International Journal of Urology最新文献

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Risk assessment of late biochemical recurrence after radical prostatectomy: Usefulness of ultra-sensitive prostate-specific antigen measurement. 前列腺根治术后晚期生化复发的风险评估:超敏感前列腺特异性抗原测量的有效性。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-23 DOI: 10.1111/iju.15660
Norihiko Kawamura, Masashi Nakayama, Takuji Hayashi, Akira Nagahara, Yasutomo Nakai, Kazuo Nishimura
{"title":"Risk assessment of late biochemical recurrence after radical prostatectomy: Usefulness of ultra-sensitive prostate-specific antigen measurement.","authors":"Norihiko Kawamura, Masashi Nakayama, Takuji Hayashi, Akira Nagahara, Yasutomo Nakai, Kazuo Nishimura","doi":"10.1111/iju.15660","DOIUrl":"https://doi.org/10.1111/iju.15660","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate predictors of late biochemical recurrence in patients with no recurrence at 5 years after radical prostatectomy (RP).</p><p><strong>Methods: </strong>We retrospectively investigated patients who underwent RP for prostate cancer in our institute from 1999 to 2016, selecting those with no biochemical recurrence at 5 years post-RP. These patients did not receive neoadjuvant and adjuvant hormone therapy. Following RP, patients were regularly monitored using ultra-sensitive prostate-specific antigen (PSA) measurements, with a detection limit of 0.01 ng/mL. Biochemical recurrence was defined as PSA level ≥0.2 ng/mL, confirmed by subsequent PSA >0.2 ng/mL.</p><p><strong>Results: </strong>Among 581 patients who underwent RP, 312 with no biochemical recurrence at 5 years post-RP were selected. The median follow-up period was 123 months. The 10-year biochemical recurrence-free survival rate for this cohort was 89.6%. Patients with a PSA value <0.02 ng/mL at 5 years post-RP had a 10-year biochemical recurrence-free survival rate of 98.5%. Multivariable regression analysis identified Grade Group ≥4 and PSA value ≥0.02 ng/mL at 5 years post-RP as independent predictors of late biochemical recurrence (hazard ratio 2.23, 95% confidence interval 1.06-4.71, p = 0.035; hazard ratio 37.5, 95% confidence interval 11.6-121.3, p < 0.001, respectively). Patients with Grade Group of 4 or more had a significantly reduced PSA doubling time at biochemical recurrence compared to those with Grade Group of 3 or less.</p><p><strong>Conclusions: </strong>Among patients whose PSA levels remain below 0.02 ng/mL at 5 years after RP, the risk of subsequent late biochemical recurrence is very low. Utilizing ultra-sensitive PSA measurements at the 5-year mark can provide useful information regarding the need for follow-up beyond 5 years.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary continence outcomes after robot-assisted laparoscopic radical prostatectomy: Significance of anterior reconstruction. 机器人辅助腹腔镜根治性前列腺切除术后尿失禁的结果:前路重建的意义。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-23 DOI: 10.1111/iju.15654
Keisuke Funajima, Sei Naito, Atsushi Fukai, Takafumi Narisawa, Hiroki Fukuhara, Shinta Suenaga, Yuki Takai, Satoshi Takai, Mayu Yagi, Hidenori Kanno, Atsushi Yamagishi, Hayato Nishida, Norihiko Tsuchiya
{"title":"Urinary continence outcomes after robot-assisted laparoscopic radical prostatectomy: Significance of anterior reconstruction.","authors":"Keisuke Funajima, Sei Naito, Atsushi Fukai, Takafumi Narisawa, Hiroki Fukuhara, Shinta Suenaga, Yuki Takai, Satoshi Takai, Mayu Yagi, Hidenori Kanno, Atsushi Yamagishi, Hayato Nishida, Norihiko Tsuchiya","doi":"10.1111/iju.15654","DOIUrl":"https://doi.org/10.1111/iju.15654","url":null,"abstract":"<p><strong>Objective: </strong>Urinary continence after radical prostatectomy is a crucial aspect of patient quality of life. The aim of this study was to identify the factors influencing urinary continence after robot-assisted laparoscopic radical prostatectomy, focusing on the role of anterior reconstruction.</p><p><strong>Methods: </strong>We collected clinical data from 375 patients at a single institution. Logistic regression analyses for urinary continence rate at 1, 3, 6, and 12 months postoperatively were performed on the entire patient population to determine the influencing factors. Anterior and posterior reconstruction was performed until August 2017, transitioning to posterior reconstruction only. The impact of anterior reconstruction on postoperative urinary continence was evaluated using logistic regression model adjusted by inverse-probability treatment weighting in nerve-sparing and non-nerve-sparing subgroups, respectively.