Hansen Lui, Phillip J Kim, Lisa H Kang, Blythe P Durbin-Johnson, Eric A Kurzrock
{"title":"Ureteral contrast findings as a potential predictor for invasive intervention in high-grade pediatric renal trauma: A retrospective analysis.","authors":"Hansen Lui, Phillip J Kim, Lisa H Kang, Blythe P Durbin-Johnson, Eric A Kurzrock","doi":"10.1111/iju.70006","DOIUrl":"https://doi.org/10.1111/iju.70006","url":null,"abstract":"<p><strong>Objectives: </strong>To determine if patient variables were associated with intervention in pediatric patients presenting with high-grade renal injuries.</p><p><strong>Methods: </strong>A retrospective review of pediatric patients presenting with grade IV/V renal injury between 2003 and 2021 at a Level 1 trauma center was performed. Renal injury grade was verified and updated based upon the 2018 American Association for the Surgery of Trauma injury scale. Multivariable logistic regression analyses were performed.</p><p><strong>Results: </strong>Seventy-five patients (median age 13 years old, IQR 9-16) with Grade IV (n = 53) or Grade V (n = 22) injury were identified. 33% (25/75) had immediate renal intervention within 24 h of admission. Of the remaining 50 children who were observed, 47 had blunt trauma, and outcomes were analyzed. The median age of observed patients was 12 years (IQR 8-14) and 30% (14/47) had intervention. Delayed images on CT showed ureteral contrast was present in 87% (41/47) of observed patients. Multivariable analysis demonstrated that the presence of contrast in the ureter is associated with significantly lower odds of intervention, OR 0.06 [0-0.73, 95% CI], p = 0.03.</p><p><strong>Conclusion: </strong>After grades IV and V blunt renal injury, for those children who are considered safe to observe, AAST grade of injury did not associate with procedural intervention. The presence of contrast in the ureter on delayed CT imaging was associated with a significantly lower odds of procedural intervention.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The usefulness of transarterial embolization before transurethral resection of bladder tumor for patients with large bladder tumors.","authors":"Yusuke Yamada, Motohiro Taguchi, Kimihiro Shimatani, Toeki Yanagi, Akihiro Kanematsu, Yasukazu Kako, Haruyuki Takaki, Koichiro Yamakado, Takashi Yamasaki, Seiichi Hirota, Shingo Yamamoto","doi":"10.1111/iju.15663","DOIUrl":"https://doi.org/10.1111/iju.15663","url":null,"abstract":"<p><strong>Objective: </strong>To assess the usefulness of transarterial embolization (TAE) before a transurethral resection of bladder tumor (TURBT) procedure for large bladder tumors, intra- and postoperative outcomes were retrospectively compared between patients with and without TAE before TURBT.</p><p><strong>Methods and results: </strong>Thirty-seven patients underwent TURBT for complete resection of bladder tumors with a diameter of 3 cm or greater between January 2013 and December 2023 at the Department of Urology, Hyogo Medical University. For 13, TAE was performed 1 or 2 days before TURBT. In the TAE group, tumor volume was significantly larger [74.1 ± 42.7 (28.9-190.5) cm<sup>3</sup> vs. 17.3 ± 14.3 (6.1-69.8) cm<sup>3</sup>, p < 0.05] and operative time significantly shorter [119 ± 49.8 (74-263) min vs. 143 ± 28.1 (107-218) min, p = 0.012] as compared with the non-TAE group. Furthermore, the change in hemoglobin level was significantly less in the TAE group [-0.6 ± 0.8 (0.4 to -2.3) mg/dL vs. -1.0 ± 0.7 (0.1 to -3.1) mg/dL, p = 0.008].</p><p><strong>Conclusion: </strong>TAE before TURBT for a large bladder tumor contributes to less blood loss and shorter operative time, thus allowing resection to be performed safely without serious complications.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stage III substaging and outcomes in patients with bladder cancer undergoing radical cystectomy.","authors":"Shuhei Hara, Wataru Fukuokaya, Jun Miki, Rikiya Taoka, Ryoichi Saito, Yoshiyuki Matsui, Shingo Hatakeyama, Takashi Kawahara, Ayumu Matsuda, Taketo Kawai, Minoru Kato, Tomokazu Sazuka, Takeshi Sano, Fumihiko Urabe, Soki Kashima, Hirohito Naito, Yoji Murakami, Makito Miyake, Kei Daizumoto, Yuto Matsushita, Takuji Hayashi, Junichi Inokuchi, Yusuke Sugino, Kenichiro Shiga, Noriya Yamaguchi, Shingo Yamamoto, Keiji Yasue, Takashige Abe, Shotaro Nakanishi, Katsuyoshi Hashine, Masato Fujii, Kiyoaki Nishihara, Hiroaki Matsumoto, Shuichi Tatarano, Koichiro Wada, Sho Sekito, Ryo Maruyama, Naotaka Nishiyama, Hiroyuki Nishiyama, Hiroshi Kitamura, Takahiro Kimura","doi":"10.1111/iju.70005","DOIUrl":"https://doi.org/10.1111/iju.70005","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between substaging and outcomes following radical cystectomy (RC) in patients with stage III bladder cancer.