{"title":"Investigation of NMR signal-to-noise ratio for RF scroll microcoils","authors":"B. Gimi, S. Grant, G. Friedman, R. Magin","doi":"10.1109/MMB.2000.893748","DOIUrl":"https://doi.org/10.1109/MMB.2000.893748","url":null,"abstract":"Although NMR has the ability to investigate biological systems non-destructively, it suffers from low sensitivity compared to other analytical techniques. Therefore, optimizing radio frequency (RF) coils to improve sensitivity is an area of significant focus in NMR Sensitivity can be improved for mass- and volume-limited samples by reducing, coil diameter, and adding sensing layers to the coil. This paper demonstrates that around skin depth, coil sensitivity can be increased with additional sensing layers, by using multilayered scroll coil geometries. While solenoids have demonstrated increased sensitivity over conventional coils (Helmholtz, Saddle, and Birdcage), their dimensions are limited by wire diameter, and difficulty in fabrication at reduced dimensions. The novel scroll geometry avails of microfabrication techniques to provide flexibility in manufacturing coils at very reduced dimensions.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"325 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132741517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On-chip microfluidics for proteomic analysis by electrospray ionization/mass spectrometry","authors":"P. Tabourier, C. Druon, C. Rolando, P. Lefebvre","doi":"10.1109/MMB.2000.893823","DOIUrl":"https://doi.org/10.1109/MMB.2000.893823","url":null,"abstract":"Describes the development of a silicon integrated demonstrator coupled to an ElectroSpray Ionization source in view of protein analysis by Mass Spectrometry (ESI/MS). The design and the making of basic components: (i) a novel thermal valveless micropump, (ii) a Solid Phase Extraction (SPE) column and (iii) a hollow cantilever nanoemitter constitute the steps of the authors' ongoing technological program which will be achieved by their gathering within a single chip. At present a manifold prototype at a 10 /spl mu/m scale has been fabricated and is currently being tested.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128916990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of isoelectric focusing for sample preconditioning in a microfluidic electrochemical flow cell","authors":"C. Cabrera, K. Macounová, M. Holl, P. Yager","doi":"10.1109/MMB.2000.893804","DOIUrl":"https://doi.org/10.1109/MMB.2000.893804","url":null,"abstract":"A novel free-flow isoelectric focusing (IEF) implementation method has been developed, called /spl mu/IEF, as part of a larger effort to design microfluidic sample preconditioning techniques. The /spl mu/IEF method consists of a novel device in which the electrodes are in intimate contact with the bulk fluid and pH gradient formation is driven by the products of electrolysis generated at the electrodes. The /spl mu/IEF flow cell is fabricated using rapid prototyping techniques. /spl mu/IEF has been used successfully to concentrate vegetative bacteria and proteins. The thickness and position of the focused band can be adjusted by varying the buffer composition and the initial pH.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124605186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flexible microfluidic-device-stamp-system with integrated electrical sensor for real time DNA detection","authors":"H. Dobrinski, M. Wilkens, W. Benecke, J. Binder","doi":"10.1109/MMB.2000.893735","DOIUrl":"https://doi.org/10.1109/MMB.2000.893735","url":null,"abstract":"Describes the design of a reusable microfluidic flow cell for real time DNA detection. This Microfluidic-Device-Stamp-System (MDSS) is realized by a microstructured Silicon-Polymer-Hybrid that is pressed onto a sensing element consists of thin metallic interdigitated electrodes with immobilized capture DNA for hybridization detection. The hybridization temperature is controlled by integrated heating and sensing elements manufactured with standard microsystem technologies. Two-dimensional FEM flow analyses using ANSYS 5.5/FLOTRAN were done to optimize the homogeneities of fluid flow and DNA mass transport in the sensing region.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130529638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of two processes applied on signals representing microvascular blood cell phenomena to diagnose patients with peripheral arterial occlusive disease","authors":"A. Humeau, J.L. Saumey, J. L'Huillier","doi":"10.1109/MMB.2000.893805","DOIUrl":"https://doi.org/10.1109/MMB.2000.893805","url":null,"abstract":"Patients with peripheral arterial occlusive disease (PAOD) can be diagnosed thanks to the determination of reactive hyperemia parameters computed on laser Doppler flowmetry (LDF) signals. However, the computation of the latter parameters is very often subjective due to the presence of marked oscillations on LDF recordings. Previous works have been carried out to improve their determination. These works use wavelets to de-noise LDF signals. A first method processes LDF blood flux signals to compute time to peak flow and peak flow value. A second method, carried out on the concentration of moving blood cell signals (CMBC), gives time to peak CMBC and peak CMBC. The goal of the present work is to compare the two studies and reactive hyperemia parameters given by each one. This analysis therefore provides the determination of the most accurate method to use in order to diagnose patients with PAOD non invasively and by processing signals representing phenomena occurring at the micro-scale.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126249572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Najafi, K. Aminian, F. Loew, Y. Blanc, P. Robert
{"title":"An ambulatory system for physical activity monitoring in elderly","authors":"B. Najafi, K. Aminian, F. Loew, Y. Blanc, P. Robert","doi":"10.1109/MMB.2000.893847","DOIUrl":"https://doi.org/10.1109/MMB.2000.893847","url":null,"abstract":"A new method of physical activity monitoring is presented, which is able to detect body postures (sitting, standing and lying) and walking period in the elderly from only one kinematic sensor attached to the chest. Wavelet analysis in conjunction with a simple kinematics model was used to recognize different postural transitions and walking periods during daily physical activity. The method was tested on 11 elderly subjects (all community walkers) in a gait laboratory where an optical motion system (Vicon) was used as reference. A close correspondence was found between the two systems. The efficiency of the system for ambulatory monitoring outside of the laboratory was tested on 3 old subjects. High sensitivity (>90%) was obtained for the classification of usual physical activities.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126561816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norbert Noury, Thierry Hervé, Vincent Rialle, Gilles Virone, E. Mercier, G. Morey, Alfonso Infante Moro, T. Porcheron