</p><p><strong>Results: </strong>For the entire cohort, the urinary continence rates at 1, 3, 6, and 12 months were 34.7%, 57.6%, 73.1%, and 83.5%, respectively. Anterior reconstruction significantly influenced early urinary continence recovery, and membrane urethral length correlated with continence rates at all postoperative time points. After adjustment using the IPTW method, the chronological trend of urinary continence recovery rate in relation to anterior reconstruction was similar between patients with and without nerve sparing.</p><p><strong>Conclusions: </strong>Anterior reconstruction contributes to early recovery from urinary incontinence after robot-assisted laparoscopic prostatectomy. However, the impact for continence rate 12 months after surgery is limited.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status of robotic surgery in pediatric genitourinary tumors: A systematic review. 儿童泌尿生殖系统肿瘤机器人手术的现状:系统综述。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-22 DOI: 10.1111/iju.15659
Priyank Yadav, Dheidan Alshammari, Ihtisham Ahmad, Mohd S Ansari, Mohan S Gundeti
{"title":"Status of robotic surgery in pediatric genitourinary tumors: A systematic review.","authors":"Priyank Yadav, Dheidan Alshammari, Ihtisham Ahmad, Mohd S Ansari, Mohan S Gundeti","doi":"10.1111/iju.15659","DOIUrl":"https://doi.org/10.1111/iju.15659","url":null,"abstract":"<p><p>Innovative surgical approaches are crucial in pediatric oncology to enhance treatment outcomes and minimize morbidity. Robotic-assisted surgery (RAS) has shown promise in both surgical precision and recovery in pediatric patients. This systematic review aims to address this gap by examining the current role and impact of RAS in managing pediatric genitourinary tumors, focusing on its feasibility, safety, and patient outcomes. This review was registered with PROSPERO (CRD42023464820). We included studies involving pediatric patients undergoing RAS for genitourinary tumors, focusing on outcomes like conversion rates, resection completeness, and complications. Studies were identified through searches in PubMed, EMBASE, and Scopus until October 2023. Study quality and bias were assessed using ROBINS-I for cohort studies and Joanna Briggs Institute tools for case reports and series. Of 2119 citations, 42 studies were included, comprising 29 case reports, five case series, and eight retrospective cohort studies. Robotic-assisted renal surgeries were most common, with favorable outcomes in terms of resection completeness and low recurrence rates. Adrenal, bladder, and retroperitoneal surgeries also showed promising results, although rare instances required conversion to open surgery. Collaborative efforts and perioperative aids like intraoperative ultrasound and three-dimensional modeling were crucial for success. This work is limited by the lack of large cohort studies and addressing the learning curve associated with these procedures. RAS shows promise in treating pediatric genitourinary tumors, offering precise resections and favorable outcomes, warranting further research and refinement.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment to “Predictive value of hematologic parameters and HALP score for testicular viability in adults with testicular torsion: A multicentric study” 对“血液学参数和HALP评分对睾丸扭转成人睾丸活力的预测价值:一项多中心研究”的社论评论。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-22 DOI: 10.1111/iju.15661
Marko Bašković MD, PhD, MPH
{"title":"Editorial Comment to “Predictive value of hematologic parameters and HALP score for testicular viability in adults with testicular torsion: A multicentric study”","authors":"Marko Bašković MD, PhD, MPH","doi":"10.1111/iju.15661","DOIUrl":"10.1111/iju.15661","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 3","pages":"306-307"},"PeriodicalIF":1.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on: “Effect of ICG fluorescence-assisted new nerve-sparing of robot-assisted radical prostatectomy on lower urinary tract symptoms” 评论:“ICG荧光辅助下新神经保留机器人辅助根治性前列腺切除术对下尿路症状的影响”。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-22 DOI: 10.1111/iju.15656
Yushi Naito M.D., Ph.D.
