International journal of ophthalmology最新文献

{"title":"Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium.","authors":"Yue-Qi Yuan, Xing-Yuan Yan, Fang Zheng, Ming Yan","doi":"10.18240/ijo.2025.02.01","DOIUrl":"10.18240/ijo.2025.02.01","url":null,"abstract":"<p><strong>Aim: </strong>To explore the effect of co-host non-coding RNA (ncRNA) MIR503HG/miR-503-5p on the angiogenesis of pterygium.</p><p><strong>Methods: </strong>MIR503HG/miR-503-5p/fibroblast growth factor 2 (FGF2) expression levels in pterygium tissues, control conjunctival tissues, and human pterygium fibroblasts (HPF) were examined by reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemical methods. Effects of MIR503HG/miR-503-5p on low molecular weight FGF2 (LWM FGF2), migration and angiogenesis of human retinal microvascular endothelial cells (HRMEC) were determined in an HPF and HRMEC co-culture model using Western blots, wound healing assay, Matrigel-based tube formation assay, and Transwell assay.</p><p><strong>Results: </strong>MIR503HG/miR-503-5p/FGF2 pathway was actively increased in pterygium tissue and there was a negative correlation between the expression of the two ncRNAs. FGF2 expression level was positively correlated with MIR503HG and negatively correlated with miR-503-5p. Overexpressed MIR503HG/miR-503-5p did not affect the migration and angiogenesis of HRMECs cultured separately, but significantly affected migration and angiogenesis of HRMEC in HPF and HRMEC co-culture models. Western blotting revealed that MIR503HG/miR-503-5p overexpression significantly increased LMW FGF2 expression in HPF.</p><p><strong>Conclusion: </strong>MIR503HG/miR-503-5p inhibits HRMEC migration and angiogenic function by interfering with the interaction between HPF and endothelial cells <i>via</i> reducing LMW FGF2 in HPF.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"199-208"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns.","authors":"Yue Xu, Yue-Cong Yin, Ze-Yu Song, Xiao-Yu Zhou, Jia-Ju Zhang, Juan Liang","doi":"10.18240/ijo.2025.02.11","DOIUrl":"10.18240/ijo.2025.02.11","url":null,"abstract":"<p><strong>Aim: </strong>To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO).</p><p><strong>Methods: </strong>This retrospective study involved 65 RVO patients (65 eyes) who received IVR and were followed-up for more than 3mo. ME was categorized into cystoid macular edema (CME), diffuse retinal thickening (DRT), and serous retinal detachment (SRD) according to optical coherence tomography (OCT) images. The comparison of best corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT) among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test. The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis.</p><p><strong>Results: </strong>BCVA tended to improve in all groups, with marked improvement in CME and DRT groups. CMT showed the greatest reduction after 1wk, and remained stable over the following 3mo. DRT patients had the worst BCVA and the highest CMT at baseline, but the differences became smaller after IVR treatment. CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR. Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up. DRT patients were most likely to transform into the other morphological groups, while SRD patients showed minimal transitions. BCVA at baseline was identified as the most important prognostic indicator in all 3 groups. Additionally, DRT patients with a longer clinical course, higher CMT and central retinal vein occlusion (CRVO) tend to exhibit worse BCVA after treatment. In addition, CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion (BRVO) patients in CME group. SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment.</p><p><strong>Conclusion: </strong>The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups. Baseline parameters including clinical course, CMT, and RVO position are also useful in predicting the BCVA at different time points after treatment.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"275-282"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunctival microbiota variations in a subset of middle-aged and elderly individuals from Beijing, China.","authors":"Tian-Yao Zhao, Yu-Chen Wang, Ying-Juan Sun, Jun-Yue Wang, Xiao-Dan Jiang, Xue-Min Li, Ai-Hua Deng","doi":"10.18240/ijo.2025.02.06","DOIUrl":"10.18240/ijo.2025.02.06","url":null,"abstract":"<p><strong>Aim: </strong>To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing factors.</p><p><strong>Methods: </strong>This study recruited 216 participants (216 eyes) from April 2022 to July 2022. Under the condition of no antibiotic use prior to cataract surgery, sterile swabs were used to collect samples from the lower conjunctival sac. Bacterial cultures were then conducted, followed by species identification through 16S rDNA gene sequencing. Clinical factors associated with positive or negative bacterial isolation rates were analyzed, including age, gender, meibomian gland dysfunction (MGD), history of hypertension, history of diabetes, history of cancer, history of infectious diseases and the habit of wearing masks.