Is Testosterone Replacement Therapy Effective and Safe Even for Eugonadal Men With Symptoms of Late-Onset Hypogonadism?

IF 1.8 3区医学 Q3 UROLOGY & NEPHROLOGY

International Journal of Urology Pub Date : 2025-06-03 DOI:10.1111/iju.70128

Keisuke Ishikawa, Akira Tsujimura, Takashi Kanda, Syuichiro Narita, Yuta Anno, Haruhiko Wakita, Ayumu Taniguchi, Yuka Uesaka, Taiji Nozaki, Masato Shirai, Kazuhiro Kobayashi, Shigeo Horie

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引用次数: 0

Abstract

Objective: To clarify the efficacy and safety of testosterone replacement treatment for eugonadal patients with symptoms of late-onset hypogonadism.

Materials and methods: 565 eugonadal men with symptoms of late-onset hypogonadism who underwent testosterone replacement treatment were included in this study. Physical factors, laboratory and endocrinologic variables, and scores of several questionnaires were evaluated. Testosterone replacement treatment was administered with intramuscular injection of 250 mg of testosterone esters, and efficacy was assessed by patient satisfaction. First, we evaluated the efficacy rate and safety of testosterone replacement treatment and then investigated the independent factors influencing its efficacy.

Results: Testosterone replacement treatment was effective in 131 of 216 patients (60.6%), 111 of 163 patients (68.1%), and 126 of 186 patients (67.7%) with mental, physical, and sexual dysfunction, respectively. The overall efficacy rate was 65.1%. No side effects were observed after testosterone replacement treatment. Only the total score of the Aging Male Symptoms rating scale was identified as a factor predictive of patient satisfaction.

Conclusions: This study is the first, to our knowledge, to report the efficacy and safety of testosterone replacement treatment for eugonadal men with symptoms of late-onset hypogonadism.

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睾酮替代疗法对有迟发性性腺功能减退症状的性腺功能正常男性有效且安全吗？

目的：探讨睾酮替代疗法治疗性腺功能正常的迟发性性腺功能减退患者的疗效和安全性。材料与方法：565例有迟发性性腺功能减退症状且接受睾酮替代治疗的男性性腺功能正常。评估了生理因素、实验室和内分泌变量以及几份问卷的得分。睾酮替代治疗采用肌肉注射睾酮酯250 mg，以患者满意度评估疗效。首先，我们评估了睾酮替代治疗的有效性和安全性，然后探讨了影响其疗效的独立因素。结果：216例精神、生理、性功能障碍患者中有131例（60.6%）、163例患者中有111例（68.1%）、186例患者中有126例（67.7%）睾酮替代治疗有效。总有效率为65.1%。睾酮替代治疗后未见副作用。只有老年男性症状评定量表的总分被确定为预测患者满意度的因素。结论：据我们所知，本研究首次报道了睾酮替代治疗具有迟发性性腺功能减退症状的性腺功能正常男性的有效性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Urology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

11.50%

发文量

340

审稿时长

3 months

期刊介绍： International Journal of Urology is the official English language journal of the Japanese Urological Association, publishing articles of scientific excellence in urology. Submissions of papers from all countries are considered for publication. All manuscripts are subject to peer review and are judged on the basis of their contribution of original data and ideas or interpretation.