Correlations between inflammatory biomarkers in peripheral blood and branch retinal vein occlusion.

IF 1.8 4区医学 Q2 OPHTHALMOLOGY

International journal of ophthalmology Pub Date : 2025-10-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.10.13

Xiao-Juan Lai, Song-Yue Yang, Chun-Yan Lei, Rui-Han Xiao, Mei-Xia Zhang

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引用次数: 0

Abstract

Aim: To investigate the possible relationship between inflammatory biomarkers in the peripheral blood of patients with branch retinal vein occlusion (BRVO).

Methods: A total of 63 BRVO patients were enrolled in this cross-sectional observational study. Meanwhile, 63 age- and gender-matched cataract patients were included as controls. Complete blood count and biochemical tests were performed, and inflammatory biomarkers including platelet to lymphocyte ratio (PLR), red blood cell distribution width to albumin ratio (RAR), neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (SII), and monocyte to high density lipoprotein cholesterol ratio (MHR) were compared between the two groups.

Results: There were no significant differences between the two groups in terms of age, sex, and prevalence of diabetes mellitus. Compared with the controls, patients with BRVO had a higher prevalence of hypertension and higher body mass index (BMI). Red blood cell distribution width (RDW), triglycerides, MHR, NLR, and RAR were elevated, whereas lymphocyte count and high-density lipoprotein were decreased in the BRVO group. Multivariate logistic regression analysis revealed that NLR (adjusted OR=1.686, 95%CI 1.075-2.646), RAR (adjusted OR=8.930, 95%CI 1.911-41.730), and body mass index (BMI; adjusted OR=1.174, 95%CI 1.010-1.365) were significantly associated with the risk of BRVO. In the receiver operating characteristic analysis, the area under the curve for NLR, RAR, and BMI were 0.602, 0.630, and 0.603, respectively. The sensitivity and specificity were 61.9% and 60.3%, 38.1% and 82.5%, and 61.9% and 57.1%, respectively.

Conclusion: Peripheral blood inflammatory biomarkers are elevated in BRVO patients, suggesting systemic inflammation involvement. NLR, RAR, and BMI are positively correlated with BRVO. Monitoring NLR and RAR and strict weight control may be beneficial for the prevention and treatment of BRVO.

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外周血炎症生物标志物与视网膜分支静脉闭塞的相关性。

目的：探讨视网膜分支静脉闭塞（BRVO）患者外周血炎症标志物之间的可能关系。方法：共纳入63例BRVO患者进行横断面观察性研究。同时，63名年龄和性别匹配的白内障患者作为对照。进行全血计数和生化检查，比较两组患者的炎症生物标志物，包括血小板与淋巴细胞比值（PLR）、红细胞分布宽度与白蛋白比值（RAR）、中性粒细胞与淋巴细胞比值（NLR）、全身免疫炎症指数（SII）、单核细胞与高密度脂蛋白胆固醇比值（MHR）。结果：两组患者在年龄、性别、糖尿病患病率方面无显著差异。与对照组相比，BRVO患者高血压患病率更高，体重指数（BMI）也更高。BRVO组红细胞分布宽度（RDW）、甘油三酯、MHR、NLR和RAR升高，而淋巴细胞计数和高密度脂蛋白降低。多因素logistic回归分析显示，NLR（校正OR=1.686, 95%CI 1.075 ~ 2.646）、RAR（校正OR=8.930, 95%CI 1.911 ~ 41.730）和体重指数（BMI，校正OR=1.174, 95%CI 1.010 ~ 1.365）与BRVO风险显著相关。在受试者工作特征分析中，NLR、RAR和BMI的曲线下面积分别为0.602、0.630和0.603。敏感性和特异性分别为61.9%和60.3%、38.1%和82.5%、61.9%和57.1%。结论：BRVO患者外周血炎症生物标志物升高，提示全身炎症累及。NLR、RAR、BMI与BRVO呈正相关。监测NLR和RAR并严格控制体重可能有利于BRVO的预防和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of ophthalmology Medicine-Ophthalmology

CiteScore

2.50

自引率

7.10%

发文量

3141

审稿时长

4-8 weeks

期刊介绍： · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.