脂肪组织调节性T细胞:分化和功能。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Allen N Fooks, Lisa Y Beppu, Adolfo B Frias, Louise M D'Cruz
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引用次数: 1

摘要

全球肥胖水平的上升导致心血管疾病、糖尿病、肾脏疾病、肌肉骨骼疾病和某些癌症的大幅增加,据估计,与肥胖相关的疾病每年在全球造成约400万人死亡。这种疾病流行的一个共同主题是伴随肥胖的慢性全身性炎症。存在于内脏脂肪组织中的CD4+ Foxp3+调节性T细胞(VAT Tregs)是一种独特的免疫细胞群,通过调节脂肪组织稳态,在限制肥胖相关的全身性炎症中发挥重要作用。已经描述了定义VAT Treg的独特转录程序,但直接将VAT Treg分化和功能与改善胰岛素敏感性联系起来已被证明更为复杂。在这里,我们回顾了新的发现,这些发现澄清了增值税Treg如何分化,以及不同的增值税Treg亚群如何调节增值税稳态、能量消耗和胰岛素敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adipose tissue regulatory T cells: differentiation and function.

Rising obesity levels, worldwide, are resulting in substantial increases in cardiovascular disease, diabetes, kidney disease, musculoskeletal disorders, and certain cancers, and obesity-associated illnesses are estimated to cause ∼4 million deaths worldwide per year. A common theme in this disease epidemic is the chronic systemic inflammation that accompanies obesity. CD4+ Foxp3+ regulatory T cells residing in visceral adipose tissues (VAT Tregs) are a unique immune cell population that play essential functions in restricting obesity-associated systemic inflammation through regulation of adipose tissue homeostasis. The distinct transcriptional program that defines VAT Tregs has been described, but directly linking VAT Treg differentiation and function to improving insulin sensitivity has proven more complex. Here we review new findings which have clarified how VAT Tregs differentiate, and how distinct VAT Treg subsets regulate VAT homeostasis, energy expenditure, and insulin sensitivity.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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