International Reviews of Immunology最新文献_第8页

The crosstalk between DNA damage response components and DNA-sensing innate immune signaling pathways. DNA损伤反应组分与DNA感知先天免疫信号通路之间的串扰。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-03-22 DOI: 10.1080/08830185.2021.1898605

Feng Lin, Yan-Dong Tang, Chunfu Zheng

引用次数: 1

Primary Immunodeficiency and Thrombocytopenia. 原发性免疫缺陷和血小板减少症。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-01-19 DOI: 10.1080/08830185.2020.1868454

Maryam Mohtashami, Azadehsadat Razavi, Hassan Abolhassani, Asghar Aghamohammadi, Reza Yazdani

引用次数: 2

Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. 色氨酸代谢物通过影响免疫系统调节炎症性肠病和结直肠癌。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-07-22 DOI: 10.1080/08830185.2021.1954638

Moein Ala

{"title":"Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.","authors":"Moein Ala","doi":"10.1080/08830185.2021.1954638","DOIUrl":"https://doi.org/10.1080/08830185.2021.1954638","url":null,"abstract":"Tryptophan is an essential amino acid, going through three different metabolic pathways in the intestines. Indole pathway in the gut microbiota, serotonin system in the enterochromaffin cells and kynurenine pathway in the immune cells and intestinal lining are the three arms of tryptophan metabolism in the intestines. Clinical, in vivo and in vitro studies showed that each one of these arms has a significant impact on IBD. This review explains how different metabolites of tryptophan are involved in the pathophysiology of IBD and colorectal cancer, as a major complication of IBD. Indole metabolites alleviate colitis and protect against colorectal cancer while serotonin arm follows a more complicated and receptor-specific pattern. Indole metabolites and kynurenine interact with aryl hydrocarbon receptor (AHR) to induce T regulatory cells differentiation, confine Th17 and Th1 response and produce anti-inflammatory mediators. Kynurenine decreases tumor-infiltrating CD8+ cells and mediates tumor cells immune evasion. Serotonin system also increases colorectal cancer cells proliferation and metastasis while, indole metabolites can profoundly decrease colorectal cancer growth. Targeted therapy for tryptophan metabolites may improve the management of IBD and colorectal cancer, e.g. supplementation of indole metabolites such as indole-3-carbinol (I3C), inhibition of kynurenine monooxygenase (KMO) and selective stimulation or inhibition of specific serotonergic receptors can mitigate colitis. Furthermore, it will be explained how indole metabolites supplementation, inhibition of indoleamine 2,3-dioxygenase 1 (IDO1), KMO and serotonin receptors can protect against colorectal cancer. Additionally, extensive molecular interactions between tryptophan metabolites and intracellular signaling pathways will be thoroughly discussed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 3","pages":"326-345"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1954638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39206521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

COVID-19: Immunology, Immunopathogenesis and Potential Therapies. 新冠肺炎：免疫学、免疫发病机制和潜在治疗。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-02-27 DOI: 10.1080/08830185.2021.1883600

Asha Bhardwaj, Leena Sapra, Chaman Saini, Zaffar Azam, Pradyumna K Mishra, Bhupendra Verma, Gyan C Mishra, Rupesh K Srivastava

{"title":"COVID-19: Immunology, Immunopathogenesis and Potential Therapies.","authors":"Asha Bhardwaj, Leena Sapra, Chaman Saini, Zaffar Azam, Pradyumna K Mishra, Bhupendra Verma, Gyan C Mishra, Rupesh K Srivastava","doi":"10.1080/08830185.2021.1883600","DOIUrl":"10.1080/08830185.2021.1883600","url":null,"abstract":"The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and affected millions of people around the globe. As of January 2021, 100 million confirmed cases of COVID-19 along with more than 2 million deaths were reported worldwide. SARS-CoV-2 infection causes excessive production of pro-inflammatory cytokines thereby leading to the development of \"Cytokine Storm Syndrome.\" This condition results in uncontrollable inflammation that further imposes multiple-organ-failure eventually leading to death. SARS-CoV-2 induces unrestrained innate immune response and impairs adaptive immune responses thereby causing tissue damage. Thus, understanding the foremost features and evolution of innate and adaptive immunity to SARS-CoV-2 is crucial in anticipating COVID-19 outcomes and in developing effective strategies to control the viral spread. In the present review, we exhaustively discuss the sequential key immunological events that occur during SARS-CoV-2 infection and are involved in the immunopathogenesis of COVID-19. In addition to this, we also highlight various therapeutic options already in use such as immunosuppressive drugs, plasma therapy and intravenous immunoglobulins along with various novel potent therapeutic options that should be considered in managing COVID-19 infection such as traditional medicines and probiotics.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 2","pages":"171-206"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1883600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

