International Journal of Urology最新文献

{"title":"The Effectiveness of Double Dorsal Dartos Flap for Urethroplasty Coverage in Distal Hypospadias Repair: A Single Surgeon Approach to Preventing Urethrocutaneous Fistula.","authors":"Nihat Karabacak, Serhat Gürocak, Mustafa Özgür Tan","doi":"10.1111/iju.70135","DOIUrl":"https://doi.org/10.1111/iju.70135","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Discordance Between Patient- and Physician-Reported Questionnaire in Japanese Male: Insight From a Prospective Observational Study Using the International Prostate Symptom Score.","authors":"Atsushi Wanifuchi, Yuki Kyoda, Ippei Muranaka, Makoto Nakamura, Keiko Fujino, Kohei Hashimoto, Toshiaki Tanaka, Naoya Masumori","doi":"10.1111/iju.70137","DOIUrl":"https://doi.org/10.1111/iju.70137","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to prospectively clarify the prevalence of discordance between patient- and physician-reported International Prostate Symptom Score in Japanese males and evaluate the factors affecting the discordant response of the questionnaire.</p><p><strong>Methods: </strong>From May 2022 to December 2023, a prospective single-institutional observational study was conducted. A total of 310 male patients with lower urinary tract symptoms were prospectively registered to the study. The International Prostate Symptom Score questionnaire was first completed by patients and then filled out by physicians during the patient interview. We compared the self-reported score with the physician-reported score to assess the accuracy of self-reporting by three age groups. Agreement of symptom score was assessed using the weighted kappa coefficient. Multivariable logistic regression analysis was performed to identify the associated factors with discordant responses.</p><p><strong>Results: </strong>A total of 281 patients were included in the final analysis. Of these, 51.7% of patients were able to concordantly self-report all seven questions of IPSS. The number of questions and patients with discordant responses in the questionnaire significantly increased with age. The most frequently discordant questions were weak stream (19.5%). The weighted kappa value between patient and physician was 0.82. Multivariable analysis showed that older age, higher International Prostate Symptom Score, and inappropriate registration forms were associated with discordant responses.</p><p><strong>Conclusions: </strong>A nearly half of male outpatients gave discordant results of the International Prostate Symptom Score questionnaire in our cohort. Given our finding, caution may be warranted when interpreting IPSS in elderly men with moderate to severe symptoms or accompanying inappropriate registration form.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Prognostic Studies of Tubularized Incised Plate Urethroplasty in Hypospadias: A Systematic Review of Methodological Rigor.","authors":"Prinnisa A Jonardi, Gerhard Reinaldi Situmorang, Irfan Wahyudi, Arry Rodjani, Tariq Abbas, Putu Angga Risky Raharja","doi":"10.1111/iju.70131","DOIUrl":"https://doi.org/10.1111/iju.70131","url":null,"abstract":"<p><strong>Introduction: </strong>Hypospadias is a congenital anomaly of male genitalia that requires surgical correction to achieve normal anatomy and function. Tubularized incised plate urethroplasty (TIP) is a common repair method, but prognostic studies of TIP outcomes are limited by their methodological quality. This systematic review evaluates the methodological rigor of prognostic studies on TIP urethroplasty in hypospadias cases, employing the Quality in Prognosis Studies (QUIPS) Cochrane tool.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a systematic review of single-arm prognostic studies of TIP was conducted. Inclusion criteria were primary studies (first attempt of surgery), evaluating prognostic factors and outcomes, with the QUIPS tool used for quality assessment. Review studies and reports without full text were excluded. Inter-rater agreement was then evaluated using Cohen's kappa analysis.