International Journal of Urology最新文献

{"title":"Editorial Comment to “Stone at the same location for 2 months predicts impacted stones and stone-free status after shock wave lithotripsy for ureteral stones: A Funabashi clinic expert study”","authors":"Ryoji Takazawa MD, PhD","doi":"10.1111/iju.70001","DOIUrl":"10.1111/iju.70001","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"32 4","pages":"378-379"},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Feasibility and Outcomes of RUS Surgical Navigation System During Robot-Assisted Partial Nephrectomy for Small Renal Masses.","authors":"Sangmin Lee, Hyun Young Lee, Cheryn Song","doi":"10.1111/iju.70014","DOIUrl":"https://doi.org/10.1111/iju.70014","url":null,"abstract":"<p><strong>Objectives: </strong>This phase I trial evaluated the RUS 3D virtual surgical navigation system's feasibility during robot-assisted partial nephrectomy.</p><p><strong>Methods: </strong>In ten patients who underwent robot-assisted partial nephrectomy at Asan Medical Center, a 3D virtual anatomical model was reconstructed from preoperative computerized tomography scans. The 3D model was integrated with the surgeon's console through TilePro, providing manipulable virtual anatomy during surgery. Following standard robot-assisted partial nephrectomy procedures performed by a single experienced surgeon using the navigation system, perioperative parameters were compared with a control group of 30 patients matched for tumor and body morphometric characteristics.</p><p><strong>Results: </strong>The navigation system was well integrated into the surgical workflow without technical issues, providing accurate anatomical visualization, particularly of the regional calyces and intrarenal vessel branches. The navigation group had shorter operative times (122 vs. 144.7 min) and less frequent collecting system entry (40% vs. 66.7%). For equivalent tumor size, resected specimen volume was significantly smaller in the navigation group (6.8 vs. 16.7 cm³, p = 0.035). The navigation group also experienced a shorter hospital stay (p = 0.046) and a more modest decrease in glomerular filtration rate postoperatively (8.9% vs. 12.2%). There were no perioperative complications in either group.</p><p><strong>Conclusions: </strong>The integration of the 3D navigation system into robot-assisted partial nephrectomy was both feasible and safe, providing enhanced anatomical information while maintaining a consistent level of operative risk. The use of the navigation system resulted in reduced renal parenchymal volume resected, suggesting potential benefits in renal function preservation.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Risk Factors for Early Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Carcinoma According to the History of Non-Muscle Invasive Bladder Cancer.","authors":"Tetsuya Shindo, Yohei Ueki, Ippei Muranaka, Genki Kobayashi, Shintaro Miyamoto, Yasuharu Kunishima, Shunsuke Sato, Manabu Okada, Shuichi Kato, Ryuichi Kato, Hideki Adachi, Masanori Matsukawa, Akio Takayanagi, Naoki Ito, Atsushi Wanifuchi, Takeshi Maehana, Yuki Kyoda, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori","doi":"10.1111/iju.70009","DOIUrl":"https://doi.org/10.1111/iju.70009","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the preoperative risk factors for early intravesical recurrence after radical nephroureterectomy (RNU) in patients with upper urinary tract carcinoma (UTUC) according to the history of non-muscle invasive bladder cancer (NMIBC).</p><p><strong>Methods: </strong>We retrospectively evaluated patients who underwent RNU for UTUC between 2012 and 2022 at 14 hospitals. Early recurrence was defined as intravesical pathologically confirmed recurrence within 1 year after RNU. Patients who received single-dose immediate intravesical instillation (IVI) as prevention for intravesical recurrence were excluded. Using preoperative factors, we examined the risk factors for early intravesical recurrences in patients with and without a history of NMIBC. Death from any cause within 1 year after RNU was regarded as a competitive risk.</p><p><strong>Results: </strong>We included 504 UTUC patients who were treated with RNU. Among these patients, 126 (25.0%) had a history of NMIBC, whereas 378 (75%) did not. According to multivariate analysis, the presence of macrohematuria, positive cytology in self-voided urine, and performing diagnostic ureteroscopy prior to RNU were risk factors in patients without a history of NMIBC. On the other hand, an NMIBC diagnosis within 1 year prior to RNU and an extravesical approach for bladder cuff management were risk factors in RNU-treated patients with a history of NMIBC.</p><p><strong>Conclusions: </strong>Early intravesical recurrence risk factors differ between UTUC patients with and without a history of NMIBC. Different stratification may be needed to predict intravesical recurrence risk in these two types of UTUC patients.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Posterior Transvaginal Mesh Surgery Using PTFE Mesh ORIHIME Effective and Safe for Advanced Posterior Vaginal Prolapse?","authors":"Kazunobu Yagi, Masami Takeyama, Yukiko Doi, Tomoko Kuwata, Hiromi Kashihara, Chikako Kato","doi":"10.1111/iju.70008","DOIUrl":"https://doi.org/10.1111/iju.70008","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the efficacy and safety of posterior tension-free vaginal mesh (TVM-P) surgery using polytetrafluoroethylene (PTFE) mesh (ORIHIME) for advanced posterior vaginal prolapse.