International Journal of Urology最新文献_第4页

Risk Model for Lymph Node-Positive Prostate Cancer After Radical Prostatectomy. 根治性前列腺切除术后淋巴结阳性前列腺癌的风险模型。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-16 DOI: 10.1111/iju.70149

Kojiro Tashiro, Keiichiro Mori, Masaki Shiota, Wataru Fukuokaya, Dai Takamatsu, Yoshiyuki Matsui, Masashi Kato, Ryoichi Saito, Akira Yokomizo, Masakazu Tsutsumi, Yoshiyuki Yamamoto, Kohei Edamura, Makito Miyake, Shuichi Morizane, Takayuki Yoshino, Ryuji Matsumoto, Shintaro Narita, Hiroshi Kitamura, Masatoshi Eto, Takahiro Kimura

{"title":"Risk Model for Lymph Node-Positive Prostate Cancer After Radical Prostatectomy.","authors":"Kojiro Tashiro, Keiichiro Mori, Masaki Shiota, Wataru Fukuokaya, Dai Takamatsu, Yoshiyuki Matsui, Masashi Kato, Ryoichi Saito, Akira Yokomizo, Masakazu Tsutsumi, Yoshiyuki Yamamoto, Kohei Edamura, Makito Miyake, Shuichi Morizane, Takayuki Yoshino, Ryuji Matsumoto, Shintaro Narita, Hiroshi Kitamura, Masatoshi Eto, Takahiro Kimura","doi":"10.1111/iju.70149","DOIUrl":"https://doi.org/10.1111/iju.70149","url":null,"abstract":"Background: Post-radical prostatectomy (RP) lymph node positivity (pN1) is associated with disease progression. However, the optimal treatment strategy for pN1 patients has remained unclear. This study aimed to establish a risk model for predicting survival outcomes in these patients.Methods: We retrospectively studied 528 eligible patients with pN1 undergoing RP with pelvic lymph node dissection between 2006 and 2019 at 33 participant institutions in the Japanese Urologic Oncology Study Group. Metastasis-free survival (MFS) was used to evaluate for survival outcome. A least absolute shrinkage and selection operator (LASSO)-penalized, multivariate Cox regression model for MFS was used to evaluate patients for their risk factors and establish a risk model with an associated nomogram.Results: Grade group (GGs 4-5 vs. GGs 1-3: HR, 7.35; 95% confidence intervals (CI), 1.76-30.7; p = 0.006), pathological T-stage (pT3b or more vs. pT2 to pT3a: HR, 2.01; 95% CI, 0.93-4.34; p = 0.075), number of positive lymph nodes (HR, 2.03; 95% CI, 0.83-4.96; p = 0.044), and positive lymph node diameter (> 2 mm vs. ≤ 2 mm: HR, 2.03; 95% CI, 1.09-9.00; p = 0.034) were identified as independent prognostic factors for predicting 60-month MFS.Conclusions: This study explored prognostic factors for pN1 prostate cancer patients for predicting their MFS and identified a risk model involving a nomogram. Randomized controlled trials are necessary in patients with pN1 prostate cancer to elucidate optimal postoperative treatment indications and selection.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Comment on "Association Between Overactive Bladder and Sarcopenia in Older Adults: A Population-Based Cohort Study". 关于“老年人膀胱过度活动与肌肉减少症的关系：一项基于人群的队列研究”的评论。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-11 DOI: 10.1111/iju.70151

Hisae Nishii

引用次数: 0

Current Evidences and Future Perspectives in the Management of Metastatic Non-Clear Cell Renal Cell Carcinoma. 转移性非透明细胞肾细胞癌治疗的当前证据和未来展望。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70144

