T细胞发育的表观遗传调控。

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2021.2022661

Avik Dutta, Harini Venkataganesh, Paul E Love

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引用次数: 6

摘要

表观遗传调控因子是影响和控制T细胞发育的关键因素。最近的研究结果继续揭示了在T细胞发育的不同阶段发挥重要和关键作用的表观遗传修饰的其他因素。通过更好地了解影响成熟T细胞形成和存活的各种表观遗传因素，可以开发出新的治疗方法来对抗由表观遗传染色质修饰失调引起的疾病。本文综述了近年来有关T细胞发育特别是β选择关键阶段的表观遗传调控的研究进展。

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Epigenetic regulation of T cell development.

Epigenetic regulators are pivotal factors that influence and control T cell development. Recent findings continue to reveal additional elements of epigenetic modifications that play significant and crucial roles at different stages of T cell development. Through gaining a better understanding of the various epigenetic factors that influence the formation and survival of maturing T cells, new therapies can potentially be developed to combat diseases caused by dysregulated epigenetic chromatin modifications. In this review, we summarize the recent studies which shed light on the epigenetic regulation of T cell development especially at the critical stage of β-selection.

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).