International Journal of Urology最新文献

{"title":"Editorial Comment on Testosterone Recovery and Quality of Life of Japanese Patients After Short-Term Neoadjuvant Androgen Deprivation Therapy With Low-Dose Rate Brachytherapy for Prostate Cancer.","authors":"Takanori Sekito, Takuya Sadahira","doi":"10.1111/iju.70035","DOIUrl":"https://doi.org/10.1111/iju.70035","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone Recovery and Quality of Life of Japanese Patients After Short-Term Neoadjuvant Androgen Deprivation Therapy With Low-Dose-Rate Brachytherapy for Prostate Cancer.","authors":"Kenta Onishi, Yasushi Nakai, Akira Tachibana, Nobutaka Nishimura, Fumisato Maesaka, Mitsuru Tomizawa, Yosuke Morizawa, Shunta Hori, Daisuke Gotoh, Makito Miyake, Kaori Yamaki, Isao Asakawa, Fumiaki Isohashi, Kiyohide Fujimoto, Nobumichi Tanaka","doi":"10.1111/iju.70018","DOIUrl":"https://doi.org/10.1111/iju.70018","url":null,"abstract":"<p><strong>Objectives: </strong>Androgen deprivation therapy is generally administered alongside radiation therapy for intermediate- or high-risk prostate cancer. However, this treatment results in low testosterone levels, even on a short-term basis. Additionally, after cessation, it may take up to a year for normal testosterone levels to return, which deteriorates quality of life. We investigated the time to testosterone recovery and its association with the hormonal quality of life.</p><p><strong>Methods: </strong>This study included 210 patients at our hospital who received low-dose-rate brachytherapy with short-term (≤ 6 months) neoadjuvant androgen deprivation therapy. Testosterone recovery consisted of three stages: recovery to supracastrate level (serum total testosterone ≥ 0.5 ng/mL), recovery to nonhypogonadism level (serum total testosterone ≥ 1.31 ng/mL), and recovery to normal level (serum total testosterone ≥ 3 ng/mL).</p><p><strong>Results: </strong>The median duration for androgen deprivation therapy was 4 months. The median times to testosterone recovery after cessation were 3.3, 5.7, and 12.2 months for supracastrate, nonhypogonadism, and normal levels, respectively. We used the Expanded Prostate Cancer Index Composite questionnaire to evaluate quality of life. The hormonal domain score deteriorated significantly after the initiation of low-dose-rate brachytherapy until 6 months after treatment and became comparable to the pre-treatment level after 12 months. We determined that the questionnaire subscales for hormonal function and bother domains returned to baseline at 12 and 6 months, respectively.</p><p><strong>Conclusions: </strong>Recovery of total testosterone level after androgen deprivation therapy cessation was a long-term process. The hormonal bother score improved earlier than the hormonal function score on subscales of the hormonal quality of life.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Rural Access to Urological Healthcare: Patient Experiences With Cystectomy and Urinary Diversion.","authors":"Erica Zeng, Megan Saucke, Bhabna Pati, Alexa Rose, Esra Alagoz, Kyle A Richards","doi":"10.1111/iju.70033","DOIUrl":"https://doi.org/10.1111/iju.70033","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious Complications Following Mini-Endoscopic Combined Intrarenal Surgery at Japanese Tertiary Institutions.","authors":"Takahiko Watanabe, Hiroki Ito, Tetsuo Fukuda, Fukashi Yamamichi, Tadashi Tabei, Takaaki Inoue, Junichi Matsuzaki, Kazuki Kobayashi","doi":"10.1111/iju.70037","DOIUrl":"https://doi.org/10.1111/iju.70037","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors of infectious complications following mini-endoscopic combined intrarenal surgery (ECIRS) in patients with renal or ureteral stones.</p><p><strong>Methods: </strong>We retrospectively analyzed consecutive patients with renal or ureteral stones who underwent mini-ECIRSs at three Japanese tertiary institutions between 2015 and 2021. Data were collected and evaluated regarding patient backgrounds, stone characteristics, and postoperative complications. Among the various complications, multivariable logistic regression analysis was performed using preoperative and intraoperative factors for postoperative fever (≥ 38°C) and septic shock to identify independent risk factors.