International journal of ophthalmology最新文献

Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.14

Xue-Lin Wang, Yu Chen, Jin-Yu Hu, Hong Wei, Qian Ling, Liang-Qi He, Cheng Chen, Yi-Xin Wang, Yan-Mei Zeng, Xiao-Yu Wang, Qian-Min Ge, Xu Chen, Yi Shao

{"title":"Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study.","authors":"Xue-Lin Wang, Yu Chen, Jin-Yu Hu, Hong Wei, Qian Ling, Liang-Qi He, Cheng Chen, Yi-Xin Wang, Yan-Mei Zeng, Xiao-Yu Wang, Qian-Min Ge, Xu Chen, Yi Shao","doi":"10.18240/ijo.2025.02.14","DOIUrl":"10.18240/ijo.2025.02.14","url":null,"abstract":"Aim: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and clinical characteristics in patients with HR.Methods: Twenty-one patients with HR and 21 age-matched healthy controls (HCs) were assessed by rs-fMRI scanning. The functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC, with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic (ROC) curve analysis. Differences in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample t-tests. The relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation analysis.Results: Mean VMHC values of the bilateral cuneus gyrus (BA19), bilateral middle orbitofrontal gyrus (BA47), bilateral middle temporal gyrus (BA39) and bilateral superior medial frontal gyrus (BA9) were lower in the HR than in the HC group.Conclusion: VMHC values can predict the development of early HR, prevent the transformation of hypertensive microangiopathy, and provide useful information explaining the changes in neural mechanism associated with HR.","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"297-307"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.04

Ahmet Mehmet Somuncu, Busra Parlak Somuncu, Ahmet Duhan Ozbay, Ibrahim Cicek, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Tugba Bal Tastan, Taha Abdulkadir Coban, Halis Suleyman, Aliyev Aydin

{"title":"Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil.","authors":"Ahmet Mehmet Somuncu, Busra Parlak Somuncu, Ahmet Duhan Ozbay, Ibrahim Cicek, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Tugba Bal Tastan, Taha Abdulkadir Coban, Halis Suleyman, Aliyev Aydin","doi":"10.18240/ijo.2025.02.04","DOIUrl":"10.18240/ijo.2025.02.04","url":null,"abstract":"Aim: To investigate the effects of adenosine triphosphate (ATP) and melatonin, which have antioxidant and anti-inflammatory activities, on potential 5-fluorouracil (5-FU)-induced optic nerve damage in rats.Methods: Twenty-four rats were categorized into four groups of six rats: healthy (HG), 5-FU (FUG), ATP+5-FU (AFU), and melatonin+5-FU (MFU). ATP (4 mg/kg) and melatonin (10 mg/kg) were administered intraperitoneally and orally, respectively. One hour after ATP and melatonin administration, rats in the AFU, MFU, and FUG were intraperitoneally injected with 5-FU (100 mg/kg). ATP and melatonin were administered once daily for 10d. 5-FU was administered at a single dose on days 1, 3, and 5 of the experiment. After 10d, the rats were euthanized and optic nerve tissues were extracted. Optic nerve tissues were biochemically and histopathologically examined.Results: ATP and melatonin treatments inhibited the increase in malondialdehyde (MDA) and interleukin-6 (IL-6) levels, which were elevated in the FUG. The treatments also prevented the decrease in total glutathione (tGSH) levels and the superoxide dismutase (SOD) and catalase (CAT) activities (P<0.001). This inhibition was higher in the ATP group than in the melatonin group (P<0.001). ATP prevented histopathological damage better than melatonin (P<0.05).Conclusion: ATP and melatonin have the potential to be used in alleviating 5-FU-induced optic nerve damage. In addition, ATP treatment shows better protective effects than melatonin.","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"222-228"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRIGENDUM.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01

引用次数: 0

Idiopathic uveal effusion syndrome with increased intraocular pressure.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.22

Zhi-Bin Wang, Xue Wang, Yu Di

引用次数: 0

Periocular skin "tattooing" caused by gel pen pigment mistaken for periorbital bruising: a case of missed diagnosis of traumatic intraorbital pen core foreign body.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.23

Chao Xiong, Zhang-Jun Ren, Xue-Mei Li, Jin-Hai Yu, Yue Li, Yun-Xiu Chen, Qi Jin, Ze-Xi Sang, Si-Yi Wang, An-An Wang, Pu-Ying Gan, Qi-Hua Xu, Yao-Hua Wang, Hong-Fei Liao

