International journal of ophthalmology最新文献

{"title":"Angle closure glaucoma in a patient with X-linked retinoschisis: a case report.","authors":"Lu Yao, Ye Lu, Kang-Yi Yang, Kun Lyu, Zong-Yi Wang, Lyu-Zhen Huang, Hui-Juan Wu","doi":"10.18240/ijo.2025.03.24","DOIUrl":"10.18240/ijo.2025.03.24","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"557-561"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries: a propensity score matched analysis.","authors":"Li-Li Zhu, Bing-Xue Zhu, Yue Han, Yong-Yan Tang, Ying-Ying Wen, Xu-Hong Zhang, Li-Yue Zhang, Ri-Lei Zhu, Dong-Yu Guo","doi":"10.18240/ijo.2025.03.06","DOIUrl":"10.18240/ijo.2025.03.06","url":null,"abstract":"<p><strong>Aim: </strong>To compare analysis of the impact of high altitude on corneal endothelial cells, and the prognosis in patients with cataract surgeries.</p><p><strong>Methods: </strong>Totally 265 plateau patients with cataract surgeries performed between January 2019 and July 2022 (average altitude=3000 m), and 524 plain patients with cataract surgeries performed between January 2020 and July 2022 were included. The propensity score matching (PSM) method was applied to match the basic information of patients in both regions on a 1:1 basis. Corneal endothelial cell density (ECD), coefficient of variation (CV), hexagonal cell ratio (HEX), duration of surgery, and pre- and postoperative visual acuity (VA) were compared retrospectively, and correlation tests were done.</p><p><strong>Results: </strong>Totally 223 pairs have been matched successfully. The HEX in the plateau group was higher than that in the plain group (61.95%±6.191% <i>vs</i> 44.91%±6.829%, <i>P</i><0.001). For ECD and CV, no significant differences were observed between both groups (<i>P</i>>0.1). The pre- and postoperative VA of patients with cataract surgeries in the plateau group were lower (1.40±0.610 <i>vs</i> 0.71±0.514, <i>P</i><0.001 & 0.68±0.479 <i>vs</i> 0.18±0.259, <i>P</i><0.001), and the duration of surgery was longer than those in the plain group (27.06±14.900 min <i>vs</i> 16.03±8.033 min, <i>P</i><0.001). No significant associations were found between the post-operative VA and the corneal endothelial parameters (<i>P</i>>0.05), while the post-operative VA was significantly related to the pre-operative VA and the duration of surgery (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The relative hypoxic environment of the plateau does not promote the apoptosis of corneal endothelial cells, but may lead to the compensatory increase of their functions. In plateau patients, no significant associations are found between the poor VA and the corneal endothelial functions early after cataract surgeries.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"409-414"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential immune involvement in cataract: from mechanisms to future scope of therapies.","authors":"Lu Chen, Ke Yao, Qiu-Li Fu","doi":"10.18240/ijo.2025.03.22","DOIUrl":"10.18240/ijo.2025.03.22","url":null,"abstract":"<p><p>The immune system is involved in many age-related pathological changes, also plays an important role in tissue regeneration after injury. But no immune involvement has been discussed regarding cataract since it is presumed that lens has no source of immune cells as an avascular zone. Latest research has challenged the longstanding view of the lens as an immune-privileged tissue, revealing the presence of resident immune cells and active immune responses within the lens. Thus, we summarized the immune involvement in maintaining lens homeostasis, which may be a deleterious role in the induction of lens opacification if inappropriately activated. Furthermore, bioengineer-based immunomodulatory therapies to fine-tune the micro immune environment within lens may be future strategies for <i>in situ</i> lens regeneration, as a novel treatment for cataract.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"541-548"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal dysfunction associated with clinical response to intravitreal conbercept therapy for diabetic macular edema.","authors":"Wei Wu, Hui-Dong Liu, Xue Xiao, Ya-Xin Wang, Song-Fu Feng, Jia-Qi Liu, Yong-Gang Yuan, Xiao-He Lu","doi":"10.18240/ijo.2025.03.12","DOIUrl":"10.18240/ijo.2025.03.12","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the impact of renal dysfunction on clinical response to intravitreal conbercept injection (IVC) for diabetic macular edema (DME).