International Journal of Peptides最新文献_第6页

Modeling the QSAR of ACE-Inhibitory Peptides with ANN and Its Applied Illustration. ace抑制肽QSAR的神经网络建模及其应用实例。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2011-06-09 DOI: 10.1155/2012/620609

Ronghai He, Haile Ma, Weirui Zhao, Wenjuan Qu, Jiewen Zhao, Lin Luo, Wenxue Zhu

{"title":"Modeling the QSAR of ACE-Inhibitory Peptides with ANN and Its Applied Illustration.","authors":"Ronghai He, Haile Ma, Weirui Zhao, Wenjuan Qu, Jiewen Zhao, Lin Luo, Wenxue Zhu","doi":"10.1155/2012/620609","DOIUrl":"https://doi.org/10.1155/2012/620609","url":null,"abstract":"A quantitative structure-activity relationship (QSAR) model of angiotensin-converting enzyme- (ACE-) inhibitory peptides was built with an artificial neural network (ANN) approach based on structural or activity data of 58 dipeptides (including peptide activity, hydrophilic amino acids content, three-dimensional shape, size, and electrical parameters), the overall correlation coefficient of the predicted versus actual data points is R = 0.928, and the model was applied in ACE-inhibitory peptides preparation from defatted wheat germ protein (DWGP). According to the QSAR model, the C-terminal of the peptide was found to have principal importance on ACE-inhibitory activity, that is, if the C-terminal is hydrophobic amino acid, the peptide's ACE-inhibitory activity will be high, and proteins which contain abundant hydrophobic amino acids are suitable to produce ACE-inhibitory peptides. According to the model, DWGP is a good protein material to produce ACE-inhibitory peptides because it contains 42.84% of hydrophobic amino acids, and structural information analysis from the QSAR model showed that proteases of Alcalase and Neutrase were suitable candidates for ACE-inhibitory peptides preparation from DWGP. Considering higher DH and similar ACE-inhibitory activity of hydrolysate compared with Neutrase, Alcalase was finally selected through experimental study.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2012 ","pages":"620609"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/620609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29916759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Proline rich motifs as drug targets in immune mediated disorders. 富脯氨酸基团作为免疫介导疾病的药物靶点。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-05-16 DOI: 10.1155/2012/634769

Mythily Srinivasan, A Keith Dunker

{"title":"Proline rich motifs as drug targets in immune mediated disorders.","authors":"Mythily Srinivasan, A Keith Dunker","doi":"10.1155/2012/634769","DOIUrl":"10.1155/2012/634769","url":null,"abstract":"The current version of the human immunome network consists of nearly 1400 interactions involving approximately 600 proteins. Intermolecular interactions mediated by proline-rich motifs (PRMs) are observed in many facets of the immune response. The proline-rich regions are known to preferentially adopt a polyproline type II helical conformation, an extended structure that facilitates transient intermolecular interactions such as signal transduction, antigen recognition, cell-cell communication and cytoskeletal organization. The propensity of both the side chain and the backbone carbonyls of the polyproline type II helix to participate in the interface interaction makes it an excellent recognition motif. An advantage of such distinct chemical features is that the interactions can be discriminatory even in the absence of high affinities. Indeed, the immune response is mediated by well-orchestrated low-affinity short-duration intermolecular interactions. The proline-rich regions are predominantly localized in the solvent-exposed regions such as the loops, intrinsically disordered regions, or between domains that constitute the intermolecular interface. Peptide mimics of the PRM have been suggested as potential antagonists of intermolecular interactions. In this paper, we discuss novel PRM-mediated interactions in the human immunome that potentially serve as attractive targets for immunomodulation and drug development for inflammatory and autoimmune pathologies.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":" ","pages":"634769"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39973188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-rich plasma peptides: key for regeneration. 富血小板血浆肽:再生的关键。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-02-22 DOI: 10.1155/2012/532519

