International journal of ophthalmology最新文献

{"title":"Alpha and Kappa angle on postoperative visual quality in cataract surgery.","authors":"Xiao-Na Chen, Ying-Yue Xiong, Jia Wei, Bin Luo, Ya-Li Gao","doi":"10.18240/ijo.2025.06.08","DOIUrl":"10.18240/ijo.2025.06.08","url":null,"abstract":"<p><strong>Aim: </strong>To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses (MIOLs) implantation on postoperative visual quality of patients.</p><p><strong>Methods: </strong>Before and 3mo after cataract surgery, Alpha angle and Kappa angle were collected using IOL Master 700, iTrace, and Pentacam for clinical observation. Postoperative visual quality indicators, including high-order aberrations (HOA), modulation transfer function (MTF) and point spread function (PSF), were collected using iTrace. multiple linear regression analysis was used to analyze the correlation of the Kappa angle and the Alpha angle with age, axial length (AL), anterior chamber depth (ACD), keratometry (K), lens thickness (LT) and corneal white to white distance (WTW). Pearson correlation coefficient was used to analyze the correlation between Alpha angle and Kappa angle; Bland Altman analysis was used to evaluate the consistency of pairwise detection results of three instruments.</p><p><strong>Results: </strong>The Alpha angle was modeled as Alpha=2.230+0.003×age-0.036×AL-0.025×K-0.058×WTW and the Kappa angle was modeled as Kappa=0.685+ 0.003×age-0.013×K-0.061×WTW. The correlation between the total Alpha angle and Kappa angle of the three instruments was weakly positive (<i>r</i>=0.291, <i>P</i>=0.000). Comparing the measurement of Alpha angle and Kappa angle using three instruments, only IOL Master 700 and iTrace showed good consistency in measuring Kappa angle (<i>P</i>=0.4254). After 3mo of surgery, the Alpha angle and Kappa angle significantly decreased (<i>P</i>=0.011, 0.018; <i>P</i>=0.008, 0.036). △Kappa=1.136-0.021×AL-0.013×K. Kappa angle could positively predict HOA (<i>β</i>=0.18, <i>P</i>=0.000), MTF (<i>β</i>=0.171, <i>P</i>=0.000), PSF (<i>β</i>=0.088, <i>P</i>=0.000), Alpha angle cannot (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The patients with older age, flatter K and shorter WTW should be alert to the possibility of larger Alpha angle and Kappa angle. Alpha angle should also consider the factor of AL. When selecting patients with MIOLs implantation, there is no need to consider the Alpha angle. Careful consideration should be given to the Kappa angle, and the preoperative standard of <0.5 mm can refer to △Kappa=1.136-0.021×AL-0.013×K and be appropriately relaxed.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1023-1031"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography findings in beta-thalassemia major: a systematic review and Meta-analysis.","authors":"Maryam Firdous, Muhammad Farooq Umer, Suriyakala Perumal Chandran","doi":"10.18240/ijo.2025.06.19","DOIUrl":"10.18240/ijo.2025.06.19","url":null,"abstract":"<p><strong>Aim: </strong>To describe the optical coherence tomography (OCT) findings of the retinal nerve fiber layer thickness (RNFLT) and choroidal thickness (CT) in beta-thalassemia major.</p><p><strong>Methods: </strong>A systematic search was conducted on PubMed, Cochrane, and Embase using a combination of specific key words. The records found were screened in two phases (title/abstract, and full-text screening). All the original observational cross-sectional studies conducted on beta-thalassemia major cases and controls reporting the RNFLT and CT were included. The Meta-analysis was run for comparing the OCT measurements between beta-thalassemia cases and controls including pooled effect size, confidence intervals (CI), quality assessment, and publication bias. The measurements included were RNFLT (average, and in various quadrants), and CT.