International Journal of Urology最新文献

Ceratonia siliqua Protects Testicular Tissue in Ischemia/Reperfusion Injury.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-04-01 DOI: 10.1111/iju.70059

Şahika Yardim, Murat Dursun, İlayda Sözmen, Abdurrahman Fatih Aydin, Ateş Kadioğlu, Ünal Uslu, Elif Kervancioğlu Demirci

{"title":"Ceratonia siliqua Protects Testicular Tissue in Ischemia/Reperfusion Injury.","authors":"Şahika Yardim, Murat Dursun, İlayda Sözmen, Abdurrahman Fatih Aydin, Ateş Kadioğlu, Ünal Uslu, Elif Kervancioğlu Demirci","doi":"10.1111/iju.70059","DOIUrl":"https://doi.org/10.1111/iju.70059","url":null,"abstract":"Objectives: Testicular torsion is a urological emergency with a risk of resulting in loss of testicular function due to ischemia/reperfusion injury (I/R) injury caused by oxidative stress. Ceratonia siliqua is known to decrease oxidative stress in urological pathologies. We investigated the protective effects of C. siliqua against I/R injury.Methods: Wistar rats (n = 28) were divided into control, i.p. C. siliqua injected, I/R injury group, and C. siliqua injected each day for a week after I/R groups. They were morphologically evaluated with light and electron microscopy, and Caspase-3, Hypoxia-inducible factor 1 alpha (HIF-1), CD68, Superoxide dismutase (SOD), and Catalase antibodies were marked. Oxidative stress markers of Glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), advanced oxidation protein products (AOPP), and ferric reducing antioxidant power (FRAP) from tissue and levels of testosterone, Anti-Müllerian hormone (AMH) and inhibin-B from blood samples were examined.Results: C.siliqua treatment preserved tissue integrity (p < 0.0001) and Leydig cells and decreased apoptotic (p = 0.0390) and necrotic changes when compared with the I/R group. The I/R group presented mitochondrial damage, intercellular edema, and vacuolization. Oxidative stress was less with treatment, but hormone levels were unchanged.Conclusions: C.siliqua preserved the testicular tissue against I/R-induced damage. The decreased apoptosis may have been caused by the significant oxidative stress protection properties of C.siliqua. One week of treatment with C.siliqua protected Leydig cell morphology but did not change hormone parameters in the rat model. The therapeutic effect of C.siliqua is promising for clinical use in testis torsion cases.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone Recovery and Health-Related Quality of Life After Short-Term Androgen Deprivation Therapy Combined With Low-Dose-Rate Brachytherapy: Limitations and Future Directions.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-31 DOI: 10.1111/iju.70056

Wenjing Xie, Keda Lu

引用次数: 0

Current Landscape of Urological Surgical Training: A Needs Assessment Survey in Japan.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-29 DOI: 10.1111/iju.70055

Noriyuki Abe, Takashige Abe, Kanta Hori, Junya Abe, Kazufumi Okada, Keita Takahashi, Shigeru Harada, Masafumi Kon, Jun Furumido, Kohei Hashimoto, Sachiyo Murai, Hiroshi Kikuchi, Naoya Masumori, Hidehiro Kakizaki, Nobuo Shinohara

{"title":"Current Landscape of Urological Surgical Training: A Needs Assessment Survey in Japan.","authors":"Noriyuki Abe, Takashige Abe, Kanta Hori, Junya Abe, Kazufumi Okada, Keita Takahashi, Shigeru Harada, Masafumi Kon, Jun Furumido, Kohei Hashimoto, Sachiyo Murai, Hiroshi Kikuchi, Naoya Masumori, Hidehiro Kakizaki, Nobuo Shinohara","doi":"10.1111/iju.70055","DOIUrl":"https://doi.org/10.1111/iju.70055","url":null,"abstract":"Objectives: To clarify the present state and issues to be resolved in urological surgical training in Japan.Methods: A web-based needs assessment survey was conducted, inviting urologists belonging to three university hospitals and 34 affiliated hospitals in Hokkaido, Japan. Physicians with less than 15 years of experience were defined as trainees, and those with more than 15 years were defined as instructors. The survey investigated the current surgical education, training environments, and issues to be resolved.Results: The response rate was 98.2% (169/172). Overall, the current surgical training in our cohort largely depended on \"on-the-job\" training. Regarding the effectiveness of surgical education materials, teaching in the operating room during procedures gained the highest scores for both trainees and instructors, followed by review of operative movies. Regarding the dedicated time for studying/training/teaching apart from routine clinical duties, 87.1% (74/85) of trainees and 96.4% (81/84) of instructors did not have any time. A total of 58.8% (50/85) of trainees considered open surgery to be undertrained, while only 8.3% (7/84) of instructors considered that open surgery was difficult to teach in their hospitals. Among instructors, 54.8% (46/84) acknowledged limitations regarding the current training program.Conclusions: The current surgical training in urology in Hokkaido, Japan, largely depends on \"on-the-job\" training methods. About two-thirds of trainees consider open surgery to be undertrained. Our observations could be utilized to update the training curriculum in Japan.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water Vapor Energy Therapy Safely Reduces Urinary Medication Use: A Multicenter Retrospective Real-World Study in Japan (SCCOP Study 24-01).

