International Journal of Pharmacy Practice最新文献

{"title":"Gastrointestinal adverse events associated with Hedgehog pathway inhibitors: a disproportionality analysis.","authors":"Anjana Shenoy, Adithya Mysore Shivakumar, Gouri Nair, Mohammed Salim Karattuthodi, Shabeer Ali Thorakkattil, Mahmathi Karuppannan","doi":"10.1093/ijpp/riaf090","DOIUrl":"https://doi.org/10.1093/ijpp/riaf090","url":null,"abstract":"<p><strong>Objective: </strong>The Hedgehog pathway inhibitors (HPIs) are effectively used to treat basal cell carcinoma (BCC). Despite the benefits, HPIs are reported to cause various gastrointestinal adverse events (GIAEs). The study was conducted to detect possible safety signals of HPIs concerning GIAE through disproportionality analysis.</p><p><strong>Methods: </strong>A retrospective case/non-case disproportionality analysis was performed in the USFDA Adverse Event Reporting System database using OpenVigil 2.1, a web-based pharmacovigilance tool. All the GIAEs reported due to the HPIs, like vismodegib, sonidegib, and glasdegib, were extracted and analysed. The reporting odds ratio (ROR) > 1 was considered the reporting threshold.</p><p><strong>Key findings: </strong>The HPIs accounted for 6781 adverse events, with 1196 GIAEs distributed across vismodegib (18.56%), sonidegib (13.89%), and glasdegib (5.39%). A potential safety signal was portrayed with atrophic glossitis [ROR: 181.88 (95% CI: 72.73-454.83)] and ageusia [153.34 (141.20-166.52)] from vismodegib. The study identified concerns of dysgeusia [17.39 (11.72-25.81)] from sonidegib and hepatotoxicity [20.25 (9.02-45.46)] from glasdegib.</p><p><strong>Conclusions: </strong>HPIs had triggered various types of GIAEs. Liver injuries were a safety concern for the HPI-treated patient, which was not listed by the USFDA. Further researches are needed to confirm these findings.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are UK pharmacists ready for advanced-level practice? A cross-sectional survey of self-assessed development needs.","authors":"Stephen Doherty, Paul Forsyth, Petra Rauchhaus, Christine Bond, Susan Roberts, Jane Brown, Laura O'Loan, Fiona Marra, Joseph Oakley, Michele Sehrawat, Debra Roberts, Andrew Radley","doi":"10.1093/ijpp/riaf085","DOIUrl":"https://doi.org/10.1093/ijpp/riaf085","url":null,"abstract":"<p><strong>Objectives: </strong>The Royal Pharmaceutical Society has developed a new curriculum and credentialling process for advanced pharmacist practice. The aim of this study was to understand the self-reported advanced practice capability of UK pharmacists using this curriculum.</p><p><strong>Methods: </strong>The study was a cross-sectional electronic survey. The inclusion criterion was that the participants be registered pharmacists practising in the UK in any professional sector. Participants rated, on a 5-point Likert scale, their confidence that their current practice aligns to the described level in the Royal Pharmaceutical Society Core Advanced Curriculum. Predictors of overall confidence that their current practice aligned to all curriculum outcomes were analysed using binomial regression.</p><p><strong>Key findings: </strong>Nine hundred and eighty-eight pharmacists participated. The median age was 42 years; 75.2% were female and the median length of registration was 17 years. A low proportion of pharmacists reported confidence across all outcomes (19.8%). The research domain had the lowest self-reported confidence (26.9%). Other domains had higher levels of reported confidence: professional practice (40.9%); leadership and management (43.8%); person-centred care and collaboration (54.3%); and education (57.6%). The strongest predictors of overall confidence across the whole curriculum were completion of an advanced clinical assessment skills module, being a frequent prescriber, and self-identifying as an advanced practice pharmacist.</p><p><strong>Conclusion: </strong>Only a minority of respondents self-reported confidence across the whole Core Advanced Curriculum. A strategy to develop and embed four pillar working for all pharmacists, as well as approaches to address systemic barriers for those working less than full-time may help deliver more 'advanced practice-ready' pharmacists.