</p><p><strong>Results: </strong>Among the 216 eyes, 78 eyes yielded isolates, with an isolation rate of 36.11%, detecting a total of 122 strains. Gram-positive rods accounted for 49.18% (60 strains), gram-positive cocci accounted for 45.08% (55 strains), gram-negative bacteria accounted for 4.92% (6 strains), and fungi accounted for 0.82% (1 strain). This study found that the most abundant genera in the conjunctival sac were <i>Corynebacterium</i> (42.62%), <i>Staphylococcus</i> (31.15%), <i>Micrococcus</i> (9.84%), <i>Acinetobacter</i> (4.10%), and <i>Bacillus</i> (3.28%). Furthermore, age (<i>P</i>=0.006), gender (<i>P</i>=0.039), diabetes (<i>P</i>=0.003), history of infectious diseases (<i>P</i>=0.02), and duration of mask replacement (<i>P</i><0.001) were important factors influencing the positive bacterial culture of the conjunctival microbiota. Although hypertensive patients exhibited a higher isolation rate of conjunctival bacteria, it did not reach statistical significance, and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before surgery.</p><p><strong>Conclusion: </strong>Potential changes are observed in the conjunctival microbiota among a sample of middle-aged and elderly individuals from Beijing, China. Notably, an increased isolation rate of <i>Corynebacterium</i> and <i>Micrococcus</i> is detected, suggesting a possible change in the microbial balance that requires further investigation and attention from the ophthalmological community. Advanced age, female gender, MGD, diabetes, a recent history of infectious diseases, and inadequate mask-wearing habits are potentially significant factors associated with the conjunctival microbiota. These factors should be considered in the development of strategies to prevent perioperative infections in cataract surgery patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"237-243"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making stereopsis related to the ability of ocular deviation: a new paradigm for assessment of intermittent exotropia.","authors":"Jian-Bing Li, Wan-Ting Kong, Tao Shen, Yong-Guang Yuan, Chong-Lin Chen, Dan-Min Peng, Min-Tong Liang, Xuan He, Dan Luo, Jia-Yi Su, Wei Wang, Rui-Xin Wang, Xin-Ping Yu","doi":"10.18240/ijo.2025.02.15","DOIUrl":"10.18240/ijo.2025.02.15","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.</p><p><strong>Methods: </strong>This was a prospective observational study. We evaluated the control ability of intermittent exotropia (IXT) patients in three conditions: natural 2D optotype viewing, 2D optotype viewing with polarized glasses, and 3D optotype viewing with polarized glasses. Recording with a smartphone, we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion. Additionally, the correlation of stereopsis were also analyzed.</p><p><strong>Results: </strong>A total of 48 patients (age range: 4-33y; 54.17% male) participated in the study. When viewing 3D optotypes with polarized glasses, their median control scores were 1 (interquartile range, 0-4) at distance and 0 (0-1) at near. These scores were significantly better than those observed under natural viewing conditions, which were 2.5 (1-5) at a distance and 1 (0-3) at near (Friedman test, <i>P</i>=0.049). Furthermore, those subjects who exhibited exophoria (realignment within 2 seconds) while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision (Kendall's τ_b=-0.344, <i>P</i>=0.018).</p><p><strong>Conclusion: </strong>IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes, notably improving realignment capabilities. This expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"308-314"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New perspectives on DNA methylation modifications in ocular diseases.","authors":"Fei-Fei Zong, Da-Dong Jia, Guang-Kun Huang, Meng Pan, Hao Hu, Shi-Yi Song, Liang Xiao, Ru-Weng Wang, Liang Liang","doi":"10.18240/ijo.2025.02.19","DOIUrl":"10.18240/ijo.2025.02.19","url":null,"abstract":"<p><p>The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases. DNA methylation can regulate gene expression, thereby affecting cell function and signal transduction. Ophthalmic diseases are a kind of complex diseases, and their pathogenesis involves many factors such as genetic, environmental and individual differences. In addition, inflammation, oxidative stress and lipid metabolism, which abnormal DNA methylation is closely related to, are also considered to be major factors in eye diseases. The current understanding of DNA methylation in eye diseases is becoming more complex and comprehensive. In addition to the simple suppression of gene expression by hypermethylation, factors such as hypomethylation or demethylation, DNA methylation in non-promoter regions, interactions with other epigenetic modifications, and dynamic changes in DNA methylation must also be considered. Interestingly, although some genes are at abnormal methylation levels, their expression is not significantly changed, which indirectly reflects the complexity of gene regulation. This review aims to summarize and compare some relevant studies, and provide with new ideas and methods for the prevention and treatment of different eye diseases, such as glaucoma, retinoblastoma, and diabetic retinopathy.