International Journal of Oral Science最新文献

Physiologically relevant coculture model for oral microbial-host interactions 口腔微生物-宿主相互作用的生理相关共培养模型

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-05-27 DOI: 10.1038/s41368-025-00365-9

Zeyang Pang, Nicole M. Cady, Lujia Cen, Thomas M. Schmidt, Xuesong He, Jiahe Li

{"title":"Physiologically relevant coculture model for oral microbial-host interactions","authors":"Zeyang Pang, Nicole M. Cady, Lujia Cen, Thomas M. Schmidt, Xuesong He, Jiahe Li","doi":"10.1038/s41368-025-00365-9","DOIUrl":"https://doi.org/10.1038/s41368-025-00365-9","url":null,"abstract":"Understanding microbial-host interactions in the oral cavity is essential for elucidating oral disease pathogenesis and its systemic implications. In vitro bacteria-host cell coculture models have enabled fundamental studies to characterize bacterial infection and host responses in a reductionist yet reproducible manner. However, existing in vitro coculture models fail to establish conditions that are suitable for the growth of both mammalian cells and anaerobes, thereby hindering a comprehensive understanding of their interactions. Here, we present an asymmetric gas coculture system that simulates the oral microenvironment by maintaining distinct normoxic and anaerobic conditions for gingival epithelial cells and anaerobic bacteria, respectively. Using a key oral pathobiont, Fusobacterium nucleatum, as the primary test bed, we demonstrate that the system preserves bacterial viability and supports the integrity of telomerase-immortalized gingival keratinocytes. Compared to conventional models, this system enhanced bacterial invasion, elevated intracellular bacterial loads, and elicited more robust host pro-inflammatory responses, including increased secretion of CXCL10, IL-6, and IL-8. In addition, the model enabled precise evaluation of antibiotic efficacy against intracellular pathogens. Finally, we validate the ability of the asymmetric system to support the proliferation of a more oxygen-sensitive oral pathobiont, Porphyromonas gingivalis. These results underscore the utility of this coculture platform for studying oral microbial pathogenesis and screening therapeutics, offering a physiologically relevant approach to advance oral and systemic health research.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"167 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Organoids in the oral and maxillofacial region: present and future. 作者更正：口腔颌面区域的类器官：现在和未来。

IF 10.8 1区医学

International Journal of Oral Science Pub Date : 2025-05-27 DOI: 10.1038/s41368-025-00377-5

Yufei Wu, Xiang Li, Hanzhe Liu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang

引用次数: 0

Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis. 骨调节素通过白细胞介素-1受体1/核因子-κB信号通路调节牙髓炎的炎症反应。

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-05-26 DOI: 10.1038/s41368-025-00369-5

Yueyi Yang,Xuchen Hu,Meiling Jing,Xiaohan Zhu,Xiaoyu Liu,Wenduo Tan,Zhanyi Chen,Chenguang Niu,Zhengwei Huang

{"title":"Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis.","authors":"Yueyi Yang,Xuchen Hu,Meiling Jing,Xiaohan Zhu,Xiaoyu Liu,Wenduo Tan,Zhanyi Chen,Chenguang Niu,Zhengwei Huang","doi":"10.1038/s41368-025-00369-5","DOIUrl":"https://doi.org/10.1038/s41368-025-00369-5","url":null,"abstract":"Pulpitis is a common infective oral disease in clinical situations. The regulatory mechanisms of immune defense in pulpitis are still being investigated. Osteomodulin (OMD) is a small leucine-rich proteoglycan family member distributed in bones and teeth. It is a bioactive protein that promotes osteogenesis and suppresses the apoptosis of human dental pulp stem cells (hDPSCs). In this study, the role of OMD in pulpitis and the OMD-induced regulatory mechanism were investigated. The OMD expression in normal and inflamed human pulp tissues was detected via immunofluorescence staining. Intriguingly, the OMD expression decreased in the inflammatory infiltration area of pulpitis specimens. The cellular experiments demonstrated that recombined human OMD could resist the detrimental effects of lipopolysaccharide (LPS)-induced inflammation. A conditional Omd knockout mouse model with pulpal inflammation was established. LPS-induced inflammatory impairment significantly increased in conditional Omd knockout mice, whereas OMD administration exhibited a protective effect against pulpitis. Mechanistically, the transcriptome alterations of OMD overexpression showed significant enrichment in the nuclear factor-κB (NF-κB) signaling pathway. Interleukin-1 receptor 1 (IL1R1), a vital membrane receptor activating the NF-κB pathway, was significantly downregulated in OMD-overexpressing hDPSCs. Additionally, the interaction between OMD and IL1R1 was verified using co-immunoprecipitation and molecular docking. In vivo, excessive pulpal inflammation in Omd-deficient mice was rescued using an IL1R antagonist. Overall, OMD played a protective role in the inflammatory response via the IL1R1/NF-κB signaling pathway. OMD may optimize the immunomodulatory functions of hDPSCs and can be used for regenerative endodontics.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"10 1","pages":"41"},"PeriodicalIF":14.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell and spatial transcriptomics reveals an anti-tumor neutrophil subgroup in microwave thermochemotherapy-treated lip cancer 单细胞和空间转录组学揭示了微波热化疗治疗的唇癌中抗肿瘤中性粒细胞亚群

