International journal of ophthalmology最新文献

{"title":"Effects of different orthokeratology lens designs on slowing axial length elongation in children with myopia.","authors":"Hai-Long Ni, Xiang Chen, Du-Ya Chen, Pei-Ke Hu, Zhi-Yi Wu","doi":"10.18240/ijo.2024.10.10","DOIUrl":"10.18240/ijo.2024.10.10","url":null,"abstract":"<p><strong>Aim: </strong>To elucidate whether differences exist in the impact on retarding the elongation of axial length (AL) among children with myopia when utilizing orthokeratology (ortho-k) lenses employing the corneal refractive therapy (CRT) design versus those employing the vision shaping treatment (VST) design.</p><p><strong>Methods: </strong>This retrospective clinical trial aimed to collect and analyze AL data from individuals who wore ortho-k lenses for three years. A total of 654 subjects were enrolled and prescribed one of the three specific brands of ortho-k lenses: CRT, Euclid, and Mouldway. The study's primary focus was to compare the rates of AL elongation and myopic progression across these three brands of ortho-k lenses.</p><p><strong>Results: </strong>In the 3-year follow-up, the AL elongation exhibited variations of 0.73±0.36 mm in the CRT lens group, 0.59±0.37 mm in the Euclid lens group, and 0.63±0.38 mm in the Mouldway lens group. A noteworthy disparity emerged between the CRT and Mouldway groups (<i>P</i><0.01), as well as between the CRT and Euclid groups (<i>P</i><0.001). Additionally, it was observed that 32.1% of participants who wore CRT lenses experienced a decelerated progression of myopia, in contrast to 47.2% in the Euclid group and 44.4% in the Mouldway group. Statistical analyses revealed a statistically significant distinction between the CRT and Euclid groups (<i>P</i><0.01), and similarly, the CRT group demonstrated a statistically significant difference when compared to the Mouldway group (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Ortho-k lenses represent a pragmatic strategy for mitigating the advancement of myopia. In contradistinction to ortho-k lenses utilizing the CRT design, those employing the VST design exhibited a more favorable impact regarding retarding AL elongation.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired pericyte-Müller glia interaction <i>via</i> PDGFRβ suppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury.","authors":"Wei Xu, Li-Jin Cui, Xiao-Ying Yang, Xiao-Yuan Cui, Jian Guo, Guo-Xing Xu","doi":"10.18240/ijo.2024.10.05","DOIUrl":"10.18240/ijo.2024.10.05","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptor β (PDGFRβ) signaling pathway in retinal pericytes on photoreceptor loss and Müller glial response.</p><p><strong>Methods: </strong>Sprague-Dawley rats were exposed to intense light to induce retinal injury. Neutralizing antibody against PDGFRβ were deployed to block the signaling pathway in retinal pericytes through intravitreal injection. Retinal histology and Müller glial reaction were assessed following light injury. <i>In vitro</i>, normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line (rMC-1) to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas (SHRs).</p><p><strong>Results: </strong>PDGFRβ blockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor loss. The upregulation of GFAP and p-STAT3, observed after intense light exposure, was significantly inhibited in the PDGFRβ blockage group. Further upregulation of cytokines monocyte chemoattractant protein 1 (MCP-1) and interleukin-1β (IL-1β) was also observed following PDGFRβ inhibition. In the <i>in vitro</i> coculture system, the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen (PCNA) expression, while Müller cells exhibited neuron-like morphology and expressed Nestin. However, PDGFRβ blockage in retinal pericytes abolished these cellular responses to light-induced damage, consistent with the <i>in vivo</i> PDGFRβ blockage findings.</p><p><strong>Conclusion: </strong>Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal injury. Impairment of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of viability of human retinal microvascular endothelial cells by vialinin A under high glucose condition.","authors":"Zhi-Gang Chen, Gao-Qin Liu, Wei-Ming Liu, Pei-Rong Lu","doi":"10.18240/ijo.2024.10.06","DOIUrl":"10.18240/ijo.2024.10.06","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effects of vialinin A on viability of human retinal endothelial cells (HRECs) under high glucose condition and its potential mechanism.</p><p><strong>Methods: </strong>The HRECs were divided into four groups: normal glucose control group (NG, 5 mmol/L D-glucose), high glucose group (HG, 30 mmol/L D-glucose), HG+1 µmol/L vialinin A group, and HG+5 µmol/L vialinin A group. The cell viabilities were measured with cell counting kit-8 (CCK-8) assay for proliferation, with scratch assay for migration, and tube formation, for evaluation of the impact of vialinin A on cellular behaviour. Real-time PCR and Western blotting were used to determine the expression level of vascular endothelial growth factor (VEGF).