</p><p><strong>Methods: </strong>We conducted a retrospective observational study using nationwide data from Japan, including 708 patients with stage III bladder cancer who underwent RC. Substaging was based on the American Joint Committee on Cancer's 8th edition. pT3-4aN0 and pTanyN1 were newly defined as stage IIIA, while pTanyN2-3 were defined as stage IIIB. Baseline covariates were balanced using inverse probability of treatment weighting. We analyzed disease-free survival (DFS) and overall survival (OS) across these substages and among the sub-groups: pT3-4aN0, pTanyN1, and pTanyN2-3.</p><p><strong>Results: </strong>We found evidence that stage IIIB bladder cancer had inferior outcomes than stage IIIA (DFS, hazard ratio, 1.61 [95% confidence interval, 1.28-2.02]; OS, 1.61 [1.25-2.09]). Furthermore, there was evidence of the difference in outcomes between pT3-4aN0 versus pTanyN2-3 (DFS, 1.73 [1.35-2.23]; OS, 1.63 [1.23-2.15]), while no evidence of the difference between pT3-4aN0 and pTanyN1 was observed (DFS, 1.27 [0.96-1.67]; OS, 1.09 [0.78-1.53]). We did not find evidence of heterogeneity in the effects of the substaging on OS by the use of perioperative chemotherapy.</p><p><strong>Conclusion: </strong>This prognostic study supports the current stage III substaging of patients with bladder cancer who underwent RC. Importantly, there was no difference in OS between pT3-4N0 and pTanyN1 in patients with stage IIIA bladder cancer. These findings may help guide treatment decisions for patients with stage III operable bladder cancer.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Influence of Preoperative Antituberculosis Chemotherapy Duration on Perioperative Complications in Patients Treated with Epididymectomy for Epididymal Tuberculosis.","authors":"","doi":"10.1111/iju.15680","DOIUrl":"https://doi.org/10.1111/iju.15680","url":null,"abstract":"<p><strong>Retraction: </strong>P. Liu, J. Sun, Y. Wang, Y. Qin, and B. Liu, \"Influence of Preoperative Antituberculosis Chemotherapy Duration on Perioperative Complications in Patients Treated with Epididymectomy for Epididymal Tuberculosis,\" International Journal of Urology 31, no. 8 (2024): 927-932, https://doi.org/10.1111/iju.15493. The above article, published online on 16 May 2024 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Osamu Ukimura; The Japanese Urological Association; and John Wiley & Sons Australia, Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inconsistencies in the underlying data of the study, specifically regarding the number of patients who underwent orchiectomy or epididymectomy. The authors acknowledged the data errors and asked to retract their article as they found that the mistakes significantly affect the results and the conclusions of the paper. The authors apologize for the oversight.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Overuse of imaging in prostate cancer staging.","authors":"Yoichiro Tohi, Takuma Kato, Kana Kohashiguchi, Asuka Kaji, Kengo Fujiwara, Satoshi Harada, Yohei Abe, Hirohito Naito, Homare Okazoe, Rikiya Taoka, Nobufumi Ueda, Mikio Sugimoto","doi":"10.1111/iju.70003","DOIUrl":"https://doi.org/10.1111/iju.70003","url":null,"abstract":"<p><strong>Objectives: </strong>To examine prostate cancer staging in real-world clinical practice.</p><p><strong>Methods: </strong>We retrospectively analyzed 698 patients referred to the Department of Urology at Kagawa University Hospital from 25 facilities for prostate cancer treatment from June 2014 to December 2023. Patients treated with dutasteride (n = 10) and who underwent staging at our institution (n = 197) were excluded. The outcomes of interest were the proportion of computed tomography and bone scintigraphy, diagnostic rates of metastasis stratified by D'Amico risk, and incidental findings on computed tomography. We estimated the number of low-risk patients based on the Japan Study Group of Prostate Cancer study and 2019 cancer statistical data. We calculated the staging costs of omitting computed tomography and bone scintigraphy in low-risk patients.