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond mechanical acts? Examining the provision for conscientious objection by pharmacy professionals in assisted suicide legislation in England and Wales.","authors":"Isaac Moore","doi":"10.1093/ijpp/riaf094","DOIUrl":"https://doi.org/10.1093/ijpp/riaf094","url":null,"abstract":"","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of policy changes on the sales of the environmentally harmful drug diclofenac in Sweden.","authors":"Christina Ljungberg Persson, Sebastian Aronsson, Helle Håkonsen","doi":"10.1093/ijpp/riaf092","DOIUrl":"https://doi.org/10.1093/ijpp/riaf092","url":null,"abstract":"<p><strong>Objectives: </strong>In Sweden, oral formulations of diclofenac became prescription-only in 2020, and over the counter (OTC) topical forms were placed behind the counter in 2023. This study investigated the effect of these policy changes on diclofenac dispensed or sold.</p><p><strong>Methods: </strong>Aggregated data on diclofenac dispensed against prescription or sold OTC from January 2019 to February 2024 were analysed descriptively.</p><p><strong>Key findings: </strong>The volume fell substantially after oral formulations became prescription-only. Placement of topical formulations behind the counter had a more modest effect.</p><p><strong>Conclusions: </strong>Policy changes have had a significant effect on the volume of diclofenac dispensed or sold in Sweden, especially the prescription requirement.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for chronic kidney disease in community pharmacy: Crierfac project.","authors":"José Espejo-Guerrero, Luis Salar-Ibáñez, Eduardo Satué-de-Velasco, Lourdes Martínez-Berganza-Asensio, Noemí Pérez-León","doi":"10.1093/ijpp/riaf088","DOIUrl":"https://doi.org/10.1093/ijpp/riaf088","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the outcomes of chronic kidney disease (CKD) screening in community pharmacies through creatinine measurement and glomerular filtration rate (GFR) estimation in patients meeting specific risk criteria.</p><p><strong>Methods: </strong>This was a multicenter observational study. People who entered participating pharmacies for any reason and met the inclusion criterion of not having a CKD diagnosis were invited to participate in the study. If they agreed, the pharmacist conducted a point-of-care blood creatinine test, and the GFR was calculated using the CKD-EPI formula. Those with a positive CKD indicator (<45 ml/min/1.73 m2) were referred to their general practitioner (GP) for evaluation. People with a GFR > 60 ml/min/1.73 m2 were not considered to have CKD. Those with a GFR between 45 and 60 ml/min/1.73 m2 were asked to return for reassessment 1 month later. Those with a GFR 45 < ml/min/1.73 m2 were then considered CKD-positive and referred to the GP. All the data were recorded by the pharmacist.</p><p><strong>Key findings: </strong>One hundred and forty-one community pharmacies from 40 provinces of Spain enrolled 2116 patients. In the first analysis, 1428 (67.5%) were negative, 165 (7.8%) were positive, and 523 (24.7%) needed a second analysis. In the second analysis, 164 (7.8%) were negative, 243 (11.5%) were positive, and 116 (5.5%) did not reattend. In summary, by intention to treat, 1592 (75.2%) were negative and 408 (19.3%) tested positive and were referred to their GP.</p><p><strong>Conclusions: </strong>The results of CKD detection in community pharmacies are in line with screening in other healthcare settings, confirming they could be a reliable resource in future population-screening strategies.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving role of pharmacists in addressing substance-related harm.","authors":"Jane L Sheridan, Mayyada Wazaify, Suzanne Nielsen","doi":"10.1093/ijpp/riaf080","DOIUrl":"https://doi.org/10.1093/ijpp/riaf080","url":null,"abstract":"","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":"33 5","pages":"455-457"},"PeriodicalIF":1.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in publicly and privately prescribed anxiolytics in Croatia: do we need a new regulatory framework.","authors":"Marta Kučan Štiglić, Tea Strbad, Andrej Belančić, Jasenka Mršić Pelčić, Dinko Vitezić","doi":"10.1093/ijpp/riaf051","DOIUrl":"10.1093/ijpp/riaf051","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to analyse changes in the prescribing trends of anxiolytics in Croatia over the past 15 years, focusing on changes in prescribing patterns and the average cost per defined daily dose (DDD) and to evaluate how frequently patients covered by the Croatian Health Insurance Fund (CHIF) received private prescriptions for anxiolytics.