International journal of ophthalmology最新文献

{"title":"Intraocular lens exchange or explantation post cataract surgery.","authors":"Arundhati Dvivedi, Somasheila I Murthy, Sukesh Manga","doi":"10.18240/ijo.2024.11.08","DOIUrl":"10.18240/ijo.2024.11.08","url":null,"abstract":"<p><strong>Aim: </strong>To report incidence, indications, and visual outcomes of intraocular lens (IOL) exchange/explantation surgery.</p><p><strong>Methods: </strong>Retrospective analysis of 60 eyes requiring IOL exchange/explantation surgery between 1^st January 2017 and 31^st December 2022. The overall outcomes as well as comparison between the trainee versus experienced surgeons were analyzed.</p><p><strong>Results: </strong>Out of 39 778 cataract surgeries (with no preexisting ocular co-morbidities) during a six-year period (2017-2022), 60 (0.15%) needed IOL exchange/explantation. Surgeons-under-training performed 36/60 cases (60%) while 24/60 (40%) were by experienced surgeons. The commonest indication was subluxated IOL in 26 (43.3%), followed by dislocated IOL in 20 (33.3%), postoperative refractive surprise in 7 (11.6%), IOL induced uveitis in five and broken haptic in two eyes. Twenty-four (40%) eyes had intraoperative complications during primary surgery. Posterior chamber IOL (PCIOL) was the commonest secondary IOL in 21 (35%) eyes, scleral fixated in 20 (31.6%), anterior chamber IOL (ACIOL) in 13 (21.6%), iris fixated IOL in three (5%) and three eyes (5%) were left aphakic. The mean time between primary and secondary surgery was 168d (168±338.8). Best corrected visual acuity (BCVA) of >20/60 was obtained in 43 eyes (71.66%), 20/80-20/200 in 14 (23.33%), 20/250 in two and hand movements in one. No statistically significant difference in visual outcome was noted at post-op one month between trainees versus experienced surgeons (UCVA 0.45±0.29 <i>vs</i> 0.53±0.32, <i>P</i>=0.20, BCVA 0.34±0.25 <i>vs</i> 0.37±0.26, <i>P</i>=0.69).</p><p><strong>Conclusion: </strong>IOL subluxation as the commonest indication and posterior capsular rupture is the commonest intraoperative risk factor. This complication can be effectively addressed with selection of the appropriate secondary IOL achieving good visual outcomes in over 70% of patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2031-2036"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone use patterns and the impact on accommodation and convergence system of the eyes among Malaysian teenagers.","authors":"Thilageswary Chellapan, Norlaila Mat Daud, Sumithira Narayanasamy","doi":"10.18240/ijo.2024.11.16","DOIUrl":"10.18240/ijo.2024.11.16","url":null,"abstract":"<p><strong>Aim: </strong>To determine the smartphone use patterns and effects of smartphone use on accommodation and convergence system of the eyes among Malaysian teenagers.</p><p><strong>Methods: </strong>A total of 62 participants aged between 13 and 17y were involved. A self-administered questionnaires containing 12 items was used to evaluate the smartphone usage patterns. This was followed by an eye examination, involving a battery of accommodation and convergence assessments before and after the smartphone use. The data analysis comprised descriptive statistics, paired <i>t</i>-test, and correlation coefficients.</p><p><strong>Results: </strong>The use of smartphones is at a high level and at an optimal distance daily, with more than 6h a day watching video films, games, and completing school projects. Majority of the participants not reported eye strain factors and eye prescription changes with the use of digital devices. The use of a smartphone continuously for 30min was found to significantly decrease amplitude of accommodation, accommodative facility, and positive relative accommodation (<i>P</i><0.001). Meanwhile, the lag of accommodation parameters and negative relative accommodation increased with the use of smartphones significantly (<i>P</i><0.001). The near point of convergence (NPC) and distance and near negative fusional vergence decreased significantly (<i>P</i><0.001). The NPC parameter was found to have a weak negative association with the frequency of smartphone use (<i>R</i>=-0.276, <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Frequent and continuous use of smartphones have increased visual stress and resulted in weakness of accommodation and vergence functions. Therefore, frequent break is mandatory when using a smartphone and appropriate visual hygiene, the 20-20-20 rule (every 20min, view something 20 feet away for 20s) are required during smartphone use to maintain visual function.