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"340-350"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19's effects on microvascular structure in a healthy retina: an OCTA study.","authors":"Kazim Kiratli, Hazan Gul Kahraman, Yusuf Ziya Guven, Fahrettin Akay, Murat Aysin","doi":"10.18240/ijo.2025.02.12","DOIUrl":"10.18240/ijo.2025.02.12","url":null,"abstract":"<p><strong>Aim: </strong>To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease (COVID-19)-related lung involvement and the healthy control group.</p><p><strong>Methods: </strong>In this prospective case-control study, 85 cases with lung involvement due to COVID-19 and 50 healthy cases were included. Best-corrected visual acuity, intraocular pressure measurement, and anterior and posterior segment examination were performed on both eyes for each individual. Choroidal and retinal changes were examined and recorded by optical coherence tomography angiography.</p><p><strong>Results: </strong>All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy individuals. When vascular density and perfusion density values were compared, there was a decrease in the average of these values in the COVID-19 group, although it was not statistically significant (<i>P</i>=0.088, <i>P</i>=0.065 respectively). When the fovea avascular zone (FAZ) area values were compared, the average was 0.57±0.38 in the COVID-19 group, while it was 0.54±0.24 in the control group.</p><p><strong>Conclusion: </strong>Although our data are not statistically significant, the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period (1^st month). These changes may anatomically alter the retina in the long term and affect functional vision. Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient's systemic assessment.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"283-289"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior and outcomes of 141 acquired lacrimal sac mucoceles treated <i>via</i> endoscopic dacryocystorhinostomy.","authors":"Ying-Jie Ma, Guang-Ming Zhou, Zhi-Rong Liu, Jin-Fei Wei, Xin-Yu Li, Bin Dong, Lin-Juan Wu, Wen-Can Wu, Bo Yu","doi":"10.18240/ijo.2025.02.07","DOIUrl":"10.18240/ijo.2025.02.07","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the clinical profile of patients with acquired lacrimal sac mucocele (ALSM) and evaluate the efficacy of endoscopic dacryocystorhinostomy (En-DCR) for this condition.</p><p><strong>Methods: </strong>En-DCRs were performed on 141 patients with ALSM patients from January 2016 to March 2022. The clinical baseline information and magnetic resonance imaging (MRI) images were recorded and summarized. To assess the effectiveness of En-DCR therapy, both anatomical and functional success rate was assessed during a 12mo follow-up.</p><p><strong>Results: </strong>A total of 141 patients, with a mean age of 57.70±14.11y, were enrolled in this study. Majority of the patients were female (<i>n</i>=91; 64.54%) and all had unilateral disease. All patients had a previous history of epiphora and purulent secretion, and the duration from lacrimal duct obstruction to mucocele formation ranged from 6 to 120mo. MRI findings consistently revealed an enlarged sac diameter, fluid accumulation separated by a thin rim from adjacent tissues, which is indicative of lacrimal sac mucocele. En-DCR was performed with an anatomical success rate of 93.62% and a functional success rate of 81.56%.</p><p><strong>Conclusion: </strong>ALSM is more commonly seen in females and unilaterally. It is essentially a complication of lacrimal duct obstruction. MRI characteristics can be used for precise clinical diagnosis, while En-DCR emerges as an optimal therapy for this condition. Our results provide a comprehensive reference for the diagnosis and treatment of ALSM.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"244-250"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.","authors":"Li-Jun Ji, Jin-Yu Hu, Yan-Mei Zeng, Qian Ling, Jie Zou, Cheng Chen, Liang-Qi He, Xiao-Yu Wang, Hong Wei, Xu Chen, Yi-Xin Wang, Yi Shao, Yao Yu","doi":"10.18240/ijo.2025.02.09","DOIUrl":"10.18240/ijo.2025.02.09","url":null,"abstract":"<p><strong>Aim: </strong>To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage (DVH) and its correlation with clinical characteristics.</p><p><strong>Methods: </strong>Twenty-one individuals with DVH (male/female 12/9; mean age 52.29±11.66y) were selected, alongside 21 appropriately matched controls with diabetes mellitus (DM). Voxel-based morphometry (VBM) techniques were employed to identify aberrant functional regions in the brain. Receiver operating characteristic (ROC) curves were utilized for classification based on the average VBM values of the two groups, and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical manifestations.