International journal of ophthalmology最新文献

{"title":"Polymorphic variants of <i>ABCA1</i>, <i>PMM2</i>, and <i>ARHGEF12</i> genes and the risk of glaucoma in an Iranian population.","authors":"Asghar Shayannia, Kobra Foroughi, Mohammad Hassan Emamian, Hassan Hashemi, Akbar Fotouhi","doi":"10.18240/ijo.2025.05.09","DOIUrl":"10.18240/ijo.2025.05.09","url":null,"abstract":"<p><strong>Aim: </strong>To examine whether rs2472493 and rs248032 in the <i>ABCA1</i> gene, rs3785176 in the <i>PMM2</i> gene, and rs11827818 in the <i>ARHGEF12</i> gene contribute to primary open angle glaucoma (POAG) in an Iranian population.</p><p><strong>Methods: </strong>Totally 82 POAG patients and 172 healthy controls were enrolled. The selected gene polymorphisms were analyzed using TaqMan SNP Genotyping Assay using deoxyribonucleic acid (DNA) extracted from blood samples. Allelic and genotypic frequencies were evaluated using the Chi-square test. The association between the genotypes of single nucleotide polymorphisms (SNPs) and POAG was assessed using multiple logistic regression models. The linkage disequilibrium and haplotype block structure were assessed using the Haploview 4.2 software.</p><p><strong>Results: </strong>The results showed a significant association between allele frequencies of rs2472493 in the <i>ABCA1</i> gene locus and POAG [odds ratio (OR)=1.58, 95% confidence intervals (CI)=1.04-2.39, <i>P</i>=0.031]. The rs3785176 in the <i>PMM2</i> gene was also associated with POAG in additive and over dominant genotypes. Moreover, haplotype analysis showed a significant association of two estimated haplotypes of rs2472493/rs2487032 with POAG. The AA haplotype showed a reduction in POAG risk (OR=0.41, 95%CI=0.202-0.834, <i>P</i>=0.012), while the GG haplotype was associated with the disease. In addition, this study could not discover any association between genotype and allele frequency of rs248032 in the <i>ABCA1</i> gene, and rs11827818 in <i>ARHGEF12</i> gene and POAG.</p><p><strong>Conclusion: </strong>rs2472493 in the <i>ABCA1</i> gene can be considered a genetic susceptibility locus for POAG. The haplotype constructed with <i>ABCA1</i> gene SNPs (rs2472493/rs2487032) is associated with POAG.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 5","pages":"846-852"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of diabetic macular edema post vitrectomy in patients with proliferative diabetic retinopathy.","authors":"Han-Tao Zhou, Jing-Hao Mei, Ke Lin, Chu-Ying Deng, Ao Pan, Zu-Shun Lin, Jue Lin, Wei Lin, Zhong Lin","doi":"10.18240/ijo.2025.05.12","DOIUrl":"10.18240/ijo.2025.05.12","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the change of diabetic macular edema (DME) post vitrectomy and its risk factors.</p><p><strong>Methods: </strong>This retrospective study included 365 eyes of 330 patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) with gradable optical coherence tomography (OCT) imaging from January 2018 to March 2022. The incidence of post vitrectomy DME (PV-DME) was defined as patients with a central retinal thickness (CRT) >300 µm by OCT among patients without preoperative DME.</p><p><strong>Results: </strong>The cumulative incidence of PV-DME at 3mo was 40.1% (89/222), with its majority subtype of single diffused retinal thickening (66.2%) followed by single cystoid macular edema (27.0%). Multivariate Cox regression analysis indicated that a thicker preoperative CRT [hazard ratio (HR)=1.01, 95% confidence interval (CI) 1.00-1.02] and intraoperative internal limiting membrane peeling (HR=3.18, 95%CI 1.85-5.47) were associated with the presence of PV-DME, while intraoperative intravitreal injection of triamcinolone acetonide (HR=0.28, 95%CI 0.13-0.57) was protective against PV-DME. In eyes with preoperative DME (<i>n</i>=143), the CRT decreased gradually from 468.3±177.7 µm preoperatively to 409.5±151.0 µm (<i>P</i>=0.027), 377.4±141.9 µm (<i>P</i><0.001), and 368.0±157.6 µm (<i>P</i><0.001) at 7d, 1 and 3mo postoperatively, respectively. Multivariate linear regression analysis indicated that only a thicker preoperative CRT (<i>β</i>=0.77, 95%CI 0.63-0.92) was associated with a decreasing postoperative CRT.