</p><p><strong>Results: </strong>Among 14 included studies, most exhibited low risk of bias (RoB). Inter-rater agreement varied across domains, being strongest for statistical analysis (κ = 0.89) and weakest for prognostic factor measurement (κ = 0.42). Nevertheless, overall assessment showed minimal agreement (κ = 0.49), indicating poor reliability of the included studies. Our findings highlight biases inherent in existing literature, particularly with respect to outcome measurement domains, underscoring the need for standardized methods and validated patient-reported outcomes. Selection bias and lack of standardized outcome measures pose significant challenges in interpreting study findings.</p><p><strong>Conclusion: </strong>Low inter-rater agreement indicates methodological shortcomings in prognostic studies of TIP in the context of hypospadias. Future research should prioritize methodological rigor to enhance the reliability and generalizability of findings, thus improving clinical practice and future patient outcomes.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Estimated Glomerular Filtration Rate and Serum C-Reactive Protein Level to Overall Survival After Second-Line Targeted Therapy Following Immuno-Oncology Combination Therapy for Advanced Renal Cell Carcinoma.","authors":"Keita Nakane, Hiromitsu Watanabe, Taku Naiki, Kiyoshi Takahara, Teruo Inamoto, Takahiro Yasui, Ryoichi Shiroki, Hideaki Miyake, Takuya Koie","doi":"10.1111/iju.70138","DOIUrl":"https://doi.org/10.1111/iju.70138","url":null,"abstract":"<p><strong>Objectives: </strong>Immune checkpoint inhibitor (ICI)-based combination therapies are first-line treatments for locally advanced or metastatic renal cell carcinoma (mRCC). However, second-line treatment efficacy remains uncertain due to limited large randomized trials. This study evaluated real-world oncological outcomes after second-line treatments in patients who received combination ICIs as first-line treatment.</p><p><strong>Methods: </strong>Among 467 patients who received ICI combination therapy as first-line treatment for mRCC between January 2018 and January 2024, those who received cabozantinib (Cabo) or axitinib (Axi) as second-line treatment were included in this study. The patient characteristics at the initiation of second-line treatment, progression-free survival (PFS), and overall survival (OS) were compared between the two groups. Prognostic factors associated with OS after the initiation of second-line treatment were evaluated.</p><p><strong>Results: </strong>The Cabo and Axi groups included 87 and 45 patients, respectively. Median OS and PFS after the initiation of secondary treatment were 32 and 9 months in the Cabo group (p = 0.269), and 33 and 12 months in the Axi group (p = 0.399). Multivariable analysis identified serum C-reactive protein (CRP) ≥ 0.6 mg/dL and estimated glomerular filtration rate (eGFR) < 40 mL/min/1.73 m² at the start of secondary treatment as independent predictors of OS. Stratification by these factors revealed a significant OS difference (p < 0.001).</p><p><strong>Conclusions: </strong>Oncological outcomes after the initiation of secondary treatment did not differ significantly between the Cabo and Axi groups. An eGFR < 40 mL/min/1.73 m² and CRP ≥ 0.6 mg/dL at the start of Cabo or Axi treatment were independent OS predictors after secondary treatment.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the Ureteral Illuminating Catheter in Securing Adhesive Ureters in Robot-Assisted Ureteral Reconstruction.","authors":"Kazumi Taguchi, Shuzo Hamamoto, Kengo Kawase, Rei Unno, Atsushi Okada, Kentaro Mizuno, Tetsuji Maruyama, Takahiro Yasui","doi":"10.1111/iju.70127","DOIUrl":"https://doi.org/10.1111/iju.70127","url":null,"abstract":"<p><strong>Objective: </strong>Ureteral strictures, a common complication of ureteral stone treatment, pose substantial challenges. These conditions often necessitate robot-assisted ureteral reconstruction (RUR), a procedure complicated by difficulty in identifying and mobilizing adhesive ureters. This study evaluated the effectiveness of a ureteral illuminating catheter (IRIS U-kit) in enhancing visualization and securing adhesive ureters during RUR.</p><p><strong>Methods: </strong>This retrospective cohort study included 24 patients who underwent RUR for stone-related ureteral strictures at two academic centers in Japan between April 2022 and June 2024. The patients were divided into two groups: those with the IRIS catheter and those with conventional indocyanine green (ICG) and near-infrared fluorescence imaging. The primary endpoint was a stent-free status with preserved renal function. Secondary outcomes included surgical time and postoperative recovery metrics.