{"title":"Editorial Comment on: “Effect of ICG fluorescence-assisted new nerve-sparing of robot-assisted radical prostatectomy on lower urinary tract symptoms”","authors":"Yushi Naito M.D., Ph.D.","doi":"10.1111/iju.15656","DOIUrl":"10.1111/iju.15656","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 3","pages":"292"},"PeriodicalIF":1.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of docetaxel addition to next-generation androgen receptor-axis-targeted therapies and androgen deprivation therapy in metastatic hormone-sensitive prostate cancer: A tumor volume-specific analysis. 多西紫杉醇联合新一代雄激素受体轴靶向治疗和雄激素剥夺治疗转移性激素敏感前列腺癌的疗效:肿瘤体积特异性分析
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-20 DOI: 10.1111/iju.15657
Wei Chen, Soichiro Yoshida, Noriyoshi Miura, Shohei Fukuda, Yuma Waseda, Hajime Tanaka, Yasuhisa Fujii
{"title":"Efficacy of docetaxel addition to next-generation androgen receptor-axis-targeted therapies and androgen deprivation therapy in metastatic hormone-sensitive prostate cancer: A tumor volume-specific analysis.","authors":"Wei Chen, Soichiro Yoshida, Noriyoshi Miura, Shohei Fukuda, Yuma Waseda, Hajime Tanaka, Yasuhisa Fujii","doi":"10.1111/iju.15657","DOIUrl":"https://doi.org/10.1111/iju.15657","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of docetaxel in addition to next-generation androgen receptor-axis-targeted therapies and androgen deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC) remains unclear. We evaluated the efficacy of this combination through tumor volume-specific analysis.</p><p><strong>Methods: </strong>Individual patient data were reconstructed from seven clinical trials focusing mHSPC (ARASENS, PEACE-1, TITAN, ENZAMET, ARCHES, STAMPEDE, and LATITUDE) through the Shiny method. Overall survival (OS), radiological progression-free survival (rPFS), and time to castration-resistant prostate cancer (CRPC) were analyzed in the overall cohort and tumor volume-specific (high/low) subgroups. Sensitivity analyses were performed based on treatment methods and metastasis onset.</p><p><strong>Results: </strong>In 6931 cases, adding docetaxel to ARAT and ADT did not significantly improve OS (hazard ratio [HR] = 1.07, 95% confidence interval [CI]: 0.95-1.22, p = 0.27), rPFS (HR = 0.88, 95% CI: 0.73-1.05, p = 0.16), or time to CRPC (HR = 0.97, 95% CI: 0.80-1.18, p = 0.74). High-volume disease showed a non-significant trend toward improved OS with the triplet regimen. Low-volume disease showed a similar trend. Sensitivity analyses for second-generation androgen receptor inhibitors indicated potentially less advantageous OS with docetaxel addition, but no significant differences when stratified by tumor volume. Analyses of the docetaxel-naïve, abiraterone, and synchronous metastasis subgroups showed no statistically significant differences in OS compared with the overall population and volume-stratified cases.</p><p><strong>Conclusions: </strong>Patients with mHSPC did not show significant improvement with docetaxel addition to ARAT-based regimens, regardless of tumor volume. Further research is needed to identify potential beneficiaries of this combination therapy.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-marketing surveillance data for avelumab + axitinib treatment in patients with advanced renal cell carcinoma in Japan: Subgroup analyses by pathological classification 日本晚期肾细胞癌患者avelumab + axitinib治疗的上市后监测数据:病理分类亚组分析
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-19 DOI: 10.1111/iju.15646
Norio Nonomura, Taito Ito, Masashi Sato, Makiko Morita, Masahiro Kajita, Mototsugu Oya
