International Journal of Peptides最新文献_第10页

Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists. 胃肠肽的相互作用:胃饥饿素及其厌氧拮抗剂。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-01-06 DOI: 10.1155/2010/817457

Anna-Sophia Wisser, Piet Habbel, Bertram Wiedenmann, Burghard F Klapp, Hubert Mönnikes, Peter Kobelt

引用次数: 16

The prokinetic face of ghrelin. 促生长素的促动力学面。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-02-10 DOI: 10.1155/2010/493614

Hanaa S Sallam, Jiande D Z Chen

{"title":"The prokinetic face of ghrelin.","authors":"Hanaa S Sallam, Jiande D Z Chen","doi":"10.1155/2010/493614","DOIUrl":"https://doi.org/10.1155/2010/493614","url":null,"abstract":"This review evaluated published data regarding the effects of ghrelin on GI motility using the PubMed database for English articles from 1999 to September 2009. Our strategy was to combine all available information from previous literature, in order to provide a complete structured review on the prokinetic properties of exogenous ghrelin and its potential use for treatment of various GI dysmotility ailments. We classified the literature into two major groups, depending on whether studies were done in health or in disease. We sub-classified the studies into stomach, small intestinal and colon studies, and broke them down further into studies done in vitro, in vivo (animals) and in humans. Further more, the reviewed studies were presented in a chronological order to guide the readers across the scientific advances in the field. The review shows evidences that ghrelin and its (receptor) agonists possess a strong prokinetic potential to serve in the treatment of diabetic, neurogenic or idiopathic gastroparesis and possibly, chemotherapy-associated dyspepsia, postoperative, septic or post-burn ileus, opiate-induced bowel dysfunction and chronic idiopathic constipation. Further research is necessary to close the gap in knowledge about the effect of ghrelin on the human intestines in health and disease.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/493614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29197389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Ghrelin and metabolic surgery. 生长素和代谢手术。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-01-27 DOI: 10.1155/2010/217267

Dimitrios J Pournaras, Carel W le Roux

引用次数: 52

Ghrelin in female and male reproduction. 生长素在女性和男性生殖中的作用。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-03-14 DOI: 10.1155/2010/158102

Joëlle Dupont, Virginie Maillard, Stéphanie Coyral-Castel, Christelle Ramé, Pascal Froment

引用次数: 44

Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats. 胃切除大鼠厌食症重建依赖性恢复及调节胃饥饿素系统的时间相关性恢复。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-02-24 DOI: 10.1155/2010/365416

Masaru Koizumi, Katsuya Dezaki, Hiroshi Hosoda, Boldbaatar Damdindorj, Hideyuki Sone, Lu Ming, Yoshinori Hosoya, Naohiro Sata, Eiji Kobayashi, Kenji Kangawa, Hideo Nagai, Yoshikazu Yasuda, Toshihiko Yada

{"title":"Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats.","authors":"Masaru Koizumi, Katsuya Dezaki, Hiroshi Hosoda, Boldbaatar Damdindorj, Hideyuki Sone, Lu Ming, Yoshinori Hosoya, Naohiro Sata, Eiji Kobayashi, Kenji Kangawa, Hideo Nagai, Yoshikazu Yasuda, Toshihiko Yada","doi":"10.1155/2010/365416","DOIUrl":"https://doi.org/10.1155/2010/365416","url":null,"abstract":"Gastrectomy reduces food intake and body weight (BW) hampering recovery of physical conditions. It also reduces plasma levels of stomach-derived orexigenic ghrelin. This study explored changes in orexigenic ghrelin system in rats receiving total gastrectomy with Billroth II (B-II) or Roux-en-Y (R-Y) method. Feeding and BW were reduced by gastrectomy and subsequently recovered to a greater extent with R-Y than B-II while plasma ghrelin decreased similarly. At postoperative 12th week, ghrelin contents increased in the duodenum and pancreas, plasma ghrelin levels increased upon fasting, and ghrelin injection promoted feeding but not in earlier periods. In summary, gastrectomized rats partially recover feeding and BW, in a reconstruction-dependent manner. At 12th week, ghrelin is upregulated in extra-stomach tissues, plasma ghrelin levels are physiologically regulated, and orexigenic effect of exogenous ghrelin is restored. This time-related recovery of ghrelin system may provide a strategy for promoting feeding, BW, and thereby physical conditions in gastrectomized patients.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/365416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29199621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The roles of motilin and ghrelin in gastrointestinal motility. 胃动素和胃饥饿素在胃肠运动中的作用。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-02-03 DOI: 10.1155/2010/820794