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2093-2099"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration.","authors":"Ji-Xian Ma, Zhuo-Yi Zhang, Rong Di, Jia-Jie Yang, Si-Wen Tian, Ya-Zhou Qin, Wan-Hu Zhang, Jian-Qin Lei, Qiu-Ping Liu, Jing-Ming Li","doi":"10.18240/ijo.2024.11.13","DOIUrl":"10.18240/ijo.2024.11.13","url":null,"abstract":"<p><strong>Aim: </strong>To compare the differences of choroidal neovascularization (CNV) measurements between swept-source and spectral-domain optical coherence tomography angiography (SS-OCTA and SD-OCTA) in neovascular age-related macular degeneration (nAMD) and the imaging reliability of the two devices.</p><p><strong>Methods: </strong>Prospective comparative study. SS-OCTA and SD-OCTA were used to scan the same eye with the modes of 3×3 and 6×6 mm² centered on the neovascularization. Only qualified images were chosen and the border of CNV was manually delineated by two graders independently. The area of CNV (ACNV), vascular perfusion density (PD), and vessel length density (VLD) within the delineation were calculated using Image J. The differences of CNV measurements between the two OCTA devices were compared using Bland-Altman analysis. The agreement between the two graders on the measurements of each device was compared using the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>A total of 18 patients (22 eyes) with nAMD were included. The measurements of ACNV, PD, and VLD were 7.247±4.586 and 4.901±3.741 mm², 43.202±9.636 and 34.904±10.489, 6.339±1.228 and 5.908±1.741 mm^-1 for SS-OCTA and SD-OCTA, respectively. The differences between the two devices were 2.346±3.030 mm² (<i>Z</i>=-3.782, <i>P</i><0.0001), 8.298±14.160 (<i>Z</i>=-2.419, <i>P</i>=0.016), and 0.431±2.114 mm^-1 (<i>Z</i>=-0.828, <i>P</i>=0.408) for ACNV, PD and VLD, respectively. The ICC between two graders were 0.893 (<i>P</i><0.001), 0.902 (<i>P</i><0.001), 0.885 (<i>P</i><0.001) for ACNV, PD, VLD in SS-OCTA, and 0.971 (<i>P</i><0.001), 0.976 (<i>P</i><0.001), 0.973 (<i>P</i><0.001) in SD-OCTA, respectively.</p><p><strong>Conclusion: </strong>Both OCTA devices have high imaging reliability. Compared with SD-OCTA, SS-OCTA has a larger ACNV measurements, but doesn't show better resolution of internal vessels of CNV and well signal strength.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2067-2073"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed endophthalmitis caused by <i>Gordonia bronchialis</i> after intraocular collamer lens implantation.","authors":"Chao-Chao Xu, Ming-Hui Qiu, Shu-Yu Zhao, Xian-Jun Liang, Jin-Xian He","doi":"10.18240/ijo.2024.11.23","DOIUrl":"10.18240/ijo.2024.11.23","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2148-2150"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double intrastromal corneal ring segment implantation: a new approach for improved clinical outcomes in keratoconus patients.","authors":"Sandro Coscarelli, Reinaldo de Oliveira Sieiro, Victoria Moreira Fernandes, Sandro P Coscarelli, Leonardo Torquetti","doi":"10.18240/ijo.2024.11.07","DOIUrl":"10.18240/ijo.2024.11.07","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the clinical outcomes after subsequent implantation of a new intrastromal corneal ring segment (ICRS) model followed by an additional short-arc ICRS implant in keratoconus patients.