International Journal of Oral Science最新文献_第4页

Expert consensus on the management of third molar health. 专家对第三磨牙健康管理的共识。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-04-15 DOI: 10.1038/s41368-025-00413-4

Rui Sun,Yifan Xu,Yang Wu,Jian Pan,Chenchen Zhou,Duohong Zou,Yujiang Wang,Yang Xue,Yu Cai,Nianhui Cui,Kaijin Hu,Wei Zhang,Bing Han,Qing Zhou,Songling Chen,Haikuo Tang,Liao Wang,Xing Wang,Bo Li,Zhigui Ma,Xiangliang Xu,Zhige Li,Ye Wu,Guowen Sun,Fudong Zhu,Yanping Hu,Kang Gao,Jian Zhou,Jihong Zhao

{"title":"Expert consensus on the management of third molar health.","authors":"Rui Sun,Yifan Xu,Yang Wu,Jian Pan,Chenchen Zhou,Duohong Zou,Yujiang Wang,Yang Xue,Yu Cai,Nianhui Cui,Kaijin Hu,Wei Zhang,Bing Han,Qing Zhou,Songling Chen,Haikuo Tang,Liao Wang,Xing Wang,Bo Li,Zhigui Ma,Xiangliang Xu,Zhige Li,Ye Wu,Guowen Sun,Fudong Zhu,Yanping Hu,Kang Gao,Jian Zhou,Jihong Zhao","doi":"10.1038/s41368-025-00413-4","DOIUrl":"https://doi.org/10.1038/s41368-025-00413-4","url":null,"abstract":"The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections. Impacted third molars significantly increase the risk of periodontitis, dental caries, and external root resorption of adjacent second molars. Third molars are associated with complex surgical procedures, and treatment decisions and clinical management of third molars in this context remain controversial. This expert consensus was generated by oral surgeons and related specialists, who synthesized the current evidence-based literature and contemporary clinical practices. This consensus addresses critical considerations: the developmental trajectory and impaction characteristics of third molars, clinical and radiographic examinations of third molars, classification of impacted third molars, adverse effects of impacted third molars on oral health, indications for extraction, preoperative preparation for impacted third molar removal, anesthetic choices for impacted third molar surgery, recommended surgical protocol for impacted third molar removal, application of implant materials in alveolar sockets, management of common severe complications in impacted third molar extraction, and functional utilization of impacted third molars. Based on a comprehensive expert deliberation, this consensus provides evidence-based clinical guidance and standardized protocols for dental practitioners in the context of third molar management and therapeutic decision-making.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"68 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway SLIT3: Akt/GSK3β/β-catenin信号通路中牙源性分化的新调控因子

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-04-13 DOI: 10.1038/s41368-026-00426-7

Lingyu Jiang, Liu Liu, Fan Yang, Yujia Cui, Jing Xie, Dongzhe Song, Yi Fan, Dingming Huang, Jianxun Sun

{"title":"SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway","authors":"Lingyu Jiang, Liu Liu, Fan Yang, Yujia Cui, Jing Xie, Dongzhe Song, Yi Fan, Dingming Huang, Jianxun Sun","doi":"10.1038/s41368-026-00426-7","DOIUrl":"https://doi.org/10.1038/s41368-026-00426-7","url":null,"abstract":"The odontogenic differentiation of Stem Cells from Apical Papilla (SCAP) are governed by various extracellular matrix proteins, playing a crucial role in dentin formation and regeneration. Extracellular matrix protein SLIT3, a classical axon guidance molecule, has been identified as a clastokine linking bone resorption to formation. However, its role in odontogenesis is not well-documented. Thus, our study aimed to explore the effects and mechanisms of SLIT3 on SCAP proliferation and differentiation. Analysis of developing mouse molars showed that while Slit3 mRNA was restricted to the dental mesenchyme, the SLIT3 protein was prominently detected on both odontoblasts and adjacent epithelial ameloblasts. Real time polymerase chain reaction (RT-PCR) and Western blot assays confirmed increased SLIT3 expression during SCAP odontogenic differentiation. SLIT3 siRNA knockdown and recombinant human SLIT3 (rhSLIT3) protein treatments were administered to SCAP. Cell Counting Kit-8 (CCK8) assays indicated that SLIT3 promotes SCAP proliferation, while alkaline phosphatase (ALP) and Alizarin red staining showed increased mineralization. Odontogenic markers DMP-1 and DSPP were also modulated accordingly. Additionally, rhSLIT3 treatment enhanced p-Akt and p-GSK3β levels in SCAP, promoting β-catenin nuclear translocation. The effects of SLIT3 were negated with an Akt/GSK3β/β-catenin signaling pathway inhibitor. Collectively, our data suggest that SLIT3 promotes SCAP proliferation and odontogenic differentiation via the Akt/GSK3β/β-catenin signaling pathway activation.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"58 1 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The structure and function of taste G protein-coupled receptors and their implications in diseases. 味觉G蛋白偶联受体的结构和功能及其在疾病中的意义。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-04-10 DOI: 10.1038/s41368-026-00436-5