</p><p><strong>Results: </strong>A total of 10 studies were included in this Meta-analysis including a total of 684 individuals, 362 cases and 322 controls. The RNFLT and CT showed a significant reduction in the values of beta-thalassemia cases as compared to controls. The heterogeneity among the included studies was found to be 92.65% for the average RNFLT and 30.13% for the CT making it obvious to use random effects model for analyzing the RNFLT values while fixed effects model for the CT. The Egger's test showed significant publication bias among all the parameters except for nasal RNFLT (<i>P</i>=0.507), and CT (<i>P</i>=0.281). The estimated average effect size for the average RNFLT was 1.04 (95%CI: 0.35 to 1.72, <i>Z</i>=2.961, <i>P</i>=0.003) and for CT was 0.74 (95%CI: 0.51 to 0.96, <i>Z</i>=6.523, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>This Meta-analysis concludes that the RNFLT and CT are significantly thinner in beta-thalassemia cases in comparison to healthy individuals. Therefore, the RNFLT and CT must be evaluated in routine clinical practice in order to avoid irreversible vision loss particularly in beta-thalassemia individuals.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1113-1122"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPARα deficiency exacerbates retinal pathological changes and dysfunction in high-fat diet mice.","authors":"Xue Wang, Jing-Jing Ding, Chao-Feng Yu, Deng-Cheng Xiao, Li-Ming Tao, Zheng-Xuan Jiang","doi":"10.18240/ijo.2025.06.03","DOIUrl":"10.18240/ijo.2025.06.03","url":null,"abstract":"<p><strong>Aim: </strong>To examined the effects of a high-fat diet (HFD) on retinal pathological changes and dysfunction using peroxisome proliferator-activated receptor-alpha (PPARα) knockout mice.</p><p><strong>Methods: </strong>For four months, C57BL/6J and <i>PPARα</i> knockout mice received either HFD or a standard diet (SD). A fluorometric method was used to determine the retinal triglycerides. The retinal malondialdehyde (MDA) content was measured. Hematoxylin-eosin was used to evaluate retinal pathological changes. Protein expression was analyzed by Western blot and immunofluorescence, while mRNA expression was evaluated by quantitative reverse transcription-polymerase chain reaction. Electroretinogram was used to assess retinal function.</p><p><strong>Results: </strong>HFD resulted in increased fatty acid β-oxidation in the inner retina, particularly retinal ganglion cells (RGCs), as well as increased weight and accumulation of retinal triglyceride. Retinal fatty acid β-oxidation and triglyceride accumulation were affected by <i>PPARα</i> ^-/- abnormalities. <i>PPARα</i> knockdown increased the infiltration and activation of inflammatory cells, as well as it upregulated the nuclear factor kappa B (NF-κB) signaling pathway and corresponding proinflammatory cytokine levels in the most retina subjected to the HFD. In the HFD mice, oxidative stress levels were elevated in the inner retina, particularly in the HFD <i>PPARα</i> ^-/- mice. HFD-induced RGCs apoptosis initiation was exacerbated by <i>PPARα</i> deficiency. Lastly, HFD feeding resulted in the lower amplitudes of scotopic a-wave, b-wave and photopic negative response (PhNR) wave, particularly in HFD <i>PPARα</i> ^-/- mice.</p><p><strong>Conclusion: </strong>In HFD-fed mice retina, particularly in the inner retina, <i>PPARα</i> knockout increases lipid metabolic abnormalities, inflammatory responses, oxidative stress, apoptosis initiation and dysfunction.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"986-995"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of artesunate in retinal diseases: from mechanism to clinical applications.","authors":"Ying-Chao Xue, Xiao-Long Liu, Bo-Yu Liu, Sheng-Xiang Zhang, Qi-Hua Xu, Ling-Dan Wu","doi":"10.18240/ijo.2025.06.22","DOIUrl":"10.18240/ijo.2025.06.22","url":null,"abstract":"<p><p>Artesunate is a derivative of artemisinin, and due to its high solubility, and it has a broader application in clinical settings. Extensive research has confirmed that artemisinin-based drugs show significant activities in anti-inflammatory, anti-tumor, anti-viral, and anti-angiogenesis aspects, suggesting that artesunate might have potential in treating retinal diseases. Currently, the etiology of most retinal diseases is not fully understood, and there is a lack of effective treatment methods. This paper summarized the research progress of artesunate in the treatment of retinal diseases, including retinoblastoma, choroidal melanoma, diabetic retinopathy, central retinal vein occlusion, proliferative retinopathy, and ocular neovascularization. In addition, the potential applications and future research directions of artesunate in the treatment of retinal diseases were also discussed.