</p><p><strong>Results: </strong>The data of 1432 cases were collected. Finally, 1035 cases of single-session mini-ECIRS were included in the analysis. In infectious complications, postoperative fever and septic shock were observed in 273 and 21 patients (26.4% and 2.0%). A multivariable logistic regression model identified female (p < 0.001), ureteral stones (p < 0.001), preoperative pyuria (p < 0.001), preoperative urinary tract infection (p = 0.045), preoperative percutaneous nephrostomy (p = 0.001), and operation time (p = 0.017) as predictors of postoperative fever. For septic shock, female (p < 0.001) was shown as a risk factor.</p><p><strong>Conclusions: </strong>To the best of our knowledge, this multicenter cohort study is the largest study investigating infectious complications following mini-ECIRS. Female was a common risk factor for both postoperative fever and septic shock, suggesting that surgeons should pay extra attention to vital signs during the procedure and postoperative infectious complications in mini-ECIRSs for these patients.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Skin Adverse Events on Prognosis in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Treated With Enfortumab Vedotin: A Real-World Multicenter Study.","authors":"Kai Ozaki, Hayato Yamamoto, Yuya Sekine, Hirotaka Horiguchi, Shogo Hosogoe, Jotaro Mikami, Naoki Fujita, Noriko Tokui, Kazutaka Okita, Teppei Okamoto, Kanami Mori, Mizuki Kobayashi, Kazuyuki Numakura, Takahiro Yoneyama, Ryuji Tabata, Satoshi Sato, Tomonori Habuchi, Chikara Ohyama, Shingo Hatakeyama","doi":"10.1111/iju.70030","DOIUrl":"https://doi.org/10.1111/iju.70030","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the impact of skin adverse events (AEs) of enfortumab vedotin (EV) on prognosis in patients with locally advanced or metastatic urothelial carcinoma in real-world practice.</p><p><strong>Methods: </strong>This study analyzed data from 115 patients with locally advanced or metastatic urothelial carcinoma. We evaluated the association between EV dose and skin AEs in these patients. The impact of skin AEs on progression-free survival (PFS) and overall survival (OS) was assessed using Kaplan-Meier curves and Cox regression analysis.</p><p><strong>Results: </strong>The median PFS and OS were 8.1 and 14.5 months, respectively. EV dose reduction was observed in 68 (59.1%) patients. An estimated dose amount in the first, second, and seventh cycles was 95%, 85%, and 81%, respectively. We observed skin AEs in 69 (60%) cases, and they were observed within 1 month in 53 (76.8%) of cases. Patients with skin AEs had significantly longer PFS and OS compared to those without skin AEs. Multivariable Cox regression analysis showed a significant association of skin AEs with prolonged PFS and OS.</p><p><strong>Conclusions: </strong>Skin AEs were significantly associated with prolonged prognosis compared to those without skin AEs, although EV dose reduction was required in 59.1% of patients. Careful dose adjustment of EV may be crucial for long-term use and optimizing oncological outcomes.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to \"Differential Risk Factors for Early Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Carcinoma According to the History of Nonmuscle Invasive Bladder Cancer\".","authors":"Tomokazu Sazuka","doi":"10.1111/iju.70028","DOIUrl":"https://doi.org/10.1111/iju.70028","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Evaluation of Nontransecting Anastomotic Urethroplasty for Pelvic Fracture Urethral Injury: Insights From a Comparison With Excision and Primary Anastomosis.","authors":"Jumpei Katsuta, Akio Horiguchi, Masayuki Shinchi, Kenichiro Ojima, Kazuki Takekawa, Yoshiyuki Furukawa, Takahiro Minami, Sadayoshi Suzuki, Hakaru Masumoto, Daisuke Watanabe, Keiichi Ito","doi":"10.1111/iju.70027","DOIUrl":"https://doi.org/10.1111/iju.70027","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the feasibility and surgical and patient-reported outcomes of nontransecting anastomotic urethroplasty (NTAU) for male patients with pelvic fracture urethral injury (PFUI) compared with excision and primary anastomosis (EPA), the current mainstay surgical approach.