The role of microRNAs in multiple sclerosis. microrna在多发性硬化中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-09-30 DOI: 10.1080/08830185.2020.1826474

Sahar Rostami Mansoor, Maryam Ghasemi-Kasman, Hanie Yavarpour-Bali

引用次数: 6

T cell transgressions: Tales of T cell form and function in diverse disease states. T 细胞的越轨行为：不同疾病状态下 T 细胞形态和功能的故事。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-06-21 DOI: 10.1080/08830185.2021.1921764

Kevin M Harris, Madison A Clements, Andrew J Kwilasz, Linda R Watkins

{"title":"T cell transgressions: Tales of T cell form and function in diverse disease states.","authors":"Kevin M Harris, Madison A Clements, Andrew J Kwilasz, Linda R Watkins","doi":"10.1080/08830185.2021.1921764","DOIUrl":"10.1080/08830185.2021.1921764","url":null,"abstract":"Insights into T cell form, function, and dysfunction are rapidly evolving. T cells have remarkably varied effector functions including protecting the host from infection, activating cells of the innate immune system, releasing cytokines and chemokines, and heavily contributing to immunological memory. Under healthy conditions, T cells orchestrate a finely tuned attack on invading pathogens while minimizing damage to the host. The dark side of T cells is that they also exhibit autoreactivity and inflict harm to host cells, creating autoimmunity. The mechanisms of T cell autoreactivity are complex and dynamic. Emerging research is elucidating the mechanisms leading T cells to become autoreactive and how such responses cause or contribute to diverse disease states, both peripherally and within the central nervous system. This review provides foundational information on T cell development, differentiation, and functions. Key T cell subtypes, cytokines that create their effector roles, and sex differences are highlighted. Pathological T cell contributions to diverse peripheral and central disease states, arising from errors in reactivity, are highlighted, with a focus on multiple sclerosis, rheumatoid arthritis, osteoarthritis, neuropathic pain, and type 1 diabetes.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"41 5","pages":"475-516"},"PeriodicalIF":4.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752099/pdf/nihms-1766811.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10455274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and challenges in CAR-T cell-mediated immunotherapy. CAR-T细胞介导免疫治疗的进展和挑战。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 DOI: 10.1080/08830185.2022.2111107

Dipayan Rudra, Himanshu Kumar

引用次数: 1

Clinical utility of CAR T cell therapy in brain tumors: Lessons learned from the past, current evidence and the future stakes. CAR - T细胞治疗脑肿瘤的临床应用:从过去、当前证据和未来风险中吸取的教训。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2022-10-03 DOI: 10.1080/08830185.2022.2125963

Abhishek Chatterjee, Sweety Asija, Sandhya Yadav, Rahul Purwar, Jayant S Goda

{"title":"Clinical utility of CAR T cell therapy in brain tumors: Lessons learned from the past, current evidence and the future stakes.","authors":"Abhishek Chatterjee, Sweety Asija, Sandhya Yadav, Rahul Purwar, Jayant S Goda","doi":"10.1080/08830185.2022.2125963","DOIUrl":"https://doi.org/10.1080/08830185.2022.2125963","url":null,"abstract":"The unprecedented clinical success of Chimeric Antigen Receptor (CAR) T cell therapy in hematological malignancies has led researchers to study its role in solid tumors. Although, its utility in solid tumors especially in neuroblastoma has begun to emerge, preclinical studies of its efficacy in other solid tumors like osteosarcomas or gliomas has caught the attention of oncologist to be tried in clinical trials. Malignant high-grade brain tumors like glioblastomas or midline gliomas in children represent some of the most difficult malignancies to be managed with conventionally available therapeutics, while relapsed gliomas continue to have the most dismal prognosis due to limited therapeutic options. Innovative therapies such as CAR T cells could give an additional leverage to the treating oncologists by potentially improving outcomes and ameliorating the toxicity of the currently available therapies. Moreover, CAR T cell therapy has the potential to be integrated into the therapeutic paradigm for aggressive gliomas in the near future. In this review we discuss the challenges in using CAR T cell therapy in brain tumors, enumerate the completed and ongoing clinical trials of different types of CAR T cell therapy for different brain tumors with special emphasis on glioblastoma and also discuss the future role of CAR T cells in Brain tumors.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"606-624"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40395131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Endothelial dysfunction sustains immune response in atherosclerosis: potential cause for ineffectiveness of prevailing drugs. 动脉粥样硬化中内皮功能障碍维持免疫反应:主流药物无效的潜在原因。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-01-13 DOI: 10.1080/08830185.2020.1866568

