International Journal of Urology最新文献

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Validation of the Japanese Association for the Surgery of Trauma Type 3 Subclassification of Renal Trauma Using the Japan Trauma Data Bank 使用日本创伤数据库验证日本创伤外科协会肾创伤3型亚分类。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-09 DOI: 10.1111/iju.70632
Masato Yanagi, Ryuta Nakae, Hayato Takeda, Yuki Endo, Yuka Toyama, Shoji Yokobori, Jun Akatsuka
{"title":"Validation of the Japanese Association for the Surgery of Trauma Type 3 Subclassification of Renal Trauma Using the Japan Trauma Data Bank","authors":"Masato Yanagi,&nbsp;Ryuta Nakae,&nbsp;Hayato Takeda,&nbsp;Yuki Endo,&nbsp;Yuka Toyama,&nbsp;Shoji Yokobori,&nbsp;Jun Akatsuka","doi":"10.1111/iju.70632","DOIUrl":"10.1111/iju.70632","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The Japanese Association for the Surgery of Trauma (JAST) renal trauma classification is widely used in Japan but has not been validated using nationwide multicenter data. This study aimed to assess its clinical validity in blunt renal trauma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study using 2019–2024 data from the Japan Trauma Data Bank (JTDB), a nationwide multicenter trauma registry. Among 1256 renal trauma patients in the JTDB, we included those with isolated JAST Type 3 blunt renal trauma (severe parenchymal renal trauma) and classified them as Type 3a or 3b. Multivariable logistic regression was used to identify factors associated with operative management (OM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 219 patients (Type 3a trauma, <i>n</i> = 136; Type 3b trauma, <i>n</i> = 83), OM was more frequent in Type 3b (14.5% vs. 2.9%, <i>p</i> = 0.002). In multivariable analysis, shock on arrival (odds ratio [OR], 7.96; 95% confidence interval [CI], 2.11–30.08; <i>p</i> = 0.002) and Type 3b trauma (OR, 4.49; 95% CI, 1.35–14.96; <i>p</i> = 0.023) were independently associated with OM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This nationwide multicenter cohort study demonstrated that JAST Type 3b trauma was independently associated with OM in patients with blunt renal trauma. The JAST Type 3 subclassification provides clinically relevant information for predicting the need for OM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative Safety and Long-Term Oncological Outcomes of En Bloc Resection of Bladder Tumor: A Multicenter Real-World Study of 668 Patients 膀胱肿瘤整体切除的围手术期安全性和长期肿瘤预后:668例患者的多中心真实世界研究。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-09 DOI: 10.1111/iju.70634
Takafumi Yanagisawa, Akihiro Matsukawa, Kosuke Iwatani, Yasushi Hayashida, Yohei Okada, Risa Kubota, Kiichi Kamikubo, Yuki Taneda, Hirotaka Kondo, Kagenori Ito, Jun Miki, Takahiro Kimura, the Japanese En bloc TUR (JET) Study Group
{"title":"Perioperative Safety and Long-Term Oncological Outcomes of En Bloc Resection of Bladder Tumor: A Multicenter Real-World Study of 668 Patients","authors":"Takafumi Yanagisawa,&nbsp;Akihiro Matsukawa,&nbsp;Kosuke Iwatani,&nbsp;Yasushi Hayashida,&nbsp;Yohei Okada,&nbsp;Risa Kubota,&nbsp;Kiichi Kamikubo,&nbsp;Yuki Taneda,&nbsp;Hirotaka Kondo,&nbsp;Kagenori Ito,&nbsp;Jun Miki,&nbsp;Takahiro Kimura,&nbsp;the Japanese En bloc TUR (JET) Study Group","doi":"10.1111/iju.70634","DOIUrl":"10.1111/iju.70634","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate perioperative safety, pathological outcomes, and oncological outcomes of en bloc resection of bladder tumor (ERBT) in a large multicenter real-world cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 668 patients who underwent ERBT at five institutions. Perioperative and pathological outcomes were assessed in the overall cohort. Recurrence-free survival (RFS) was evaluated in patients with pathologically confirmed non-muscle-invasive bladder cancer (NMIBC) without a history of upper tract urothelial carcinoma (<i>n</i> = 