视觉功能在多发性硬化症和视神经炎诊断中的应用。

IF 1.8 4区 医学 Q2 OPHTHALMOLOGY
International journal of ophthalmology Pub Date : 2025-10-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.10.15
Bardia Behnia, Ameer Mohammed Hadi Layedh, Hassan Hashemi, Alireza Jamali, Abbasali Yekta, Navidreza Zamani, Raheleh Moravej, Mehdi Khabazkhoob
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引用次数: 0

摘要

目的:探讨多发性硬化症(MS)伴视神经炎(ON)和不伴视神经炎(ON)患者各种视觉功能的诊断能力。方法:在这项横断面研究中,我们评估并比较了MS患者和匹配对照组健康个体的屈光不正、视力(VA)和对比敏感度(CS)。MS患者进一步分为ON组和非ON组。结果:133名参与者共133只眼睛被评估,其中66名被诊断为MS, MS组和健康对照组的平均年龄分别为37.5±4.27岁和38.45±4.60岁(P=0.346)。在66例MS患者中,18例有ON。MS的存在与最佳矫正视力(BCVA)和球面屈光误差(PP>0.05)下降有关。在每度6和18周期的空间频率(CPD; PP=0.03)下,MS与CS下降有关。圆柱形分量(AC)在区分MS患者与健康个体以及有ON的MS患者与无ON的MS患者方面的敏感性最为显著[相关标准(AC) >-0.75 D;71.21%]和CS在6 CPD的空间频率下(AC≤1.56;72.22%)。相反,这些诊断指标的最高特异性分别与BCVA (AC >0 logMAR; 97.01%)和CS在12 CPD的空间频率(AC≤0.60;93.75%)相关。结论:MS显著影响屈光不正和CS, ON进一步降低CS。评估这些可视化参数可以改善MS的监测和管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visual function in the diagnosis of multiple sclerosis and optic neuritis.

Aim: To determine the diagnostic ability of various visual functions in patients with multiple sclerosis (MS) with and without optic neuritis (ON).

Methods: In this cross-sectional study, we assessed and compared refractive error, visual acuity (VA), and contrast sensitivity (CS) between patients with MS and a matched control group of healthy individuals. The MS patients were further categorized into those with ON and those without.

Results: A total of 133 eyes from 133 participants were assessed, including 66 individuals diagnosed with MS. The mean ages for the MS group and the healthy control group were 37.5±4.27y and 38.45±4.60y, respectively (P=0.346). Among the 66 patients with MS, 18 had ON. The presence of MS was associated with a decrease in best-corrected visual acuity (BCVA) and spherical component of refractive error (P<0.05), whereas ON did not lead to any further decline in these parameters (P>0.05). MS was linked to decreased CS at spatial frequencies of 6 and 18 cycles per degree (CPD; P<0.05), while ON in MS patients resulted in an additional decrease in CS at 3 CPD (P=0.03). The most significant sensitivity for distinguishing MS patients from healthy individuals as well as MS patients with ON from those without ON was found with cylindrical component [associated criterion (AC) >-0.75 D; 71.21%] and CS at spatial frequency of 6 CPD (AC ≤1.56; 72.22%), respectively. Conversely, the highest specificity for these diagnostic measures was associated with BCVA (AC >0 logMAR; 97.01%) and CS at a spatial frequency of 12 CPD (AC ≤0.60; 93.75%), respectively.

Conclusion: MS significantly affects refractive error and CS, with ON further reducing CS. Assessing these visual parameters can improve MS monitoring and management.

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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
3141
审稿时长
4-8 weeks
期刊介绍: · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
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