Dolores Javier Sánchez-González, Enrique Méndez-Bolaina, Nayeli Isabel Trejo-Bahena

引用次数: 191

Diverse Effects of Glutathione and UPF Peptides on Antioxidant Defense System in Human Erythroleukemia Cells K562. 谷胱甘肽和UPF肽对人红白血病细胞K562抗氧化防御系统的不同影响

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-02-15 DOI: 10.1155/2012/124163

Ceslava Kairane, Riina Mahlapuu, Kersti Ehrlich, Kalle Kilk, Mihkel Zilmer, Ursel Soomets

引用次数: 9

Synthesis of hemopressin peptides by classical solution phase fragment condensation. 经典液相片段缩合法合成加压素多肽。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-11-27 DOI: 10.1155/2012/186034

P Anantha Reddy, Sean T Jones, Anita H Lewin, F Ivy Carroll

引用次数: 7

Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease. 血管紧张素转换酶2 (ACE2)是肾素血管紧张素系统在健康和疾病中的关键调节剂。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-03-20 DOI: 10.1155/2012/256294

Chris Tikellis, M C Thomas

引用次数: 488

A Novel Cellular Model to Study Angiotensin II AT2 Receptor Function in Breast Cancer Cells. 研究乳腺癌细胞中血管紧张素II AT2受体功能的新细胞模型。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2011-12-06 DOI: 10.1155/2012/745027

Sylvie Rodrigues-Ferreira, Marina Morel, Rosana I Reis, Françoise Cormier, Véronique Baud, Claudio M Costa-Neto, Clara Nahmias

引用次数: 9

Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi. 人5HT1a受体胞内环2肽是Gi的差异激活因子。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-05-09 DOI: 10.1155/2012/490734

Brian Hall, Carley Squires, Keith K Parker

{"title":"Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi.","authors":"Brian Hall, Carley Squires, Keith K Parker","doi":"10.1155/2012/490734","DOIUrl":"https://doi.org/10.1155/2012/490734","url":null,"abstract":"Peptide mimics of intracellular loop 2 (ic2) of the human 5HT1a receptor have been studied with respect to their ability to inhibit agonist binding via interference with receptor-G-protein coupling. These peptides give shallow concentration-effect relationships. Additionally, these peptides have been studied with respect to their ability to trigger the signal transduction system of this Gi-coupled receptor. Two signaling parameters have been quantified: concentration of intracellular cAMP and changes in incorporation into the G protein of a stable analog of GTP. In both cases, peptide mimics near midloop of ic2 actually show agonist activity with efficacy falling off toward both loop termini near TM 3 and TM 4. Previous results have suggested that the loop region near the TM3/ic2 interface is primarily responsible for receptor-G-protein coupling, while the current result emphasizes the mid-ic2 loop region's ability to activate the G protein following initial coupling. A limited number of peptides from the receptor's TM5/ic3 loop vicinity were also studied regarding agonist inhibition and G-protein activation. These peptides provide additional evidence that the human 5HT1a receptor, TM5/ic3 loop region, is involved in both coupling and activation actions. Overall, these results provide further information about potential pharmacological intervention and drug development with respect to the human 5HT1a receptor/G-protein system. Finally, the structural evidence generated here provides testable models pending crystallization and X-ray analysis of the receptor.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2012 ","pages":"490734"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/490734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30656300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1. 人类肠道二肽/三肽转运蛋白hPEPT1一种新的非翻译序列变异的鉴定和表征。

International Journal of Peptides Pub Date : 2012-01-01 Epub Date: 2012-12-30 DOI: 10.1155/2012/743472

Helle Bach Søndergaard, Carsten Uhd Nielsen, Birger Brodin

引用次数: 1

Ghrelin, appetite regulation, and food reward: interaction with chronic stress. 胃饥饿素、食欲调节和食物奖励:与慢性应激的相互作用。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-09-21 DOI: 10.1155/2011/898450

Yolanda Diz-Chaves

引用次数: 41