551). Clinicopathological prognosticators of recurrence were identified using Cox proportional hazards regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age was 73 years, and the median maximum tumor diameter was 15 mm. The median operative time and postoperative catheterization period were 48 min and 3 days, respectively. Perioperative complications occurred in 60 patients (9.0%), including eight (1.2%) with Clavien–Dindo Grade III or higher complications. Detrusor muscle was identified in 77.2% of evaluable specimens. Final pathology showed pTa, pT1, pTis, and pT2 disease in 377 (56.4%), 239 (35.8%), 16 (2.4%), and 25 patients (3.7%), respectively. With a median follow-up of 42 months, the estimated 1-, 2-, and 5-year RFS rates were 80.9%, 73.2%, and 57.1%, respectively. RFS did not differ significantly between pTa and pT1 disease (log-rank <i>p</i> = 0.39). Patients presenting with recurrent tumors had a significantly higher risk of subsequent intravesical recurrence than those with primary tumors (HR 2.06, 95% CI 1.38–3.07; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ERBT demonstrated favorable perioperative safety and acceptable oncological outcomes in this large multicenter cohort. Post-ERBT recurrence remained strongly influenced by prior recurrence history, highlighting the importance of risk-adapted postoperative management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-Control Outcomes of Japanese Vs. German Metastatic Hormone-Sensitive Prostate Cancer Patients: A Real-World Cross-Country Comparison of Patients Undergoing Combination Therapies 日本和德国转移性激素敏感前列腺癌患者的癌症控制结果:接受联合治疗的患者的真实世界跨国比较
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-09 DOI: 10.1111/iju.70633
Mike Wenzel, Keiichiro Miyajima, Maximilian Filzmayer, Axel S. Merseburger, Carolin Siech, Benedikt Lauer, Felix K.-H. Chun, Shin Koike, Yoichiro Tohi, Takafumi Yanagisawa, Kojiro Tashiro, Takahiro Kimura, Fumihiko Urabe, Philipp Mandel
{"title":"Cancer-Control Outcomes of Japanese Vs. German Metastatic Hormone-Sensitive Prostate Cancer Patients: A Real-World Cross-Country Comparison of Patients Undergoing Combination Therapies","authors":"Mike Wenzel,&nbsp;Keiichiro Miyajima,&nbsp;Maximilian Filzmayer,&nbsp;Axel S. Merseburger,&nbsp;Carolin Siech,&nbsp;Benedikt Lauer,&nbsp;Felix K.-H. Chun,&nbsp;Shin Koike,&nbsp;Yoichiro Tohi,&nbsp;Takafumi Yanagisawa,&nbsp;Kojiro Tashiro,&nbsp;Takahiro Kimura,&nbsp;Fumihiko Urabe,&nbsp;Philipp Mandel","doi":"10.1111/iju.70633","DOIUrl":"10.1111/iju.70633","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Differences in tumor biology, ethnicities, and healthcare structures across populations may contribute to variability in oncologic outcomes. This study compared baseline characteristics and oncologic outcomes of Japanese and German metastatic hormone-sensitive prostate cancer (mHSPC) patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A pooled analysis of 1 215 mHSPC patients from Japan (JIKEI-YAYOI database, <i>n</i> = 639) and Germany (FRAMCAP database, <i>n</i> = 576) undergoing combination therapies between 2015 and 2025 was performed. Cox regression models were used to evaluate time to castration-resistant prostate cancer (ttCRPC) and overall survival (OS). Propensity score matched analyses (PSM) validation was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Japanese patients were older at diagnosis (median 73 vs. 70 years) and had higher PSA at mHSPC diagnosis (260 vs. 43 ng/mL). Moreover, Japanese patients had more frequently synchronous mHSPC (95% vs. 75%), high-volume disease (78% vs. 54%), and visceral metastases (16% vs. 8%). ADT plus androgen receptor pathway inhibitors (ARPI) was used more frequently in Japan (76% vs. 71%), as was the combination of ADT + ARPI + docetaxel (17% vs. 11%). Conversely, ADT + docetaxel was less commonly used in Japan (7% vs. 19%). Median ttCRPC was 39 vs. 