</p><p><strong>Methods: </strong>This retrospective study analyzed 233 male PFUI patients treated with EPA (n = 223) or NTAU (n = 10) from 2008 to 2024 by a single surgeon (AH). NTAU involves preserving urethral continuity and maintaining bilateral bulbar artery integrity while excising scar tissue and achieving tension-free urethral anastomosis. Anatomical success was defined as the ability to pass a 17Fr flexible cystourethroscope through the anastomotic site without resistance and no need for additional treatments. Postoperative functional outcomes were assessed using validated patient-reported measures, including the LUTS-specific quality-of-life (QOL) questionnaire, the Sexual Health Inventory for Men (SHIM), and the EuroQol Visual Analog Scale (EQ-VAS).</p><p><strong>Results: </strong>Although the median follow-up period was significantly shorter for NTAU (12 vs. 69 months, p < 0.0001), the anatomical success rate was 100% for NTAU and 94.6% for EPA, with no significant difference between the groups (p = 0.45). No significant differences were observed in the perioperative complication rate (p = 0.54). The changes in LUTS-QOL, SHIM, and EQ-VAS scores from preoperative to postoperative assessments were also comparable, indicating similar patient-reported outcome improvements in both groups (p = 0.71, p = 0.16, p = 0.92, respectively).</p><p><strong>Conclusion: </strong>NTAU has the potential to achieve surgical and patient-reported outcomes comparable to EPA. Further studies are warranted to validate its long-term benefits and define its optimal indications.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Health-Related Quality of Life and Impact of Urinary Incontinence on Health-Related Quality of Life 7 Years After Robot-Assisted Radical Prostatectomy.","authors":"Yusuke Kimura, Masashi Honda, Hiroshi Yamane, Ryutaro Shimizu, Ryoma Nishikawa, Noriya Yamaguchi, Shuichi Morizane, Katsuya Hikita, Atsushi Takenaka","doi":"10.1111/iju.70025","DOIUrl":"https://doi.org/10.1111/iju.70025","url":null,"abstract":"<p><strong>Objective: </strong>We evaluated the long-term outcomes in health-related quality of life (QOL) after robot-assisted radical prostatectomy (RARP) and the factors influencing them.</p><p><strong>Methods: </strong>Overall, 246 patients who underwent RARP were included. The Expanded Prostate Cancer Index Composite (EPIC) and Short Form-8 (SF-8) questionnaires were utilized. Continence was defined as a score of ≤ 1 on question 1 of the International Consultation on Incontinence Questionnaire-Short Form. Questionnaires were collected preoperatively until 84 months postoperatively. For EPIC, each score was compared to preoperative values to examine the changes in HRQOL. For SF-8, the change in each score was examined separately for groups with and without urinary incontinence. Furthermore, factors influencing the SF-8 scores at 60 and 84 months postoperatively were analyzed.</p><p><strong>Results: </strong>In EPIC urinary function, urinary incontinence, and sexual function scores decreased significantly beginning from 1 month postoperatively and did not return to preoperative levels even after 84 months. In SF-8, social function, mental health, and mental health summary scores were significantly lower postoperatively in those with urinary incontinence. Multivariate analysis showed that urinary incontinence was a significant factor that affected the SF-8 scores at 60 and 84 months postoperatively (p = 0.003 and p = 0.039, respectively).</p><p><strong>Conclusions: </strong>The QOL related to urinary and sexual function showed a sustained decline up to 84 months postoperatively compared to preoperative levels. Urinary incontinence was a significant predictor of HRQOL at 60 and 84 months postoperatively.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder Preservation: An Overview of Novel Prospects and Limitations.","authors":"Mazyar Zahir, Chirag Doshi, Domenique Escobar, Siamak Daneshmand","doi":"10.1111/iju.70022","DOIUrl":"https://doi.org/10.1111/iju.70022","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to \"Combining Percentage Prostate-Specific Antigen Reduction and Multiparametric Magnetic Resonance Imaging to Reduce Unnecessary Biopsy After Focal Therapy With High-Intensity Focused Ultrasound for Prostate Cancer\".","authors":"Yoh Matsuoka","doi":"10.1111/iju.70031","DOIUrl":"https://doi.org/10.1111/iju.70031","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}