P Anantha Reddy, Sean T Jones, Anita H Lewin, F Ivy Carroll
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引用次数: 7
摘要
报道了天然存在的CB(1)反激动剂非肽，pro - val - asn - ph - lys - phe /Leu-Leu-Ser-His-OH(加压素)的片段缩合液相组装，以及其他两个同源物:n端2氨基酸(二肽)延伸的非肽，val - asp - pro - val - asn - ph - lys -Leu-Leu-Ser-His-OH，和三氨基酸(三肽)延伸的十二肽，arg - val - asp - pro - val - asn - ph - lys -Leu-Leu-Ser-His-OH，都是CB(1)激动剂。
Synthesis of hemopressin peptides by classical solution phase fragment condensation.
A fragment condensation solution phase assembly of the naturally occurring CB(1) inverse agonist nonapeptides, Pro-Val-Asn-Phe-Lys-Phe/Leu-Leu-Ser-His-OH (hemopressins), and two other homologues: N-terminal 2-amino acid (dipeptide) extended undecapeptide, Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, and three-amino acid (tripeptide) extended dodecapeptide, Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, both CB(1) agonists, is reported.
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