23 months, and median OS was 80 vs. 51 months (Japan vs. Germany). After adjustment for relevant clinical covariates, Japanese cohort affiliation remained an independent predictor of prolonged ttCRPC (HR 0.53, <i>p</i> &lt; 0.001) and improved OS (HR 0.54, <i>p</i> &lt; 0.001). PSM analyses confirmed similar findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite presenting with more adverse baseline characteristics, Japanese mHSPC patients demonstrated longer ttCRPC and improved OS compared with patients in Germany. These differences may reflect not only potential biological variations but also differences in treatment strategies and healthcare structures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Not applicable</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct Prognostic Roles of Grade Group and Intraductal Carcinoma of the Prostate in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors 前列腺癌分级组和导管内癌在雄激素受体信号抑制剂治疗转移性激素敏感前列腺癌中的预后作用
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-04 DOI: 10.1111/iju.70630
Junichi Ikeda, Hisanori Taniguchi, Monta Inoue, Yuki Masuo, Takahiro Nakamoto, Makoto Taguchi, Seiji Shimada, Takao Mishima, Masaaki Yanishi, Katsunori Uchida, Hidefumi Kinoshita
{"title":"Distinct Prognostic Roles of Grade Group and Intraductal Carcinoma of the Prostate in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors","authors":"Junichi Ikeda,&nbsp;Hisanori Taniguchi,&nbsp;Monta Inoue,&nbsp;Yuki Masuo,&nbsp;Takahiro Nakamoto,&nbsp;Makoto Taguchi,&nbsp;Seiji Shimada,&nbsp;Takao Mishima,&nbsp;Masaaki Yanishi,&nbsp;Katsunori Uchida,&nbsp;Hidefumi Kinoshita","doi":"10.1111/iju.70630","DOIUrl":"10.1111/iju.70630","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The study aimed to evaluate the impact of grade group (GG) and intraductal carcinoma of the prostate (IDC-P), as established prognostic factors, on clinical endpoints in metastatic hormone-sensitive prostate cancer (mHSPC) patients treated with androgen receptor signaling inhibitors (ARSIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 147 patients with mHSPC treated with androgen deprivation therapy and ARSIs (abiraterone acetate, enzalutamide, or apalutamide). Associations between clinicopathological factors, including GG 5 and IDC-P, and prostate-specific antigen progression-free survival (PSA-PFS), cancer-specific survival (CSS), and overall survival (OS) were evaluated by Kaplan–Meier analysis and Cox proportional hazards models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GG 5 was identified in 66% of patients, and IDC-P was present in 51% of patients. GG 5 was an independent predictor of PSA-PFS, whereas IDC-P was not. In contrast, IDC-P was independently associated with poorer CSS, while GG was not. Neither IDC-P nor GG was significantly associated with OS. The combined evaluation of GG 5 and IDC-P showed the best prognostic predictive ability for PSA-PFS, CSS, and OS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In patients with ARSI-treated mHSPC, both GG 5 and IDC-P are important prognostic factors, although they play distinct roles in predicting clinical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Test Accuracy to Clinical Risk Interpretation: A Bayesian Perspective on Pre-Biopsy Biomarkers 从检测准确性到临床风险解释:活检前生物标志物的贝叶斯视角。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-03 DOI: 10.1111/iju.70618
Shugo Yajima, Soichiro Yoshida, Yasuhisa Fujii
{"title":"From Test Accuracy to Clinical Risk Interpretation: A Bayesian Perspective on Pre-Biopsy Biomarkers","authors":"Shugo Yajima,&nbsp;Soichiro Yoshida,&nbsp;Yasuhisa Fujii","doi":"10.1111/iju.70618","DOIUrl":"10.1111/iju.70618","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instructional Design for Surgical Novices Based on Cognitive Load Theory: Implications for Urologic Surgery Training. 基于认知负荷理论的外科新手教学设计:对泌尿外科训练的启示。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-01 DOI: 10.1111/iju.70637