Shotaro Nakanishi, Junichi Inokuchi

{"title":"Current Evidences and Future Perspectives in the Management of Metastatic Non-Clear Cell Renal Cell Carcinoma.","authors":"Shotaro Nakanishi, Junichi Inokuchi","doi":"10.1111/iju.70144","DOIUrl":"https://doi.org/10.1111/iju.70144","url":null,"abstract":"Renal cell carcinoma is a heterogeneous disease with diverse phenotypes. Renal cell carcinoma classification is based on morphological and molecular characteristics and falls into 2 main categories: clear cell renal cell carcinoma and non-clear cell renal cell carcinoma. Clear cell renal cell carcinoma is the predominant subtype, accounting for approximately 70%-80%, while non-clear cell renal cell carcinoma constitutes 20%-30%. Non-clear cell renal cell carcinoma comprises multiple histologic types, each with distinct clinicopathologic features. The fifth edition of the World Health Organization classification of urinary and male genital tumors, published in 2022, introduced significant updates and revisions in kidney tumor classification. The new classification incorporated molecular biological factors into the existing framework and introduced additional tumor subtypes. Most clinical trials have excluded or included only small numbers of patients with non-clear cell renal cell carcinoma. Due to the scarcity of prospective studies focusing on this population, data on response rates and survival outcomes remain limited. However, recent evidence suggests the efficacy of combination therapy with immune checkpoint inhibitors and tyrosine kinase inhibitors in non-clear cell renal cell carcinoma. This review examines immunotherapy and tyrosine kinase inhibitor outcomes across non-clear cell renal cell carcinoma subtypes and highlights opportunities for enhanced care through novel therapies, biomarker-driven approaches, and more inclusive clinical trial designs.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Characteristics of Upper Tract Urothelial Cancer With Loss of Immunohistochemical Expression of Mismatch Repair Proteins. 错配修复蛋白免疫组织化学表达缺失的上尿路上皮癌的临床病理特征。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70146

Go Kobayashi, Tetsutaro Hayashi, Yohei Sekino, Kenichiro Ikeda, Hikaru Nakahara, Kohei Kobatake, Keisuke Goto, Daiki Taniyama, Kazuya Kuraoka, Shintaro Akabane, Hiroaki Niitsu, Takao Hinoi, Kazuhiro Sentani, Nobuyuki Hinata

{"title":"Clinicopathological Characteristics of Upper Tract Urothelial Cancer With Loss of Immunohistochemical Expression of Mismatch Repair Proteins.","authors":"Go Kobayashi, Tetsutaro Hayashi, Yohei Sekino, Kenichiro Ikeda, Hikaru Nakahara, Kohei Kobatake, Keisuke Goto, Daiki Taniyama, Kazuya Kuraoka, Shintaro Akabane, Hiroaki Niitsu, Takao Hinoi, Kazuhiro Sentani, Nobuyuki Hinata","doi":"10.1111/iju.70146","DOIUrl":"https://doi.org/10.1111/iju.70146","url":null,"abstract":"Objectives: Lynch syndrome (LS) is an inherited cancer predisposition caused by germline mutations in DNA mismatch repair (MMR) genes. Upper tract urothelial carcinoma (UTUC) is the third most common cancer associated with LS. In this study, we examined MMR protein expression in UTUC using immunohistochemistry to clarify the clinicopathological characteristics and prognostic significance of LS-associated UTUC.Methods: We analyzed the expression of MLH1, MSH2, MSH6, and PMS2 by immunohistochemistry in 118 cases of UTUC treated with radical nephroureterectomy. MMR deficiency was defined as tumors exhibiting less than 5% MMR protein expression. We conducted further investigations using public databases.Results: MMR deficiency was identified in 15 (13%) of the 118 UTUC cases. These cases were associated with younger age, papillary morphology, low grade, low stage, low neutrophil-to-lymphocyte ratio, high levels of CD8-positive tumor-infiltrating lymphocytes, and favorable prognosis. Similar findings were observed through in silico analysis. Public datasets revealed that tumor mutational burden in UTUC was significantly higher in MMR-mutated cases compared to MMR-normal cases. A waterfall plot showed a high frequency of FGFR3 mutation in MMR-mutated cases in UTUC. Bioinformatics analysis using RNA-Seq datasets showed that MMR-mutated UTUC was associated with enriched gene sets for MYC targets v1 and oxidative phosphorylation. Furthermore, gene expression levels of GALNT12 and FRMD3 emerged as potential predictors of MMR mutation in UTUC.Conclusions: These findings highlight the clinical value of evaluating MMR protein expression by immunohistochemistry, which could inform treatment strategies and surveillance protocols for UTUC patients.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Penile Prosthesis Implantation in Patients Under 40: Insights and Efficacy. 40岁以下患者阴茎假体植入术的疗效观察。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70145

