International Journal of Urology最新文献

{"title":"Symptom-Based Testosterone Therapy in Japanese Men With Late-Onset Hypogonadism Syndrome: A Real-World Single-Arm Study Following the 2022 Guideline.","authors":"Yoshikazu Sato, Keigo Akagashi, Musashi Tobe, Kazunori Haga, Kosuke Uchida, Ichiya Honma, Megumi Hirobe, Junji Ishizaki, Takashi Shimizu, Keitarou Watanabe, Hisao Nakajima","doi":"10.1111/iju.70257","DOIUrl":"https://doi.org/10.1111/iju.70257","url":null,"abstract":"<p><strong>Objectives: </strong>Following the 2022 revision of the Japanese clinical practice guidelines for late-onset hypogonadism, more flexible diagnostic criteria have been recommended, emphasizing both clinical symptoms and testosterone levels. This study aimed to evaluate the clinical characteristics of late-onset hypogonadism syndrome and the effectiveness of testosterone replacement therapy combined with daily phosphodiesterase-5 inhibitors in symptomatic men, including those with normal testosterone levels.</p><p><strong>Methods: </strong>From 2019 to 2023, 704 men presenting with late-onset hypogonadism-related symptoms were assessed for serum testosterone levels and symptom profiles. Of these, 227 received combination therapy with testosterone replacement therapy and daily phosphodiesterase-5 inhibitors. Changes in mood, vitality, sexual function and lower urinary tract symptoms were evaluated using validated questionnaires.</p><p><strong>Results: </strong>The most frequent symptoms were depressive mood, loss of energy, and easy fatigue, which may represent core features of late-onset hypogonadism syndrome. No significant association was found between testosterone levels and symptom severity. Combination therapy significantly improved symptom scores, as well as subjective feelings of vigor, confidence, and masculinity. Among the patients, 48.4% reported feeling \"better\" or \"much better,\" 47.2% reported feeling \"slightly better,\" and 4.4% experienced \"no change\" or \"worsening.\" Patients with normal testosterone levels showed greater improvement in symptom scores. Recovery of morning erections independently predicted overall improvement.</p><p><strong>Conclusions: </strong>Testosterone replacement therapy combined with daily phosphodiesterase-5 inhibitors is effective for late-onset hypogonadism-related symptoms, even in patients with normal testosterone levels. These findings support the revised Japanese guidelines, which promote a symptom-oriented treatment strategy alongside biochemical evaluation.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Most Men With Varicocele Are Fertile, but the Number of Offspring Is Reduced.","authors":"Koji Shiraishi","doi":"10.1111/iju.70265","DOIUrl":"https://doi.org/10.1111/iju.70265","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Events in Testicular Cancer Survivors Using EORTC QLQ-TC26: A Multi-Institutional, Cross-Sectional Study in Japan.","authors":"Takuro Goto, Shinichi Yamashita, Kenichi Kakimoto, Motohide Uemura, Takeshi Kishida, Takashi Kawahara, Terukazu Nakamura, Takayuki Goto, Takahiro Osawa, Kazuo Nishimura, Norio Nonomura, Hiroyuki Nishiyama, Takumi Shiraishi, Osamu Ukimura, Osamu Ogawa, Nobuo Shinohara, Yoshimi Suzukamo, Akihiro Ito, Yoichi Arai","doi":"10.1111/iju.70261","DOIUrl":"https://doi.org/10.1111/iju.70261","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate adverse events in testicular cancer survivors using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 (EORTC QLQ-TC26).</p><p><strong>Methods: </strong>Testicular cancer survivors at eight high-volume institutions in Japan were surveyed regarding age, International Germ Cell Consensus Classification, number of chemotherapy cycles, paclitaxel use, follow-up period after treatment, and adverse events scores of EORTC QLQ-TC26. Adverse events scores were assessed by the number of chemotherapy cycles and the follow-up period.</p><p><strong>Results: </strong>A total of 551 testicular cancer survivors responded to the adverse events questionnaires of EORTC QLQ-TC26. Median age at response was 43 years and median follow-up was 61 months. Chemotherapy was administered to 393 (71%) survivors, and paclitaxel was used in 91 (17%) survivors. Testicular cancer survivors who received three or more cycles of chemotherapy showed significantly worse adverse events scores than those without chemotherapy. Scores for tingling or numbness in the fingers or toes, pale/cold fingers or toes, and problems with hearing were affected by chemotherapy. Tingling or numbness tended to improve over time, whereas problems with hearing showed no evidence of improvement. In addition, scores for tingling or numbness were worse when paclitaxel was used.