</p><p><strong>Methods: </strong>Data on total consumption of anxiolytics in Croatia were obtained from two sources: the IMS database and the CHIF database for the period from 2006 to 2022.</p><p><strong>Key findings: </strong>The total usage of anxiolytic drugs increased from 61.13 DDD/1000 in 2006 to 82.78 DDD/1000 in 2022, an increase of 35.42%, while the financial expenditure in the same period decreased by 15.57%. Diazepam is the anxiolytic drug with the highest prescription rate, with an increase of 67.42%. The highest increase overall was in the total consumption of alprazolam, despite a decrease from 21.22% in 2011 to 16.53% in 2022 in private prescriptions, indicating a substantial increase in prescriptions covered by insurers.</p><p><strong>Conclusions: </strong>Despite being either not recommended by clinical guidelines or of doubtful efficacy in many cases, prescribing of anxiolytics is common. There is a noticeable increase in anxiolytic drug use in Croatia during the investigated period, while the total financial expenditure has decreased due to price pressure on medications imposed by the national insurer. The high rate of private prescription of anxiolytics is observed. An enhanced national regulatory framework for prescribing anxiolytics in Croatia is needed.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":"515-520"},"PeriodicalIF":1.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community pharmacists' counselling practices for topical corticosteroid therapy in the management of atopic dermatitis-a cross-sectional survey.","authors":"Ella Cocoman, Juliette O'Connell, Ana Šešelja Perišin, Josipa Bukić, Doris Rušić, Mihaela Grgić, Dario Leskur","doi":"10.1093/ijpp/riaf053","DOIUrl":"10.1093/ijpp/riaf053","url":null,"abstract":"<p><strong>Objectives: </strong>Safe and effective use of topical corticosteroids (TCS) relies heavily on appropriate pharmacist counselling in community pharmacies, to optimize treatment and improve outcomes for patients suffering from atopic dermatitis. This study aimed to investigate community pharmacists (CPs)' counselling practices on TCS and their attitudes towards the fingertip unit (FTU) method, patients' knowledge, and adverse drug reactions (ADRs).</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among CPs in Croatia. A questionnaire was developed, which explored CPs' counselling practices on TCS, their awareness and implementation of the FTU method, and their experience with ADRs. Data was analysed using descriptive statistics.</p><p><strong>Key findings: </strong>A total of 351 participants engaged with the survey. Over half (57.5%, CI: 52.2%-62.8%) of CPs use a combination of verbal and written counselling, and the majority (>96.6%) explain the dose, method of administration, frequency, and duration of topical corticosteroid therapy to most of their patients. Most (75.2%) are familiar with the FTU method; however, less than half (43.9%) routinely explain it in their counselling. Approximately half of CPs (49%) believe that patients have insufficient information knowledge on the correct TCS application (dose, frequency, and duration of treatment).</p><p><strong>Conclusions: </strong>CPs' counselling practices focus primarily on the method of administration, frequency, and duration of treatment. CPs have a good awareness of the FTU method, however, are less likely to explain it routinely in practice. Additional education around TCS and ADR training may be beneficial for CPs to enhance their counselling practices.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":"501-507"},"PeriodicalIF":1.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study of pharmacy academics' perspectives on the scope of minor ailments in Indonesia and implications for pharmacy education.","authors":"Vinci Mizranita, Bruce Sunderland, Jeffery David Hughes, Tin Fei Sim","doi":"10.1093/ijpp/riaf052","DOIUrl":"10.1093/ijpp/riaf052","url":null,"abstract":"<p><strong>Objectives: </strong>To describe pharmacy academics' perceptions of scopes of practice, knowledge, and skills required for the education of pharmacists and pharmacy technicians in the management of minor ailments (MMAs) in Indonesia.