Ruohan Zhai,Xihao Yong,Peihua Jiang,Marco Tizzano,Zhenhua Shao,Wei Yan,Xin Zheng

{"title":"The structure and function of taste G protein-coupled receptors and their implications in diseases.","authors":"Ruohan Zhai,Xihao Yong,Peihua Jiang,Marco Tizzano,Zhenhua Shao,Wei Yan,Xin Zheng","doi":"10.1038/s41368-026-00436-5","DOIUrl":"https://doi.org/10.1038/s41368-026-00436-5","url":null,"abstract":"Taste G protein-coupled receptors (GPCRs), including sweet (TAS1Rs) and bitter (TAS2Rs) taste receptors, are essential for detecting nutrients and avoiding toxins, influencing dietary behavior, metabolism, and overall health. Beyond their role in taste perception, these receptors are widely expressed in extra-gustatory tissues, including the respiratory and gastrointestinal systems, where they regulate innate immune responses, hormone secretion, and energy balance. Dysfunctions or polymorphisms in TAS1Rs and TAS2Rs have been linked to various diseases such as asthma, type 2 diabetes, obesity, dental caries, periodontitis, and certain cancers. The structural features of these receptors, including their ligand-binding domains and signaling pathways, are central to their diverse functions. Recent studies also highlight their potential as therapeutic targets for managing conditions like metabolic syndrome and immune-related disorders. This review provides a detailed examination of the structural and functional dynamics of TAS1Rs and TAS2Rs, emphasizing their roles in disease mechanisms and exploring therapeutic strategies. While challenges remain in structural resolution and functional characterization, advancements in molecular modeling and pharmacological approaches shed light on their clinical potential. Understanding the tissue-specific roles and molecular mechanisms of taste GPCRs can pave the way for innovative treatments targeting these receptors, offering significant promise in addressing a range of health conditions.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"21 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147649006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development. OGT介导MEIS2的o - glcn酰化并影响腭成骨发育。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-04-06 DOI: 10.1038/s41368-026-00431-w

Zhongyin Zhang,Zerui Shan,Xinyu Chen,Yu Xia,Li Meng,Yuxin Zhang,Caihong Wu,Lichan Yuan,Junqing Ma

{"title":"OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development.","authors":"Zhongyin Zhang,Zerui Shan,Xinyu Chen,Yu Xia,Li Meng,Yuxin Zhang,Caihong Wu,Lichan Yuan,Junqing Ma","doi":"10.1038/s41368-026-00431-w","DOIUrl":"https://doi.org/10.1038/s41368-026-00431-w","url":null,"abstract":"Post-translational modifications (PTMs) have been gradually elucidated in congenital malformations such as cleft palate. Among them, O-GlcNAcylation as a dynamic PTM of proteins regulates various critical biological processes including transcription, translation, and cell fate determination. In this study, a substantial decline in O-linked β-D-N-acetylglucosamine (O-GlcNAc) levels was detected within the palatine plates of all-trans retinoic acid (atRA)-induced cleft palate mice. The role of O-GlcNAc transferase (OGT), the sole enzyme responsible for catalyzing O-GlcNAcylation, was investigated in the process of palatal development. In a zebrafish model, the loss of O-GlcNAc resulted in an elevated prevalence of cleft palate and compromised palatal bone formation. Mechanistically, O-GlcNAcylation of myeloid ecotropic viral integration site 2 (MEIS2), which is mediated by OGT, was found to maintain osteogenic homeostasis by modulating its protein stability through inhibition of ubiquitination. Notably, the serine 237 residue (Ser237) was identified as a critical site for MEIS2 O-GlcNAcylation. Together, the present study uncovers the important function of MEIS2 O-GlcNAcylation in palatal bone development and establishes a novel theoretical framework for understanding the regulatory network of palatal development. This finding may provide novel avenues for the future diagnosis and prevention of cleft palate.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"2 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study. 早期慢性肾病患者牙周炎与肾功能下降和蛋白尿的关系：一项基于人群的研究