</p><p><strong>Results: </strong>Each group included 12 patients during the study period. The IRIS catheter group demonstrated a 54% reduction in ureter securing time (38.0 vs. 82.5 min, p = 0.001) and a 33-min shorter console duration (144.0 vs. 177.0 min, p = 0.005) than the ICG group. All patients in both groups achieved a stent-free status by 6-7 weeks postoperatively, with no significant differences in serum creatinine levels or estimated glomerular filtration rates between the preoperative and postoperative periods. Additionally, both groups showed significant improvement in hydronephrosis, with moderate to severe grades decreasing from 41.7% preoperatively to 8.3% postoperatively.</p><p><strong>Conclusion: </strong>The IRIS catheter significantly enhanced the efficiency of RUR by improving the visualization of adhesive ureters without compromising the ability to observe other anatomical structures.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to \"Clinical Outcomes of Untreated Recurrence After Radical Surgery for Upper Urinary Tract Carcinoma: A Multicenter Retrospective Study\".","authors":"Toru Kanno","doi":"10.1111/iju.70126","DOIUrl":"https://doi.org/10.1111/iju.70126","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on the Paper Titled \"Double-Sided Heinecke-Mikulicz Urethroplasty for Short Stricture Around Penoscrotal Junction: Description of Technique and Clinical Outcome of Initial Cases\".","authors":"Akio Horiguchi","doi":"10.1111/iju.70130","DOIUrl":"https://doi.org/10.1111/iju.70130","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comments on \"Research Landscape on Adrenocortical Carcinoma Over Four Decades\".","authors":"Alok Singh, Sudip Bhattacharya","doi":"10.1111/iju.70129","DOIUrl":"https://doi.org/10.1111/iju.70129","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to Penile Cancer: Differences Between Patients Over and Under the Age of 75 Years.","authors":"Daiji Takamoto","doi":"10.1111/iju.70124","DOIUrl":"https://doi.org/10.1111/iju.70124","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Impact on Quality of Life, and Predictive Factors of Co-Existent Overactive-Underactive Bladder in Women.","authors":"Noritoshi Sekido, Kenji Omae, Nobuhiro Haga, Yasue Kubota, Motoaki Saito, Ryuji Sakakibara, Mikako Yoshida, Takahiko Mitsui, Naoya Masumori, Satoru Takahashi","doi":"10.1111/iju.70120","DOIUrl":"https://doi.org/10.1111/iju.70120","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the prevalence, impact on health-related quality of life (HRQOL), and predictive factors of co-existent overactive-underactive bladder (COUB) in women.</p><p><strong>Methods: </strong>3088 Japanese women aged ≥ 20 years responding to a nationwide internet survey on lower urinary tract symptoms (LUTS) were included. Participants were divided into COUB, overactive bladder (OAB) alone, underactive bladder (UAB) alone, and non-OAB/UAB groups based on the OAB symptom score and the International Continence Society-Working Group definition of UAB. In addition to the prevalence, we assessed each group's HRQOL and physician visit rates. We further explored predictors of COUB as well as OAB and UAB using multinomial logistic regression analysis.</p><p><strong>Results: </strong>The prevalences of COUB, OAB alone, and UAB alone were 1.6%, 8.2%, and 2.4%, respectively, and all increased significantly with age. The proportions of COUB in OAB and UAB overall were 16.4% and 40.7%, respectively. The proportions of participants who responded that their HRQOL was affected and those visiting physicians were both highest in the COUB group. Multinomial logistic regression analysis showed that age, frailty, neurological disorders, anorectal dysfunction, pelvic organ prolapse, and parity (≥ 3) were independent predictors for COUB, of which age, neurological disorders, and parity were exclusively associated with COUB.</p><p><strong>Conclusions: </strong>Although not highly prevalent, COUB may have a significant impact on adult women, especially frail and multimorbid elderly women. More attention should be paid to this unique condition for optimal LUTS management.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}