</p><p><strong>Results: </strong>The proportion of D'Amico low-, intermediate-, and high-risk patients was 15.7% (n = 77), 45.2% (n = 222), and 39.1% (n = 192), respectively. The percentages of computed tomography and bone scintigraphy performed according to risk were 88.3% and 67.5% for low risk, 98.6% and 80.2% for intermediate risk, and 98.4% and 94.3% for high risk, respectively. The diagnostic percentages for lymph node, organ, and bone metastases by risk were 0%/0%/0%, 0%/0%/0.5%, and 8.9%/0.5%/9.3% for low-, intermediate-, and high-risk, respectively. Incidental findings were present in 2.7% of cases. By omitting computed tomography and bone scintigraphy for low-risk patients, the total staging cost could be reduced by USD 4.07 million (607 million Japanese yen) annually.</p><p><strong>Conclusions: </strong>We highlight the potential overuse of imaging in prostate cancer staging. Recognizing the excessive use of diagnostic imaging can reduce medical costs.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Comments to \"An overview of renorrhaphy techniques for partial nephrectomy\".","authors":"Tsunenori Kondo","doi":"10.1111/iju.15685","DOIUrl":"https://doi.org/10.1111/iju.15685","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Comment from Dr Miyake to α1-blockers as a risk factor for hypotension in combination with oral 5-aminolevulimic acid for photodynamic diagnosis in patients with bladder cancer.","authors":"Makito Miyake","doi":"10.1111/iju.15687","DOIUrl":"https://doi.org/10.1111/iju.15687","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trends in age and antithrombotic therapy in patients who underwent transurethral resection of bladder tumor and perioperative complications.","authors":"Naoki Wada, Tsubasa Hatakeyama, Haruka Takagi, Ryoken Tsunekawa, Shin Kobayashi, Masaya Nagabuchi, Takeya Kitta, Hidehiro Kakizaki","doi":"10.1111/iju.15684","DOIUrl":"https://doi.org/10.1111/iju.15684","url":null,"abstract":"<p><strong>Introduction: </strong>We investigated the subsequent trends in age and antithrombotic therapy in patients who underwent transurethral resection of bladder tumor (TURBT) and examined the rate of perioperative complications.</p><p><strong>Methods: </strong>Medical records of patients who underwent TURBT were retrospectively analyzed. We arbitrarily divided the observation years into three periods (I: 2007-2013, II: 2014-2018, and III: 2019-2023) to compare the trends in age and frequency of perioperative complications after TURBT between patients taking and those not taking antithrombotic drugs.</p><p><strong>Results: </strong>The number of patients who underwent TURBT was 173, 224, and 224 in periods I, II, and III, respectively. The proportion of patients receiving antithrombotic drugs was similar among the three periods (34.1%, 29.9%, and 37.5% in periods I, II, and III, respectively). The percentage of patients taking antithrombotic medications who were aged ≥80 was gradually increasing. The usage of warfarin (25.4%, 13%, and 4.2% in periods I, II, and III, respectively) and aspirin (65.1%, 40.3%, and 32.3% in periods I, II, and III, respectively) was decreased, whereas direct oral anticoagulant (1.6%, 18.2%, and 35.4% in periods I, II, and III, respectively) and clopidogrel (4.8%, 15.6%, and 16.7% in periods I, II, and III, respectively) administrations was increased. The rate of hemorrhagic and cardiocirculatory complications was higher in patients receiving antithrombotic drugs than in patients not receiving them. Of the patients receiving antithrombotic therapy, two patients with a history of cardiac infarction and deep vein thrombosis passed away after TURBT due to ischemic heart disease.</p><p><strong>Conclusion: </strong>The age of patients receiving antithrombotic drugs has increased, and antithrombotic drug types have changed among those who underwent TURBT. Further attention to hemorrhagic and lethal cardiocirculatory complications after TURBT will be required in a super-aged society.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}