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-04-06 DOI: 10.1038/s41368-026-00435-6

Christian Schmidt-Lauber,Merle Ebinghaus,Katrin Borof,Berit Lieske,Alexandre Klopp,Christina Thompson,Loujain Wees,Zambaka Dawood,Guido Heydecke,Thomas Beikler,Tobias B Huber,Ghazal Aarabi

{"title":"Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study.","authors":"Christian Schmidt-Lauber,Merle Ebinghaus,Katrin Borof,Berit Lieske,Alexandre Klopp,Christina Thompson,Loujain Wees,Zambaka Dawood,Guido Heydecke,Thomas Beikler,Tobias B Huber,Ghazal Aarabi","doi":"10.1038/s41368-026-00435-6","DOIUrl":"https://doi.org/10.1038/s41368-026-00435-6","url":null,"abstract":"Periodontitis has been linked to chronic kidney disease (CKD) through systemic inflammation. However, evidence in early CKD remains limited. We analyzed 6 179 participants from a population-based cohort (median age 62 years; 51% women). Periodontitis was classified according to the 2017 American Academy of Periodontology / European Federation of Periodontology criteria. Kidney function was assessed by the combined creatinine- and cystatin C-based estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (uACR). Associations of periodontitis stages and mean clinical attachment loss (CAL) with eGFR and uACR were examined using multivariable linear regression adjusted for age, sex, diabetes, and smoking. Mediation analyses tested indirect effects of high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). Prevalence of severe periodontitis increased from 14% in individuals with normal kidney function (eGFR ≥60 mL/min per 1.73 m²) to 36% in those with moderately reduced eGFR (<60 mL/min per 1.73 m²) and from 21% in individuals without albuminuria (<10 mg/g) to 32% in those with moderately increased albuminuria (29-300 mg/g). After adjustment, Stage IV periodontitis was independently associated with lower eGFR (β-1.08 mL/min per 1.73 m²; 95% CI-2.04 to -0.12) and higher Blom-transformed uACR (β 0.09; 95% CI 0.01-0.16) compared with Stage I/II. hsCRP partially mediated these associations, accounting for 35% of the association with eGFR and 10% with uACR. These findings suggest that both inflammatory and non-inflammatory pathways may link periodontitis to early CKD. Periodontitis was associated with reduced eGFR and higher uACR in early CKD. While overlapping risk factors contribute, an independent association remained, only partly explained by systemic inflammation.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"52 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress in heterogeneity of dental mesenchymal stem cells. 牙间充质干细胞异质性的研究进展。

IF 17.6 1区医学

International Journal of Oral Science Pub Date : 2026-04-03 DOI: 10.1038/s41368-026-00433-8

Hanqi Fu, Peng Chen, Zuping Wu, Xiangwei Kong, Li Xu, Xinyi Fang, Chi Liao, Xinlei Yu, Qianming Chen, Xiaoyan Chen

{"title":"Research progress in heterogeneity of dental mesenchymal stem cells.","authors":"Hanqi Fu, Peng Chen, Zuping Wu, Xiangwei Kong, Li Xu, Xinyi Fang, Chi Liao, Xinlei Yu, Qianming Chen, Xiaoyan Chen","doi":"10.1038/s41368-026-00433-8","DOIUrl":"10.1038/s41368-026-00433-8","url":null,"abstract":"Dental tissues development involves two distinct cell lineages: mesenchymal cells (derived from the cranial neural crest) and epithelial cells (derived from oral ectoderm and pharyngeal epithelium). Emerging evidence highlights the remarkable functional heterogeneity of cranial neural crest-derived dental mesenchymal stem cells (DMSCs), exhibiting pluripotency, self-renewal, and differentiation capacities. This heterogeneity enables a single DMSC population to generate specialized subpopulations with unique roles in teeth and periodontal tissues formation. Significant progress has been made in characterizing six major types of DMSCs and two populations of closely related cells: Tooth germ progenitor cells (TGPCs) and dental follicle stem cells (DFSCs), critical during early morphogenesis; Stem cells from human exfoliated deciduous teeth (SHEDs) and apical papilla stem cells (SCAPs), pivotal for root development; Dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), gingival mesenchymal stem cells (GMSCs) and alveolar bone mesenchymal stem cells (ABMSCs), essential for maintaining and regenerating mature dental tissues. A key breakthrough has unveiled the development and hierarchy of DMSCs by applying new techniques like single-cell RNA sequencing (scRNA-seq). To integrate insights into the development of teeth and periodontal tissues, this review synthesizes current knowledge on both developmental heterogeneity and subpopulation heterogeneity within DMSCs and related cells. These insights not only advance fundamental understanding of the developmental mechanisms of teeth and periodontal tissues, but also establish a promising framework for achieving more efficient tissue regeneration and repair engineering.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"18 1","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients. 专家对成人正畸患者牙槽嵴增强术的共识。