</p><p><strong>Conclusion: </strong>PV-DME is a very common postoperative complication in patients with PDR. Triamcinolone acetonide could prevent its formation. Attention should be paid to patients with a thicker preoperative CRT and internal limiting membrane peeling.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 5","pages":"868-875"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of perifoveal exudative vascular anomalous complex with laser treatment: a case report.","authors":"Qing Chen, Bin-Jian Wang, Yu-Zhu Gao, Xue Wu, Ming Zhang","doi":"10.18240/ijo.2025.05.25","DOIUrl":"10.18240/ijo.2025.05.25","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 5","pages":"965-968"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced choroidal vascular index and choroid structural changes extended beyond subfoveal area in chronic central serous chorioretinopathy eyes with macular neovascularization.","authors":"Xiang-Gui Zhang, Zhen-De Deng, Yan-Nian Hui, Zhen Huang, Ya Ye, Ming Yan, Yan-Ping Song","doi":"10.18240/ijo.2025.05.10","DOIUrl":"10.18240/ijo.2025.05.10","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the choroidal vascular index (CVI) and the choroidal structural changes beyond the subfoveal area (analyzed across a 20 mm×24 mm scanning area) in eyes with chronic central serous chorioretinopathy (cCSC) eyes with macular neovascularization (MNV) using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA).</p><p><strong>Methods: </strong>This retrospective comparative study included 46 cCSC with MNV eyes (With MNV group), 52 cCSC without MNV eyes (Without MNV group), and 40 age-matched healthy controls. UWF SS-OCTA imaging with a 20 mm×24 mm protocol was used to quantify CVI across 9 subfields (superotemporal, superior, superonasal, temporal, central, nasal, inferotemporal, inferior, and inferonasal). The CVI was compared among the groups.</p><p><strong>Results: </strong>With MNV group demonstrated significantly older mean age than Without MNV group (56.2±6.1 <i>vs</i> 47.5±8.6y, <i>P</i><0.001). The CVI was significantly lower in the With MNV group than in the Without MNV group, except in the superotemporal, superior, and temporal regions (all <i>P</i><0.05). Notably, despite MNV-associated CVI reductions, the With MNV group maintained a higher CVI than the control group in all 5 subfields (superior, temporal, central, inferior, and inferonasal; all <i>P</i><0.05). In the central region, the CVI (%) in With MNV, Without MNV, and control groups were 35.63±3.33, 37.37±2.07, and 32.67±5.00 (<i>P</i><0.05), respectively.</p><p><strong>Conclusion: </strong>CVI decreases, and choroidal structural changes extend beyond the subfoveal area in cCSC with MNV eyes, providing with an imaging evidence for the important role of choroidal ischemia in the pathogenesis of MNV in cCSC.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 5","pages":"853-859"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fenofibrate mitigates the dysfunction of high glucose-driven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome.","authors":"Yi Shi, Hao-Min Chen, Ai-Hua Liu, Xiao-Rong Li","doi":"10.18240/ijo.2025.05.04","DOIUrl":"10.18240/ijo.2025.05.04","url":null,"abstract":"<p><strong>Aim: </strong>To determine the therapeutic benefits of fenofibrate (Feno) on the dysfunction of high glucose (HG)-induced human retinal microvascular endothelial cells (HRMECs) and to elucidate the underlying molecular mechanism.