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1146-1151"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic features of 89 patients with lacrimal gland prolapse.","authors":"Yu-Yao Qu, Le Dong, Ya-Guang Hu, Ning Gao, Jing-Ming Li, Qiao-Chu Cheng, Shan Gao, Ting Wei, Jian-Min Ma, Wan-Hu Zhang","doi":"10.18240/ijo.2025.06.06","DOIUrl":"10.18240/ijo.2025.06.06","url":null,"abstract":"<p><strong>Aim: </strong>To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse (LGP).</p><p><strong>Methods: </strong>This retrospective study included 89 patients presenting as LGP. Magnetic resonance imaging (MRI) scan was performed for all patients. Pathology and immunohistochemical staining of prolapsed tissue were performed during the surgery. The histopathological subtype was obtained, and the related clinical manifestations of different subtype were marked.</p><p><strong>Results: </strong>Among the 89 patients involved, the histopathological subtype includes dacryoadenitis (43%; <i>n</i>=38), focal lymphocytes infiltration (20%; <i>n</i>=18), immunoglobulin G4 (IgG4)-related lacrimal gland inflammatory disease (15%; <i>n</i>=13), lacrimal gland (13%; <i>n</i>=12), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (9%; <i>n</i>=8). As for manifestations of different subtypes, eyelid swelling was found the most frequent of lymphocytes infiltration (44%, <i>n</i>=8), and palpable lacrimal gland mass of dacryoadenitis (55%, <i>n</i>=21). All the IgG4-related lacrimal gland inflammatory disease (100%, <i>n</i>=13) and most dacryoadenitis (97%, <i>n</i>=37) presented as bilateral.</p><p><strong>Conclusion: </strong>LGP has the histopathological subtype most commonly as inflammation, followed by structural and lymphoproliferative changes. Most of patients present as eyelid swelling. Clinical manifestations can be significant to differentiate the diagnosis.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1011-1015"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal stromal lenticule transplantation for covering macular hole during vitrectomy.","authors":"Wen-Ting Ding, Yi-Le Xu, Di Li, Xiao-Xiao Qian, Jian Li, Hong-Wei Ge, Xiao-Hua Zhang, Ren-Jian Hu, Yong-Ping Hu","doi":"10.18240/ijo.2025.06.24","DOIUrl":"10.18240/ijo.2025.06.24","url":null,"abstract":"<p><strong>Aim: </strong>To describe an innovative surgical technique for pathologic myopia and macular holes accompanied by retinal detachment using allogeneic corneal stromal lenticule transplantation combined with pars plana vitrectomy.</p><p><strong>Methods: </strong>The allogeneic corneal stromal lenticule was harvested through small incision lenticule extraction (SMILE) and stored at -30°C in advance. After pars plana vitrectomy, an allogeneic corneal stromal lenticule was thawed, trimmed into approximately 60 µm thick and 100 µm larger than the macular hole and transferred to cover the macular hole through the trocar. Autologous whole blood was dripped to seal the corneal stromal lenticule. The vitreous cavity was then filled with perfluoropropane (C₃F₈) or sterile air.</p><p><strong>Results: </strong>The technique was performed on three eyes of three patients. The mean postoperative follow-up period was 77.3±50.0d. Postoperatively, the macular hole of all eyes was restored. All patients' visual acuities also improved. No complications occurred during the follow-up period.</p><p><strong>Conclusion: </strong>The innovative corneal stromal lenticule transplantation technique provides convenient operations, less surgical invasion, effective results, and reliable safety for macular hole repair during follow-up time.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1163-1168"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological inflammation biomarkers in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.","authors":"Alper Can Yilmaz, Hayati Yilmaz","doi":"10.18240/ijo.2025.06.10","DOIUrl":"10.18240/ijo.2025.06.10","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate complete blood count and biochemical parameters in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) and compare the results with healthy controls.