Tetsuro Ohno, Erito Mochiki, Hiroyuki Kuwano

引用次数: 73

The avian proghrelin system. 鸟类促生长素系统。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-02-10 DOI: 10.1155/2010/749401

Mark P Richards, John P McMurtry

{"title":"The avian proghrelin system.","authors":"Mark P Richards, John P McMurtry","doi":"10.1155/2010/749401","DOIUrl":"https://doi.org/10.1155/2010/749401","url":null,"abstract":"To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system. These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues. Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it. While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals. This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system. Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/749401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29271719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1). 肽Pro-Leu-Gly-NH(2) (MIF-1)的脑激活。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-03-28 DOI: 10.1155/2010/537639

Reas S Khan, Chuanhui Yu, Abba J Kastin, Yi He, Rudolph H Ehrensing, Hung Hsuchou, Kirsten Prufer Stone, Weihong Pan

{"title":"Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1).","authors":"Reas S Khan, Chuanhui Yu, Abba J Kastin, Yi He, Rudolph H Ehrensing, Hung Hsuchou, Kirsten Prufer Stone, Weihong Pan","doi":"10.1155/2010/537639","DOIUrl":"https://doi.org/10.1155/2010/537639","url":null,"abstract":"MIF-1 (Pro-Leu-Gly-NH(2)) is a tripeptide for which the therapeutic potential in Parkinson's disease and depression has been indicated by many studies. However, the cellular mechanisms of action of MIF-1 are not yet clear. Here, we show the specific brain regions responsive to MIF-1 treatment by c-Fos mapping, and determine the kinetics of cellular signaling by western blotting of pERK, pSTAT3, and c-Fos in cultured neurons. The immunoreactivity of c-Fos was increased 4 hours after MIF-1 treatment in brain regions critically involved in the regulation of mood, anxiety, depression, and memory. The number of cells activated was greater after peripheral treatment (intravenous delivery) than after intracerebroventricular injection. In cultured SH-SY5Y neuronal cells, c-Fos was induced time- and dose-dependently. The activation of cellular c-Fos was preceded by a transient increase of mitogen-activated protein kinase pERK but a reduction of phosphorylated Signal Transducer and Activator of Transcription (pSTAT3) initially. We conclude that MIF-1 can modulate multiple cellular signals including pERK, and pSTAT3 to activate c-Fos. The cellular activation in specific brain regions illustrates the biochemical and neuroanatomical basis underlying the therapeutic effect of MIF-1 in Parkinson's disease and depression.","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/537639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29200122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Ghrelin in diabetes and metabolic syndrome. 胃饥饿素在糖尿病和代谢综合征中的作用。

International Journal of Peptides Pub Date : 2010-01-01 Epub Date: 2010-04-27 DOI: 10.1155/2010/248948

Leena Pulkkinen, Olavi Ukkola, Marjukka Kolehmainen, Matti Uusitupa

引用次数: 70

Effect of microwave radiation on enzymatic and chemical Peptide bond synthesis on solid phase. 微波辐射对固相酶和化学肽键合成的影响。

International Journal of Peptides Pub Date : 2009-01-01 Epub Date: 2009-03-25 DOI: 10.1155/2009/362482

Alessandra Basso, Loris Sinigoi, Lucia Gardossi, Sabine Flitsch

引用次数: 5