</p><p><strong>Methods: </strong>HRMEC dysfunction model was established by 48h glucose (30 mmol/L) treatment and treated with Feno/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activator (Nigericin). Cell viability/apoptosis were assessed by cell counting kit-8 (CCK-8)/terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) staining and flow cytometry assays. Levels of apoptosis- (Bcl-2-associated X protein, Bax/B-cell lymphoma 2, Bcl-2), vascular permeability-(vascular endothelial growth factor, VEGF) and inflammasome activation-related proteins (NLRP3/cleaved caspase-1/apoptosis-associated speck-like protein containing a CARD, ASC), as well as inflammatory factors (interleukin, IL-6/IL-1β/tumor necrosis factor, TNF-α/IL-18) were determined with Western blot/enzyme linked immunosorbent assay (ELISA). Cell permeability/reactive oxygen species (ROS) level/superoxide dismutase (SOD) activity/malondialdehyde (MDA) content were assessed by Evans blue staining/2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescent probe/SOD kit/MDA kit.</p><p><strong>Results: </strong>HRMEC dysfunction was successfully induced by HG, evidenced by decreased viability (<i>P</i><0.001), increased apoptosis (<i>P</i><0.001), permeability (<i>P</i><0.001), and inflammatory factor levels (<i>P</i><0.001). Feno treatment significantly ameliorated HG-induced HRMEC dysfunction (<i>P</i><0.01). Meanwhile, HG induction increased ROS production (<i>P</i><0.001) and MDA content (<i>P</i><0.001) in HRMECs, while reducing SOD activity (<i>P</i><0.001), indicative of oxidative stress. This was, however, abolished by Feno (<i>P</i><0.05). Moreover, Feno eliminated activation of NLRP3 inflammasomes (<i>P</i><0.05) in HG-induced HRMECs. Strikingly, activation of NLRP3 inflammasomes partially averted the inhibition of Feno on HG-induced HRMEC dysfunction (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Feno represses oxidative stress and NLRP3 inflammasome activation, consequently alleviating HG-induced HRMEC dysfunction.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 5","pages":"792-801"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreous surgery in treating complex retinal capillary hemangioma.","authors":"Wan Cheng, Wei-Ling Yan, Shi-Yong Li, Ke-Ran Li","doi":"10.18240/ijo.2025.04.23","DOIUrl":"https://doi.org/10.18240/ijo.2025.04.23","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 4","pages":"748-750"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of post-infectious anti-myelin oligodendrocyte glycoprotein antibody-positive optic neuritis.","authors":"Yu Bin Son, Kye-Hyung Kim, Hee-Young Choi, Hyeshin Jeon","doi":"10.18240/ijo.2025.04.24","DOIUrl":"https://doi.org/10.18240/ijo.2025.04.24","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 4","pages":"751-752"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleb revision and transscleral cyclophotocoagulation for congenital glaucoma patient with Turner syndrome and <i>DMPK</i> gene mutation: a case report.","authors":"An-Qi Guo, Wei-Jia Zhang, Ying Hong, Chun Zhang","doi":"10.18240/ijo.2025.04.22","DOIUrl":"https://doi.org/10.18240/ijo.2025.04.22","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 4","pages":"744-747"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating decisional conflict: laser peripheral iridotomy for primary angle-closure glaucoma prevention.","authors":"Yi-Jie Chen, Jing-Yao Dai, Rong-Rong Le, Xiao-Xian Zhang, Jia-Li Huang, Hu-Jie Lu, Yi-Wen Sun, Yuan-Bo Liang, Yan-Yan Chen, Wen-Zhe Zhou","doi":"10.18240/ijo.2025.04.08","DOIUrl":"https://doi.org/10.18240/ijo.2025.04.08","url":null,"abstract":"<p><strong>Aim: </strong>To investigate decisional conflict among patients diagnosed with primary angle-closure suspect (PACS) or primary angle-closure (PAC) who are considering laser peripheral iridotomy (LPI) treatment.</p><p><strong>Methods: </strong>A total of 111 individuals diagnosed with PACS or PAC were selected through convenient sampling from March 2023 to December 2023. These participants then completed a general information questionnaire and the Decision Conflict Scale. Data analysis was performed using multiple linear regression to reveal factors influencing decisional conflict.