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-05-13 DOI: 10.1038/s41368-025-00366-8

Bingjun Chen, Huayang Fan, Xin Pang, Zeliang Shen, Rui Gao, Haofan Wang, Zhenwei Yu, Tianjiao Li, Mao Li, Yaling Tang, Xinhua Liang

{"title":"Single-cell and spatial transcriptomics reveals an anti-tumor neutrophil subgroup in microwave thermochemotherapy-treated lip cancer","authors":"Bingjun Chen, Huayang Fan, Xin Pang, Zeliang Shen, Rui Gao, Haofan Wang, Zhenwei Yu, Tianjiao Li, Mao Li, Yaling Tang, Xinhua Liang","doi":"10.1038/s41368-025-00366-8","DOIUrl":"https://doi.org/10.1038/s41368-025-00366-8","url":null,"abstract":"Microwave thermochemotherapy (MTC) has been applied to treat lip squamous cell carcinoma (LSCC), but a deeper understanding of its therapeutic mechanisms and molecular biology is needed. To address this, we used single-cell transcriptomics (scRNA-seq) and spatial transcriptomics (ST) to highlight the pivotal role of tumor-associated neutrophils (TANs) among tumor-infiltrating immune cells and their therapeutic response to MTC. MNDA+ TANs with anti-tumor activity (N1-phenotype) are found to be abundantly infiltrated by MTC with benefit of increased blood perfusion, and these TANs are characterized by enhanced cytotoxicity, ameliorated hypoxia, and upregulated IL1B, activating T&NK cells and fibroblasts via IL1B-IL1R. In this highly anti-tumor immunogenic and hypoxia-reversed microenvironment under MTC, fibroblasts accumulated in the tumor front (TF) can recruit N1-TANs via CXCL2-CXCR2 and clear N2-TANs (pro-tumor phenotype) via CXCL12-CXCR4, which results in the aggregation of N1-TANs and extracellular matrix (ECM) deposition. In addition, we construct an N1-TANs marker, MX2, which positively correlates with better prognosis in LSCC patients, and employ deep learning techniques to predict expression of MX2 from hematoxylin-eosin (H&E)-stained images so as to conveniently guide decision making in clinical practice. Collectively, our findings demonstrate that the N1-TANs/fibroblasts defense wall formed in response to MTC effectively combat LSCC.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"121 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels 用可逆热离子交联三维水凝胶扩增功能性人唾液腺泡细胞球体

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-05-09 DOI: 10.1038/s41368-025-00368-6

Jose G. Munguia-Lopez, Sangeeth Pillai, Yuli Zhang, Amatzia Gantz, Dimitria B. Camasao, Showan N. Nazhat, Joseph M. Kinsella, Simon D. Tran

{"title":"Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels","authors":"Jose G. Munguia-Lopez, Sangeeth Pillai, Yuli Zhang, Amatzia Gantz, Dimitria B. Camasao, Showan N. Nazhat, Joseph M. Kinsella, Simon D. Tran","doi":"10.1038/s41368-025-00368-6","DOIUrl":"https://doi.org/10.1038/s41368-025-00368-6","url":null,"abstract":"Xerostomia (dry mouth) is frequently experienced by patients treated with radiotherapy for head and neck cancers or with Sjögren’s syndrome, with no permanent cure existing for this debilitating condition. To this end, in vitro platforms are needed to test therapies directed at salivary (fluid-secreting) cells. However, since these are highly differentiated secretory cells, the maintenance of their differentiated state while expanding in numbers is challenging. In this study, the efficiency of three reversible thermo-ionically crosslinked gels: (1) alginate–gelatin (AG), (2) collagen-containing AG (AGC), and (3) hyaluronic acid-containing AG (AGHA), to recapitulate a native-like environment for human salivary gland (SG) cell expansion and 3D spheroid formation was compared. Although all gels were of mechanical properties comparable to human SG tissue (~11 kPa) and promoted the formation of 3D spheroids, AGHA gels produced larger (>100 cells/spheroid), viable (>93%), proliferative, and well-organized 3D SG spheroids while spatially and temporally maintaining the high expression of key SG proteins (aquaporin-5, NKCC1, ZO-1, α-amylase) for 14 days in culture. Moreover, the spheroids responded to agonist-induced stimulation by increasing α-amylase secretory granules. Here, we propose alternative low-cost, reproducible, and reversible AG-based 3D hydrogels that allow the facile and rapid retrieval of intact, highly viable 3D-SG spheroids.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"72 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling and functional characterization of long noncoding RNAs during human tooth development 长链非编码rna在人类牙齿发育过程中的分析和功能表征