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving patients who underwent TVM-P surgery with PTFE mesh for pelvic organ prolapse quantification stage III or IV posterior vaginal prolapse between December 2018 and March 2023. All patients were followed for a minimum of 1 year postoperatively. The primary outcome was the recurrence rate in the operated compartment. Secondary outcomes comprised recurrence in other pelvic compartments, mesh-related complications, and an analysis of risk factors for recurrence.</p><p><strong>Results: </strong>Seventy-one patients underwent TVM-P surgery during the study period. The recurrence rate in the operated compartment was 4.2%, while the overall recurrence rate was 18.3%. Eleven cases of recurrence occurred within the first year; 13 cases were observed within 3 years postsurgery. Patients who experienced recurrence in other compartments had a significantly higher incidence of preoperative Ba point score ≥ -1 versus the nonrecurrence group. Preoperative Ba point score ≥ -1 was associated with a higher risk of recurrence in other compartments (crude odds ratio: 4.17, 95% confidence interval: 1.03-26.7; adjusted odds ratio: 2.58, 95% confidence interval: 0.56-11.8).</p><p><strong>Conclusions: </strong>The recurrence rate in the operated compartment following TVM-P surgery for advanced rectoceles or enteroceles was 4.2%. These findings suggest that TVM-P surgery using PTFE mesh may be an effective surgical option for treating severe posterior vaginal pelvic organ prolapse.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Antithrombotic Management in Transurethral Resection of Bladder Tumor: A Call for Evidence-Based Strategies.","authors":"Fumihiko Urabe","doi":"10.1111/iju.70012","DOIUrl":"https://doi.org/10.1111/iju.70012","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Is Seated Voiding Associated With Lower Urinary Tract Symptoms, Health Conditions, or Marital Status? Findings by Age Group From the 2023 Japan Community Health Survey.","authors":"Ewelina Wojciechowska, Hanna Garnier","doi":"10.1111/iju.70007","DOIUrl":"https://doi.org/10.1111/iju.70007","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lymph node dissection during surgery on the efficacy of pembrolizumab in patients with metastatic urothelial carcinoma.","authors":"Toru Kanno, Katsuhiro Ito, Yuki Kita, Takanori Mochizuki, Tomoyasu Sano, Akira Yokomizo, Takashige Abe, Kazunari Tsuchihashi, Shuichi Tatarano, Junichi Inokuchi, Atsushi Takahashi, Yoshiyuki Matsui, Hiroyuki Nishiyama, Hiroshi Kitamura, Ryoichi Saito, Takashi Kobayashi","doi":"10.1111/iju.70002","DOIUrl":"https://doi.org/10.1111/iju.70002","url":null,"abstract":"<p><strong>Objectives: </strong>The impact of lymph node dissection (LND) on the efficacy of pembrolizumab in patients with urothelial carcinoma (UC) who develop metastasis after surgery remains unclear. This study aimed to investigate the efficacy of pembrolizumab in patients with metastatic UC who underwent primary tumor resection with LND.</p><p><strong>Patients and methods: </strong>This retrospective study included patients who initially underwent radical surgery with or without LND for non-metastatic UC and later received pembrolizumab for recurrent lesions. Data were collected from a retrospective nationwide Japanese cohort study in patients with metastatic UC treated with pembrolizumab. The primary endpoints were overall response rate (ORR) and overall survival (OS). Multivariate analysis was performed to identify predictors of OS.</p><p><strong>Results: </strong>A total of 393 patients (273 [69.5%] underwent LND, and 120 (30.5%) did not) were included in this study. The ORRs for patients with and without LND were 30.8% and 27.3%, respectively (p = 0.460). No significant difference in OS was observed between the two groups (p = 0.471). Multivariate Cox regression analysis revealed that a neutrophil-to-lymphocyte ratio ≥3.0, Eastern Cooperative Oncology Group performance status ≥2, hemoglobin <11, and liver metastasis were associated with worse OS. However, LND was not associated with OS.</p><p><strong>Conclusions: </strong>LND during primary tumor resection did not affect the efficacy of pembrolizumab in patients with metastatic UC.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of best objective response to first-line treatment on survival outcomes in advanced urothelial carcinoma in the era of sequential therapy with enfortumab vedotin.","authors":"Kohei Kobatake, Keisuke Goto, Yuki Sakamoto, Kyohsuke Iwane, Kensuke Nishida, Kunihiro Hashimoto, Akihiro Asami, Hideo Iwamoto, Tetsutaro Hayashi, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata","doi":"10.1111/iju.15686","DOIUrl":"https://doi.org/10.1111/iju.15686","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated whether first-line treatment affects survival outcomes in patients with advanced urothelial carcinoma undergoing sequential therapy with chemotherapy, immune checkpoint inhibitors, and enfortumab vedotin.</p><p><strong>Methods: </strong>This multicenter retrospective study included 57 patients treated at Hiroshima University Hospital and its affiliated institutions between 2009 and 2024. Patients received chemotherapy as a first-line treatment (gemcitabine plus cisplatin or carboplatin), followed by second-line immune checkpoint inhibitors (pembrolizumab or avelumab) and third-line enfortumab vedotin. Assessed outcomes included overall survival and time to treatment failure. Cox regression analysis identified prognostic factors for overall survival.