</p><p><strong>Results: </strong>The proliferative capacity and migration of HRECs was reduced by 5 µmol/L vialinin A in high glucose environment (both <i>P</i><0.05). Vialinin A also inhibited high-glucose-induced tube formation of HRECs. The expression level of VEGF and PI3K in HRECs was also significantly decreased by vialinin A (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Vialinin A inhibits the cell viability of HRECs. It may serve as a potential target for anti-angiogenic therapy.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing surgical approaches for lacrimal gland adenoid cystic carcinoma to minimize cross-organ invasion.","authors":"Ming-Shen Ma, Ting-Ting Ren, Fu-Xiao Luan, Jing Li, Nan Wang, Yong Tao, Jian-Min Ma","doi":"10.18240/ijo.2024.10.22","DOIUrl":"10.18240/ijo.2024.10.22","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the outcomes of eye-sparing surgery for lacrimal gland adenoid cystic carcinoma and the impact on tumor recurrence and orbital integrity.</p><p><strong>Methods: </strong>The study enrolled four patients with recurrent lacrimal gland adenoid cystic carcinoma. The outcome focused on the relevance of the integrity of the lateral orbital wall to the occurrence of extraorbital metastasis in the local recurrence of lacrimal gland adenoid cystic carcinoma.</p><p><strong>Results: </strong>Three patients underwent eye-sparing surgery <i>via</i> lateral orbitotomy without postoperative radiotherapy, and one patient who underwent eye-sparing surgery <i>via</i> sub-brow approach. These four patients all demonstrated a recurrence involving the invasion of extraorbital tissues as metastatic form through surgical bone seams.</p><p><strong>Conclusion: </strong>Preserving intact orbital bone tissue is crucial for mitigating direct cross-organ metastasis of lacrimal gland adenoid cystic carcinoma. The findings suggest avoiding the lateral orbitotomy approach with no or limited orbital bone wall invasion.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease.","authors":"Li-Ming Chen, Min Kang, Jun-Yi Wang, San-Hua Xu, Cheng Chen, Hong Wei, Qian Ling, Liang-Qi He, Jie Zou, Yi-Xin Wang, Xu Chen, Ping Ying, Hui Huang, Yi Shao, Rui Wu","doi":"10.18240/ijo.2024.10.14","DOIUrl":"10.18240/ijo.2024.10.14","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnormal eyes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;For a retrospective case-control study, a total of 16 patients (32 eyes) diagnosed with CTD-ILD were selected as the ILD group. The 16 healthy volunteers with 32 eyes, matched in terms of age and sex with the patients, were recruited as control group. The macular retina's superficial retinal layer (SRL) and deep retinal layer (DRL) were examined and scanned using OCTA in each individual eye. The densities of retinal microvascular (MIR), macrovascular (MAR), and total microvascular (TMI) were calculated and compared. Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods: central annuli segmentation method (C1-C6), hemispheric segmentation method [uperior right (SR), superior left (SL), inferior left (IL), and inferior right (IR)], and Early Treatment Diabetic Retinopathy Study (ETDRS) methods [superior (S), inferior (I), left (L), and right (R)]. The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The OCTA data demonstrated a statistically significant difference (&lt;i&gt;P&lt;/i&gt;&lt;0.05) in macular retinal microvessel density between the two groups. Specifically, in the SRL and DRL analyses, the ILD group exhibited significantly lower surface density of MIR and TMI compared to the HCs group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Furthermore, using the hemispheric segmentation method, the ILD group showed notable reductions in SL, SR, and IL in the superficial retina (&lt;i&gt;P&lt;/i&gt;&lt;0.05), as well as marked decreases in SL and IR in the deep retina (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Similarly, when employing the ETDRS method, the ILD group displayed substantial drops in superficial retinal S and I (&lt;i&gt;P&lt;/i&gt;&lt;0.05), along with notable reductions in deep retinal L, I, and R (&lt;i&gt;P&lt;/i&gt;&lt;0.05). In the central annuli segmentation method, the ILD group exhibited a significant decrease in the superficial retinal C2-4 region (&lt;i&gt;P&lt;/i&gt;&lt;0.05), whereas the deep retina showed a notable reduction in the C3-5 region (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Additionally, there was an observed higher positive likelihood ratio in the superficial SR region and deep MIR. Furthermore, there