</p><p><strong>Methods: </strong>This retrospective single-arm cohort study evaluated 25 eyes of 21 keratoconus patients implanted with the new ICRS followed by 140-arch length ICRS (140-ICRS) implantation. Uncorrected distance visual acuity (UDVA, logMAR), corrected distance visual acuity (CDVA, logMAR), sphere, astigmatism, keratometry, spherical equivalent (SE), and asphericity were compared preoperatively and postoperatively after both ICRS implantation.</p><p><strong>Results: </strong>The average follow-up time after 140-ICRS implantation was 6.40±2.20mo. The mean preoperative UDVA improved from 1.27±0.14 preoperative to 0.52±0.26 after both ICRS implantation (<i>P</i>=0.03). The mean sphere value reduced from -5.34±2.74 preoperatively to -2.06±1.84 postoperatively (<i>P</i><0.001) after the first ICRS implantation and decreased to -0.59±1.54 postoperatively (<i>P</i><0.001) after 140-ICRS implantation. The mean preoperative astigmatism was -3.72±1.56 and improved to -2.82±1.08 after the first ICRS implantation, and following the 140-ICRS implantation, the mean astigmatism was -1.37±0.67 (<i>P</i>=0.001). The SE and asphericity changes were statistically significant (<i>P</i><0.001). The researchers did not find intraoperative or postoperative complications for both procedures.</p><p><strong>Conclusion: </strong>The combination of 2 different ICRSs can efficiently regularize the cornea, reduce the SE, and improve visual acuity in selected keratoconus patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2023-2030"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMI, POLR3G and APIP are the key molecules connecting glaucoma with high intraocular pressure: a clue for early diagnostic biomarker candidates.","authors":"Nawaf Almarzouki","doi":"10.18240/ijo.2024.11.03","DOIUrl":"10.18240/ijo.2024.11.03","url":null,"abstract":"<p><strong>Aim: </strong>To understand the molecular connectivity between the intraocular pressure (IOP) and glaucoma which will provide possible clues for biomarker candidates.</p><p><strong>Methods: </strong>The current study uncovers the important genes connecting IOP with the core functional modules of glaucoma. An integrated analysis was performed using glaucoma and IOP microarray datasets to screen for differentially expressed genes (DEGs) in both conditions. To the selected DEGs, the protein interaction network was constructed and dissected to determine the core functional clusters of glaucoma. For the clusters, the connectivity of IOP DEGs was determined. Further, enrichment analyses were performed to assess the functional annotation and potential pathways of the crucial clusters.</p><p><strong>Results: </strong>The gene expression analysis of glaucoma and IOP with normal control showed that 408 DEGs (277 glaucoma and 131 IOP genes) were discovered from two GEO datasets. The 290 DEGs of glaucoma were extended to form a network containing 1495 proteins with 9462 edges. Using ClusterONE, the network was dissected to have 12 clusters. Among them, three clusters were linked with three IOP DEGs [N-Myc and STAT Interactor (NMI), POLR3G (RNA Polymerase III Subunit G), and APAF1-interacting protein (APIP)]. In the clusters, ontology analysis revealed that RNA processing and transport, p53 class mediators resulting in cell cycle arrest, cellular response to cytokine stimulus, regulation of phosphorylation, regulation of type I interferon production, DNA deamination, and cellular response to hypoxia were significantly enriched to be implicated in the development of glaucoma. Finally, NMI, POLR3G, and APIP may have roles that were noticed altered in glaucoma and IOP conditions.</p><p><strong>Conclusion: </strong>Our findings could help to discover new potential biomarkers, elucidate the underlying pathophysiology, and identify new therapeutic targets for glaucoma.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"1987-1994"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of N⁶-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract.","authors":"Hong-Fei Ye, Xiang Zhang, Zhen-Nan Zhao, Ce Zheng, Ping Fei, Yu Xu, Jiao Lyu, Ji-Li Chen, Xun-Xiang Guo, Huang Zhu, Pei-Quan Zhao","doi":"10.18240/ijo.2024.11.02","DOIUrl":"10.18240/ijo.2024.11.02","url":null,"abstract":"<p><strong>Aim: </strong>To characterize the N⁶-methyladenosine (m⁶A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).