</p><p><strong>Methods: </strong>Forty-four patients with PEXS, 61 patients with PEXG, and 55 healthy subjects were enrolled in this retrospective study. All systemic and especially pseudoexfoliation-related ophthalmic examination findings of the participants were evaluated. Complete blood count, glucose, creatinine, and serum lipid values were obtained. In line with these data, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-high density lipoprotein (HDL) ratio (MHR), and mean platelet volume-to-platelet count ratio were obtained and comparison were made among groups.</p><p><strong>Results: </strong>Diabetes mellitus and hypertension were significantly more common in the PEXS and PEXG groups than in the control group (<i>P</i>=0.021, <i>P</i>=0.016, respectively). In the analysis of complete blood count parameters, NLR and MHR values were statistically significantly higher in PEXS and PEXG compared to the control group (<i>P</i>=0.037, <i>P</i>=0.025, respectively). In addition, glucose, low-density lipoprotein, and triglyceride values were significantly higher in the PEXS and PEXG groups compared to the control group (<i>P</i><0.001, <i>P</i>=0.035, <i>P</i><0.001, respectively), and HDL value was significantly lower (<i>P</i>=0.031).</p><p><strong>Conclusion: </strong>The hematological inflammation biomarkers we evaluated in our study provide evidence that systemic inflammation and oxidative stress processes play an important role in the pathogenesis of PEXS and PEXG.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1042-1052"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitrectomy combined with internal limiting membrane peeling for refractory macular telangiectasia type 1.","authors":"Dan Liao, Xiao-Li Yang, Rong Li","doi":"10.18240/ijo.2025.06.25","DOIUrl":"10.18240/ijo.2025.06.25","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1169-1172"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consecutive superior oblique palsy following surgical management of brown syndrome: case series.","authors":"Hajar Farvardin, Majid Farvardin","doi":"10.18240/ijo.2025.06.27","DOIUrl":"10.18240/ijo.2025.06.27","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1178-1180"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of axial length measurements with RS-1 spectral domain optical coherence tomography and OA-2000 biometer.","authors":"Hitomi Fujihara, Shinji Kakihara, Takao Hirano, Toshinori Murata","doi":"10.18240/ijo.2025.06.15","DOIUrl":"10.18240/ijo.2025.06.15","url":null,"abstract":"<p><strong>Aim: </strong>To determine the utility of the RS-1 spectral domain optical coherence tomography (SD-OCT), which incorporates an \"OCT Analysis Correction Parameter\" for approximating axial length, in comparison with measurements obtained from the OA-2000.</p><p><strong>Methods: </strong>Twenty-five right eyes of healthy individuals were included. Two horizontal line scans were conducted using the RS-1, and OCT Analysis Correction Parameters were recorded. Axial length was measured twice per eye using the OA-2000. Correlation between devices was assessed using Pearson correlation coefficient, coefficient of repeatability (CR%), and Bland-Altman analysis.</p><p><strong>Results: </strong>High correlation was found between axial length measurements from RS-1 and OA-2000 (<i>r</i>=0.986, <i>P</i><0.0001). The coefficient of repeatability was 1.56% for RS-1 and 0.115% for OA-2000. Mean axial length was 25.12±1.38 mm for RS-1 and 24.90±1.54 mm for OA-2000, with RS-1 showing a statistically significant larger value (paired <i>t</i>-test, <i>P</i>=0.0009).</p><p><strong>Conclusion: </strong>The axial length measurements of RS-1 demonstrate a strong positive correlation with those from the OA-2000. This indicates that it could potentially be used to forecast scan ranges and choose suitable databases according to axial length categories.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1085-1089"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}