Ahmet Halil Sevinç, Samet Şenel, İlker Teke, Mehmet Gürcan, Rıfat Burak Ergül, Murat Dursun, Ateş Kadıoğlu

{"title":"Outcomes of Penile Prosthesis Implantation in Patients Under 40: Insights and Efficacy.","authors":"Ahmet Halil Sevinç, Samet Şenel, İlker Teke, Mehmet Gürcan, Rıfat Burak Ergül, Murat Dursun, Ateş Kadıoğlu","doi":"10.1111/iju.70145","DOIUrl":"https://doi.org/10.1111/iju.70145","url":null,"abstract":"Objectives: Erectile dysfunction (ED) is a common sexual disorder in men, with a notable prevalence among young patients. This study aims to evaluate the clinical characteristics, perioperative parameters, patient satisfaction, and complication rates in men under 40 years old undergoing penile prosthesis implantation (PPI).Materials and methods: A retrospective analysis was conducted on 64 patients under 40 years of age who underwent PPI between 2006 and 2024. Preoperative assessments included history, physical examination, dynamic duplex ultrasound, and injection tests. Perioperative data, including incision type and prosthesis model, were recorded. Postoperative follow-up assessed complications, revision rates, and satisfaction levels using a Likert scale.Results: The mean age was 31.7 ± 5.8 years, and the median duration of ED was 6 years. Vascular causes, including arterial deficiency and cavernosal dysfunction, were identified in 64% of cases. Idiopathic ED was observed in 28.1% of patients. Three-piece inflatable prostheses were implanted, with infrapubic incisions used in 57.8% of cases. During a median follow-up of 7 years, 4.7% of patients required revisions due to mechanical failure or implant erosion. No infections were reported. Satisfaction was high, with 92.8% of respondents rating their experience as \"satisfied\" or \"very satisfied\" (mean satisfaction score: 4.5 ± 0.7).Conclusion: PPI is an effective and safe treatment for ED in young men, with outcomes comparable to those of the general population. The study highlights the importance of thorough preoperative evaluation and counseling to optimize postoperative satisfaction. Further research is needed to refine patient selection and improve long-term outcomes in this population.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Xing Technique for Intracorporeal Ileal Conduit: Outcomes From a Single Center. Xing技术用于体外回肠导管：单中心的结果。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70096

Mingshuai Wang, Bolin Jia, Feiya Yang, Sujun Han, Xiongjun Ye, Yong Zhang, Nianzeng Xing

{"title":"The Xing Technique for Intracorporeal Ileal Conduit: Outcomes From a Single Center.","authors":"Mingshuai Wang, Bolin Jia, Feiya Yang, Sujun Han, Xiongjun Ye, Yong Zhang, Nianzeng Xing","doi":"10.1111/iju.70096","DOIUrl":"https://doi.org/10.1111/iju.70096","url":null,"abstract":"Objective: To describe our surgical technique for intracorporeal ureteroileal anastomosis and to assess its safety and short-term outcomes.Patients and methods: We performed a retrospective review of medical records for 90 consecutive patients who received an intracorporeal ileal conduit constructed using the Xing technique at our center from March 2018 to October 2022. In all cases, an intracorporeal ileal conduit was constructed using the Xing technique with a da Vinci Surgical System robot in a four-arm configuration or a Storz 3D laparoscopic system. Intraoperative variables, postoperative complications, and short-term follow-up data were assessed. A descriptive statistical analysis was performed.Results: The median operative time was 244 min. No conversion to open surgery was needed. One patient needed a red blood cell transfusion (800 mL) for hemorrhage during surgery. Five patients (5.5%) experienced renal hydronephrosis after surgery because of a ureteroileal anastomosis stricture. The study is limited by its retrospective nature, lack of a control group, and short follow-up.Conclusion: Use of the Xing technique may simplify the ureteroileal anastomosis procedure for an intracorporeal ileal conduit and reduce the incidence of anastomosis stricture. The short-term results are satisfactory.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Outcomes of Redo Ureteroneocystostomy Subsequent to Kidney Transplantation in Pediatric Recipients. 儿童肾移植后再行输尿管膀胱造瘘的系统评价。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70148

