International Journal of Peptides最新文献_第7页

An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. 脑源性神经营养因子的概述及其对海马兴奋毒性易感性的影响。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-09-28 DOI: 10.1155/2011/654085

Patrick S Murray, Philip V Holmes

{"title":"An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus.","authors":"Patrick S Murray, Philip V Holmes","doi":"10.1155/2011/654085","DOIUrl":"https://doi.org/10.1155/2011/654085","url":null,"abstract":"The present paper examines the nature and function of brain-derived neurotrophic factor (BDNF) in the hippocampal formation and the consequences of changes in its expression. The paper focuses on literature describing the role of BDNF in hippocampal development and neuroplasticity. BDNF expression is highly sensitive to developmental and environmental factors, and increased BDNF signaling enhances neurogenesis, neurite sprouting, electrophysiological activity, and other processes reflective of a general enhancement of hippocampal function. Such increases in activity may mediate beneficial effects such as enhanced learning and memory. However, the increased activity also comes at a cost: BDNF plasticity renders the hippocampus more vulnerable to hyperexcitability and/or excitotoxic damage. Exercise dramatically increases hippocampal BDNF levels and produces behavioral effects consistent with this phenomenon. In analyzing the literature regarding exercise-induced regulation of BDNF, this paper provides a theoretical model for how the potentially deleterious consequences of BDNF plasticity may be modulated by other endogenous factors. The peptide galanin may play such a role by regulating hippocampal excitability.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"654085"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/654085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30180805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 128

Applications of propargyl esters of amino acids in solution-phase Peptide synthesis. 氨基酸丙炔酯在固相多肽合成中的应用。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-06-16 DOI: 10.1155/2011/854952

Ramesh Ramapanicker, Rohit Gupta, Rajendran Megha, Srinivasan Chandrasekaran

引用次数: 1

Prenatal programming of human neurological function. 人类神经功能的产前编程。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-04-05 DOI: 10.1155/2011/837596

Curt A Sandman, Elysia P Davis, Claudia Buss, Laura M Glynn

引用次数: 176

The effects of ghrelin on energy balance and psychomotor activity in a goldfish model: an overview. 胃饥饿素对金鱼模型能量平衡和精神运动活动的影响:综述。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-05-24 DOI: 10.1155/2011/171034

Ki Sung Kang, Satowa Yahashi, Kouhei Matsuda

{"title":"The effects of ghrelin on energy balance and psychomotor activity in a goldfish model: an overview.","authors":"Ki Sung Kang, Satowa Yahashi, Kouhei Matsuda","doi":"10.1155/2011/171034","DOIUrl":"10.1155/2011/171034","url":null,"abstract":"The goldfish (Carassius auratus) has a number of merits as a laboratory animal, and we have extensively identified the mechanisms by which ghrelin regulates food intake in this species. For the first time, we have purified and characterized 11 molecular variants of ghrelin that are present in goldfish intestine and shown that 17-residue ghrelin, the predominant form with n-octanoyl modification, is biologically active and implicated in the regulation of food intake as an endogenous orexigenic factor. Ghrelin and its receptor system are present not only in peripheral tissues such as stomach and intestine, but also in the central nervous system. Recent studies have also revealed that a number of neuropeptides are widely distributed in the brain in key areas of emotional regulation, and their role as modulators of behavioral states is being increasingly recognized. Interestingly, administration of ghrelin induces an orexigenic effect and also modifies locomotor activity, suggesting the involvement of ghrelin in feeding control and regulation of energy balance. Information derived from studies of ghrelin has been increasing, and important results have been obtained from both fish and mammals. Here, we present an overview of the effects of ghrelin on energy balance and psychomotor activity in the goldfish as an animal model. The available data provide an insight into evolutionary background of ghrelin's multiple actions on energy homeostasis in vertebrates.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"171034"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/171034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30007719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro. 胃饥饿素是一种成骨细胞有丝分裂原，在体外增加破骨细胞骨吸收。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-09-08 DOI: 10.1155/2011/605193

Jessica L Costa, Dorit Naot, Jian-Ming Lin, Maureen Watson, Karen E Callon, Ian R Reid, Andrew B Grey, Jillian Cornish

{"title":"Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro.","authors":"Jessica L Costa, Dorit Naot, Jian-Ming Lin, Maureen Watson, Karen E Callon, Ian R Reid, Andrew B Grey, Jillian Cornish","doi":"10.1155/2011/605193","DOIUrl":"https://doi.org/10.1155/2011/605193","url":null,"abstract":"Ghrelin is released in response to fasting, such that circulating levels are highest immediately prior to meals. Bone turnover is acutely responsive to the fed state, with increased bone resorption during fasting and suppression during feeding. The current study investigated the hypothesis that ghrelin regulates the activity of bone cells. Ghrelin increased the bone-resorbing activity of rat osteoclasts, but did not alter osteoclast differentiation in a murine bone marrow assay nor bone resorption in ex vivo calvarial cultures. Ghrelin showed mitogenic activity in osteoblasts, with a strong effect in human cells and a weaker effect in rat osteoblasts. The expression of the human ghrelin receptor, GHSR, varied among individuals and was detectable in 25-30% of bone marrow and osteoblast samples. However, the rodent Ghsr expression was undetectable in bone cells and cell lines from rat and mouse. These data suggest that elevated levels of ghrelin may contribute to the higher levels of bone turnover that occurs in the fasted state.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"605193"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/605193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30137762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Antifungal activities of peptides derived from domain 5 of high-molecular-weight kininogen. 源自高分子量激肽原结构域 5 的多肽的抗真菌活性。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-09-14 DOI: 10.1155/2011/761037