{"title":"Post-marketing surveillance data for avelumab + axitinib treatment in patients with advanced renal cell carcinoma in Japan: Subgroup analyses by pathological classification","authors":"Norio Nonomura,&nbsp;Taito Ito,&nbsp;Masashi Sato,&nbsp;Makiko Morita,&nbsp;Masahiro Kajita,&nbsp;Mototsugu Oya","doi":"10.1111/iju.15646","DOIUrl":"10.1111/iju.15646","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Clinical trials have demonstrated the efficacy and safety of avelumab + axitinib in patients with advanced clear cell renal cell carcinoma (ccRCC). However, information is limited regarding the activity of avelumab + axitinib in patients with non-clear cell RCC (nccRCC). In Japan, post-marketing surveillance (PMS) of patients with RCC receiving avelumab + axitinib treatment in general clinical practice was undertaken. We report ad hoc analyses of PMS data according to RCC pathological classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Of 328 patients with RCC who received ≥1 dose of avelumab and were enrolled between December 2019 and May 2021, 271 (82.6%) had ccRCC, 22 (6.7%) had nccRCC, and 35 (10.7%) had missing or unknown RCC pathology. Among patients with nccRCC, pathological subtypes were papillary in 12 (3.7%), translocation in 3 (0.9%), acquired cystic disease associated in 3 (0.9%), chromophobe in 2 (0.6%), mucinous tubular and spindle cell in 1 (0.3%), and Bellini duct in 1 (0.3%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among patients with ccRCC or nccRCC, any-grade adverse drug reactions of safety specifications occurred in 140 (51.7%) and 15 (68.2%), and of grade ≥3 in 48 (17.7%) and 6 (27.3%), respectively. The objective response rate in patients with ccRCC or nccRCC was 36.9% and 22.7%, respectively; in patients with papillary tumors, it was 33.3%. Median overall survival was not reached in patients with ccRCC or nccRCC, and 12-month overall survival rates were 86.8% and 76.7%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, subgroup analyses of PMS data suggest that avelumab + axitinib improved clinical outcomes in nccRCC in addition to ccRCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 3","pages":"293-299"},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990–2021) 南亚前列腺癌负担:全球疾病负担数据的系统分析(1990-2021)。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-13 DOI: 10.1111/iju.15641
Vijay Kumar, Diptismita Jena, Quazi Syed Zahiruddin, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, Nagavalli Chilakam, Ganesh Bushi, Hassan Basri Jahubar Sathik, Rachana Mehta, Sanjit Sah, Muhammed Shabil, Abhay M. Gaidhane, Hashem Abu Serhan
{"title":"Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990–2021)","authors":"Vijay Kumar,&nbsp;Diptismita Jena,&nbsp;Quazi Syed Zahiruddin,&nbsp;R. Roopashree,&nbsp;Mandeep Kaur,&nbsp;Manish Srivastava,&nbsp;Amit Barwal,&nbsp;G. V. Siva Prasad,&nbsp;Pranchal Rajput,&nbsp;Rukshar Syed,&nbsp;Gajendra Sharma,&nbsp;Sunil Kumar,&nbsp;Nagavalli Chilakam,&nbsp;Ganesh Bushi,&nbsp;Hassan Basri Jahubar Sathik,&nbsp;Rachana Mehta,&nbsp;Sanjit Sah,&nbsp;Muhammed Shabil,&nbsp;Abhay M. Gaidhane,&nbsp;Hashem Abu Serhan","doi":"10.1111/iju.15641","DOIUrl":"10.1111/iju.15641","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal. Age-standardized rates (ASRs) for prostate cancer metrics, including incidence (ASIR), prevalence (ASPR), mortality (ASMR), and DALYs (ASDR), were analyzed via joinpoint and ARIMA modeling techniques. Geographic variations in ASRs were mapped via QGIS software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prostate cancer ASIR, ASPR, and ASDR significantly increased from 1990 to 2021, particularly among individuals aged 60–65 years. The highest incidence and mortality rates were observed in Pakistan. The total percentage change in incidence in India was the highest at 61%. Projections indicate a continued rise in prostate cancer incidence, with South Asia's ASIR expected to reach 9.34 per 100 000 by 2031.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The growing burden of prostate cancer in South Asia highlights the need for enhanced screening programs, public awareness, and healthcare infrastructure improvements. Without intervention, the increasing incidence and mortality rates could strain healthcare resources, emphasizing the urgency of region-specific public health strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 3","pages":"277-284"},"PeriodicalIF":1.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AQUABEAM robotic system use-results survey: Aquablation for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia in the Japanese Population AQUABEAM 机器人系统使用效果调查:日本人口中用于治疗良性前列腺增生引起的下尿路症状的水消融术。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-13 DOI: 10.1111/iju.15651
