International Reviews of Immunology最新文献_第8页

The therapeutic implications of activated immune responses via the enigmatic immunoglobulin D. 通过神秘免疫球蛋白D激活免疫反应的治疗意义。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-01-07 DOI: 10.1080/08830185.2020.1861265

Tue Gia Nguyen

{"title":"The therapeutic implications of activated immune responses via the enigmatic immunoglobulin D.","authors":"Tue Gia Nguyen","doi":"10.1080/08830185.2020.1861265","DOIUrl":"https://doi.org/10.1080/08830185.2020.1861265","url":null,"abstract":"Immunoglobulin D (IgD) is an enigmatic antibody and the least appreciated member of the immunoglobulin (Ig) family. Since its discovery over half a century ago, the essence of its function in the immune system has been somewhat enigmatic and less well-defined than other antibody classes. Membrane-bound IgD (mIgD) is mostly recognized as B-cell receptor (BCR) while secreted IgD (sIgD) has been recently implicated in 'arming' basophils and mast cells in mucosal innate immunity. Activations of immune responses via mIgD-BCR or sIgD by specific antigens or anti-IgD antibody thereby produce a broad and complex mix of cellular, antibody and cytokine responses from both the innate and adaptive immune systems. Such broadly activated immune responses via IgD were initially deemed to potentiate and exacerbate the onset of autoimmune and allergic conditions. Paradoxically, treatments with anti-IgD antibody suppressed and ameliorated autoimmune conditions and allergic inflammations in mouse models without compromising the host's general immune defence, demonstrating a unique and novel therapeutic application for anti-IgD antibody treatment. Herein, this review endeavored to collate and summarize the evidence of the unique characteristics and features of activated immune responses via mIgD-BCR and sIgD that revealed an unappreciated immune-regulatory function of IgD in the immune system via an amplifying loop of anti-inflammatory Th2 and tolerogenic responses, and highlighted a novel therapeutic paradigm in harnessing these immune responses to treat human autoimmune and allergic conditions.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 2","pages":"107-122"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1861265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38793147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Insights into the modulation of the interferon response and NAD⁺ in the context of COVID-19. COVID-19背景下干扰素反应和NAD+调节的新见解

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 DOI: 10.1080/08830185.2021.1961768

Nada J Habeichi, Cynthia Tannous, Andriy Yabluchanskiy, Raffaele Altara, Mathias Mericskay, George W Booz, Fouad A Zouein

引用次数: 7

Extracellular vesicles in obesity and its associated inflammation. 肥胖的细胞外囊泡及其相关炎症。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 DOI: 10.1080/08830185.2021.1964497

Vijay Kumar, Sonia Kiran, Santosh Kumar, Udai P Singh

{"title":"Extracellular vesicles in obesity and its associated inflammation.","authors":"Vijay Kumar, Sonia Kiran, Santosh Kumar, Udai P Singh","doi":"10.1080/08830185.2021.1964497","DOIUrl":"https://doi.org/10.1080/08830185.2021.1964497","url":null,"abstract":"Obesity is characterized by low-grade, chronic inflammation, which promotes insulin resistance and diabetes. Obesity can lead to the development and progression of many autoimmune diseases, including inflammatory bowel disease, psoriasis, psoriatic arthritis, rheumatoid arthritis, thyroid autoimmunity, and type 1 diabetes mellitus (T1DM). These diseases result from an alteration of self-tolerance by promoting pro-inflammatory immune response by lowering numbers of regulatory T cells (Tregs), increasing Th1 and Th17 immune responses, and inflammatory cytokine production. Therefore, understanding the immunological changes that lead to this low-grade inflammatory milieu becomes crucial for the development of therapies that suppress the risk of autoimmune diseases and other immunological conditions. Cells generate extracellular vesicles (EVs) to eliminate cellular waste as well as communicating the adjacent and distant cells through exchanging the components (genetic material [DNA or RNA], lipids, and proteins) between them. Immune cells and adipocytes from individuals with obesity and a high basal metabolic index (BMI) produce also release exosomes (EXOs) and microvesicles (MVs), which are collectively called EVs. These EVs play a crucial role in the development of autoimmune diseases. The current review discusses the immunological dysregulation that leads to inflammation, inflammatory diseases associated with obesity, and the role played by EXOs and MVs in the induction and progression of this devastating conditi8on.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 1","pages":"30-44"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770589/pdf/nihms-1760223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10804714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Scaling up and scaling out: Advances and challenges in manufacturing engineered T cell therapies. 扩大规模和缩小规模：制造工程 T 细胞疗法的进展与挑战。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2022-04-29 DOI: 10.1080/08830185.2022.2067154

Hannah W Song, Robert P Somerville, David F Stroncek, Steven L Highfill

引用次数: 0

A comprehensive overview on the genetics of Behçet's disease. behaperet病遗传学的全面综述。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-12-01 DOI: 10.1080/08830185.2020.1851372

