Bardia Behnia, Ameer Mohammed Hadi Layedh, Hassan Hashemi, Alireza Jamali, Abbasali Yekta, Navidreza Zamani, Raheleh Moravej, Mehdi Khabazkhoob
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Among the 66 patients with MS, 18 had ON. The presence of MS was associated with a decrease in best-corrected visual acuity (BCVA) and spherical component of refractive error (<i>P</i><0.05), whereas ON did not lead to any further decline in these parameters (<i>P</i>>0.05). MS was linked to decreased CS at spatial frequencies of 6 and 18 cycles per degree (CPD; <i>P</i><0.05), while ON in MS patients resulted in an additional decrease in CS at 3 CPD (<i>P</i>=0.03). The most significant sensitivity for distinguishing MS patients from healthy individuals as well as MS patients with ON from those without ON was found with cylindrical component [associated criterion (AC) >-0.75 D; 71.21%] and CS at spatial frequency of 6 CPD (AC ≤1.56; 72.22%), respectively. Conversely, the highest specificity for these diagnostic measures was associated with BCVA (AC >0 logMAR; 97.01%) and CS at a spatial frequency of 12 CPD (AC ≤0.60; 93.75%), respectively.</p><p><strong>Conclusion: </strong>MS significantly affects refractive error and CS, with ON further reducing CS. Assessing these visual parameters can improve MS monitoring and management.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 10","pages":"1922-1928"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454017/pdf/","citationCount":"0","resultStr":"{\"title\":\"Visual function in the diagnosis of multiple sclerosis and optic neuritis.\",\"authors\":\"Bardia Behnia, Ameer Mohammed Hadi Layedh, Hassan Hashemi, Alireza Jamali, Abbasali Yekta, Navidreza Zamani, Raheleh Moravej, Mehdi Khabazkhoob\",\"doi\":\"10.18240/ijo.2025.10.15\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To determine the diagnostic ability of various visual functions in patients with multiple sclerosis (MS) with and without optic neuritis (ON).</p><p><strong>Methods: </strong>In this cross-sectional study, we assessed and compared refractive error, visual acuity (VA), and contrast sensitivity (CS) between patients with MS and a matched control group of healthy individuals. The MS patients were further categorized into those with ON and those without.</p><p><strong>Results: </strong>A total of 133 eyes from 133 participants were assessed, including 66 individuals diagnosed with MS. The mean ages for the MS group and the healthy control group were 37.5±4.27y and 38.45±4.60y, respectively (<i>P</i>=0.346). Among the 66 patients with MS, 18 had ON. The presence of MS was associated with a decrease in best-corrected visual acuity (BCVA) and spherical component of refractive error (<i>P</i><0.05), whereas ON did not lead to any further decline in these parameters (<i>P</i>>0.05). MS was linked to decreased CS at spatial frequencies of 6 and 18 cycles per degree (CPD; <i>P</i><0.05), while ON in MS patients resulted in an additional decrease in CS at 3 CPD (<i>P</i>=0.03). The most significant sensitivity for distinguishing MS patients from healthy individuals as well as MS patients with ON from those without ON was found with cylindrical component [associated criterion (AC) >-0.75 D; 71.21%] and CS at spatial frequency of 6 CPD (AC ≤1.56; 72.22%), respectively. Conversely, the highest specificity for these diagnostic measures was associated with BCVA (AC >0 logMAR; 97.01%) and CS at a spatial frequency of 12 CPD (AC ≤0.60; 93.75%), respectively.</p><p><strong>Conclusion: </strong>MS significantly affects refractive error and CS, with ON further reducing CS. 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Visual function in the diagnosis of multiple sclerosis and optic neuritis.
Aim: To determine the diagnostic ability of various visual functions in patients with multiple sclerosis (MS) with and without optic neuritis (ON).
Methods: In this cross-sectional study, we assessed and compared refractive error, visual acuity (VA), and contrast sensitivity (CS) between patients with MS and a matched control group of healthy individuals. The MS patients were further categorized into those with ON and those without.
Results: A total of 133 eyes from 133 participants were assessed, including 66 individuals diagnosed with MS. The mean ages for the MS group and the healthy control group were 37.5±4.27y and 38.45±4.60y, respectively (P=0.346). Among the 66 patients with MS, 18 had ON. The presence of MS was associated with a decrease in best-corrected visual acuity (BCVA) and spherical component of refractive error (P<0.05), whereas ON did not lead to any further decline in these parameters (P>0.05). MS was linked to decreased CS at spatial frequencies of 6 and 18 cycles per degree (CPD; P<0.05), while ON in MS patients resulted in an additional decrease in CS at 3 CPD (P=0.03). The most significant sensitivity for distinguishing MS patients from healthy individuals as well as MS patients with ON from those without ON was found with cylindrical component [associated criterion (AC) >-0.75 D; 71.21%] and CS at spatial frequency of 6 CPD (AC ≤1.56; 72.22%), respectively. Conversely, the highest specificity for these diagnostic measures was associated with BCVA (AC >0 logMAR; 97.01%) and CS at a spatial frequency of 12 CPD (AC ≤0.60; 93.75%), respectively.
Conclusion: MS significantly affects refractive error and CS, with ON further reducing CS. Assessing these visual parameters can improve MS monitoring and management.
期刊介绍:
· International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication
and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online).
This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from
WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed,
PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166.
IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific
Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO);
Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President,
Chinese Academy of Engineering.
International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of
blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of
AAO/PAAO) et al.
Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of
Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and
Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society).
Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press).
Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and
Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics).
Associate Editors-in-Chief include:
Prof. Ning-Li Wang (President Elect of APAO);
Prof. Ke Yao (President of Chinese Ophthalmological Society) ;
Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ;
Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA);
Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society);
Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA);
Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA).
IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles,
both basic and clinical papers.
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