</p><p><strong>Results: </strong>Relative to the DM controls, DVH patients exhibited reduced VBM values in the right superior temporal pole, the right superior temporal gyrus, the right medial orbital frontal gyrus, and the left superior frontal gyrus. Furthermore, ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy, as indicated by the area under the curve. The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale (HADS).</p><p><strong>Conclusion: </strong>Pathological alterations in four distinct brain regions are observed in patients with DVH, potentially reflecting neuropathological changes associated with this condition.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"258-267"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lycium barbarum</i> polysaccharide inhibits retinal neovascularization and inflammation <i>in vitro</i> and <i>in vivo</i>.","authors":"Bin Wu, Xue Wang, Wei Zhang, Xin Wang, Qi-Miao Wang, Ya-Ju Pang, Yi-Chun Kong","doi":"10.18240/ijo.2025.02.03","DOIUrl":"10.18240/ijo.2025.02.03","url":null,"abstract":"<p><strong>Aim: </strong>To explore the effect and mechanism of <i>Lycium barbarum</i> polysaccharide (LBP) inhibiting retinal neovascularization.</p><p><strong>Methods: </strong><i>In vitro</i> tests were performed on human retinal microvascular endothelial cells (HRECs) from three groups, including control group (normal oxygen), hypoxic group (hypoxia at 37°C, 1% O₂, 5% CO₂, and 94% N₂), and LBP group (hypoxic group with LBP 100 µg/mL). <i>In vivo</i> experiments, C57 mice were divided into three groups: control group (normal rearing group), the oxygen-induced ischemic retinopathy (OIR) group, and the OIR with 50 mg/kg LBP group. Retinal neovascularization was observed by fluorescein angiography and quantified. Retinal thickness was evaluated by Hematoxylin and eosin (HE) stain. The expression of epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), phosphorylated mammalian target of rapamycin (p-mTOR), protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-α (TNF-α) in each group were analyzed by Western blot. IL-1β level in retina was analyzed using immunohistochemical staining.</p><p><strong>Results: </strong>The increased area of neovascular clusters in OIR mice was significantly decreased by LBP. Retinal thickness of OIR mice was significantly thinner compared with normal oxygenated mice and was increased in LBP group. Compared with those in the hypoxic groups, Western blotting of HRECs and retinal tissues revealed that the expression of EGFR, PI3K, p-mTOR, p-AKT, IL-1β, iNOS, and TNF-α decreased in the LBP group but was still greater than that in control group. Moreover, IL-1β was reduced in retinal sections treated with LBP. In the scratch test, the cell migration of the hypoxic group was significantly greater than that of the control group, while LBP treatment attenuated this increase in migration.</p><p><strong>Conclusion: </strong>LBP reduces retinal neovascularization and inflammation <i>in vivo</i> and inhibits the migration of HRECs <i>in vitro</i> by regulating the EGFR/PI3K/Akt/mTOR signaling pathway.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"216-221"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study.","authors":"Parinee Kemchoknatee, Duanghathai Tangon, Thansit Srisombut","doi":"10.18240/ijo.2025.02.13","DOIUrl":"10.18240/ijo.2025.02.13","url":null,"abstract":"<p><strong>Aim: </strong>To determine the risk factors and time to non-arteric ischemic optic neuropathy (NAION) occurrence among Thai type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methods: </strong>A retrospective review of 266 newly diagnosed T2DM cases at Rajavithi Hospital between 2007 and 2016 was conducted to determine time to occurrence of NAION and evaluate associated risk factors.</p><p><strong>Results: </strong>Hypertension and dyslipidemia were the most common pre-existing vascular diseases and there was a significant male predominance in the NAION group. The mean age of the NAION group was significantly higher than that of the group without NAION. A higher proportion of subjects in the NAION group had hypertension, dyslipidemia, high diastolic blood pressure, smokers, and had a small cup-to-disc ratio (CDR). Higher levels of triglycerides and low-density lipoprotein-cholesterol in the group with NAION. Fifty-five patients among 266 participants (20.68%) developed NAION during a mean follow-up time of 81.26±25.04mo. In a multivariable logistic regression analysis, dyslipidemia (OR=8.36, 95%CI, 3.447-20.273, <i>P</i><0.001), high low density lipoprotein levels (OR=1.017, 95%CI, 1.004-1.029, <i>P</i>=0.009), and small CDR (OR=11.92, 95%CI, 4.477-31.741, <i>P</i><0.001) were significant risk factors for NAION development. Smoking was the strongest predictive risk (OR=12.843, 95%CI, 3.959-41.659, <i>P</i><0.001). Vascular complications of T2DM and aspirin were not associated with NAION.</p><p><strong>Conclusion: </strong>T2DM patients with dyslipidemia or a small CDR should be carefully followed up as they are at increased risk of developing NAION.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 2","pages":"290-296"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}