N. Zine, A. Ivorra, J. Aguiló, R. Villa, J. Millan, J. Bausells, A. Errachid, P. Godignon, A. Benvenuto, L. Beccai, F. Valvo, A. Menciassi, P. Dario, M. Carrozza
{"title":"Multisensor silicon needle for cardiac applications","authors":"N. Zine, A. Ivorra, J. Aguiló, R. Villa, J. Millan, J. Bausells, A. Errachid, P. Godignon, A. Benvenuto, L. Beccai, F. Valvo, A. Menciassi, P. Dario, M. Carrozza","doi":"10.1109/MMB.2000.893775","DOIUrl":"https://doi.org/10.1109/MMB.2000.893775","url":null,"abstract":"An integrated chemical sensor with multiple ion and temperature sensors, composed of two ISFETs (pH and K/sup +/), one platinum pseudo-reference electrode and temperature sensor based on a platinum resistor has been realised by using a CMOS-compatible technology and silicon micromachining. This paper describes a summary of the fabrication process and results of the device characterisation in vitro. The feasibility of the fabrication technology has been demonstrated and all devices have operated satisfactory, with a response showing good sensitivity and linearity. This multisensor will be used in the on-line early detection of myocardial ischemia during cardiac surgery while the heart is artificially arrested (extracorporeal circulation).","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125742717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Khalifa, M. H. Bedoui, R. Raytchev, Mohamed Dogui
{"title":"A portable device for alertness detection","authors":"K. Khalifa, M. H. Bedoui, R. Raytchev, Mohamed Dogui","doi":"10.1109/MMB.2000.893852","DOIUrl":"https://doi.org/10.1109/MMB.2000.893852","url":null,"abstract":"The authors' aim is to conceive a tool that permits to characterize the levels of vigilance of vehicle drivers by recording in real time the physiological signal variation. The adopted way consists in developing a portable device composed of two parts: the first is analogical for signal shaping and the second is a numerical part. The latter is built up around a DSP (TMS320C31) which ensures signal acquisition from analogue/digital converters, storage, real time treatment and display decision. In this report the authors have implemented an algorithm that permits the treatment and detection of hypovigilance detection. They are currently studying the implementation of a decision algorithm, according to a database of 12 files of 24 hour-EEG registered in volunteers. The authors are studying variations of alpha, beta, theta and delta waves of the EEG in order to define decision levels about transitions of a vigilance state to another.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122377656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disposable CMOS catheter-tip pressure sensor for intracranial pressure measurement","authors":"L. Liew, V. Bright","doi":"10.1109/MMB.2000.893756","DOIUrl":"https://doi.org/10.1109/MMB.2000.893756","url":null,"abstract":"Presents a highly cost-effective sensor for intermittent measurement of average intracranial pressure. The key to the sensor's cost-effectiveness is its design for commercial-foundry fabrication and simple packaging approach. Unlike most conventional pressure sensors that require custom fabrication, the transducer chip in this work was fabricated entirely through a commercial CMOS process. The number of process steps required to fabricate an array of transducers is thus reduced, decreasing overall fabrication cost. The package design is simple, requiring no electrical feedthroughs or pressure ports, thereby also reducing manufacturing cost. The sensor has an accuracy of 90% over the range of 0 to 10 mmHg gauge, sensitivity of 0.7mV/V/mmHg, and a resolution of 1.25 mmHg, which is sufficient to measure the cardiac effect on intracranial pressure. The sensor has been found to be suitable for short-term (up to 0.5 hours continuous) or intermittent use, such as during surgery. The unconventional low-cost approach to the development of this sensor makes it a better candidate than existing sensors for disposable applications.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130565937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SPR sensor for detection of /spl beta/2-microglobulin","authors":"F. Abdelmalek, L. Kaabi, Z. Sassi, J. Bureau","doi":"10.1109/MMB.2000.893807","DOIUrl":"https://doi.org/10.1109/MMB.2000.893807","url":null,"abstract":"An optical fiber sensor based on the resonant coupling between a surface plasmon wave and a guided mode of the optical fiber sensor has been reported. A technique based on the surface plasmon resonance phenomenon offers a sensitive method for studying the stability of optical sensors. In this work, the authors consider a layered structure consisting of three-layer optical waveguides incorporating silver-monolayer of bovine serum albumin coating layers. Tests include exposing these films to /spl beta/2-microglobulin have been studied. Experimental and theoretical results have been mutually compared, and the operation characteristics of this novel sensing device have been briefly described.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123358309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Kaabi, F. Abdelmalek, Z. Sassi, J. Bureau, W. Belhadj, B. Ballard
{"title":"On the knocked oxygen contribution to low energy implanted boron diffusion retardation","authors":"L. Kaabi, F. Abdelmalek, Z. Sassi, J. Bureau, W. Belhadj, B. Ballard","doi":"10.1109/MMB.2000.893806","DOIUrl":"https://doi.org/10.1109/MMB.2000.893806","url":null,"abstract":"Boron was implanted in crystalline silicon through oxide layers with different thicknesses. The implantation is carried out at various doses and energies of interest in Ultra Large Scale Integration (ULSI) applications. Rapid thermal annealings (RTA) are used in a way to obtain shallow junctions and electrical activation of the B atoms. However, transient enhanced diffusion induced by implantation damage can be observed on boron profiles before and after annealing obtained with secondary ion mass spectrometry (SIMS). It is found that the diffusion transient in the tail region of the boron profile increases with decreasing oxide thickness. Even more, if the implantation damage concerns mostly the oxide, i.e. when the concentration peak is located into this oxide, the oxygen knocked into the silicon substrate could play an important role in restricting the boron diffusion.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123687528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ballandras, P. Guine, P. Maitre, W. Steichen, B. Piranda, J. Gelly