IF 17.6 1区医学

International Journal of Oral Science Pub Date : 2026-03-25 DOI: 10.1038/s41368-026-00430-x

Runzhi Guo, Xiaotong Li, Jianxia Hou, Yiping Huang, Bing Fang, Hong He, Zuolin Jin, Fuhua Yan, Lin Wang, Yuxing Bai, Wenjie Hu, Lili Chen, Jinlin Song, Xianglong Han, Fang Jin, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Haiping Lu, Bin Yan, Yan Xu, Wensheng Ma, Yifan Lin, Xiao Xu, Li Xu, Weiran Li

{"title":"Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients.","authors":"Runzhi Guo, Xiaotong Li, Jianxia Hou, Yiping Huang, Bing Fang, Hong He, Zuolin Jin, Fuhua Yan, Lin Wang, Yuxing Bai, Wenjie Hu, Lili Chen, Jinlin Song, Xianglong Han, Fang Jin, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Haiping Lu, Bin Yan, Yan Xu, Wensheng Ma, Yifan Lin, Xiao Xu, Li Xu, Weiran Li","doi":"10.1038/s41368-026-00430-x","DOIUrl":"10.1038/s41368-026-00430-x","url":null,"abstract":"Alveolar bone defects, including dehiscence and fenestration, are commonly encountered in adult patients seeking orthodontic treatment. These anatomical deficiencies increase the risk of periodontal complications and may significantly compromise orthodontic tooth movement. Alveolar bone defects can also develop during orthodontic treatment, particularly in adult patients with narrow alveolar ridges requiring excessive tooth movement. Orthodontic-associated alveolar ridge augmentation (OARA) is an effective treatment approach that provides additional bone support and facilitates tooth movement, thereby reducing the incidence of periodontal complications and accelerating and broadening the scope of movement. At present, standardized diagnostic and treatment protocols for OARA in adult patients are lacking. This expert consensus aims to provide evidence-based recommendations for OARA in adult patients. A multidisciplinary panel of 27 experts conducted a Delphi-style process incorporating a targeted literature review and three voting rounds, achieving ≥70% agreement. Twenty-nine consensus statements across seven clinical domains, including pre-OARA examination, indications, bone graft material selection, timing, surgical protocols, standard operating procedures and considerations, were established with recommendations graded according to adapted GRADE criteria. This report presents a structured clinical framework for OARA and identifies future research priorities.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"18 1","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis. Gli2和Gli3协同介导间充质祖细胞中HH-TGF-β串音，协调牙根形态发生。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-03-12 DOI: 10.1038/s41368-026-00427-6

Tao Zhou,Linyang Huang,Yaxin Xie,Yijia Yin,Yufei Yao,Li Mei,Paul R Cooper,Hu Zhao,Xianglong Han,Junjun Jing

