{"title":"伊朗鸦片使用者血铅水平和肝功能测试的调节","authors":"Mohammad Reza Eskandarion, Maryam Kohansal, Maral Chavoshi, Maryam Forutan, Raheb Ghorbani, Farid Heidari, Reza Azizian, Mehdi Norouzi, Bashir Nazparvar, Mohsen Tabasi, Maryam Akhgari","doi":"10.4103/ijpvm.ijpvm_52_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Opium users are at risk of lead poisoning. Therefore, this study aimed to compare opium users with healthy controls in terms of blood lead levels (BLLs), blood biochemistry, and liver function tests.</p><p><strong>Methods: </strong>A total of 100 people participated in the study. Biological samples (blood and urine) obtained from participants were prepared before analysis for the detection of opium alkaloids (morphine, codeine, papaverine, noscapine,…), amphetamine-type stimulants, and other licit and illicit drugs. Atomic absorption spectroscopy was used to calculate BLLs. We evaluated biochemical parameters and function tests. All statistical analysis was performed by using SPSS. In addition, biochemical parameters and liver function tests were evaluated.</p><p><strong>Results: </strong>The BLLs of opium addicts living in Tehran and healthy controls were 18.8 and 7.1 g/dL, respectively. A strong correlation was observed between the route of opium consumption and the average amount of BLL ± SEM (<i>P</i> = 0.037). As compared with the control group, opium users showed a statistically significant (p 0.001) association between the serum levels of the enzyme's aspartate aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, alanine aminotransferase, alkaline phosphatase, and total bilirubin and an increase in white blood cell and hematocrit levels.</p><p><strong>Conclusions: </strong>Results of the present study showed that opium users had elevated BLLs in comparison to the control group, which profoundly affected biochemical parameters and liver enzymes.</p>","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":"16 ","pages":"37"},"PeriodicalIF":1.5000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303400/pdf/","citationCount":"0","resultStr":"{\"title\":\"Modulation of Blood Lead Level and Liver Function Tests in Iranian Opium Users.\",\"authors\":\"Mohammad Reza Eskandarion, Maryam Kohansal, Maral Chavoshi, Maryam Forutan, Raheb Ghorbani, Farid Heidari, Reza Azizian, Mehdi Norouzi, Bashir Nazparvar, Mohsen Tabasi, Maryam Akhgari\",\"doi\":\"10.4103/ijpvm.ijpvm_52_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Opium users are at risk of lead poisoning. Therefore, this study aimed to compare opium users with healthy controls in terms of blood lead levels (BLLs), blood biochemistry, and liver function tests.</p><p><strong>Methods: </strong>A total of 100 people participated in the study. Biological samples (blood and urine) obtained from participants were prepared before analysis for the detection of opium alkaloids (morphine, codeine, papaverine, noscapine,…), amphetamine-type stimulants, and other licit and illicit drugs. Atomic absorption spectroscopy was used to calculate BLLs. We evaluated biochemical parameters and function tests. All statistical analysis was performed by using SPSS. In addition, biochemical parameters and liver function tests were evaluated.</p><p><strong>Results: </strong>The BLLs of opium addicts living in Tehran and healthy controls were 18.8 and 7.1 g/dL, respectively. A strong correlation was observed between the route of opium consumption and the average amount of BLL ± SEM (<i>P</i> = 0.037). As compared with the control group, opium users showed a statistically significant (p 0.001) association between the serum levels of the enzyme's aspartate aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, alanine aminotransferase, alkaline phosphatase, and total bilirubin and an increase in white blood cell and hematocrit levels.</p><p><strong>Conclusions: </strong>Results of the present study showed that opium users had elevated BLLs in comparison to the control group, which profoundly affected biochemical parameters and liver enzymes.</p>\",\"PeriodicalId\":14342,\"journal\":{\"name\":\"International Journal of Preventive Medicine\",\"volume\":\"16 \",\"pages\":\"37\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303400/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Preventive Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijpvm.ijpvm_52_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Preventive Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijpvm.ijpvm_52_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Modulation of Blood Lead Level and Liver Function Tests in Iranian Opium Users.
Background: Opium users are at risk of lead poisoning. Therefore, this study aimed to compare opium users with healthy controls in terms of blood lead levels (BLLs), blood biochemistry, and liver function tests.
Methods: A total of 100 people participated in the study. Biological samples (blood and urine) obtained from participants were prepared before analysis for the detection of opium alkaloids (morphine, codeine, papaverine, noscapine,…), amphetamine-type stimulants, and other licit and illicit drugs. Atomic absorption spectroscopy was used to calculate BLLs. We evaluated biochemical parameters and function tests. All statistical analysis was performed by using SPSS. In addition, biochemical parameters and liver function tests were evaluated.
Results: The BLLs of opium addicts living in Tehran and healthy controls were 18.8 and 7.1 g/dL, respectively. A strong correlation was observed between the route of opium consumption and the average amount of BLL ± SEM (P = 0.037). As compared with the control group, opium users showed a statistically significant (p 0.001) association between the serum levels of the enzyme's aspartate aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, alanine aminotransferase, alkaline phosphatase, and total bilirubin and an increase in white blood cell and hematocrit levels.
Conclusions: Results of the present study showed that opium users had elevated BLLs in comparison to the control group, which profoundly affected biochemical parameters and liver enzymes.
期刊介绍：
International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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