Mahdi Mahmoudi, Saeed Aslani, Akira Meguro, Maryam Akhtari, Yousef Fatahi, Nobuhisa Mizuki, Farhad Shahram

{"title":"A comprehensive overview on the genetics of Behçet's disease.","authors":"Mahdi Mahmoudi, Saeed Aslani, Akira Meguro, Maryam Akhtari, Yousef Fatahi, Nobuhisa Mizuki, Farhad Shahram","doi":"10.1080/08830185.2020.1851372","DOIUrl":"https://doi.org/10.1080/08830185.2020.1851372","url":null,"abstract":"Abstract Behçet's disease (BD) is a systemic and inflammatory disease, characterized mainly by recurrent oral and genital ulcers, eye involvement, and skin lesions. Although the exact etiopathogenesis of BD remains unrevealed, a bulk of studies have implicated the genetic contributing factors as critical players in disease predisposition. In countries along the Silk Road, human leukocyte antigen (HLA)-B51 has been reported as the strongest genetically associated factor for BD. Genome-wide association studies, local genetic polymorphism studies, and meta-analysis of combined data from Turkish, Iranian, and Japanese populations have also identified new genetic associations with BD. Among these, other HLA alleles such as HLA-B*15, HLA-B*27, HLA-B*57, and HLA-A*26 have been found as independent risk factors for BD, whereas HLA-B*49 and HLA-A*03 are independent protective alleles for BD. Moreover, other genes have also reached the genome-wide significance level of association with BD susceptibility, including IL10, IL23R-IL12RB2, IL12A, CCR1-CCR3, STAT4, TNFAIP3, ERAP1, KLRC4, and FUT2. Also, several rare nonsynonymous variants in TLR4, IL23R, NOD2, and MEFV genes have been reported to be involved in BD pathogenesis. According to genetic determinants in the loci outside the MHC region that are contributed to the host defense, immunity, and inflammation pathways, it is suggested that immune responses to the pathogen as an important environmental factor and mucosal immunity contribute to BD susceptibility.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 2","pages":"84-106"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1851372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38657731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Neutrophil extracellular trap-associated molecules: a review on their immunophysiological and inflammatory roles. 中性粒细胞胞外陷阱相关分子:免疫生理和炎症作用的研究进展。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-05-26 DOI: 10.1080/08830185.2021.1921174

Abraham U Morales-Primo, Ingeborg Becker, Jaime Zamora-Chimal

{"title":"Neutrophil extracellular trap-associated molecules: a review on their immunophysiological and inflammatory roles.","authors":"Abraham U Morales-Primo, Ingeborg Becker, Jaime Zamora-Chimal","doi":"10.1080/08830185.2021.1921174","DOIUrl":"https://doi.org/10.1080/08830185.2021.1921174","url":null,"abstract":"Neutrophil extracellular traps (NETs) are a defense mechanism against pathogens. They are composed of DNA and various proteins and have the ability to hinder microbial spreading and survival. However, NETs are not only related to infections but also participate in sterile inflammatory events. In addition to DNA, NETs contain histones, serine proteases, cytoskeletal proteins and antimicrobial peptides, all of which have immunomodulatory properties that can augment or decrease the inflammatory response. Extracellular localization of these molecules alerts the immune system of cellular damage, which is triggered by recognition of damage-associated molecular patterns (DAMPs) through specific pattern recognition receptors. However, not all of these molecules are DAMPs and may have other immunophysiological properties in the extracellular space. The release of NETs can lead to production of pro-inflammatory cytokines (due to TLR2/4/9 and inflammasome activation), the destruction of the extracellular matrix, activation of serine proteases and of matrix metallopeptidases (MMPs), modulation of cellular proliferation, induction of cellular migration and adhesion, promotion of thrombogenesis and angiogenesis and disruption of epithelial and endothelial permeability. Understanding the dynamics of NET-associated molecules, either individually or synergically, will help to unravel their role in inflammatory events and open novel perspectives for potential therapeutic targets. We here review molecules contained within NETS and their immunophysiological roles.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 2","pages":"253-274"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1921174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39020140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer. 芳烃受体、幽门螺杆菌、色氨酸和精氨酸在胃癌发病中的相互作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-11-25 DOI: 10.1080/08830185.2020.1851371