</p><p><strong>Methods: </strong>This retrospective study included a total of 100 eyes from 100 patients with DME treated with IVC with 3+PRN regimen. Based on the estimated glomerular filtration rate (eGFR), the patients were divided into normal renal function group (<i>n</i>=37), impaired renal function group (<i>n</i>=27), and renal insufficiency group (<i>n</i>=36). The main outcome measures were best-corrected visual acuity (BCVA) and central subfield macular thickness (CST). Clinical parameters included blood urea nitrogen, serum creatinine, serum uric acid, glycosylated hemoglobin (HbA1c), and hemoglobin.</p><p><strong>Results: </strong>The mean follow-up time was 3.9mo. The mean number of IVCs was 2.07±1.22 in the three groups. Mean BCVA improved significantly from 0.81±0.49 logMAR at baseline to 0.72±0.52 logMAR in the three groups at the final visit (<i>P</i><0.001). Mean CST decreased significantly from 427.85±148.99 µm at baseline to 275.31±108.31 µm at final visit (<i>P</i><0.001). Patients in the normal renal function group had higher baseline hemoglobin levels and thinner baseline CST than those in the impaired renal function and insufficiency renal function group (all <i>P</i><0.001). Patients in the normal renal function group had higher baseline hemoglobin levels and thinner baseline CST than those in the impaired renal function and insufficiency renal function group (all <i>P</i><0.001). The three groups had no differences in baseline HbA1c levels (<i>P</i>>0.05). Good baseline BCVA (logMAR, <i>P</i>=0.001) and thicker baseline CST (<i>P</i>=0.041) were associated with visual acuity improvement. Higher eGFR (<i>P</i><0.001), hemoglobin (<i>P</i>=0.032) and thicker baseline CST (<i>P</i>=0.017) were associated with macular edema retrogression in the conbercept-treated diabetic patients, which showed better anatomical response to IVC.</p><p><strong>Conclusion: </strong>Our results indicate that the renal dysfunction is the risk factor associated with the efficacy of IVC for DME.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"454-461"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes of spontaneous brain activity in patients after LASIK: a resting-state fMRI study.","authors":"Hui Zhang, Zi-Song Xu, Jin-Yu Hu, Zhen-Zhe Liu, Lei Zhong, Liang-Qi He, Cheng Chen, Xiao-Yu Wang, Hong Wei, Yan-Mei Zeng, Qian Ling, Xu Chen, Yi-Xin Wang, Yi Shao","doi":"10.18240/ijo.2025.03.16","DOIUrl":"10.18240/ijo.2025.03.16","url":null,"abstract":"<p><strong>Aim: </strong>To investigate changes in local brain activity after laser assisted <i>in situ</i> keratomileusis (LASIK) in myopia patients, and further explore whether post-LASIK (POL) patients and healthy controls (HCs) can be distinguished by differences in dynamic amplitude of low-frequency fluctuations (dALFF) in specific brain regions.</p><p><strong>Methods: </strong>The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic patients who underwent LASIK and 15 matched healthy controls. This method was selected to calculate the corresponding dALFF values of each participant, to compare dALFF between the groups and to determine whether dALFF distinguishes reliably between myopic patients after LASIK and HCs using the linear support vector machine (SVM) permutation test (5000 repetitions).</p><p><strong>Results: </strong>dALFF was lower in POL than in HCs at the right precentral gyrus and right insula. Classification accuracy of the SVM was 89.1% (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>The activity of spontaneous neurons in the right precentral gyrus and right insula of myopic patients change significantly after LASIK. SVM can correctly classify POL patients and HCs based on dALFF differences.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"487-495"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of ultrasound cyclo-plasty in patients with refractory glaucoma.","authors":"Hui-Min Zhong, Xiao-Hong Liu, Shou-Yue Huang, Hui-Ping Yao, Yi-Sheng Zhong, Jing Wang","doi":"10.18240/ijo.2025.03.08","DOIUrl":"10.18240/ijo.2025.03.08","url":null,"abstract":"<p><strong>Aim: </strong>To assess the efficacy and safety of ultrasound cyclo-plasty (UCP) in lowering intraocular pressure (IOP) among Chinese patients suffering from refractory glaucoma.</p><p><strong>Methods: </strong>In this 12-month retrospective study, 28 patients with refractory glaucoma (IOP≥25 mm Hg) were treated with 8-second UCP using either 8 or 10 probe sectors. The principal measure of efficacy was the decrease in IOP at the following intervals after UCP: 1d, 1, 3, 6, and 12mo, with each measurement compared to baseline.