Shamima Akhtar, Alpana Sharma

{"title":"Endothelial dysfunction sustains immune response in atherosclerosis: potential cause for ineffectiveness of prevailing drugs.","authors":"Shamima Akhtar, Alpana Sharma","doi":"10.1080/08830185.2020.1866568","DOIUrl":"https://doi.org/10.1080/08830185.2020.1866568","url":null,"abstract":"Vascular endothelial dysfunction (ED) forms the cornerstone in the development of atherosclerotic lesions that clinically manifest as ischemia, myocardial infarction, stroke or peripheral arterial disease. ED can be triggered by various risk factors including hypercholesterolemia, hypertension, hyperhomocystenemia and chronic low-grade inflammation. These risk factors also activate immune response systemically. Current drugs used for managing atherosclerosis not only aid in subsiding the risk factor but also suppress the immune activation. Nonetheless, their effectiveness in treating ED is still questionable. Here, we discuss how pathologic molecules and processes pertaining to ED can activate innate and adaptive arms of the immune system leading to disease progression even in the absence of cardiovascular risk factors and the potential of the current drugs, used in the management of atherosclerotic patients, in reversing them. We mainly focus on activated endothelium, endothelial microparticles, mechanically stretched endothelial cells, endothelial mesenchymal transition and endothelial glycocalyx sheds.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"123-134"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1866568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38748073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

MDSCs interactions with other immune cells and their role in maternal-fetal tolerance. MDSCs与其他免疫细胞的相互作用及其在母胎耐受中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-06-15 DOI: 10.1080/08830185.2021.1938566

Yi Zhang, Xiaoya Wang, Rongchao Zhang, Xi Wang, Haiying Fu, Wei Yang

{"title":"MDSCs interactions with other immune cells and their role in maternal-fetal tolerance.","authors":"Yi Zhang, Xiaoya Wang, Rongchao Zhang, Xi Wang, Haiying Fu, Wei Yang","doi":"10.1080/08830185.2021.1938566","DOIUrl":"https://doi.org/10.1080/08830185.2021.1938566","url":null,"abstract":"MDSCs (myeloid-derived suppressor cells) are a population of immature and heterogeneous bone marrow cells with immunosuppressive functions, and they are mainly divided into two subgroups: granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (M-MDSCs). Immunosuppression is the main and most important function of MDSCs, and they mainly exert an inhibitory effect through endoplasmic reticulum stress and some enzymes related to inhibitors, as well as some cytokines and other factors. In addition, MDSCs also interact with other immune cells, especially NK cells, DCs and Tregs, to participate in immune regulation. A large number of MDSCs are found during normal pregnancy. Combined with their immunosuppressive effects, these results suggest that MDSCs are likely to be closely related to maternal-fetal immune tolerance. This review mainly shows the interaction of MDSCs with other immune cells and the important role of MDSCs in maternal-fetal tolerance. The current research shows that MDSCs are mainly mediated by STAT3, HLA-G, CXCR2, Arg-1 and HIF1-α in immune regulation during pregnancy. Interpreting maternal-fetal tolerance from the perspective of MDSCs provides a special perspective for research on immune regulation and maternal-fetal tolerance of MDSCs to obtain a more comprehensive understanding of immune regulation and immune tolerance.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"534-551"},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1938566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39232885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7