引用次数: 0

Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.05

Xu Li, Ping Hou, Xiao-Lin Qi, Su-Xia Li, Wei-Yun Shi, Hua Gao, Ting Zhang

{"title":"Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation.","authors":"Xu Li, Ping Hou, Xiao-Lin Qi, Su-Xia Li, Wei-Yun Shi, Hua Gao, Ting Zhang","doi":"10.18240/ijo.2025.02.05","DOIUrl":"10.18240/ijo.2025.02.05","url":null,"abstract":"Aim: To investigate the clinical signs of blepharokeratoconjunctivitis (BKC) and evaluate the efficacy of penetrating keratoplasty (PKP) for the disease.Methods: Sixteen patients (16 eyes) with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively analyzed. All patients received PKP. Participants were assessed for symptoms, clinical manifestations, the activity and damage grading of BKC. A paired t-test was used to compare the uncorrected visual acuity (UCVA) before and after surgery for the perforated eye.Results: The mean age of the patients was 16.3y. Blurred vision is the most common discomfort, followed by redness, and then photophobia. The duration of ocular discomfort lasted for 3.2y, on average. Three (18.8%) participants were associated with rosacea, while 11 (68.8%) patients had recurrent chalazion or hordeolum. Demodex in eyelash follicles was positive in 11 (68.8%) cases. All corneal perforations were ≤3.0 mm in diameter. The perforation was located mainly in the inferior cornea (68.8%). The mean area of corneal vascularisation was 3.0 quadrants. All patients manifested bilateral BKC, with the perforated eyes ranked as severely damaged and presenting with severe inflammation. Most contralateral eyes manifested mild damage with no active inflammation. Majority (68.8%) of the perforated eyes were treated with PKP using a minimal graft. The UCVA increased significantly at the final follow-up (mean, 21mo; P<0.001), with the manifestation of BKC alleviated greatly. None of the patients developed immune rejection or other serious complications.Conclusion: BKC combined with corneal perforation occurs mainly among young people with a long history of ocular discomfort. PKP, especially using a minimal graft, is an effective and safe option for treating the disease.","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"229-236"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomic characteristics of the lacrimal sac and adjacent bony structures-a computed tomographic-dacryocystography research.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.08

Xin-Han Cui, Yan-Wen Fang, Li-Min Zhang, Ji-Ni Qiu, Chao-Ran Zhang, Yan Wang

{"title":"Anatomic characteristics of the lacrimal sac and adjacent bony structures-a computed tomographic-dacryocystography research.","authors":"Xin-Han Cui, Yan-Wen Fang, Li-Min Zhang, Ji-Ni Qiu, Chao-Ran Zhang, Yan Wang","doi":"10.18240/ijo.2025.02.08","DOIUrl":"10.18240/ijo.2025.02.08","url":null,"abstract":"Aim: To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy (EN-DCR).Methods: This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 patients. Computed tomographic-dacryocystography (CT-DCG) scans were performed before lacrimal surgery, and image reconstruction was used to obtain continuous 0.75-mm axial, coronal, and segmental sections for review. The morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement, as well as the obstructed location.Results: The height of the lacrimal sac was 12.99±2.10 mm in this study. The operculum of the middle turbinate (OMT) was located vertically in the lower third of the lacrimal sac. Horizontally, the junction between the maxillary bone and the lacrimal bone (MB-LB) was close to, mostly (60.2%) posterior to, the lacrimal sac. The uncinate process was more frequently attached to the lacrimal bones (75.1%). The obstructions were generally located around the entrance of the nasolacrimal duct (NLD). However, some were placed higher, with 7.63% blocked not lower than the OMT. There was a negative correlation between the diameter of the lacrimal sac and the level of obstruction (r=-0.35, P<0.01).Conclusion: In this study, the OMT and MB-LB can be served as the landmarks in EN-DCR. Partial uncinectomy should be performed in most cases. The obstructions were generally located around the entrance of the NLD, but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"251-257"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRIGENDUM.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01

引用次数: 0

Lens coloboma with bilateral ectopia lentis in Marfan syndrome: a case report.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.21

Zhen-Bo Zhao, Kai-Li Tang, Yu-Xi Ding, Ji-Kun Yang, Huan-Ping Wang, Li-Wei Ma

引用次数: 0

Photobiomodulation in ocular therapy: current status and future perspectives.

IF 1.9 4区医学

International journal of ophthalmology Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.02.20

Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal

{"title":"Photobiomodulation in ocular therapy: current status and future perspectives.","authors":"Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal","doi":"10.18240/ijo.2025.02.20","DOIUrl":"10.18240/ijo.2025.02.20","url":null,"abstract":"Photobiomodulation has been known to have potential medicinal effects for ages. It involves the use of specific wavelengths to target specific regions in the cell. Different health conditions have been reported to be treated with exposure to light such as cardiovascular conditions, inflammatory diseases, infectious diseases, and most importantly ocular diseases. This review specifically targets the treatment of retinal diseases including age-related macular degeneration, diabetic macular edema, myopia and acute retinal light injury with photobiomodulation. Red light is used in this therapy since this wavelength has lower frequency and hence minimal chance of causing any damage. Red light has the potential to penetrate cellular structures such as mitochondria and facilitate cellular processes. For ocular diseases, the target wavelength ranges between 630 to 800 nm. In most of the cases the primary target for red light is the cytochrome C oxidase enzyme in mitochondria, which alters the gene expression and promotes cellular energy production. Clinical evidence shows improvement of visual activity and reduction in thickness of retina post treatment. Future prospects of photobiomodulation involve target-specific treatment, combinational therapy to treat complex retinal diseases including gene therapy, and longitudinal studies to predict long-term efficacy and the chance of any recurrence in the patients. Hence the future of photobiomodulation holds significant potential in medicine especially in ocular diseases characterized by progress in research, technology, and clinical trials.","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"351-357"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0