{"title":"Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis.","authors":"Tao Zhou,Linyang Huang,Yaxin Xie,Yijia Yin,Yufei Yao,Li Mei,Paul R Cooper,Hu Zhao,Xianglong Han,Junjun Jing","doi":"10.1038/s41368-026-00427-6","DOIUrl":"https://doi.org/10.1038/s41368-026-00427-6","url":null,"abstract":"Hedgehog (HH) signaling is essential in directing the fate determination of postmigratory cranial neural crest cells (CNCCs) to ensure proper craniofacial development. Gli transcription factors (TFs) are established as primary effectors of HH signaling, yet their distinct roles and regulatory mechanisms in governing cell commitment and differentiation of postmigratory CNCCs remain poorly understood. Here, using tooth root as a model, we combined transgenic mouse models with bioinformatic analyses to interrogate the functions of Gli2 and Gli3 in CNCC-derived root progenitor cells of the mouse molar. We revealed that loss of Gli3 alone in dental mesenchymal root progenitor cells caused shortened roots and that concurrent loss of Gli2 and Gli3 exacerbated root malformations, concomitant with profound impairments in cell proliferation and multilineage differentiation, suggesting a synergistic interaction between Gli2 and Gli3 during tooth root development. Mechanistically, Gli2 and Gli3 cooperatively regulated the transcription of Acvr2b, thereby modulating the activity of TGF-β/SMAD signaling within the dental mesenchyme. This Gli2/Gli3-TGF-β signaling cascade was critical for the lineage specification of tooth root progenitor cells during molar morphogenesis. Collectively, this work uncovers synergistic interactions of Gli2 and Gli3 in orchestrating tooth root morphogenesis and provides a novel insight into HH-TGF-β crosstalk in cell fate decisions of postmigratory CNCCs.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"26 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models. 通过机械应力和关节盘紊乱模型确定TMJ骨关节炎发病时的亚细胞滑膜反应。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-03-12 DOI: 10.1038/s41368-025-00411-6

Kazuhiro Shibusaka,Soichiro Negishi,Asuka Terashima,Miki Maemura,Hiroshi Yoshida,Masahiro Hosonuma,Nobuhiro Sakai,Young Kwan Kim,Yutaka Suzuki,Hiroyuki Okada,Fumiko Yano

{"title":"Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models.","authors":"Kazuhiro Shibusaka,Soichiro Negishi,Asuka Terashima,Miki Maemura,Hiroshi Yoshida,Masahiro Hosonuma,Nobuhiro Sakai,Young Kwan Kim,Yutaka Suzuki,Hiroyuki Okada,Fumiko Yano","doi":"10.1038/s41368-025-00411-6","DOIUrl":"https://doi.org/10.1038/s41368-025-00411-6","url":null,"abstract":"Temporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various adaptive, inflammatory, and mechanical stressors. In this study, we describe molecular alterations of the synovium of the articular disk in response to mechanical and inflammatory stimuli. Using an integrated transcriptomic approach combining subcellular spatial transcriptomics and single-cell RNA sequencing in murine models of mechanical stress and articular disk derangement, we characterized synovial changes associated with adipogenesis, fibrosis, and macrophage activation. In addition, cell type-and cluster-specific catabolic changes were observed under these stress conditions, suggesting potential contributions to TMJ-OA onset. These results provide a methodology-oriented resource for investigating the molecular pathology of TMJ disorders and may help guide future studies toward the development of targeted therapeutic strategies.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"15 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion 带有GKG连接体的生物工程α-发夹肽TKH：用于纤维内再矿化和牙本质深部小管闭塞的llps介导的仿生矿化系统

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2026-03-05 DOI: 10.1038/s41368-026-00425-8

Yeling Ou, Jing Wang, Luoyao Wang, Haisheng Wang, Fengfan He, Longjiang Ding, Yanping Zhou, Sili Han, Linglin Zhang

{"title":"Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion","authors":"Yeling Ou, Jing Wang, Luoyao Wang, Haisheng Wang, Fengfan He, Longjiang Ding, Yanping Zhou, Sili Han, Linglin Zhang","doi":"10.1038/s41368-026-00425-8","DOIUrl":"https://doi.org/10.1038/s41368-026-00425-8","url":null,"abstract":"Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abrasion or demineralization. For an effective long-term therapeutic desensitizing agent, the ability to achieve deep tubular occlusion, stable remineralization, and satisfactory biocompatibility simultaneously is essential. In this study, we designed a novel α-hairpin peptide, TKH, engineered by incorporating a flexible GKG linker into an α-helical template, and provide an analysis of its liquid–liquid phase separation (LLPS) and self-assembly properties. TKH effectively stabilized amorphous calcium phosphate and facilitated intrafibrillar mineralization within collagen fibrils. In vitro and in vivo remineralization studies combined with molecular dynamics (MD) simulations demonstrated that TKH promoted the peptide self-assembly through LLPS, hydroxyapatite (HA) adsorption, and amorphous calcium phosphate (ACP) stabilization, ultimately achieving intrafibrillar and extrafibrillar mineralization to seal DTs, alongside excellent biosafety. These findings highlight the potential of TKH as a promising peptide-based biomaterial for dentin remineralization and the treatment of dentin hypersensitivity.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"61 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0