International Journal of Urology最新文献

{"title":"Editorial Comment to Niraparib With Abiraterone Acetate Plus Prednisone as First-Line Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Repair Gene Alterations: Final Analysis of the Asian Subgroup From the MAGNITUDE Study.","authors":"Yoshiyuki Miyazawa","doi":"10.1111/iju.70488","DOIUrl":"https://doi.org/10.1111/iju.70488","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70488"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Trend in Timing of Surgery for Cryptorchidism: Has Earlier Surgical Intervention Been Achieved.","authors":"Taiju Hyuga, Koki Sugimura, Tatsuya Muto, Kimihiko Moriya","doi":"10.1111/iju.70475","DOIUrl":"https://doi.org/10.1111/iju.70475","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate age at surgery for cryptorchidism and to identify factors associated with early surgery.</p><p><strong>Methods: </strong>This retrospective study investigated 664 cases of cryptorchidism treated surgically between 2007 and 2023. Early surgery was defined as surgery at less than 1 year old. The cases detected at birth or at the 1-month checkup were defined as early detected cases and age at initial visit less than 6 months old was defined as early initial visit.</p><p><strong>Results: </strong>The proportion of early surgery increased over time, from 6.3% in 2007-2011 to 30.9% in 2020-2023 (OR 1.67, 95% CI 1.39-2.02; p < 0.001). Multivariate analyses demonstrated that early initial visit, era of surgery, hypospadias and multiple congenital anomalies were independently associated with early surgery. Among 200 early detected cases, 55.5% of these had delayed initial visits (at or over 6 months old). In early detected cases, multivariate analysis demonstrated that the shorter intervals from detection to initial visit and from surgical plan to the date of surgery were independently associated with early surgery. Even among early detected and early visiting cases, some surgeries were delayed due to patient-related factors.</p><p><strong>Conclusions: </strong>Age at initial visit is getting earlier, and surgery for cases less than 1 year old is also increasing, but remains insufficient. To achieve earlier surgical intervention for cryptorchidism, an early initial visit is essential. When findings suggestive of cryptorchidism are identified, immediate referral is crucial, and further observation is unnecessary.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70475"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on \"Comparison of Infectious Complications After Transrectal Prostate Biopsy Under Two Antibiotic Prophylaxis Regimens: Ceftriaxone Plus Cefixime Versus Ciprofloxacin Plus Gentamicin\".","authors":"Shirin Razdan","doi":"10.1111/iju.70466","DOIUrl":"https://doi.org/10.1111/iju.70466","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70466"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal Flap Urethroplasty and Dorsal Onlay Buccal Mucosal Graft Urethroplasty for Female Urethral Stricture: A Single-Center Experience.","authors":"Madoka Higuchi, Akio Horiguchi, Misaki Ashiya, Yuhei Segawa, Kazuki Yanagida, Daisuke Watanabe, Kenichiro Ojima, Masayuki Shinchi, Keiichi Ito","doi":"10.1111/iju.70477","DOIUrl":"https://doi.org/10.1111/iju.70477","url":null,"abstract":"<p><strong>Objective: </strong>Female urethral stricture (FUS) is a rare pathology often managed with ineffective repetitive transurethral treatments. Although guidelines recommend urethroplasty, high-quality evidence remains scarce due to the limited number of reported cases. We reviewed our institutional series to compare the surgical and functional outcomes between vaginal flap urethroplasty (VFU) and dorsal onlay buccal mucosal graft urethroplasty (DOBMGU), aiming to clarify the optimal surgical strategy.</p><p><strong>Methods: </strong>We retrospectively reviewed 15 female patients undergoing urethroplasty at a single center between 2012 and 2025. VFU was mainly indicated for strictures confined to the distal urethra, whereas DOBMGU was applied to strictures involving any anatomical segment. Surgical success was strictly defined as the absence of anatomical re-stricture on cystoscopy without secondary interventions.</p><p><strong>Results: </strong>VFU was performed in 7 (46.7%) and DOBMGU in 8 (53.3%). The DOBMGU group comprised distal (n = 2), mid-to-proximal (n = 3), and pan-urethral (n = 3) strictures. At a median follow-up of 12 months, DOBMGU achieved a higher success rate (87.5%, 7/8) compared to VFU (57.1%, 4/7). Both groups showed significant improvement in maximum urinary flow rate (p < 0.05). Notably, all 7 patients presenting with preoperative urinary retention achieved catheter-free status. De novo incontinence was rare (n = 1), while urinary spraying was noted only in the VFU group (n = 2).</p><p><strong>Conclusion: </strong>While VFU remains a valid option for distal strictures, DOBMGU demonstrated highly favorable functional reliability and anatomical stability, regardless of stricture location. Urethroplasty is a definitive treatment for FUS, offering high success rates and preservation of urinary continence.