{"title":"Miniaturised annular transducers built using ultrasound micromachining for medical imaging application","authors":"S. Ballandras, P. Guine, P. Maitre, W. Steichen, B. Piranda, J. Gelly","doi":"10.1109/MMB.2000.893769","DOIUrl":"https://doi.org/10.1109/MMB.2000.893769","url":null,"abstract":"Fabrication and test of a 2 mm diameter 4 channel annular array is described. Comparison between experimentally measured and theoretically predicted admittance of the transducer elements is reported. The theoretical 3D finite element analysis is finally used to identify the electrically measured vibration mode of the device.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"242 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121294371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of RF spiral surface coils for NMR spectroscopy","authors":"S. Erogin, S. Grant, G. Friedman, R. Magin","doi":"10.1109/MMB.2000.893749","DOIUrl":"https://doi.org/10.1109/MMB.2000.893749","url":null,"abstract":"Although used extensively in magnetic resonance imaging, radio frequency (RF), surface coils have not been applied widely to high-resolution spectroscopy. Inherent sensitivity limitations and potential field distortions primarily have hampered their utility. However, surface coils do offer several benefits that could prove useful in NMR spectroscopy. Easy to construct through the use of photolithography, these coils can be scaled and configured to the samples under investigation, especially cultured cells and other ex vivo biological samples. Surface coils also can be arrayed to improve coverage areas and signal-to-noise ratios (SNR). However, in designing microcoils, optimization of the geometrical parameters by taking the eddy current losses into account has considerable importance and can substantialy improve SNR. Here, the authors develop an semi-analytical model to estimate the losses for the spiral geometry that is valid for wide range of geometrical parameters.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114732924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and implementation of denoising filter for echocardiographic images based on wavelet method","authors":"Su Cheol Kang, S. Hong","doi":"10.1109/MMB.2000.893746","DOIUrl":"https://doi.org/10.1109/MMB.2000.893746","url":null,"abstract":"One of the most important aspects of diagnostic echocardiography is the need to reduce speckle noise and to improve image quality. Here the authors prepose a simple and effective filter design for image denoising and contrast enhancement based on the multiscale wavelet denoising method. Wavelet threshold algorithms replace wavelet coefficients of small magnitude with zero and keep or shrink the other coefficients. This is basically a local procedure, since wavelet coefficients characterize the local regularity of a function. Next, the authors estimate the distribution of noise within the echocardiographic image. Then they apply a wavelet threshold algorithm. A common way of the estimating the speckle noise level in coherent imaging to calculate the mean-to-standard-deviation ratio of the pixel intensity, often termed the Equivalent Number of Looks (ENL) over a uniform image area. Unfortunately, the authors found this measure not very robust, mainly because of the difficulty in identification of a uniform area in a real image. For this reason, they only use here the S/MSE ratio which corresponds to the standard SNR in the case of additive noise. The authors have simulated some echocardiographic images by specialized hardware for real-time application: processing of a 512*512 images takes about 1 min. The authors' experiments show that the optimal threshold level depends on the spectral content of the image. High spectral content tends to over-estimate the noise standard deviation estimation performed at the finest level of the DWT. As a result, a lower threshold parameter is required to get the optimal S/MSE. The standard WCS theory predicts a threshold that depends on the number of signal samples only.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128094745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biotranport and biocompatibility of nanoporous biocapsules","authors":"L. Leoni, Tejal, Desai","doi":"10.1109/MMB.2000.893753","DOIUrl":"https://doi.org/10.1109/MMB.2000.893753","url":null,"abstract":"This study investigates whether nanoporous micromachined biocapsules, with uniform membrane pore sizes of 24.5 nm, can be used to encapsulate insulin secreting cells in vitro. This approach to cell encapsulation is based on microfabrication technology whereby immunoisolation membranes are bulk and surface micromachined to present uniform and well-controlled pore sizes as small as 10 nanometers, tailored surface chemistries, and precise microarchitectures. This study evaluates the behavior of insulinoma cells with micromachined membranes, the effect of matrix configurations within the biocapsule on cell behavior, as well as insulin and glucose transport through the biocapsule membranes.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125980107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioluminescent based chemchip for point-of-care diagnostics","authors":"D. Bartholomeusz, J. Andrade, A. B. Frazier","doi":"10.1109/MMB.2000.893856","DOIUrl":"https://doi.org/10.1109/MMB.2000.893856","url":null,"abstract":"The design and progress of a MEMS prototype biochip device, which uses bioluminescence as a means for detecting a potential of 10-100 total analytes from biofluid samples, is discussed. Light enhancement was explored by coating etched square chambers with chromium and silver. Light enhancement was also investigated by observing the transmittance of light along micro channels molded in PDMS. Bioluminescent light generated from a 1-mM ATP with firefly luciferase/luciferin solution was placed inside the channels and chambers and the light output was observed through a close up lens by a CCD. Light enhancement effectiveness was determined from the CCD count increase per nL of sample volume for the cross sectional viewing areas of the channels or chambers. Uncoated silicon, chromium coated and silver coated square chambers enhanced light output about 1-4 CCD counts/nL, 3-13 CCD counts/nL, and 300 to 1,300 CCD counts/nL respectively. Uncoated PDMS channels enhance light by about 79-101 CCD counts/nL.","PeriodicalId":141999,"journal":{"name":"1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129381345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}