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-29 DOI: 10.1111/iju.70052

Junya Abe, Yuki Kyoda, Kazunori Haga, Takumi Sasao, Daito Nishiyama, Seisuke Nofuji, Koji Ichihara, Yohei Matsuda, Tomohiro Toyota, Yohei Ueki, Shuto Konta, Sho Nakayama, Jurai Shibuya, Genki Kobayashi, Takeshi Maehana, Yusuke Nakajima, Naoya Masumori

{"title":"Water Vapor Energy Therapy Safely Reduces Urinary Medication Use: A Multicenter Retrospective Real-World Study in Japan (SCCOP Study 24-01).","authors":"Junya Abe, Yuki Kyoda, Kazunori Haga, Takumi Sasao, Daito Nishiyama, Seisuke Nofuji, Koji Ichihara, Yohei Matsuda, Tomohiro Toyota, Yohei Ueki, Shuto Konta, Sho Nakayama, Jurai Shibuya, Genki Kobayashi, Takeshi Maehana, Yusuke Nakajima, Naoya Masumori","doi":"10.1111/iju.70052","DOIUrl":"https://doi.org/10.1111/iju.70052","url":null,"abstract":"Objective: The Japanese guidelines for male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) recommend the water vapor energy therapy (WAVE) procedure only for patients in whom conventional BPH surgery is unsuitable due to advanced age or comorbidities. This study aims to evaluate the efficacy and safety of the WAVE procedure using the Rezum system in Japan.Methods: This multicenter retrospective study included patients who underwent the WAVE procedure between August 2022 and December 2023. A total of 311 patients from 13 institutions were registered. The number of medications for LUTS was determined before surgery and 6 months after surgery. Additionally, voiding function and perioperative complications were analyzed.Results: Of the 311 patients, 291 were eligible for analysis. The mean number of LUTS medications significantly decreased from 1.4 to 0.6 (p < 0.001). The mean maximum urinary flow rate significantly improved from 9.8 mL/s preoperatively to 12.2 mL/s at 6 months postoperatively (p < 0.001). The mean post-void residual volume also significantly decreased from 124 to 78 mL (p < 0.001). Furthermore, the mean total International Prostate Symptom Score significantly improved from 17.8 to 8.9 (p < 0.001). Complications classified as Clavien-Dindo Grade III or higher occurred in four cases (1.2%).Conclusion: This large-scale, multicenter study demonstrates that the WAVE procedure improves LUTS, reduces the number of LUTS medications, and is both effective and safe for elderly patients with multiple comorbidities in Japan.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Pressure Bag Fluid Irrigation During Flexible Cystoscopy Reduces Patient Discomfort.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-29 DOI: 10.1111/iju.70053

David Armany, Ankur Dhar, Ashan Canasingham, Lawrence H Kim, Audrey Wang

引用次数: 0

The Efficacy of Capsaicin-Containing Film to Prevent Dry Mouth Induced by Anticholinergics for Overactive Bladder, Multicenter Prospective Pilot Study.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-29 DOI: 10.1111/iju.70051

Yuki Kyoda, Atsushi Takahashi, Tetsuya Shindo, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori

引用次数: 0

Pathological Analysis of False-Positive Samples in Photodynamic Diagnosis of Bladder Cancer According to a History of Intravesical Bacillus Calmette-Guérin Therapy.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-26 DOI: 10.1111/iju.70045

Takeshi Sano, Chisato Ohe, Takahiro Nakamoto, Takashi Yoshida, Hisanori Taniguchi, Masaaki Yanishi, Hidefumi Kinoshita

