International Medical Case Reports Journal最新文献_第2页

Management and Long-Term Monitoring of a Young Patient with Pheochromocytoma and RET Mutation: A Case Report. 年轻嗜铬细胞瘤合并RET突变患者的管理和长期监测：1例报告。

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International Medical Case Reports Journal Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S504562

Qingqing Zhang, Xue Wei, Jing Zheng, Bangkui Xu, Yu Lu, Shufang Yang, Yucheng Wu

{"title":"Management and Long-Term Monitoring of a Young Patient with Pheochromocytoma and RET Mutation: A Case Report.","authors":"Qingqing Zhang, Xue Wei, Jing Zheng, Bangkui Xu, Yu Lu, Shufang Yang, Yucheng Wu","doi":"10.2147/IMCRJ.S504562","DOIUrl":"10.2147/IMCRJ.S504562","url":null,"abstract":"Background: Pheochromocytoma is a rare catecholamine-secreting tumor that can present with severe hypertensive episodes and other symptoms due to excessive catecholamine release. Approximately 30% of pheochromocytomas are associated with hereditary syndromes, including multiple endocrine neoplasia type 2A (MEN2A), an autosomal dominant disorder caused by mutations in the RET proto-oncogene. MEN2A is characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism.Case presentation: We report the case of a 19-year-old female who presented with pheochromocytoma without experiencing a crisis, despite having a significant adrenal mass and undergoing high-dose glucocorticoid treatment. Genetic testing revealed a heterozygous missense mutation in the RET gene (c.1900T > C: p. Cys634Arg), associated with MEN2A. Further endocrine evaluation identified a thyroid nodule with mildly elevated calcitonin levels, but normal electrolyte and parathyroid hormone levels. Over a 15-month postoperative follow-up, the patient exhibited persistently mild hypercalcitoninemia with stable thyroid nodule size, while PTH and serum calcium levels showed a progressive increase. Further parathyroid scintigraphy using 99mTc-MIBI was performed, yielding a negative result for parathyroid adenoma.Conclusion: Patients with MEN2A require comprehensive, long-term follow-up to monitor for recurrence of pheochromocytoma and the development of additional endocrine neoplasms. This case highlights the role of genetic testing in guiding the management of hereditary pheochromocytoma and supports the importance of personalized monitoring strategies in patients with MEN2A.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"395-404"},"PeriodicalIF":0.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Late Diagnosis Pituitary Stalk Interruption Syndrome and Literature Review. 晚期诊断垂体柄中断综合征2例并文献复习。

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International Medical Case Reports Journal Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S507989

Malak Alkhalifa, Zaenb Alsalman, Abdulmohsen Al Elq, Zahra Al-Khadrawi, Huda Radwan

{"title":"Two Cases of Late Diagnosis Pituitary Stalk Interruption Syndrome and Literature Review.","authors":"Malak Alkhalifa, Zaenb Alsalman, Abdulmohsen Al Elq, Zahra Al-Khadrawi, Huda Radwan","doi":"10.2147/IMCRJ.S507989","DOIUrl":"10.2147/IMCRJ.S507989","url":null,"abstract":"Background: Pituitary stalk interruption syndrome (PSIS) is a rare congenital condition that includes the triad of a thin pituitary stalk, an ectopic posterior pituitary gland, and an absent or hypoplastic anterior pituitary gland and is usually diagnosed in infancy. This report presents two cases of late diagnosis of PSIS and a literature review of the relevant cases. The objective is to update data on such an uncommon syndrome to avoid the consequences of pituitary dysfunction including short stature, impaired cognitive function, negative impact on bone health, adrenal crises and delayed puberty.Case report: In this paper, we report on two cases of late diagnosis of PSIS with a history of growth hormone deficiency. The first case is a 21-year-old female presenting with generalized fatigability, dizziness and delayed puberty, while the second case is a 19-year-old female presenting with secondary amenorrhea. The hormonal profile of the first patient revealed panhypopituitarism; the second case had growth hormone deficiency subsequently had secondary hypogonadism with intact thyroid and adrenal functions. The diagnosis of PSIS was confirmed by magnetic resonance imaging (MRI), and both cases were treated with hormone supplements. Progress was also tracked through planned follow-up sessions. To the best of our knowledge, this is the first case series of such late diagnosis PSIS from Saudi Arabia.Conclusion: The key message of this paper is that rare etiologies such as PSIS should be kept in mind, especially for young patients presenting with clinical evidence of pituitary hormonal deficiencies, and MRI should be considered to confirm diagnosis. The early diagnosis, hormonal replacement, and long-term follow-up are crucial to reducing negative impacts of pituitary hormonal deficiencies.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"345-354"},"PeriodicalIF":0.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal Fistula Following Appendectomy as an Unusual Late Complication: A Rare Case Report. 阑尾切除术后大便瘘管是一种罕见的晚期并发症：一个罕见的病例报告。