</p><p><strong>Results: </strong>Mean IOP (in mm Hg) was reduced from 46.8±8.9 to 24.5±3.2, 27.0±4.8, 29.1±4.6, 26.1±4.5, and 28.3±4.8 at 1d, 1, 3, 6, and 12mo postoperatively, respectively. Compared to baseline, IOP reductions at these time points were 45.0%, 39.9%, 35.3%, 41.4%, and 36.7%, respectively. Most patients experienced relief from ocular pain after surgery. No cases of choroidal detachment or hypotony was observed.</p><p><strong>Conclusion: </strong>UCP is effective in reducing IOP among Chinese patients with refractory glaucoma and shows a favorable safety profile.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"420-423"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive status and histological changes after posterior scleral reinforcement in guinea pig.","authors":"Yu-Yan Huang, Li-Yang Zhou, Guo-Fu Chen, Duo Peng, Miao-Zhen Pan, Ji-Bo Zhou, Jia Qu","doi":"10.18240/ijo.2025.03.01","DOIUrl":"10.18240/ijo.2025.03.01","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the refractive and the histological changes in guinea pig eyes after posterior scleral reinforcement with scleral allografts.</p><p><strong>Methods: </strong>Four-week-old guinea pigs were implanted with scleral allografts, and the changes of refraction, corneal curvature and axis length were monitored for 51d. The effects of methylprednisolone (MPS) on refraction parameters were also evaluated. And the microstructure and ultra-microstructure of eyes were observed on the 9d and 51d after operation. Repeated-measures analysis of variance and one-way analysis of variance were used.</p><p><strong>Results: </strong>The refraction outcome of the implanted eye decreased after operation, and the refraction change of the 3 mm scleral allografts group was significantly different with control group (<i>P</i>=0.005) and the sham surgical group (<i>P</i>=0.004). After the application of MPS solution, the reduction of refraction outcome was statistically suppressed (<i>P</i>=0.008). The inflammatory encapsulation appeared 9d after surgery. On 51d after operation, the loose implanted materials were absorbed, while the adherent implanted materials with MPS group were still tightly attached to the recipient's eyeball.</p><p><strong>Conclusion: </strong>After implantation of scleral allografts, the refraction of guinea pig eyes fluctuated from a decrease to an increase. The outcome of the scleral allografts is affected by implantation methods and the inflammatory response. Stability of the material can be improved by MPS.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"375-382"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central alterations of brain networks in patients with optic neuritis: a resting state fMRI study.","authors":"Liang Huang, Dan Song, Lei Zhong, Xuan Liao, Xian-Mei Zhou, Qian-Min Ge, Qian Ling, Yan-Mei Zeng, Xiao-Yu Wang, Jin-Yu Hu, Cheng Chen, Liang-Qi He, Qiong Zhou, Yi Shao","doi":"10.18240/ijo.2025.03.14","DOIUrl":"10.18240/ijo.2025.03.14","url":null,"abstract":"<p><strong>Aim: </strong>To assess the alterations in the resting-state function connections between the two cerebral hemispheres in patients with optic neuritis (ON) and healthy controls (HCs).</p><p><strong>Methods: </strong>A total of 12 ON patients (six males and six females) and 12 HCs (six males and six females) who were highly matched for sex, age, and educational level were recruited. They underwent functional magnetic resonance imaging (fMRI), testing and brain activities were assessed using the degree centrality (DC) method. Correlation analysis between the mean DC values in specific brain areas and behavior performances was analyzed as well. Linear correlations between A anxiety scale (AS) and depression scale (DS) values and DC values in brain regions of patients with ON were also analyzed.</p><p><strong>Results: </strong>The areas that showed a higher DC value in ON patients were the right angular gyrus and bilateral precuneus, while the left insula and left superior temporal gyrus (LSTG) were regions that presented a lower DC value in ON patients. A receiver operating characteristic (ROC) curve analysis confirmed the accuracy of the area under the curve (AUC) assessment. Linear analysis showed anxiety scale (AS) and depression scale (DS) values in the left insula were both negatively correlated with DC values, while best corrected visual acuity logMAR-R (BCVA logMAR-R) showed a negative correlation with DC in the LSTG.</p><p><strong>Conclusion: </strong>The study explores altered brain activities of specific regions in patients with ON. The results provide clues for revealing the underlying mechanism of ON development.