{"title":"Pathological Analysis of False-Positive Samples in Photodynamic Diagnosis of Bladder Cancer According to a History of Intravesical Bacillus Calmette-Guérin Therapy.","authors":"Takeshi Sano, Chisato Ohe, Takahiro Nakamoto, Takashi Yoshida, Hisanori Taniguchi, Masaaki Yanishi, Hidefumi Kinoshita","doi":"10.1111/iju.70045","DOIUrl":"https://doi.org/10.1111/iju.70045","url":null,"abstract":"Objectives: To demonstrate the diagnostic performance of photodynamic diagnosis (PDD) for bladder cancer using oral 5-aminolaevulinic acid in patients with or without a history of intravesical Bacillus Calmette-Guérin (BCG) therapy, and to investigate the potential causes of false-positive results.Methods: This retrospective study included 110 patients with suspected non-muscle-invasive bladder cancer who underwent PDD. Among them, 80 patients had no history of BCG therapy (BCG-naïve group) and 30 had received BCG therapy (BCG group). Pathological examination of false-positive and true-negative PDD samples was performed.Results: In the BCG-naïve group, 215 samples were PDD-positive, of which 53 (24.7%) showed no malignancy. In the BCG group, 94 samples were PDD-positive, of which 51 (54.3%) showed no malignancy. The sensitivity, specificity, positive predictive value, and negative predictive value of PDD in the BCG-naïve versus BCG group were 70.1 versus 76.8, 82.6 versus 56.0, 75.3 versus 45.7, and 78.5 versus 83.3, respectively. Only six of 100 samples (6%) with false-positive PDD results showed precancerous findings. Irrespective of whether patients had received intravesical BCG therapy, > 90% of the samples with false positivity in PDD showed reactive changes, whereas 22 of 95 samples (23.2%) with true negativity in PDD showed reactive changes (p < 0.0001).Conclusions: Both the specificity and positive predictive value of PDD were lower in the BCG group than in the BCG-naïve group. In most false-positive PDD samples, reactive changes, rather than precancerous findings, were observed-even in the BCG-naïve group.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

This Issue 32-4.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-24 DOI: 10.1111/iju.70047

Tomohiko Ichikawa

引用次数: 0

Editorial Comments to "Overuse of Imaging in Prostate Cancer Staging".

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-24 DOI: 10.1111/iju.70021

Yutaka Yamamoto

引用次数: 0

Advances in Adjuvant Therapy for Renal Cell Carcinoma: Perspectives on Risk Stratification and Treatment Outcomes.

IF 1.8 3区医学

International Journal of Urology Pub Date : 2025-03-24 DOI: 10.1111/iju.70050

Junya Furukawa, Ryotaro Tomida, Kei Daizumoto, Yutaro Sasaki, Tomoya Fukawa

{"title":"Advances in Adjuvant Therapy for Renal Cell Carcinoma: Perspectives on Risk Stratification and Treatment Outcomes.","authors":"Junya Furukawa, Ryotaro Tomida, Kei Daizumoto, Yutaro Sasaki, Tomoya Fukawa","doi":"10.1111/iju.70050","DOIUrl":"https://doi.org/10.1111/iju.70050","url":null,"abstract":"Radical surgery is effective for localized renal cell carcinoma (RCC). However, recurrence occurs in up to 40% of patients, underscoring the need for adjuvant therapy to improve the prognosis. Historically, adjuvant treatments, including tyrosine kinase inhibitors, have shown limited success, failing to improve overall survival. The introduction of the immune checkpoint inhibitor pembrolizumab, as demonstrated in the KEYNOTE-564 trial, has revolutionized the field by showing significant overall survival benefits and prompting updates to RCC treatment guidelines. Accurate risk assessment is critical for identifying high-risk patients most likely to benefit from adjuvant therapy. Established risk models, such as the UCLA Integrated Staging System and the Leibovich score, incorporate clinical and pathological factors to stratify recurrence risk. Recent enhancements in these models have improved predictive accuracy, enabling better optimization of inclusion criteria for clinical trials targeting high-risk recurrence and the development of individualized surveillance protocols to refine patient selection for adjuvant treatment. This review examines the evolution of risk stratification models and adjuvant therapy for RCC, highlighting the potential of innovative biomarkers, such as liquid biopsies, to further enhance patient selection and optimize treatment outcomes. Ongoing clinical trials investigating new combinations of immune checkpoint inhibitors hold promise, and integrating accurate risk assessment with advanced immunotherapy will be key to improving postoperative survival rates for patients with RCC.","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0