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International Medical Case Reports Journal Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S518439

Fareed Ahmad Nazari, GhulamYahia Baset, Saied Karim Zarif, Muhammad Anwar Rahimdeen, Ahmad Amiri, Farukh Seyar

引用次数: 0

Five Years Follow-Up Outcomes of Femtosecond Laser-Assisted Cataract Surgery on Patients with Preexisting Corneal Astigmatism. 飞秒激光辅助白内障手术治疗既往角膜散光患者的5年随访结果。

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International Medical Case Reports Journal Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S506198

Thi Minh Khanh Pham, Xuan Hiep Nguyen, Thi Thu Thuy Pham, Tran Thanh Hoang

{"title":"Five Years Follow-Up Outcomes of Femtosecond Laser-Assisted Cataract Surgery on Patients with Preexisting Corneal Astigmatism.","authors":"Thi Minh Khanh Pham, Xuan Hiep Nguyen, Thi Thu Thuy Pham, Tran Thanh Hoang","doi":"10.2147/IMCRJ.S506198","DOIUrl":"10.2147/IMCRJ.S506198","url":null,"abstract":"Purpose: Evaluating the long-term clinical efficacy and safety of femtosecond laser-assisted cataract surgery for correcting corneal astigmatism.Patients and methods: In this cohort study on follow-up records from preoperative, postoperative 1 week, 1 month, 3 months, 1 year, 3 years, and 5 years, thirty-four eyes with cataract and corneal astigmatism (>0.50D) were treated with corneal arcuate incisions and femtosecond-laser assisted cataract surgery in Vietnam National Eye Hospital, from January 2017 to February 2023.Results: The rate of postoperative refraction spherical equivalent was within ± 0.50D and ± 1.0D at 3 months (in 91.2% and 100% of the eyes, respectively). The average of preoperative corneal astigmatism was 1.63 ± 0.886D, decreased to 0.53 ± 0.628D in the third month after surgery and stable to 5 years. Surgically induced astigmatism was 1.09 ± 0.413D, which indicated under-correction. However, no complications were recorded.Conclusion: The femtosecond laser-assisted cataract surgery is safe and long effective in correcting the corneal astigmatism in patients with preexisting corneal astigmatism.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"373-379"},"PeriodicalIF":0.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urticaria-Like Hypersensitivity Reaction Following Botulinum Toxin Injection: A Case Report of Possible Interaction with β-Lactam Antibiotics. 注射肉毒杆菌毒素后致荨麻疹样超敏反应：可能与β-内酰胺类抗生素相互作用1例报告。

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International Medical Case Reports Journal Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S510203

Weifeng Feng, Heqi Liu

引用次数: 0

A Rare Case of Postpartum Cerebral Venous Thrombosis and Hemorrhagic Infarction From Somalia. 索马里产后脑静脉血栓及出血性梗死1例。

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International Medical Case Reports Journal Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S516258

Mustafa Mumin Adem, Abdirahman Omer Ali, Muhiadin Ismail Abdi, Jama Osman Hirsi, Ahmed Abdi Aw Egge, Mohamoud Hashi Abdi, Mohamed Abubakar Muhumed, Hassan Elmi Moumin, Hodo Abdi Abdilahi