was a negative correlation between conjunctival vascular density and both deep and superficial retinal TMI (&lt;i&gt;P&lt;/i&gt;&lt;0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients with CTD-ILD exhibits a significantly higher conjunctival vascular density compared to the HCs group. Conversely, their fundus retinal microvascular density is significantly lower. Furthermore, CTD-ILD patients display notably lower superficial and deep retinal vascular density in comparison to the HCs group. The inve","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular endothelial growth factor/connective tissue growth factor and proteomic analysis of aqueous humor after intravitreal conbercept for proliferative diabetes retinopathy.","authors":"Hou-Shuo Li, Xiao Lyu, Ao Rong, Yan-Long Bi, Wei Xu, Hong-Ping Cui","doi":"10.18240/ijo.2024.10.07","DOIUrl":"10.18240/ijo.2024.10.07","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the role of connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) in the protein profile of the aqueous humor in patients with proliferative diabetic retinopathy (PDR) following intravitreal injection of conbercept.</p><p><strong>Methods: </strong>This study included 72 PDR patients and 8 cataract patients as controls. PDR patients were divided into 3 groups according to the intervals of 3, 5, and 7d between intravitreal conbercept (IVC, 0.5 mg/0.05 mL) injection and pars plana vitrectomy (PPV) performed. Aqueous humor samples were collected before and after IVC and PPV for VEGF and CTGF levels detected with enzyme-linked immunosorbent assay (ELISA). The differential proteomics of 10 patients who underwent PPV surgery 5d after IVC and 8 normal controls was studied, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on the data, and the protein interaction network of 23 differential proteins was studied.</p><p><strong>Results: </strong>Post-IVC, VEGF levels decreased and CTGF levels increased significantly in aqueous humor, with the CTGF/VEGF ratio rising significantly at all intervals. Liquid chromatography tandem mass spectrometry (LC-MS/MS) identified differentially expressed proteins between pre- and post-IVC samples. GO and KEGG analyses revealed involvement in immune response, stress response, complement and coagulation cascades, ferroptosis, and PPAR signaling pathways. PPI analysis highlighted key proteins like APOA1, C3, and transferrin (TF). ELISA assay confirmed the differential expression of proteins such as HBA1, SERPINA1, COL1A1, and ACTB, with significant changes in the IVC groups.</p><p><strong>Conclusion: </strong>The study demonstrates that IVC effectively reduces VEGF levels while increasing CTGF levels, thereby modifying the CTGF/VEGF ratio, and IVC significantly alters the protein profile in the aqueous humor of patients with PDR. Proteomic analysis reveals that these changes are associated with critical biological pathways and protein interactions involved in immune response, stress response, and cellular metabolism.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"αB-crystallin mini-peptides support corneal healing <i>in vitro</i> and <i>in vivo</i> in rabbit model.","authors":"Namrata Maity, Aditya Konar, Sarbani Hazra","doi":"10.18240/ijo.2024.10.02","DOIUrl":"10.18240/ijo.2024.10.02","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate if topical use of αB-crystallin mini-peptides supports corneal healing following flap surgery.</p><p><strong>Methods: </strong>Cultured corneal cells were treated with fluorescent tagged αB-crystallin mini-peptides to assess its internalization. Cultured corneal cells pre-treated with or without the mini-peptides were exposed to H₂O₂ and cell viability was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Elongation of neurites of cultured trigeminal neurones was examined following treatment either with αB-crystallin mini-peptides or protein. Cultured trigeminal neurones were pre-treated either with αB-crystallin mini-peptides or crystallin protein and exposed to H₂O₂ and presence of beading in the dendrites and axons was assessed. Corneal flap surgery was conducted on rabbit cornea and treated topically either with αB-crystallin peptide (0.5 mg/mL thrice daily for 14d) or phosphate-buffered saline (PBS). Corneal healing was evaluated under slit-lamp biomicroscope, mRNA expression of inflammatory cytokines were assessed and the corneas were evaluated by histopathology.</p><p><strong>Results: </strong>Internalization of αB-crystallin mini-peptides was ascertained by the detection of fluorescence within the corneal cells. The MTT assay revealed that treatment with αB-crystallin mini-peptide reduced cell death induced by H₂O₂ treatment. The mini-peptides did not influence the elongation of trigeminal neurites, but significantly (<i>P</i><0.05) reduced beading in the neurites. In rabbit eye, the treated corneas showed reduced hyper-reflective zones (<i>P</i><0.05) and suppression in the expression of inflammatory cytokines. Histopathological examination also revealed reduction of inflammatory response in treated corneas.