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-05-09 DOI: 10.1038/s41368-025-00375-7

Xiuge Gu, Wei Wei, Chuan Wu, Jing Sun, Xiaoshan Wu, Zongshan Shen, Hanzhang Zhou, Chunmei Zhang, Jinsong Wang, Lei Hu, Suwen Chen, Yuanyuan Zhang, Songlin Wang, Ran Zhang

{"title":"Profiling and functional characterization of long noncoding RNAs during human tooth development","authors":"Xiuge Gu, Wei Wei, Chuan Wu, Jing Sun, Xiaoshan Wu, Zongshan Shen, Hanzhang Zhou, Chunmei Zhang, Jinsong Wang, Lei Hu, Suwen Chen, Yuanyuan Zhang, Songlin Wang, Ran Zhang","doi":"10.1038/s41368-025-00375-7","DOIUrl":"https://doi.org/10.1038/s41368-025-00375-7","url":null,"abstract":"The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs (lncRNAs). However, the dynamics of lncRNA expression during human tooth development remain poorly understood. In this research, we examined the lncRNAs present in the dental epithelium (DE) and dental mesenchyme (DM) at the late bud, cap, and early bell stages of human fetal tooth development through bulk RNA sequencing. Developmental regulators co-expressed with neighboring lncRNAs were significantly enriched in odontogenesis. Specific lncRNAs expressed in the DE and DM, such as PANCR, MIR205HG, DLX6-AS1, and DNM3OS, were identified through a combination of bulk RNA sequencing and single-cell analysis. Further subcluster analysis revealed lncRNAs specifically expressed in important regions of the tooth germ, such as the inner enamel epithelium and coronal dental papilla (CDP). Functionally, we demonstrated that CDP-specific DLX6-AS1 enhanced odontoblastic differentiation in human tooth germ mesenchymal cells and dental pulp stem cells. These findings suggest that lncRNAs could serve as valuable cell markers for tooth development and potential therapeutic targets for tooth regeneration.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"56 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community dynamics during de novo colonization of the nascent peri-implant sulcus 新生种植体周围沟重新定植期间的群落动态

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-29 DOI: 10.1038/s41368-025-00367-7

Tamires Pereira Dutra, Nicolas Robitaille, Khaled Altabtbaei, Shareef M. Dabdoub, Purnima S. Kumar

{"title":"Community dynamics during de novo colonization of the nascent peri-implant sulcus","authors":"Tamires Pereira Dutra, Nicolas Robitaille, Khaled Altabtbaei, Shareef M. Dabdoub, Purnima S. Kumar","doi":"10.1038/s41368-025-00367-7","DOIUrl":"https://doi.org/10.1038/s41368-025-00367-7","url":null,"abstract":"Dental implants have restored masticatory function to over 100 000 000 individuals, yet almost 1 000 000 implants fail each year due to peri-implantitis, a disease triggered by peri-implant microbial dysbiosis. Our ability to prevent and treat peri-implantitis is hampered by a paucity of knowledge of how these biomes are acquired and the factors that engender normobiosis. Therefore, we combined a 3-month interventional study of 15 systemically and periodontally healthy adults with whole genome sequencing, fine-scale enumeration and graph theoretics to interrogate colonization dynamics in the pristine peri-implant sulcus. We discovered that colonization trajectories of implants differ substantially from adjoining teeth in acquisition of new members and development of functional synergies. Source-tracking algorithms revealed that this niche is initially seeded by bacteria trapped within the coverscrew chamber during implant placement. These pioneer species stably colonize the microbiome and exert a sustained influence on the ecosystem by serving as anchors of influential hubs and by providing functions that enable cell replication and biofilm maturation. Unlike the periodontal microbiome, recruitment of new members to the peri-implant community occurs on nepotistic principles. Maturation is accompanied by a progressive increase in anaerobiosis, however, the predominant functionalities are oxygen-dependent over the 12-weeks. The peri-implant community is easily perturbed following crown placement, but demonstrates remarkable resilience; returning to pre-perturbation states within three weeks. This study highlights important differences in the development of the periodontal and peri-implant ecosystems, and signposts the importance of placing implants in periodontally healthy individuals or following the successful resolution of periodontal disease.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"35 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B 下颌骨来源的细胞外囊泡通过靶向KDM2B调控小型猪早期牙齿发育

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-27 DOI: 10.1038/s41368-025-00348-w