</p><p><strong>Conclusions: </strong>Testicular cancer survivors suffered from adverse events with three or more cycles of chemotherapy, and problems with hearing did not improve after treatment. We should provide testicular cancer survivors with adequate information about long-lasting adverse events, particularly problems with hearing.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Androgen Receptor Signaling Inhibitors in Non-Metastatic Castration-Resistant Prostate Cancer in Japan: The ARASHI Study.","authors":"Takashi Kawahara","doi":"10.1111/iju.70259","DOIUrl":"https://doi.org/10.1111/iju.70259","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Prostate-Specific Antigen Dynamics and Bone Predominance as Predictors of Efficacy in Radium-223 Treatment for Castration-Resistant Prostate Cancer.","authors":"Ammar Alanbuki","doi":"10.1111/iju.70264","DOIUrl":"https://doi.org/10.1111/iju.70264","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to: Needlestick Injury During Urological Surgery: A 15-Year Review From a Multi-Institutional Study in the Chugoku-Shikoku Japan Urological Consortium.","authors":"M İrfan Dönmez","doi":"10.1111/iju.70260","DOIUrl":"https://doi.org/10.1111/iju.70260","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on the Benefits of Preemptive Living Kidney Transplantation: Reduced Rates of Cerebro-Cardiovascular Events and Neoplasm Development.","authors":"Shunta Hori","doi":"10.1111/iju.70263","DOIUrl":"https://doi.org/10.1111/iju.70263","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Critical Appraisal of 'Impact and Risk Factors of Diagnostic Delay in Patients With Testicular Cancer: A Multicenter Retrospective Study'\".","authors":"Taketo Kawai, Kazuki Honda, Satoru Taguchi","doi":"10.1111/iju.70258","DOIUrl":"https://doi.org/10.1111/iju.70258","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Glucocorticoid Receptor Beta in Bladder Cancer and Its Clinicopathological Significance: A Novel Diagnostic Marker to Predict Progression and Recurrence of Cancer.","authors":"Takashi Kukimoto, Yasuhiro Nakamura, Shuko Hata, Hiroki Shimada, Tomoaki Ogata, Masashi Kato, Haruka Saito, Hiroki Kusumoto, Masaaki Oikawa, Kento Morozumi, Kazuyuki Numakura, Shintaro Narita, Makoto Sato, Tomonori Habuchi, Yasuhiro Kaiho","doi":"10.1111/iju.70254","DOIUrl":"https://doi.org/10.1111/iju.70254","url":null,"abstract":"<p><strong>Objectives: </strong>The glucocorticoid receptor beta (GRβ) not only inhibits the function of the glucocorticoid receptor but also possesses unique transcriptional activity. Whereas the role of GRβ varies among different cancer types, its significance in bladder cancer remains unclear. This study aimed to investigate the clinical significance of GRβ expression in bladder cancer.</p><p><strong>Methods: </strong>Immunohistochemical analysis was performed on tissue samples obtained from 106 patients who underwent surgery for bladder cancer. The immunoreactivity of GRβ was evaluated using the labeling index (0%-100%). The association between GRβ expression and clinical parameters obtained from medical records was analyzed.</p><p><strong>Results: </strong>GRβ expression was significantly lower in muscle-invasive bladder cancer (≥ pT2) compared with non-muscle-invasive cases (≤ pT1) (p = 0.0177). Furthermore, patients who experienced intravesical recurrence after surgery exhibited significantly lower GRβ expression (p = 0.0179).</p><p><strong>Conclusions: </strong>These findings suggest that GRβ may serve as a potential biomarker for predicting the progression and recurrence of bladder cancer.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian Reanalysis of Enzalutamide Plus Androgen Deprivation Therapy in Japanese Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Methodological Complement to Frequentist Analysis From the ARCHES Trial.","authors":"Shugo Yajima, Soichiro Yoshida, Hiroshi Fukushima, Akihiro Hirakawa, Hitoshi Masuda, Yasuhisa Fujii","doi":"10.1111/iju.70256","DOIUrl":"https://doi.org/10.1111/iju.70256","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}