{"title":"A Rare Case of Postpartum Cerebral Venous Thrombosis and Hemorrhagic Infarction From Somalia.","authors":"Mustafa Mumin Adem, Abdirahman Omer Ali, Muhiadin Ismail Abdi, Jama Osman Hirsi, Ahmed Abdi Aw Egge, Mohamoud Hashi Abdi, Mohamed Abubakar Muhumed, Hassan Elmi Moumin, Hodo Abdi Abdilahi","doi":"10.2147/IMCRJ.S516258","DOIUrl":"10.2147/IMCRJ.S516258","url":null,"abstract":"Introduction: Cerebral venous thrombosis (CVT) is a rare but serious complication that can occur during pregnancy and the postpartum period. This case report discusses a unique instance of postpartum CVT complicated by hemorrhagic infarction in a patient from Somalia.Case presentation: We report the case of a 35-year-old woman, gravida 9, para 8, who presented on the 13th postpartum day with right-sided weakness, seizures, and severe headache. Initially misdiagnosed as impending eclampsia due to the absence of hypertension and proteinuria, she underwent CT and MRI scans, revealing a significant superior sagittal sinus thrombosis with hemorrhagic infarction. The patient was treated in the ICU with increased intracranial pressure management, seizure prophylaxis, and anticoagulation therapy, resulting in substantial clinical improvement.Discussion: This case emphasizes the necessity of maintaining a high index of suspicion for CVT in postpartum women displaying neurological symptoms. Misdiagnosis can impede timely intervention, highlighting the need for access to advanced imaging and a multidisciplinary approach. Increasing awareness and training for healthcare providers are essential for timely diagnosis.Conclusion: The management of this case illustrates the importance of early recognition of CVT in the postpartum population. Enhancing diagnostic resources and treatment strategies, particularly in resource-limited settings, can significantly improve maternal health outcomes and reduce morbidity and mortality.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"355-365"},"PeriodicalIF":0.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Site of BCC Reported in a Saudi Female: A Case Report. 沙特女性非典型基底细胞癌1例报告。

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International Medical Case Reports Journal Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S504537

Zahraa Ali Alwayel, Mohammed Ali Alkhars, Jumana Ali Alibrahim, Rawan Adel Alawadh, Alya Saleh AlKhars, Eman Hussain Alkhalaf

引用次数: 0

Uterine Manifestation of Sarcoidosis Diagnosed in the Setting of Fever of Unknown Origin. 不明原因发热诊断结节病的子宫表现。

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International Medical Case Reports Journal Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S501279

Rie Utsunomiya-Nishimizu, Yuki Tsutsui, Noboru Horinouchi, Katsuhiko Yoshimura, Masakazu Nishida, Seiji Shiota, Eishi Miyazaki

引用次数: 0

Diagnosis and Management Challenges of Spontaneous Quadruplet Pregnancy in a Resource-Limited Setting: A Case Report. 资源有限环境中自然四胞胎妊娠的诊断和管理难题：病例报告。

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International Medical Case Reports Journal Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S491180

Kevin Dominique Tjandraprawira, Dhanny Primantara Johari Santoso, Hartanto Bayuaji, Annisa Dewi Nugrahani, Dadan Susandi

{"title":"Diagnosis and Management Challenges of Spontaneous Quadruplet Pregnancy in a Resource-Limited Setting: A Case Report.","authors":"Kevin Dominique Tjandraprawira, Dhanny Primantara Johari Santoso, Hartanto Bayuaji, Annisa Dewi Nugrahani, Dadan Susandi","doi":"10.2147/IMCRJ.S491180","DOIUrl":"https://doi.org/10.2147/IMCRJ.S491180","url":null,"abstract":"Introduction: Higher-order pregnancy is considered as a high-risk pregnancy, followed by various maternal and foetal complications. The diagnosis and management of higher order pregnancy have abundant and complex challenges, especially in rural areas where antenatal care (ANC) is often inadequate. Late booking and low awareness of complications necessitates priority management and referral to a tertiary center for fetal medicine expertise. This is our experience managing a spontaneously conceived quadruplet pregnancy delivered prematurely in a low-resource setting.Case presentations: A 27-years-old primigravida of 7.5 months of gestation presented with preterm labor. Her membrane was intact, and she noted active fetal movements. Her history was notable due to her pregnancy being spontaneously conceived and that her antenatal consultations had mistakenly identified her pregnancy as a triplet pregnancy. At presentation, her fundal height was 49 cm, and her cervix was 5-6 cm dilated. As she was in active labor, she underwent an emergency caesarean section. Four neonates were delivered but only two were transferred to the neonatal intensive care unit due to infrastructure limitations. She made an uneventful recovery and was discharged 2 days later. However, only two of four neonates eventually survived. This quadruplet pregnancy signified the pertinent complications of multifetal pregnancy: misidentification of chorionicity; preterm delivery; and early neonatal deaths due to prematurity.Conclusion: Higher order pregnancies present their own challenges for diagnosis and treatment. Preterm delivery and its associated neonatal complications are well-known complications, and a multidisciplinary management is crucial.","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"325-332"},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: A Giant Gallstone Was Found at End of the Duodenum. 病例报告：在十二指肠末端发现一巨大胆结石。

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International Medical Case Reports Journal Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.2147/IMCRJ.S509006

Lintao Chen, Yu Zhang, Zhaoqing Du

引用次数: 0