Nobuyuki Hinata, Masato Fujisawa, Raizo Yamaguchi, Daiki Katsura, Hiroyuki Kitano, Yohei Sekino, Kunihiko Yoshioka, Shin Koike, Yu Odagaki, Yu Ozawa, Keisuke Aoki, Toshihide Miyauchi, Susumu Watanabe, Neil Barber, Dean Elterman, Ali Afshar, Keisuke Saito, Hisamitsu Ide, Shigeo Horie
{"title":"AQUABEAM robotic system use-results survey: Aquablation for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia in the Japanese Population","authors":"Nobuyuki Hinata,&nbsp;Masato Fujisawa,&nbsp;Raizo Yamaguchi,&nbsp;Daiki Katsura,&nbsp;Hiroyuki Kitano,&nbsp;Yohei Sekino,&nbsp;Kunihiko Yoshioka,&nbsp;Shin Koike,&nbsp;Yu Odagaki,&nbsp;Yu Ozawa,&nbsp;Keisuke Aoki,&nbsp;Toshihide Miyauchi,&nbsp;Susumu Watanabe,&nbsp;Neil Barber,&nbsp;Dean Elterman,&nbsp;Ali Afshar,&nbsp;Keisuke Saito,&nbsp;Hisamitsu Ide,&nbsp;Shigeo Horie","doi":"10.1111/iju.15651","DOIUrl":"10.1111/iju.15651","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the safety, efficacy, and patient-reported outcomes of Aquablation therapy using the AQUABEAM Robotic System for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) in a Japanese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This post-market use-results survey included 103 Japanese men with BPH who underwent Aquablation across five centers with previously Aquablation naïve physicians. Data were collected at baseline, during the procedure, at discharge, and at 3 and 6 months post-procedure. Key outcomes included International Prostate Symptom Score (IPSS), quality of life (QoL), uroflowmetry parameters, and adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of patients was 71.1 years, and the average prostate size was 82.3 mL. At 6 months, the mean IPSS significantly improved from 18.1 ± 9.0 to 6.1 ± 5.0 (<i>p</i> &lt; 0.0001), and QoL scores improved from 4.9 ± 1.3 to 1.8 ± 1.3 (<i>p</i> &lt; 0.0001). Uroflowmetry showed a significant increase in Qmax from 8.3 ± 4.4 to 15.5 ± 7.8 mL/s (<i>p</i> &lt; 0.0001) and a decrease in post-void residual volume (PVR) from 85.6 ± 107.2 to 43.3 ± 60.0 mL (<i>p</i> = 0.0006). At the 30-day primary safety endpoint, there were no reported adverse events of pad-use incontinence, erectile dysfunction, or ejaculatory dysfunction reported, and no device-related serious adverse events were reported. One subject (0.97%) experienced a Clavien–Dindo grade 3 adverse event.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Aquablation therapy using the AQUABEAM Robotic System is a reproducible, safe, and effective treatment for Japanese men with BPH, providing significant improvements in LUTS and QoL with a favorable safety profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 3","pages":"308-313"},"PeriodicalIF":1.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of photodynamic diagnosis for non-muscle-invasive bladder cancer: Exploratory analysis of anatomical locations and tumor types using data from a prospective, single-arm, multicenter phase III trial 光动力学诊断非肌肉侵袭性膀胱癌的准确性:一项前瞻性、单臂、多中心III期试验数据对解剖位置和肿瘤类型的探索性分析
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-12-13 DOI: 10.1111/iju.15653
Rikiya Taoka M.D., Ph.D., Kiyohide Fujimoto M.D., Ph.D., Keiji Inoue M.D., Ph.D., Toyonori Tsuzuki M.D., Ph.D., Mototsugu Oya M.D., Ph.D., Mikio Sugimoto M.D., Ph.D.
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