Hakan Bahadir Haberal, Beatriz Bañuelos Marco, Muhammet Irfan Donmez, Alessio Pecoraro, Alberto Piana, Thomas Prudhomme, Alicia López-Abad, Alberto Breda, Angelo Territo

{"title":"A Systematic Review of Outcomes of Redo Ureteroneocystostomy Subsequent to Kidney Transplantation in Pediatric Recipients.","authors":"Hakan Bahadir Haberal, Beatriz Bañuelos Marco, Muhammet Irfan Donmez, Alessio Pecoraro, Alberto Piana, Thomas Prudhomme, Alicia López-Abad, Alberto Breda, Angelo Territo","doi":"10.1111/iju.70148","DOIUrl":"https://doi.org/10.1111/iju.70148","url":null,"abstract":"Objectives: Ureteral obstruction, vesicoureteral reflux (VUR), and urine leak constitute the most common urological complications following pediatric kidney transplantation (KT). Redo ureteroneocystostomy (UNC) is one of the methods used in the treatment of these complications. This study aims to systematically review the available evidence regarding the success and complications associated with redo UNC in pediatric KT recipients.Methods: This systematic review (SR) focused on studies examining the success and complications of redo UNC in pediatric KT recipients, limited to English-language publications. The SR was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines with the searches encompassing databases of Web of Science, PubMed, and Scopus.Results: After screening 253 abstracts, nine studies with a total of 78 patients were included. The most common indication for redo UNC was VUR (50/78, 64.1%), followed by obstruction (19/78, 24.4%), urine leak (5/78, 6.4%), urinary fistula (3/78, 3.8%), and ureteral necrosis (1/78, 1.3%). The extravesical method was used in 15 patients, with the modified Lich-Gregoir technique being the most frequent. The intravesical approach, most commonly the Cohen technique, was used in 14 patients. The average success rate for redo UNC was 91.4%. Postoperative complications included urinary tract infections and urinary obstruction.Conclusion: Based on currently limited available data, redo UNC is an effective and safe option for pediatric KT recipients with ureteral complications.Trial registration: PROSPERO: CRD42024592989.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Comment for “One-Sided Dorsal Onlay Urethroplasty With Penile Invagination (Kulkarni Urethroplasty) for Complex Anterior Urethral Strictures: A Single-Center Experience” 编辑评论“单侧背侧尿道成形术伴阴茎内陷（Kulkarni尿道成形术）治疗复杂前尿道狭窄：单中心经验”。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70110

Ali Ersin Zumrutbas

引用次数: 0

PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer. PARP抑制剂在泌尿生殖系统癌中的应用：前列腺癌之外的新范式。

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70100

Yohei Okuda, Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Junko Murai, Norio Nonomura