</p><p><strong>Conclusion: </strong>The αB-crystallin mini-peptides restrict the damage to corneal cells and neurons and aids in corneal healing.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion.","authors":"Yuan-Yuan Zhong, Chong Tang, Lan-Yue Zhang, Xue-Dong Zhang, Shu-Lin Liu","doi":"10.18240/ijo.2024.10.09","DOIUrl":"10.18240/ijo.2024.10.09","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy, timing of retreatment and safety of dexamethasone (DEX) implant on macular edema (ME) secondary to diabetic retinopathy (DME) and retinal vein occlusion (RVO-ME) patients who were refractory to anti-vascular endothelial growth factor (VEGF) treatment.</p><p><strong>Methods: </strong>This retrospective study included 37 eyes received at least one DEX implant treatment for DME or RVO-ME between January 1, 2019, and January 1, 2023. These refractory DME and RVO-ME cases received at least 5 anti-VEGF injections and failure to gain more than 5 letters or a significant reduction in central retinal thickness (CRT). The best corrected visual acuity (BCVA) and CRT were measured at baseline, and at 1, 3, 4 and 6mo post-DEX implant injection. Adverse events such as elevated intraocular pressure (IOP) and cataract were recorded.</p><p><strong>Results: </strong>For RVO cases (<i>n</i>=22), there was a significant increase in BCVA from 0.27±0.19 to 0.35±0.20 at 6mo post-DEX injection (<i>P</i><0.05) and CRT decreased from 472.1±90.6 to 240.5±39.0 µm at 6mo (<i>P</i><0.0001). DME cases (<i>n</i>=15) experienced an improvement in BCVA from 0.26±0.15 to 0.43±0.20 at 6mo post-DEX implant injection (<i>P</i>=0.0098), with CRT reducing from 445.7±55.7 to 271.7±34.1 µm at 6mo (<i>P</i><0.0001). Elevated IOP occurred in 45.9% of patients but was well-controlled with topical medications. No cases of cataract or other adverse events were reported.</p><p><strong>Conclusion: </strong>DEX implants effectively improve BCVA and reduce CRT in refractory DME and RVO-ME. Further research with larger cohorts and longer follow-up periods is needed to confirm these findings and assess long-term outcomes.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide risk in juvenile open angle glaucoma patients.","authors":"Hye-Jeong Seong, Sukyoung Jung, Sooyeon Choe","doi":"10.18240/ijo.2024.10.15","DOIUrl":"10.18240/ijo.2024.10.15","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the association between juvenile open angle glaucoma (JOAG) and mental health among Koreans.</p><p><strong>Methods: </strong>This study used nationally representative data from the 8^th Korea National Health and Nutrition Examination Survey (KNHANES) 2021. Glaucoma diagnosis followed the International Society of Geographical and Epidemiological Ophthalmology criteria based on glaucomatous structural defects, visual field defects, corrected vision, and intraocular pressure. As outcomes, suicidal behaviors, psychiatric counseling, and depression were evaluated through mental health questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic regression models, adjusting for covariates.</p><p><strong>Results: </strong>Among 7090 participants, 3446 met the inclusion criteria for analysis, and 88 (2.6%) were diagnosed with open angle glaucoma (OAG). After adjusting for age, sex, and best-corrected visual acuity (VA), participants with OAG were revealed to have significantly higher odds of suicidal behaviors (<i>i.e.</i>, ideation, planning, or attempts) compared with those without OAG (OR: 2.70; 95%CI: 1.12-6.54; <i>P</i>=0.028). This association remained significant after further adjustments for socioeconomic status, lifestyle factors, and presence of chronic conditions (<i>P</i>=0.031 and 0.035, respectively). However, there was no significant difference for the other two outcomes, psychiatric counseling and depression. An age-stratified analysis revealed a stronger association between OAG and suicidal behaviors in younger JOAG participants (<40y) than in older OAG participants (≥40y; OR: 3.80 <i>vs</i> 2.22; 95%CI: 0.79-18.22 <i>vs</i> 0.56-8.80, respectively).</p><p><strong>Conclusion: </strong>OAG patients show a higher risk of suicidal behaviors than those without glaucoma particularly in JOAG patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral macular edema secondary to nab-paclitaxel therapy for breast cancer.","authors":"Zi-Yi Zhou, Ya-Ting Ye, Jing-Ting Zhu, Dong-Jie Sun, Yu-Sheng Wang, Guo-Rui Dou","doi":"10.18240/ijo.2024.10.26","DOIUrl":"10.18240/ijo.2024.10.26","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}