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"469-477"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red tinted contact lenses on Ishihara test error scores in color deficient subjects: a pilot study.","authors":"Haliza Abdul Mutalib, Sharanjeet Sharanjeet-Kaur, Ong Yi Lin, Bashirah Ishak, Mohd Norhafizun Bin Mohd Saman, Mohd Izzuddin Hairol","doi":"10.18240/ijo.2025.03.13","DOIUrl":"10.18240/ijo.2025.03.13","url":null,"abstract":"<p><strong>Aim: </strong>To compare the Ishihara test errors scores of colour vision deficiency (CVD) subjects when wearing four different types of red-tinted contact lenses (RCL) that differ in their transmittance as determined using a spectrophotometer.</p><p><strong>Methods: </strong>Six congenital CVD subjects volunteered to participate in this study. Ishihara plates were used to determine the colour vision errors made, whereas Farnsworth-Munsell 100 Hue test was conducted to determine the total error scores (TES) and type of CVD. Four types of RCL (Types A, B, C and D) were inserted in the non-dominant eye and tested in a randomised manner by a masked operator. Errors scores in Ishihara test were determined at baseline without any contact lens and after wearing the four different RCL. The subjects were then divided into two groups based on the mean TES.</p><p><strong>Results: </strong>Repeated measures ANOVA with Greenhouse-Geisser corrections showed that there was a highly significant effect of RCL type on Ishihara error score [<i>F</i>(2.056, 10.282)=30.214, <i>P</i><0.001]. Error scores with RCL Type B were significantly lower than errors made when no lens was worn, and with RCL Type C and Type D (all <i>P</i><0.001). Error scores with RCL Type B were also lower than those made with RCL Type A, however, they were not significantly different. For subjects with TES values less than 180, RCL type B showed the largest improvement in Ishihara error score (50%) compared to the other three RCLs. RCL type A showed the best performance in TES value of more than 180, with an improvement of 80% in Ishihara score. RCL Type A has the lowest transmittance at the confusion wavelength (450-568 nm), followed by RCL Types B, D and C.</p><p><strong>Conclusion: </strong>This study shows that RCL can improve Ishihara error scores. RCL with lower transmission at 450-568 nm and 90% transmittance beyond 637 nm are the most effective. Lenses which could block more light between 550-580 nm are more effective for colour defectives with more severe colour defects.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"462-468"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between objective and subjective refraction measurements in patients with mild keratoconus.","authors":"Masoud Khorrami-Nejad, Ahmed Kamil Dakhil, Hesam Hashemian, Masoud Sadeghi, Reza Yousefi, Foroozan Narooie-Noori","doi":"10.18240/ijo.2025.03.04","DOIUrl":"10.18240/ijo.2025.03.04","url":null,"abstract":"<p><strong>Aim: </strong>To compare objective dry retinoscopy and subjective refraction measurements in patients with mild keratoconus (KCN) and quantify any differences.</p><p><strong>Methods: </strong>This cross-sectional study was done on 68 eyes of 68 patients diagnosed with mild KCN. Objective dry retinoscopy using autorefractometer and subjective refraction measurements were performed. Sphere, cylinder, J0, J45, and spherical equivalent values were compared between the two techniques.</p><p><strong>Results: </strong>The mean age of 68 patients with mild KCN was 21.32±5.03y (12-35y). There were 37 (54.4%) males. Objective refraction yielded significantly more myopic sphere (-1.44 D <i>vs</i> -0.57 D), higher cylinder magnitude (-2.24 D <i>vs</i> -1.48 D), and more myopic spherical equivalent (-2.56 D <i>vs</i> -1.31 D) compared to subjective refraction (all <i>P</i><0.05). The mean differences were -0.87 D for sphere, -0.76 D for cylinder, and -1.25 D for spherical equivalent. No significant differences were found for J0 and J45 values, indicating agreement in astigmatism axis (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>In patients with mild KCN, objective dry retinoscopy overestimates the degree of myopia and astigmatism compared to subjective refraction. The irregular cornea in KCN likely impacts objective measurements. Subjective refraction allows compensation for irregularity, providing a more accurate correction. When determining refractive targets, the tendency of objective methods to overcorrect should be considered.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"398-403"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}