{"title":"PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer.","authors":"Yohei Okuda, Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Junko Murai, Norio Nonomura","doi":"10.1111/iju.70100","DOIUrl":"https://doi.org/10.1111/iju.70100","url":null,"abstract":"Alterations in the homologous recombination repair genes, such as BRCA1 and BRCA2, are prevalent in various cancers, presenting a unique opportunity to develop synthetic lethal strategies that target homologous recombination deficiency (HRD). Poly ADP-ribose polymerase inhibitors (PARPis) have been developed to induce synthetic lethality in tumors with HRD by inhibiting the repair of single-strand DNA breaks. Beyond the initial approach to target cancers associated with HRD, the utility of PARPis has expanded to combination therapy with immune checkpoint inhibitors, anti-angiogenic drugs, or anti-androgen drugs based on the molecular biological rationale. In the field of genitourinary (GU) cancer, PARPis, such as olaparib, rucaparib, and talazoparib, are approved by the Food and Drug Administration in metastatic prostate cancer patients with BRCA1/2 mutations, sometimes in combination with other agents (e.g., olaparib plus abiraterone acetate, or talazoparib plus enzalutamide). More recently, pivotal clinical trials have broadened the potential of PARPis to the other GU cancers, including urothelial carcinoma and renal cell carcinoma. In this review, we examine the biomarkers for the response to PARPis beyond mutations in BRCA1/2 and discuss the current state and future perspectives of PARPis in GU cancers.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative Pyuria as a Predictor of False-Positive Rates in the Photodynamic Diagnosis of Nonmuscle-Invasive Bladder Cancer Using Oral 5-Aminolevulinic Acid. 术前脓尿作为口服5-氨基乙酰丙酸光动力学诊断非肌肉侵袭性膀胱癌假阳性率的预测因子

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-06-09 DOI: 10.1111/iju.70134

Shinkuro Yamamoto, Hideo Fukuhara, Hajime Kuroiwa, Ryu Shigehisa, Hiroto Osakabe, Tomoya Nao, Tsutomu Shimamoto, Nobutaka Shimizu, Satoshi Fukata, Shingo Ashida, Takashi Karashima, Keiji Inoue

{"title":"Preoperative Pyuria as a Predictor of False-Positive Rates in the Photodynamic Diagnosis of Nonmuscle-Invasive Bladder Cancer Using Oral 5-Aminolevulinic Acid.","authors":"Shinkuro Yamamoto, Hideo Fukuhara, Hajime Kuroiwa, Ryu Shigehisa, Hiroto Osakabe, Tomoya Nao, Tsutomu Shimamoto, Nobutaka Shimizu, Satoshi Fukata, Shingo Ashida, Takashi Karashima, Keiji Inoue","doi":"10.1111/iju.70134","DOIUrl":"https://doi.org/10.1111/iju.70134","url":null,"abstract":"Objectives: Although photodynamic diagnosis (PDD) using 5-aminolevulinic acid (ALA) is a highly a sensitive and excellent method for detecting nonmuscle-invasive bladder cancer, false-positive rates should not be overlooked. One of the factors causing false-positive results is inflammation. Currently, the relationship between pyuria and PDD accuracy remains unclear. Therefore, this study aimed to clarify the influence of preoperative pyuria on the diagnostic accuracy of PDD.Methods: This study retrospectively analyzed 101 patients who underwent PDD-assisted transurethral resection of bladder tumors at Kochi Medical School Hospital between January 2018 and December 2020. After dividing the patients into two groups according to the presence or absence of preoperative pyuria, the diagnostic accuracy of each group was analyzed.Results: A total of 616 specimens from 101 patients were analyzed, among which 460 specimens from 75 patients belonged to the no pyuria group and 156 specimens from 26 patients belonged to the pyuria group. The sensitivity, specificity, positive predictive value, and negative predictive value of PDD were 90.2%, 64.1%, 38.6%, and 96.3% for the no pyuria group and 92.9%, 45.6%, 38.6%, and 94.5% for the pyuria group, respectively. The pyuria group had a lower specificity than did the no pyuria group, indicating a significantly higher false positive rate in the former.Conclusions: Our findings suggest that the presence of preoperative pyuria did not affect the ability of PDD to detect cancer but may increase its false-positive rate and that preoperative pyuria is a useful predictor of false-positive PDD rates.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0