</p><p><strong>Results: </strong>Over a median follow-up of 20.5 months, median overall survival was not reached after first-line treatment. Gemcitabine with cisplatin was selected in 31.6% of cases, while gemcitabine and carboplatin was chosen in 68.4% of cases as the first-line treatment; subsequently, 66.7% received pembrolizumab, and 33.3% received avelumab in the second-line treatment. Patients who achieved a complete or partial response with the first-line treatment had significantly longer overall survivals from both first-line and enfortumab vedotin initiation than those with stable or progressive disease. In cases that achieved complete or partial responses, avelumab was more frequently selected as a second-line therapy. However, in the first-line treatment, multivariate analysis identified only stable or progressive disease as a significant predictor of worse overall survival.</p><p><strong>Conclusion: </strong>The best response to first-line treatment predicted both overall survival from first-line initiation and outcomes following enfortumab vedotin treatment, underscoring its prognostic value in sequential therapy for patients with advanced urothelial carcinoma.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of the clinical practice guideline for the management of urinary stones, third edition.","authors":"Katsuhito Miyazawa, Satoshi Yamaguchi, Taro Iguchi, Ippei Chikazawa, Takahiro Yasui, Satoru Takahashi, Shiro Hinotsu, Koichiro Akakura, Shizuka Iida, Noritaka Ishito, Takaaki Inoue, Yasuo Kohjimoto, Shinichi Sakamoto, Yoshikazu Sato, Ryoji Takazawa, Tatsuya Takayama, Masao Tsujihata, Yukio Naya, Shuzo Hamamoto, Motoyuki Masai, Takuro Masaki, Junichi Matsuzaki, Soichi Mugiya","doi":"10.1111/iju.70004","DOIUrl":"https://doi.org/10.1111/iju.70004","url":null,"abstract":"<p><p>This third edition of the Japanese Clinical Practice Guidelines for Urinary stones (2023) has been developed under the leadership of the Japanese Urological Association, the Japanese Society of Endourology and Robotics, and the Japanese Society on Urolithiasis Research. This revision adheres to the Minds Manual for Guideline Development (2017) and incorporates new findings from a nationwide survey conducted in 2015, which highlighted the epidemiological characteristics of urolithiasis in Japan since the previous guidelines were published in 2013. A significant advancement in this edition is the systematic review (SR) methodology applied to formulate recommendations for 12 clinical questions (CQs). Both quantitative and qualitative SRs were performed, leading to recommendations determined through consensus among 21 members of the guideline development group. Additionally, nine algorithms were created to support clinical decision-making based on these findings. Topics not addressed by the CQs, considered as foundational knowledge, are outlined in an \"Explanation of Related Matters\" section, which includes 26 items. This article provides an overview of these guidelines. This section ensures that practitioners have access to comprehensive information, covering aspects of urolithiasis management beyond the scope of the systematic reviews. This article provides an overview of the guidelines, emphasizing their relevance and importance in improving the management and treatment outcomes for patients with urinary stones. The guidelines are designed to be a practical resource for clinicians, facilitating evidence-based care in the evolving landscape of urolithiasis treatment.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral contrast findings as a potential predictor for invasive intervention in high-grade pediatric renal trauma: A retrospective analysis.","authors":"Hansen Lui, Phillip J Kim, Lisa H Kang, Blythe P Durbin-Johnson, Eric A Kurzrock","doi":"10.1111/iju.70006","DOIUrl":"https://doi.org/10.1111/iju.70006","url":null,"abstract":"<p><strong>Objectives: </strong>To determine if patient variables were associated with intervention in pediatric patients presenting with high-grade renal injuries.</p><p><strong>Methods: </strong>A retrospective review of pediatric patients presenting with grade IV/V renal injury between 2003 and 2021 at a Level 1 trauma center was performed. Renal injury grade was verified and updated based upon the 2018 American Association for the Surgery of Trauma injury scale. Multivariable logistic regression analyses were performed.</p><p><strong>Results: </strong>Seventy-five patients (median age 13 years old, IQR 9-16) with Grade IV (n = 53) or Grade V (n = 22) injury were identified. 33% (25/75) had immediate renal intervention within 24 h of admission. Of the remaining 50 children who were observed, 47 had blunt trauma, and outcomes were analyzed. The median age of observed patients was 12 years (IQR 8-14) and 30% (14/47) had intervention. Delayed images on CT showed ureteral contrast was present in 87% (41/47) of observed patients. Multivariable analysis demonstrated that the presence of contrast in the ureter is associated with significantly lower odds of intervention, OR 0.06 [0-0.73, 95% CI], p = 0.03.</p><p><strong>Conclusion: </strong>After grades IV and V blunt renal injury, for those children who are considered safe to observe, AAST grade of injury did not associate with procedural intervention. The presence of contrast in the ureter on delayed CT imaging was associated with a significantly lower odds of procedural intervention.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}