</p><p><strong>Methods: </strong>Online surveys were designed for academic staff teaching pharmacy and pharmacy technician students from all 30 institutions in Central Java, Indonesia. Those teaching both courses received both questionnaires. Percentage of common responses (PCR) described the level of similarity of perceived scopes of practice. Descriptive analyses described respondents' demographics and characteristics.</p><p><strong>Key findings: </strong>No clear consensus was evident regarding the scopes of MA practice from academics teaching each group of students. The majority of academics teaching pharmacy students perceived that MAs such as migraine and indigestion (with the PCR >80%) should be exclusively managed by pharmacists, showing a strong consensus on the role of pharmacists in managing these ailments. Only a 50%-60% consensus was achieved on the scopes of MAs managed by pharmacy technicians. Some academics perceived pharmacy technicians were not competent to manage any MA. Notably, 52.9% of academics teaching pharmacy students taught management of MAs as a separate course, compared to 26.7% who taught pharmacy technician students.</p><p><strong>Conclusions: </strong>Discord in the scope of practice perceptions between academics teaching pharmacy and pharmacy technician students requires resolution, including the diverse nature of training involving MMAs. Clearly defined scopes of practice are required to achieve consistent education of MAs for pharmacy and pharmacy technician students.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":"526-533"},"PeriodicalIF":1.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality prescribing strategy for respiratory conditions in Scotland: improving patient care and promoting environmental sustainability.","authors":"Emily Kennedy, Karen Vint, Alpana Mair, Iain Wilson, Lesley Rose, Fiona Eastop, Stuart Law","doi":"10.1093/ijpp/riaf054","DOIUrl":"10.1093/ijpp/riaf054","url":null,"abstract":"<p><strong>Objectives: </strong>The respiratory prescribing strategy previously published by the Scottish Government did not include any environmental sustainability information and required updating to incorporate this. It was recognized that ~3% of the carbon footprint of NHS Scotland results from the use of pressurized metered dose inhalers due to the high global warming potential of inhaler propellants. The aims of the guide were to support clinicians and people with respiratory illness in the appropriate use of medicines, while applying the principles of value-based health care and realistic medicine, including environmental sustainability. Person-centred medication review, including optimising appropriate inhaler use, is promoted using the 7-step methodology described in the Scottish polypharmacy guidance.</p><p><strong>Methods: </strong>Stakeholders, including people with lived experience, third sector patient organizations and multidisciplinary team representatives from across primary and secondary care were invited to update the respiratory guide. Open consultation was undertaken before publication. Tools and resources to assist in implementation of the recommendations were developed, including data and patient facing resources.</p><p><strong>Key findings: </strong>The 'Quality Prescribing Strategy for Respiratory Conditions: a guide for improvement (2024-2027)' was published by the Scottish Government in April 2024. It highlights key recommendations for respiratory prescribing, to improve care of people living with respiratory conditions and to reduce environmental impact of respiratory care.</p><p><strong>Conclusions: </strong>The guide supports the implementation of national UK-based guidance, including the Scottish Intercollegiate Guidelines Network and National Institute for Health and Care Excellence guidance, together with the indicators and tools to drive improvement in prescribing and patient care by assisting clinicians with practical guidance and prescribing resources. It also supports healthcare organizations and sustainability committees to prioritize actions.</p>","PeriodicalId":14284,"journal":{"name":"International Journal of Pharmacy Practice","volume":" ","pages":"534-540"},"PeriodicalIF":1.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}