{"title":"Monitoring behavior in home using a smart fall sensor and position sensors","authors":"Norbert Noury, Thierry Hervé, Vincent Rialle, Gilles Virone, E. Mercier, G. Morey, Alfonso Infante Moro, T. Porcheron","doi":"10.1109/MMB.2000.893857","DOIUrl":"https://doi.org/10.1109/MMB.2000.893857","url":null,"abstract":"The authors developed a system for remotely monitoring human behavior during daily life at home, to improve the security and the quality of life. The activity was monitored through infrared position sensors and magnetic switches. For the falls detection the authors had to develop a smart sensor. The local communications were performed using RF wireless links to reduce the cabling and to allow mobility of the person. An application software performs data exploitation locally but it also performs remote data transmission through the network. This project aim at expanding the telecare solution to a larger population of elderly people who are presently forced to live in hospices.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115961097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the integration of a microdialysis-based /spl mu/TAS with calibration facility on a silicon-glass sandwich","authors":"A. Sprenkels, W. Olthuis, P. Bergveld","doi":"10.1109/MMB.2000.893797","DOIUrl":"https://doi.org/10.1109/MMB.2000.893797","url":null,"abstract":"The integration is discussed of all parts of a microdialysis-based micro Total Analysis System or /spl mu/TAS. In particular a microdialysis probe, a potentiometric and amperometric ion- and enzyme sensor and a calibration dosing pump have been developed separately using different precision machining techniques. By modifying and adapting these parts they can be realized in one generic technology consisting of a stack of a silicon and a glass wafer. The silicon wafer contains the double lumen microdialysis probe connections, a dosing pump chamber with meander formed cavities containing the calibration solutions and small cavities for both the potentiometric and amperometric sensor. The glass wafer contains all the electrical contacts and wires for the sensors, the pump and Interconnections. Both wafers are anodically bonded to each other, yielding a hermetically sealed liquid handling system.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127014548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Takahashi, T. Ejiri, M. Nakao, K. Matsumoto, F. Mase, Y. Hatamura, T. Hervé, N. Nakamura, K. Kaga
{"title":"Surface multipoint microelectrode for direct recording of auditory evoked potentials on the auditory cortex of a rat","authors":"H. Takahashi, T. Ejiri, M. Nakao, K. Matsumoto, F. Mase, Y. Hatamura, T. Hervé, N. Nakamura, K. Kaga","doi":"10.1109/MMB.2000.893837","DOIUrl":"https://doi.org/10.1109/MMB.2000.893837","url":null,"abstract":"Stimulation of the cochlear nucleus has been used for rehabilitation of deafened patients with bilateral acoustic neuromas, but current prosthetic devices bring few benefits. The goals of the authors' study are to develop such a system that could provide neuronal data with a high spatiotemporal resolution, reveal auditory pathway functions, and develop efficient guidelines for designing prostheses. Here, the authors propose and fabricate the surface microelectrode for direct cortical recordings, which is flexible enough to stick onto the cortex and consists of 32 recording sites on 2-mm square area. In addition, the spike microelectrode array, in which four microelectrodes are aligned at even intervals of 400 /spl mu/m, was developed, and used for micro-stimulation of the cochlear nucleus. The system using these electrodes was developed and its feasibility was shown on rats' animal experiments. In the experiments, the authors show that the surface electrode can provide high-resolution data of cortical activities elicited by both acoustic and electrical stimulation and can demonstrate the functional stimulation of the spike microelectrode array.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133404886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Santana-Diaz, N. Hernández-Gress, D. Estève, B. Jammes
{"title":"Discriminating sensors for driver's impairment detection","authors":"A. Santana-Diaz, N. Hernández-Gress, D. Estève, B. Jammes","doi":"10.1109/MMB.2000.893851","DOIUrl":"https://doi.org/10.1109/MMB.2000.893851","url":null,"abstract":"In this work, the authors present a statistical analysis applied to different sensors on the driver's impairment detection problem. Their goal is to get a minimal number of discriminating sensors to match the requirements of an industrial prototype. The signals coming from these group of sensors are used to create artificial variables based on several mathematical transformations (wavelets, standard deviations) in order to fuse this information at a first level. The authors' statistical study is based on several steps: 1) the observation of the variation of the mean and variance of the different variables, 2) the test of Hypothesis F concerning a population's variance and then, an hypotheses test based on Student's t distribution for the means, 3) principal components analysis (PCA); and 4) general performance of the diagnosis system using or not the different variables. This study has been performed using experimental data coming from 10 drivers in real experiments involving fatigued drivers at a closed circuit and over a motorway. These experiments have been realised using the CopiTech demonstrator which is equipped with a group of sensors measuring physiologic, mechanical and environmental status in real time. The analysis is validated by the physical state of the driver based on EEG. Results stress that the better discriminating sensors are: a) lateral position, b) steering wheel angle, and c) vehicle speed.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116106640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}