</p><p><strong>Results: </strong>The mean Decisional Conflict Score among patients with PACS or PAC was 48.58±10.01, with 99.1% of these individuals reporting experiencing decisional conflict. Multiple linear regression analysis revealed that females (<i>P</i>=0.002) and patients with a shorter duration of the disease (<i>P</i>=0.006) had higher levels of decisional conflict. Additionally, patients diagnosed during medical visits (<i>P</i>=0.049), those who refused LPI treatment (<i>P</i>=0.032), and individuals facing significant economic burdens related to medical expenses (<i>P</i>=0.005) exhibited higher levels of decisional conflict. Furthermore, patients who preferred to make medical decisions independently (<i>P</i>=0.023) and those who favored involving family members in decision-making (<i>P</i>=0.005) experienced increased levels of decisional conflict.</p><p><strong>Conclusion: </strong>Patients with PACS or PAC who undergo LPI treatment often encounter significant decisional conflict. Healthcare professionals should thoroughly assess a range of factors that influence this conflict, including gender, duration of disease, method of diagnosis acquisition, LPI treatment, economic burden of medical expenses, and patient preferences regarding medical decision-making. By considering these variables, tailored decision support can be developed to address individual patient needs, ultimately reducing decisional conflict and optimizing the quality of decisions made regarding treatment options.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 4","pages":"627-636"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents: a Meta-analysis.","authors":"Hao-Bo Fan, Zhi-Lin Li, Xue-Min Zhang, Ai-Rui Xie, Qiu-Mei Wei, Ting-Ting Song, Jun-Guo Duan","doi":"10.18240/ijo.2025.04.20","DOIUrl":"https://doi.org/10.18240/ijo.2025.04.20","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effects of microlens design of peripheral defocus modifying spectacle lenses (PDMSLs) and non-microlens design of PDMSLs on controlling myopia progression in children and adolescents.</p><p><strong>Methods: </strong>A systematic search was carried out in the PubMed, Cochrane Library, Embase, CNKI, and Web of Science databases. The search targeted randomized controlled trials (RCTs) and cohort studies (CTs) that explored the effects of PDMSLs on myopia control among children and adolescents. The Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale were employed to evaluate the risk of bias in the included studies. The published biases of the included studies were evaluated using Egger's test.</p><p><strong>Results: </strong>Nine studies (7 RCTs, 2 CTs) were included, involving 4332 participants in the PDMSLs group and 7317 participants in the single vision lenses (SVLs) group. Meta-analysis showed that PDMSLs with microlens design had lower change in spherical equivalent refraction (SER) than SVLs at 6, 12, 18, and 24mo after wearing glasses, with reductions of 0.19 D (95%CI: 0.14 to 0.24, <i>P</i><0.00001), 0.36 D (95%CI: 0.25 to 0.46, <i>P</i><0.00001), 0.43 D (95%CI: 0.32 to 0.55, <i>P</i><0.00001), and 0.51 D (95%CI: 0.33 to 0.69, <i>P</i><0.00001), respectively. The changes in axial length (AL) were also lower in PDMSLs compared to SVLs, with reductions of -0.09 mm (95%CI: -0.13 to -0.04, <i>P</i>=0.0002), -0.15 mm (95%CI: -0.21 to -0.08, <i>P</i><0.00001), -0.27 mm (95%CI: -0.34 to -0.20, <i>P</i><0.00001), and -0.29 mm (95%CI: -0.38 to -0.20, <i>P</i><0.00001), respectively. There was no significant difference between the non-microlens group and SVLs in controlling the changes of SER and AL in myopia (both <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The synthesized evidence indicates superior myopia management outcomes with microlens design of PDMSLs compared to both SVLs and non-microlens design of PDMSLs in children and adolescents.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 4","pages":"723-734"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}