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70477"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on Midterm Outcomes of Combination Therapy With Immune Checkpoint Inhibitors and VEGFR-TKIs in Real-World Patients With Advanced Renal Cell Carcinoma.","authors":"Hiroshi Fukushima, Soichiro Yoshida, Yasuhisa Fujii","doi":"10.1111/iju.70480","DOIUrl":"https://doi.org/10.1111/iju.70480","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70480"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to Real-World Outcomes After Radical Cystectomy for Muscle-Invasive Bladder Cancer in Japan: A Nationwide Descriptive Study From the National Clinical Database.","authors":"Makito Miyake","doi":"10.1111/iju.70481","DOIUrl":"https://doi.org/10.1111/iju.70481","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70481"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.","authors":"Mattia Longoni, Andrea Marmiroli, Fabian Falkenbach, Quynh Chi Le, Michele Nicolazzini, Calogero Catanzaro, Federico Polverino, Jordan A Goyal, Markus Graefen, Gennaro Musi, Felix K H Chun, Carlotta Palumbo, Riccardo Schiavina, Nicola Longo, Fred Saad, Shahrokh F Shariat, Marco Moschini, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz","doi":"10.1111/iju.70483","DOIUrl":"https://doi.org/10.1111/iju.70483","url":null,"abstract":"<p><strong>Introduction: </strong>We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific mortality (CSM).</p><p><strong>Methods: </strong>Within the SEER database (2004-2021), we identified PC patients undergoing PLND and tabulated the number of lymph nodes (LNs) removed according to PC eligibility. Multivariable Cox-regression models tested the effect of PLND extent on CSM after adjusting for age, sex, T stage, N stage, and chemotherapy.</p><p><strong>Results: </strong>Of 1017 PC patients undergoing PLND, 197 (19.4%) were eligible vs. 820 (80.6%) ineligible according to PC eligibility criteria. Median number of LNs removed at PLND was 6 (IQR: 3-11) in eligible versus 7 (IQR: 3-14) in ineligible patients (p = 0.09). Mean numbers of LNs removed at PLND increased over the study period, from 7 to 16 (p = 0.007) in PC-eligible and from 8 to 13 (p = 0.001) in PC-ineligible patients. In 1017 patients regardless of PC eligibility, 5-year CSM-free survival rate was 65.6%, and PLND extent predicted lower CSM (multivariable hazard ratio [mHR]: 0.99, p = 0.036). In 197 PC-eligible patients, 5-year CSM-free survival rate was 84.2%, and the PLND extent was not associated with CSM (mHR: 0.96, p = 0.2). Conversely, in 820 PC-ineligible patients, 5-year CSM-free survival rate was 61.1%, and PLND extent predicted lower CSM (mHR: 0.99, p = 0.043).</p><p><strong>Conclusion: </strong>In all PC patients regardless of eligibility status, more extensive PLND was associated with improved cancer-specific survival.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70483"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on Optimizing Patient Selection for Aquablation During the Initial Adoption Phase: Prostate Smaller Than 100 mL.","authors":"Taiki Kato","doi":"10.1111/iju.70467","DOIUrl":"https://doi.org/10.1111/iju.70467","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70467"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression.","authors":"Douglas Edgard Lemes, Aline Áurea de Souza Santos, Jéssica Lopes de Oliveira, Henrique Roman-Ramos, Ana Carolina Ramos Moreno, Cleber Pinto Camacho, José Pontes-Junior, Humberto Dellê","doi":"10.1111/iju.70491","DOIUrl":"10.1111/iju.70491","url":null,"abstract":"<p><p>L-tryptophan (Trp) metabolism through the L-kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3-dioxygenase-1 (IDO1) is a key enzyme, and its catabolites-Kyn, 3-hydroxykynurenine (3HK), and 3-hydroxyanthranilate (3HAA)-depend on other enzymes and play a crucial role in immunomodulation.</p><p><strong>Objectives: </strong>We investigated the association between Kyn pathway enzyme expression and BC prognostic factors.</p><p><strong>Methods: </strong>Data from 165 bc patients in the GEO DataSets were analyzed, comparing staging, tumor grade, progression, and recurrence with the expression of IDO1, arylformamidase (AFMID), kynurenine-oxoglutarate transaminase (KAT), kynureninase (KYNU), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), and aminocarboxymuconate-semialdehyde decarboxylase (ACMSD). Predictive genes were further evaluated in RT4 (low-grade, non-invasive) and T24 (high-grade, invasive) BC cells treated with IFN-gamma and the IDO1 inhibitor INCB024360. Trp catabolites were quantified in the supernatant.</p><p><strong>Results: </strong>Enzyme expression varied widely, especially for IDO1, AFMID, KAT, KMO, and KYNU. IDO1 correlated positively with KMO and negatively with KAT. High IDO1 and KMO levels were linked to advanced-stage disease, while KAT and KYNU were associated with earlier stages and lower tumor grade. RT4 and T24 cells showed distinct basal enzyme expression, with T24 cells being more responsive to IFN-gamma, increasing IDO1 and KYNU while decreasing KAT and KMO. These effects were inhibited by INCB024360. High Trp consumption increased Kyn and 3HAA but not 3HK.</p><p><strong>Conclusions: </strong>Kyn pathway enzyme expression varies with disease progression and may indicate immune activity by influencing tumor microenvironment catabolites. BC cell sensitivity to immune stimuli differs, potentially shaping distinct immune escape mechanisms.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70491"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to \"Prognostic Significance of Hypoalbuminemia in Maintenance Avelumab Therapy After First-Line Chemotherapy for Metastatic Urothelial Carcinoma: A Multicenter Real-World Study (YUSHIMA Study)\".","authors":"Nozomi Hayakawa, Eiji Kikuchi","doi":"10.1111/iju.70490","DOIUrl":"https://doi.org/10.1111/iju.70490","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 5","pages":"e70490"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}