gel containing arginine-releasing chitosan nanofibers improves and accelerates the healing of DFUs. However, more studies are required to confirm these effects.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"37"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Problematic Internet Use and Health Literacy with Health-Promoting Lifestyle among Students. 大学生不良网络使用与健康素养与健康生活方式的关系
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_382_24
Sajad Javanbakht, Faeze Sobhanifar, Reza Ahmadi Jirandeh, Mohsen Vahedi, Abolfazl Rahgoi
{"title":"Relationship Between Problematic Internet Use and Health Literacy with Health-Promoting Lifestyle among Students.","authors":"Sajad Javanbakht, Faeze Sobhanifar, Reza Ahmadi Jirandeh, Mohsen Vahedi, Abolfazl Rahgoi","doi":"10.4103/ijpvm.ijpvm_382_24","DOIUrl":"10.4103/ijpvm.ijpvm_382_24","url":null,"abstract":"<p><strong>Background: </strong>Studying at university is a transitional and dynamic period, which provides an optimal opportunity for fostering healthy behaviors. But the high prevalence of problematic internet use (PIU) among students may hinder the development and establishment of healthy behaviors and a health-promoting lifestyle (HPL). PIU is important due to its impact on academic performance, social relationships, and policymaking on this issue. This study aimed to investigate the relationship between PIU and health literacy (HL) with HPL among students.</p><p><strong>Methods: </strong>This cross-sectional descriptive-analytical study was performed on 525 students of the University of Social Welfare and Rehabilitation Sciences in 2024, who were selected by convenience sampling. An electronic questionnaire was sent to students, which consisted of demographic, Walker's HPL, Caplan's PIU, and Tavousi's HL questionnaire. Data were analyzed using SPSS Statistics version 25 (IBM Corp., Armonk, NY, USA).</p><p><strong>Results: </strong>The mean score of PIU was 55.55 ± 15.63. The mood regulation dimension had the highest score, and negative outcomes had the lowest score. HPL score was at a moderate level, and the severity of PIU was at a mild level. There was a significant negative correlation between HPL and PIU. Also a positive correlation was observed between HL and HPL.</p><p><strong>Conclusions: </strong>PIU and HL are significantly related to HPL. Managers and policymakers are encouraged to develop special programs to reduce the negative effects of PIU by enriching students' free time, teaching media literacy, as well as increasing HL and health-promoting behaviors to improve students' quality of life, which affects their academic performance and careers.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"42"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the Mental Health Impact of Smartphone Addiction in Higher Secondary Students: A Call for Action. 解决智能手机成瘾对高中生心理健康的影响:行动呼吁。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_78_25
M S Neeraj, K Neena Narayanan, U P Mohammed Shamil Hussain
{"title":"Addressing the Mental Health Impact of Smartphone Addiction in Higher Secondary Students: A Call for Action.","authors":"M S Neeraj, K Neena Narayanan, U P Mohammed Shamil Hussain","doi":"10.4103/ijpvm.ijpvm_78_25","DOIUrl":"10.4103/ijpvm.ijpvm_78_25","url":null,"abstract":"","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"39"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Fish Oil in Modulating Metabolic Disorders: Implications for Cardiovascular Health, Endothelial Dysfunction Biomarkers, and Hypercholesterolemia. 鱼油在调节代谢紊乱中的作用:对心血管健康、内皮功能障碍生物标志物和高胆固醇血症的影响
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_71_25
Hessah M Al-Muzafar, Kamal A Amin
{"title":"The Role of Fish Oil in Modulating Metabolic Disorders: Implications for Cardiovascular Health, Endothelial Dysfunction Biomarkers, and Hypercholesterolemia.","authors":"Hessah M Al-Muzafar, Kamal A Amin","doi":"10.4103/ijpvm.ijpvm_71_25","DOIUrl":"10.4103/ijpvm.ijpvm_71_25","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hypercholesterolemia is a significant risk factor for various metabolic disorders, such as diabetes, cardiovascular disease (CVD), and atherosclerosis, which contribute to morbidity and mortality worldwide. Fish intake has been associated with a lower risk of CVD; however, the administration of n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) has shown limited effects on cholesterol levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;This study aimed to investigate the role of fish oil in maintaining a healthy metabolism; explore the impact of hypercholesterolemia on oxidative stress, endothelial dysfunction, and inflammatory biomarkers; and determine the biochemical relationships among lipid profiles, inflammatory mediators, and endothelial dysfunction biomarkers. Additionally, we compared the potential roles and mechanisms of action of fish oil and atorvastatin in the treatment and prevention of cardiovascular events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Eighty rats, weighing 100-150 g, were divided into five equal groups. The first group (control) was fed a standard diet. The second group was fed a high-cholesterol diet (HCD) for 8 weeks to induce hypercholesterolemia. The third group was given HCD supplemented with fish oil. The fourth group received HCD along with 20 mg of atorvastatin. Blood and tissue samples were analyzed to measure serum lipid profiles, including triglycerides (TG), cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and homocysteine levels. Inflammatory mediators (C-reactive protein, TNF, IL-6) and endothelial dysfunction markers (nitric oxide, nitric oxide synthase) were also measured. The statistical analysis method used for the study was one-way analysis of variance (ANOVA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared to the control group, the final body weight and mean body weight gain were significantly greater in the HCD group. The HCD-fed rats exhibited increased levels of serum lipids, including LDL, TG, total cholesterol (TC), and HDL (P &lt; 0.05), as well as elevated heart function markers (LDH and CK-MB), homocysteine, and inflammatory markers (TNF and CRP). These changes were ameliorated with the administration of atorvastatin and fish oil. HCD increased the levels of nitric oxide synthase and VCAM, while the administration of fish oil improved these markers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Fish oil effectively ameliorates hypercholesterolemia-induced dyslipidemia and inhibits inflammatory biomarkers. Additionally, it lowers cardiac biomarkers, potentially reducing the risk of inflammation, arteriosclerosis, and vascular endothelial dysfunction. These beneficial effects may be attributed to the active components in fish oil. We suggest that fish oils could be used as functional dietary ingredients or supplements to manage the risk of developing CVD. Overall, this study contributes new insights into the biochemical relationships between lipid metabolism, inflammation, a","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"38"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Gross Motor Function through Integrated Play Therapy and Neurodevelopmental Treatment in Spastic Diplegic Cerebral Palsy. 通过综合游戏治疗和神经发育治疗增强痉挛性双瘫脑瘫的大运动功能。
IF 1.8
International Journal of Preventive Medicine Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.4103/ijpvm.ijpvm_315_25
Mandar Malawade
{"title":"Enhancing Gross Motor Function through Integrated Play Therapy and Neurodevelopmental Treatment in Spastic Diplegic Cerebral Palsy.","authors":"Mandar Malawade","doi":"10.4103/ijpvm.ijpvm_315_25","DOIUrl":"10.4103/ijpvm.ijpvm_315_25","url":null,"abstract":"<p><p>The present study aims to evaluate the efficacy of a combined treatment of neurodevelopmental technique (NDT) and play therapy on gross motor function in children with spastic diplegic cerebral palsy. Fifteen children (4 to 10 years) received a combined intervention of NDT and play therapy three times a week for six weeks. Gross motor function was measured using the gross motor function measure scale (GMFM-88). Data were analyzed using paired <i>t</i>-tests. The pre-intervention score was 61.13 ± 18.94, and the post-intervention score was 73.00 ± 16.87 (<i>t</i> = 9.587, <i>P</i> < 0.001). The combination of NDT and play therapy resulted in significant improvement in the GMFM-88 scores of the participants. The findings suggest that combining play therapy with NDT can significantly improve gross motor function in children with spastic diplegic cerebral palsy, indicating implications of this integrated approach in pediatric rehabilitation programs.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"17 ","pages":"41"},"PeriodicalIF":1.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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