Marzieh Pirzadeh, Nastaran Khalili, Nima Rezaei

{"title":"The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer.","authors":"Marzieh Pirzadeh, Nastaran Khalili, Nima Rezaei","doi":"10.1080/08830185.2020.1851371","DOIUrl":"https://doi.org/10.1080/08830185.2020.1851371","url":null,"abstract":"Several risk factors are known to be involved in the initiation and development of gastric cancer. Among them, H. pylori is one of the most prominent with multiple virulence factors contributing to its pathogenicity. In this study, we have discussed an interesting immunological cycle exploring the interplay between H. pylori, aryl hydrocarbon receptor (AHR), tryptophan, arginine, and the metabolites of these two amino acids in the development of gastric cancer. AHR is a ligand-activated transcription factor which acts as a regulator for a diverse set of genes and has various types of exogenous and endogenous ligands. The tryptophan metabolite, kynurenine, is one of these ligands that can interact with AHR, leading to immune suppression and subsequently, susceptibility to gastric cancer. On the other hand, H. pylori downregulates the expression of AHR and AHR repressor (AHRR), leading to increased inflammatory cytokine production. A metabolite of the kynurenine pathway, xanthurenic acid, is a potent inhibitor of a terminal enzyme in the synthetic pathway of tetrahydrobiopterin (BH4). BH4, itself, is a cofactor in the process of nitric oxide (NO) production from arginine that has been shown to have immune-enhancing properties. Arginine has also been evidenced to have anti-tumoral function through inducing apoptosis in gastric cell lines; however, controversy exists regarding the anti-tumor role of arginine and BH4, since they are also associated with increased NO production, subsequently promoting tumor angiogenesis. Hence, although several synergistic connections result in immunity improvement, these correlations can also act as a double-edged sword, promoting tumor development. This emphasizes on the need for further investigations to better understand this complex interplay.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 3","pages":"299-312"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1851371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38739144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases. 吲哚胺2,3 -双加氧酶:一种专业免疫调节剂及其在免疫相关疾病中的潜在功能

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-10-29 DOI: 10.1080/08830185.2020.1836176

Fahimeh Heidari, Amin Ramezani, Nasrollah Erfani, Mahboobeh Razmkhah

{"title":"Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases.","authors":"Fahimeh Heidari, Amin Ramezani, Nasrollah Erfani, Mahboobeh Razmkhah","doi":"10.1080/08830185.2020.1836176","DOIUrl":"https://doi.org/10.1080/08830185.2020.1836176","url":null,"abstract":"Indoleamine 2, 3-dioxygenase (IDO) as an intracellular cytosolic enzyme converts tryptophan (Trp) to N-formyl kynurenine which leads to proinflammatory T-cell apoptosis and prevention of immune cells maturation via decreasing the level of cellular energy. Trp catabolism products such as kynurenine increase the recruitment of regulatory T cells and induce immune tolerance in dendritic cells. IDO expression can locally suppress immunity in the tumor microenvironment and tumor progression actively recruits IDO expressing cells in tumor-draining lymph nodes. Also, tumor infiltrating Tregs' activity leads to IDO expression in the tumor microenvironment. In this review, we described the immunomodulatory function of IDO and IDO-based therapeutic strategies for immune related diseases. According to positive-feedback loop between Tregs and IDO in the tumor microenvironment, IDO can be targeted as a promising immunostimulatory approach for immunotherapy of cancer. However, several studies revealed controversial consequences for influences of IDO in immunity. Considering the common concept, IDO1 and also IDO2 repress the function of T lymphocytes, while inactivation of IDO results in aggravation of some autoimmune diseases. Eventually, the extensive evaluation of IDO function in immunomodulatory procedure can help achieve IDO inhibitors as optimal drugs to inhibit tumor growth without motivating autoimmunity.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 3","pages":"346-363"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1836176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38645052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Innate immunity: Trained immunity and innate allorecognition against the allograft. 先天免疫:针对同种异体移植物的训练免疫和先天异体识别。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-05-03 DOI: 10.1080/08830185.2021.1921175

Mohammad Mirzakhani, Mehdi Shahbazi, Sara Shamdani, Sina Naserian, Mousa Mohammadnia-Afrouzi

引用次数: 7

Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms. 免疫记忆在控制感染中的阴阳作用:超越自我防御机制。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-04-19 DOI: 10.1080/08830185.2021.1912037

Roshan Kumar Roy, Rakhi Yadav, Aklank Jain, Vishwas Tripathi, Manju Jain, Sandhya Singh, Hridayesh Prakash

{"title":"Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms.","authors":"Roshan Kumar Roy, Rakhi Yadav, Aklank Jain, Vishwas Tripathi, Manju Jain, Sandhya Singh, Hridayesh Prakash","doi":"10.1080/08830185.2021.1912037","DOIUrl":"https://doi.org/10.1080/08830185.2021.1912037","url":null,"abstract":"Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their central and effector memory arms contributing in prolonged immunity/defence mechanisms of host. While central memory helps in maintaining prolonged immunity for a particular infection, effector memory helps in keeping local/seasonal infection in control. In addition to this, generation of long-lived plasma cells is pivotal for generating neutralizing antibodies which can enhance recall and B cell memory to control re-infection. In view of this, scaling up memory response is one of the major objectives for the expected outcome of vaccination. In this line, this review deals with the significance of memory cells, molecular pathways of their development, maintenance, epigenetic regulation and negative regulation in various infections. We have also highlighted the significance of both T and B cell memory responses in the vaccination approaches against range of infections which is not fully explored so far.[Box: see text].","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 2","pages":"240-252"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1912037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38893373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1