The Fundamental Place of Pap Test in Iran, Does Primary HPV-Genotyping Seem Cost-Effective in Replace? A Cohort Study.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Preventive Medicine Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.4103/ijpvm.ijpvm_283_23

Azam Zafarbakhsh, Fariba Behnamfar, Matin Shariati, Atefeh Vaezi, Leila Mousavi Seresht

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引用次数: 0

Abstract

Background: Human papillomavirus (HPV) is a known risk factor for cervical cancer, and currently, primary HPV typing is recommended for screening instead of cervical cytology. However, there are limited studies on the prevalence of HPV in Iran.

Methods: This cross-sectional study evaluated the liquid-based cervical smears of 700 women with no history of HPV vaccination and cervical dysplastic disease from 2017 to 2020 in Isfahan, Iran. Here, we compare the prevalence of HPV genotypes using COBAS with Pap smear cytology results in evaluating the most appropriate cervical cancer screening test.

Results: The prevalence of HPV infection was 23.3%, including 8.7% with HPV 16/18 and 14.6% with other HR (high-risk) HPVs. In cytology reports, 8 out of 16 individuals with high-risk lesions were negative for any type of HPV; on the other hand, there were 129 HR HPV-positive patients out of 570 negative or low-risk Pap smear results.

Conclusions: It assumed that there is no superiority for HPV genotyping over cytology or vice versa in detecting high-risk patients for cervical cancer; as only 26.8% of women with HPV show abnormal cytology; and from those with normal cytology, 17.9% were positive for HR HPV.

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巴氏涂片检查在伊朗的基础地位，原发性hpv基因分型是否具有成本效益？一项队列研究。

背景：人乳头瘤病毒（HPV）是一种已知的宫颈癌危险因素，目前，推荐进行原发性HPV分型而不是宫颈细胞学筛查。然而，关于伊朗HPV患病率的研究有限。方法：本横断面研究评估了2017年至2020年伊朗伊斯法罕700名无HPV疫苗接种史和宫颈发育不良疾病的妇女的宫颈液体涂片。在这里，我们比较了使用COBAS和巴氏涂片细胞学结果的HPV基因型患病率，以评估最合适的宫颈癌筛查试验。结果：HPV感染率为23.3%，其中HPV 16/18感染率为8.7%，其他高危HPV感染率为14.6%。在细胞学报告中，16例高危病变患者中有8例HPV检测呈阴性；另一方面，570例阴性或低风险巴氏涂片结果中有129例HR hpv阳性。结论：在宫颈癌高危人群的检测中，HPV基因分型不优于细胞学，反之亦然；只有26.8%的女性HPV患者表现出细胞学异常；在细胞学正常的人群中，17.9%的人HR HPV呈阳性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

4.80%

发文量

107

期刊介绍： International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.