Sachiyo Nishida, Naoya Masumori
{"title":"Instructional Design for Surgical Novices Based on Cognitive Load Theory: Implications for Urologic Surgery Training.","authors":"Sachiyo Nishida, Naoya Masumori","doi":"10.1111/iju.70637","DOIUrl":"10.1111/iju.70637","url":null,"abstract":"<p><strong>Background: </strong>The rapid adoption of robot-assisted surgery has fundamentally altered urology training pathways. Although robotic platforms may reduce workload in experienced surgeons, these benefits may not extend to novice trainees. Apparent technical fluency during supervised console participation may conceal cognitive demands related to system control, anatomical interpretation, procedural sequencing, tissue handling, and team communication.</p><p><strong>Objectives: </strong>This review examined how cognitive load theory (CLT) can inform instructional design for novice trainees in robot-assisted urologic surgery.</p><p><strong>Methods: </strong>A narrative review of the literature on CLT, surgical education, and urological training was conducted using PubMed and Google Scholar. The articles were selected based on their relevance to cognitive load management, surgical training, and video-based learning.</p><p><strong>Key findings: </strong>CLT distinguishes intrinsic load arising from task complexity, extraneous load arising from avoidable features of instruction or the environment, and cognitive resources devoted to schema construction. In novice trainees, unfamiliar interfaces and the simultaneous demands of console operation and procedural decision-making may consume much of the available working memory capacity. CLT-informed strategies-including procedural segmentation, signaling, pre-training, part-task practice, scaffolded supervision, cognitive aids, and simulation-may help align task demands with trainee expertise. A practical framework can structure instruction before surgery, provide brief prioritized guidance during surgery, and use focused debriefing afterward.</p><p><strong>Conclusions: </strong>CLT provides a useful framework for robotic surgical education, but the current evidence is heterogeneous and not specific to all urologic settings. Prospective studies should determine whether CLT-informed training improves learning, proficiency, and patient outcomes.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":"e70637"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Resistance to Immune Checkpoint Inhibitor Combination Therapy in Metastatic Renal Cell Carcinoma: Focus on Nivolumab Plus Ipilimumab. 转移性肾细胞癌对免疫检查点抑制剂联合治疗的原发性耐药:集中于纳沃单抗和伊匹单抗。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-01 DOI: 10.1111/iju.70597
Kazuyuki Numakura, Noriyuki Abe
{"title":"Primary Resistance to Immune Checkpoint Inhibitor Combination Therapy in Metastatic Renal Cell Carcinoma: Focus on Nivolumab Plus Ipilimumab.","authors":"Kazuyuki Numakura, Noriyuki Abe","doi":"10.1111/iju.70597","DOIUrl":"10.1111/iju.70597","url":null,"abstract":"<p><p>Immune checkpoint inhibitors have become a standard treatment for patients with metastatic renal cell carcinoma (mRCC). The combination of nivolumab and ipilimumab has demonstrated durable responses and survival benefits; however, approximately 20%-25% of patients exhibit primary resistance and derive limited clinical benefit. This review provides a comprehensive overview of current evidence regarding the incidence, clinical predictors, and biological mechanisms of primary resistance to nivolumab plus ipilimumab in mRCC. Key contributing factors include an immunosuppressive tumor microenvironment, metabolic reprogramming, interferon signaling abnormalities, and T-cell exhaustion. Potential strategies to overcome resistance, such as vascular endothelial growth factor receptor-targeted combinations, biomarker-driven treatment selection, and novel immune checkpoint targets, are also discussed. A deeper understanding of primary resistance will be essential for the development of mechanism-based therapeutic strategies and for achieving durable clinical benefit in patients with mRCC.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":"e70597"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on "From Test Accuracy to Clinical Risk Interpretation: A Bayesian Perspective on Pre-Biopsy Biomarkers". 社论评论“从检测准确性到临床风险解释:活检前生物标志物的贝叶斯视角”。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-01 DOI: 10.1111/iju.70648