Andreas Sonesson, Emma Andersson Nordahl, Martin Malmsten, Artur Schmidtchen

{"title":"Antifungal activities of peptides derived from domain 5 of high-molecular-weight kininogen.","authors":"Andreas Sonesson, Emma Andersson Nordahl, Martin Malmsten, Artur Schmidtchen","doi":"10.1155/2011/761037","DOIUrl":"10.1155/2011/761037","url":null,"abstract":"In both immunocompromised and immunocompetent patients, Candida and Malassezia are causing or triggering clinical manifestations such as cutaneous infections and atopic eczema. The innate immune system provides rapid responses to microbial invaders, without requiring prior stimulation, through a sophisticated system of antimicrobial peptides (AMPs). High molecular weight kininogen (HMWK) and components of the contact system have previously been reported to bind to Candida and other pathogens, leading to activation of the contact system. A cutaneous Candida infection is characterized by an accumulation of neutrophils, leading to an inflammatory response and release of enzymatically active substances. In the present study we demonstrate that antifungal peptide fragments are generated through proteolytic degradation of HMWK. The recombinant domain 5 (rD5) of HMWK, D5-derived peptides, as well as hydrophobically modified D5-derived peptides efficiently killed Candida and Malassezia. Furthermore, the antifungal activity of modified peptides was studied at physiological conditions. Binding of a D5-derived peptide, HKH20 (His(479)-His(498)), to the fungal cell membrane was visualized by fluorescence microscopy. Our data disclose a novel antifungal activity of D5-derived peptides and also show that proteolytic cleavage of HMWK results in fragments exerting antifungal activity. Of therapeutic interest is that structurally modified peptides show an enhanced antifungal activity.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"761037"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30160970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiolabeling of cramoll 1,4: evaluation of the biodistribution. cramoll 1,4的放射性标记:生物分布的评价。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-06-30 DOI: 10.1155/2011/945397

Beatriz Ferreira de Carvalho Patricio, Maria Helena Madruga Lima-Ribeiro, Maria Tereza Dos Santos Correia, Ana Maria Dos Anjos Carneiro-Leão, Marta de Souza Albernaz, Thiago Barboza, Sergio Augusto Lopes de Souza, Ralph Santos-Oliveira

引用次数: 7

In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH. 在中性 pH 值下体外筛选胰蛋白酶 E 活性增强肽肽合体。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-03-22 DOI: 10.1155/2011/834525

Madhu Biyani, Masae Futakami, Koichiro Kitamura, Tomoyo Kawakubo, Miho Suzuki, Kenji Yamamoto, Koichi Nishigaki

引用次数: 0

Use of ghrelin as a treatment for inflammatory bowel disease: mechanistic considerations. 使用胃饥饿素治疗炎症性肠病:机制考虑。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-08-09 DOI: 10.1155/2011/189242

Mark D Deboer

引用次数: 34

Structural and Functional Consequences Induced by Post-Translational Modifications in α-Defensins. α-防御素翻译后修饰诱导的结构和功能影响。

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-08-28 DOI: 10.1155/2011/594723

Enrico Balducci, Alessio Bonucci, Monica Picchianti, Rebecca Pogni, Eleonora Talluri

{"title":"Structural and Functional Consequences Induced by Post-Translational Modifications in α-Defensins.","authors":"Enrico Balducci, Alessio Bonucci, Monica Picchianti, Rebecca Pogni, Eleonora Talluri","doi":"10.1155/2011/594723","DOIUrl":"https://doi.org/10.1155/2011/594723","url":null,"abstract":"HNP-1 is an antimicrobial peptide that undergoes proteolytic cleavage to become a mature peptide. This process represents the mechanism commonly used by the cells to obtain a fully active antimicrobial peptide. In addition, it has been recently described that HNP-1 is recognized as substrate by the arginine-specific ADP-ribosyltransferase-1. Arginine-specific mono-ADP-ribosylation is an enzyme-catalyzed post-translational modification in which NAD(+) serves as donor of the ADP-ribose moiety, which is transferred to the guanidino group of arginines in target proteins. While the arginine carries one positive charge, the ADP-ribose is negatively charged at the phosphate moieties at physiological pH. Therefore, the attachment of one or more ADP-ribose units results in a marked change of cationicity. ADP-ribosylation of HNP-1 drastically reduces its cytotoxic and antibacterial activities. While the chemotactic activity of HNP-1 remains unaltered, its ability to induce interleukin-8 production is enhanced. The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"594723"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/594723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30130909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8