Ye Li, Meng Sun, Yi Ding, Ang Li

引用次数: 0

Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane 单细胞测序系统分析 Emdogain 对延迟再植牙周膜修复的作用机制

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-17 DOI: 10.1038/s41368-024-00345-5

Yanyi Liu, Yuhao Peng, Lanhui Chen, Yangfan Xiang, Ximu Zhang, Jinlin Song

{"title":"Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane","authors":"Yanyi Liu, Yuhao Peng, Lanhui Chen, Yangfan Xiang, Ximu Zhang, Jinlin Song","doi":"10.1038/s41368-024-00345-5","DOIUrl":"https://doi.org/10.1038/s41368-024-00345-5","url":null,"abstract":"The repair of the periodontal membrane is essential for the successful management of periodontal disease and dental trauma. Emdogain® (EMD) is widely used in periodontal therapy due to its ability to promote repair. Despite substantial research, the cellular and molecular mechanisms underlying EMD’s effects, particularly at the single-cell resolution, remain incompletely understood. This study established a delayed tooth replantation model in rats to investigate these aspects. Tooth loss rate and degree of loosening were evaluated at 4 and 8 weeks. Micro-CT, HE staining, TRAP staining, and immunofluorescence staining were evaluated to assess EMD’s efficacy. Single-cell sequencing analyses generated single-cell maps that explored enrichment pathways, cell communication, and potential repair mechanisms. Findings indicated that EMD could reduce the rate of tooth loss, promote periodontal membrane repair, and reduce root and bone resorption. Single-cell analysis revealed that EMD promotes the importance of Vtn+ fibroblasts, enhancing matrix and tissue regeneration functions. Additionally, EMD stimulated osteogenic pathways, reduced osteoclastic activity, and promoted angiogenesis-related pathways, particularly bone-related H-type vessel expression in endothelial cells. Gene modules associated with angiogenesis, osteogenesis, and odontoblast differentiation were identified, suggesting EMD might facilitate osteogenesis and odontoblast differentiation by upregulating endothelium-related genes. Immune cell analysis indicated that EMD did not elicit a significant immune response. Cell communication analysis suggested that EMD fostered pro-regenerative networks driven by interactions between mesenchymal stem cells, fibroblasts, and endothelial cells. In conclusion, EMD proves to be an effective root surface therapy agent that supports the restoration of delayed replantation teeth.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"5 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression 赖氨酸特异性去甲基化酶1通过CDK7磷酸化在肿瘤进展和免疫抑制过程中控制关键的OSCC瘤前病变诱导因子STAT3

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-17 DOI: 10.1038/s41368-025-00363-x

Amit Kumar Chakraborty, Rajnikant Dilip Raut, Kisa Iqbal, Chumki Choudhury, Thabet Alhousami, Sami Chogle, Alexa S. Acosta, Lana Fagman, Kelly Deabold, Marilia Takada, Bikash Sahay, Vikas Kumar, Manish V. Bais

{"title":"Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression","authors":"Amit Kumar Chakraborty, Rajnikant Dilip Raut, Kisa Iqbal, Chumki Choudhury, Thabet Alhousami, Sami Chogle, Alexa S. Acosta, Lana Fagman, Kelly Deabold, Marilia Takada, Bikash Sahay, Vikas Kumar, Manish V. Bais","doi":"10.1038/s41368-025-00363-x","DOIUrl":"https://doi.org/10.1038/s41368-025-00363-x","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) progresses from preneoplastic precursors via genetic and epigenetic alterations. Previous studies have focused on the treatment of terminally developed OSCC. However, the role of epigenetic regulators as therapeutic targets during the transition from preneoplastic precursors to OSCC has not been well studied. Our study identified lysine-specific demethylase 1 (LSD1) as a crucial promoter of OSCC, demonstrating that its knockout or pharmacological inhibition in mice reversed OSCC preneoplasia. LSD1 inhibition by SP2509 disrupted cell cycle, reduced immunosuppression, and enhanced CD4+ and CD8+ T-cell infiltration. In a feline model of spontaneous OSCC, a clinical LSD1 inhibitor (Seclidemstat or SP2577) was found to be safe and effectively inhibit the STAT3 network. Mechanistic studies revealed that LSD1 drives OSCC progression through STAT3 signaling, which is regulated by phosphorylation of the cell cycle mediator CDK7 and immunosuppressive CTLA4. Notably, LSD1 inhibition reduced the phosphorylation of CDK7 at Tyr170 and eIF4B at Ser422, offering insights into a novel mechanism by which LSD1 regulates the preneoplastic-to-OSCC transition. This study provides a deeper understanding of OSCC progression and highlights LSD1 as a potential therapeutic target for controlling OSCC progression from preneoplastic lesions.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"13 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0