Shingo Hatakeyama
{"title":"Editorial Comment on \"From Test Accuracy to Clinical Risk Interpretation: A Bayesian Perspective on Pre-Biopsy Biomarkers\".","authors":"Shingo Hatakeyama","doi":"10.1111/iju.70648","DOIUrl":"10.1111/iju.70648","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":"e70648"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-Procedural Gamma-Glutamyltransferase-To-Lymphocyte Ratio as an Adjunctive Biomarker for Differentiating Hunner-Type Interstitial Cystitis From Bladder Pain Syndrome. 术前γ -谷氨酰转移酶与淋巴细胞比值作为鉴别hunner型间质性膀胱炎与膀胱疼痛综合征的辅助生物标志物。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-01 DOI: 10.1111/iju.70638
Shota Kakita, Tomohiro Matsuo, Shota Yamada, Asato Otsubo, Kyohei Araki, Kensuke Mitsunari, Kojiro Ohba, Hiroko Hayashi, Ryoichi Imamura
{"title":"Pre-Procedural Gamma-Glutamyltransferase-To-Lymphocyte Ratio as an Adjunctive Biomarker for Differentiating Hunner-Type Interstitial Cystitis From Bladder Pain Syndrome.","authors":"Shota Kakita, Tomohiro Matsuo, Shota Yamada, Asato Otsubo, Kyohei Araki, Kensuke Mitsunari, Kojiro Ohba, Hiroko Hayashi, Ryoichi Imamura","doi":"10.1111/iju.70638","DOIUrl":"10.1111/iju.70638","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the potential role of the pre-procedural gamma-glutamyltransferase-to-lymphocyte ratio (GLR) as an adjunctive biomarker for differentiating Hunner-type interstitial cystitis (HIC) from bladder pain syndrome (BPS).</p><p><strong>Methods: </strong>Consecutive patients who underwent cystoscopic evaluation with hydrodistension for suspected interstitial cystitis/bladder pain syndrome between April 2016 and September 2025 were retrospectively analyzed. HIC and BPS were diagnosed by expert adjudication based on cystoscopic, clinical, and histopathological findings. GLR was calculated as serum gamma-glutamyltransferase divided by peripheral lymphocyte count. Diagnostic performance was assessed using receiver operating characteristic analysis, and associations with HIC were evaluated using logistic regression.</p><p><strong>Results: </strong>Among 106 patients, 62 had HIC and 44 had BPS. GLR was significantly higher in HIC than BPS (21.4 ± 14.7 vs. 14.2 ± 15.2, p = 0.016) and correlated with total histological activity score (ρ = 0.606, p < 0.001). GLR showed an AUC of 0.759, while GGT showed similar discrimination (AUC 0.776; p = 0.592 vs. GLR). Adding GLR to a clinical model did not improve discrimination (AUC 0.948 vs. 0.949; p = 0.879). In the covariate-adjusted multivariable analysis, GLR remained associated with HIC (odds ratio 1.04, 95% confidence interval 1.01-1.10, p = 0.032).</p><p><strong>Conclusions: </strong>Pre-procedural GLR may serve as a practical blood-based adjunct reflecting bladder-inflammatory histopathology and supporting early phenotyping across the IC/BPS spectrum, although prospective external validation is required.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 9","pages":"e70638"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaplan-Meier Analysis Inconsistencies in a TriNetX Study of Intervention Rates for Rezum vs. Urolift. 一项TriNetX研究中Rezum与Urolift干预率的Kaplan-Meier分析的不一致性。
IF 2.9 3区 医学
International Journal of Urology Pub Date : 2026-09-01 DOI: 10.1111/iju.70641
Joshua Wang
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