</p><p><strong>Methods: </strong>Anterior capsule of the lens were collected from patients with CC and ARC. Methylated RNA immunoprecipitation with next-generation sequencing and RNA sequencing were performed to identify m⁶A-tagged lncRNAs and lncRNAs expression. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses and Gene Ontology annotation were used to predict potential functions of the m⁶A-lncRNAs.</p><p><strong>Results: </strong>Large amount of m⁶A peaks within lncRNA were identified for both CC and ARC, while the level was much higher in ARC (49 870 peaks) than that in CC (18 688 peaks), yet those difference between ARC in younger age group (ARC-1) and ARC in elder age group (ARC-2) was quite slight. A total of 1305 hypermethylated and 1178 hypomethylated lncRNAs, as well as 182 differential expressed lncRNAs were exhibited in ARC compared with CC. On the other hand, 5893 hypermethylated and 5213 hypomethylated lncRNAs, as well as 155 significantly altered lncRNA were identified in ARC-2 compared with ARC-1. Altered lncRNAs in ARC were mainly associated with the organization and biogenesis of intracellular organelles, as well as nucleotide excision repair.</p><p><strong>Conclusion: </strong>Our results for the first time present an overview of the m⁶A methylomes of lncRNA in CC and ARC, providing a solid basis and uncovering a new insight to reveal the potential pathogenic mechanism of CC and ARC.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"1973-1986"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography.","authors":"Goksu Alacamli","doi":"10.18240/ijo.2024.11.24","DOIUrl":"10.18240/ijo.2024.11.24","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2151-2152"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retardation of myopia by atropine regimes.","authors":"Qin Zhu, Li Chen, Jia-Rui Liang, Min Hu, Li-Ping Xue, Guang-Long Zhou, Yuan Zhou, Jie-Ying Zhang, David Fernandez-Hazoury, Allison Helman, Ying-Ting Zhu, Xiao-Fan Zhang","doi":"10.18240/ijo.2024.11.20","DOIUrl":"10.18240/ijo.2024.11.20","url":null,"abstract":"<p><p>Myopia is a huge health problem due to its high frequency, vision losses and public health cost. According to the World Health Organization, at least 2.2 billion people have vision impairment. Although myopia can be controlled at its early and middle stages, unfortunately, no cure can be achieved so far. Among the methods to control myopia, atropine, a muscarinic receptor antagonist, is the oldest but still the most effective for retardation of myopia progression. Despite such a fact, standard protocols have not been established for clinicians to use atropine for treatment of myopia. In this article, a concise and up to date summary of myopia epidemiology and pathogenesis and summarized therapeutic effects and side effects, possible mechanisms and application methods of atropine were provided in hope for clinical doctors to effectively control this problematic disease. At present, the protocol is recommend: use higher dose (1%) of atropine intermittently to effectively slowdown myopia progression in schoolchildren for 2y, and to significantly reduce side effects of atropine by decrease of atropine frequency for 1y and inhibit myopic rebound by withdrawal of topical atropine gradually for 1y. Application of a lower dose (0.05%) atropine regime should also be considered due to its effectiveness and application at regular basis.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2129-2140"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral circumscribed choroidal hemangioma: a case report.","authors":"Wei-Yi Zhang, Jia Chen, Hong-Ming Liu, Xin-Hong Jiang, Zhi-Ping Chen, Zhi-Peng You, Yu-Ling Zou","doi":"10.18240/ijo.2024.11.21","DOIUrl":"10.18240/ijo.2024.11.21","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"17 11","pages":"2141-2144"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}