International Journal of Oral Science最新文献

Emerging roles of extracellular vesicles in oral and maxillofacial areas

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-02-04 DOI: 10.1038/s41368-024-00341-9

Qianting Wang, Jiayu Sun, Haci Jiang, Mengfei Yu

{"title":"Emerging roles of extracellular vesicles in oral and maxillofacial areas","authors":"Qianting Wang, Jiayu Sun, Haci Jiang, Mengfei Yu","doi":"10.1038/s41368-024-00341-9","DOIUrl":"https://doi.org/10.1038/s41368-024-00341-9","url":null,"abstract":"The oral and maxillofacial region is a highly complex area composed of multiple tissue types and bears various critical functions of the human body. Diseases in this region pose significant diagnostic and management challenges; therefore, exploring new strategies for early diagnosis, targeted treatment, and tissue reconstruction is key to improving patient prognosis and quality of life. Extracellular vesicles are a group of heterogeneous lipid-bilayer membrane structures secreted by most cell types, including exosomes, microvesicles, and apoptotic bodies. Present in various body fluids and tissues, they act as messengers via the transfer of nucleic acids, proteins, and metabolites to recipient cells. To date, studies have revealed the different roles of extracellular vesicles in physiological or pathological processes, as well as applications in disease diagnosis, prognosis, and treatment. The importance and tissue specificity of the dental and maxillofacial tissues indicate that extracellular vesicles derived from this region are promising for further research. This paper reviews the published data on extracellular vesicles derived from cells, body fluids, and tissues in oral and maxillofacial regions, summarizes the latest advances in extracellular vesicles from extensive sources, and concludes with a focus on the current research progress and application prospects of engineered exosomes in oral science.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"25 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on orthodontic treatment of protrusive facial deformities

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-02-01 DOI: 10.1038/s41368-024-00338-4

Jie Pan, Yun Lu, Anqi Liu, Xuedong Wang, Yu Wang, Shiqiang Gong, Bing Fang, Hong He, Yuxing Bai, Lin Wang, Zuolin Jin, Weiran Li, Lili Chen, Min Hu, Jinlin Song, Yang Cao, Jun Wang, Jin Fang, Jiejun Shi, Yuxia Hou, Xudong Wang, Jing Mao, Chenchen Zhou, Yan Liu, Yuehua Liu

{"title":"Expert consensus on orthodontic treatment of protrusive facial deformities","authors":"Jie Pan, Yun Lu, Anqi Liu, Xuedong Wang, Yu Wang, Shiqiang Gong, Bing Fang, Hong He, Yuxing Bai, Lin Wang, Zuolin Jin, Weiran Li, Lili Chen, Min Hu, Jinlin Song, Yang Cao, Jun Wang, Jin Fang, Jiejun Shi, Yuxia Hou, Xudong Wang, Jing Mao, Chenchen Zhou, Yan Liu, Yuehua Liu","doi":"10.1038/s41368-024-00338-4","DOIUrl":"https://doi.org/10.1038/s41368-024-00338-4","url":null,"abstract":"Protrusive facial deformities, characterized by the forward displacement of the teeth and/or jaws beyond the normal range, affect a considerable portion of the population. The manifestations and morphological mechanisms of protrusive facial deformities are complex and diverse, requiring orthodontists to possess a high level of theoretical knowledge and practical experience in the relevant orthodontic field. To further optimize the correction of protrusive facial deformities, this consensus proposes that the morphological mechanisms and diagnosis of protrusive facial deformities should be analyzed and judged from multiple dimensions and factors to accurately formulate treatment plans. It emphasizes the use of orthodontic strategies, including jaw growth modification, tooth extraction or non-extraction for anterior teeth retraction, and maxillofacial vertical control. These strategies aim to reduce anterior teeth and lip protrusion, increase chin prominence, harmonize nasolabial and chin-lip relationships, and improve the facial profile of patients with protrusive facial deformities. For severe skeletal protrusive facial deformities, orthodontic-orthognathic combined treatment may be suggested. This consensus summarizes the theoretical knowledge and clinical experience of numerous renowned oral experts nationwide, offering reference strategies for the correction of protrusive facial deformities.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"22 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-02-01 DOI: 10.1038/s41368-024-00329-5

Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

{"title":"Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment","authors":"Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang","doi":"10.1038/s41368-024-00329-5","DOIUrl":"https://doi.org/10.1038/s41368-024-00329-5","url":null,"abstract":"The ambiguity of etiology makes temporomandibular joint osteoarthritis (TMJOA) “difficult-to-treat”. Emerging evidence underscores the therapeutic promise of exosomes in osteoarthritis management. Nonetheless, challenges such as low yields and insignificant efficacy of current exosome therapies necessitate significant advances. Addressing lower strontium (Sr) levels in arthritic synovial microenvironment, we studied the effect of Sr element on exosomes and miRNA selectively loading in synovial mesenchymal stem cells (SMSCs). Here, we developed an optimized system that boosts the yield of SMSC-derived exosomes (SMSC-EXOs) and improves their miRNA profiles with an elevated proportion of beneficial miRNAs, while reducing harmful ones by pretreating SMSCs with Sr. Compared to untreated SMSC-EXOs, Sr-pretreated SMSC-derived exosomes (Sr-SMSC-EXOs) demonstrated superior therapeutic efficacy by mitigating chondrocyte ferroptosis and reducing osteoclast-mediated joint pain in TMJOA. Our results illustrate Alix’s crucial role in Sr-triggered miRNA loading, identifying miR-143-3p as a key anti-TMJOA exosomal component. Interestingly, this system is specifically oriented towards synovium-derived stem cells. The insight into trace element-driven, site-specific miRNA selectively loading in SMSC-EXOs proposes a promising therapeutic enhancement strategy for TMJOA.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"24 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral submucous fibrosis: pathogenesis and therapeutic approaches

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-02-01 DOI: 10.1038/s41368-024-00344-6

Jianfei Tang, Junjie Liu, Zekun Zhou, Xinyan Cui, Hua Tu, Jia Jia, Baike Chen, Xiaohan Dai, Ousheng Liu

{"title":"Oral submucous fibrosis: pathogenesis and therapeutic approaches","authors":"Jianfei Tang, Junjie Liu, Zekun Zhou, Xinyan Cui, Hua Tu, Jia Jia, Baike Chen, Xiaohan Dai, Ousheng Liu","doi":"10.1038/s41368-024-00344-6","DOIUrl":"https://doi.org/10.1038/s41368-024-00344-6","url":null,"abstract":"Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosal tissue sclerosis, and even cancer transformation, is a chronic, progressive fibrosis disease. However, despite some advancements in recent years, no targeted antifibrotic strategies for OSF have been approved; likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined. In this review, we briefly introduce the epidemiology and etiology of OSF. Then, we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors, secretion function, and activation of ECM-producing myofibroblasts. In addition, we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF. Finally, we summarize strategies to interrupt key mechanisms that cause OSF, including modulation of the ECM, inhibition of inflammation, improvement of vascular disturbance. This review will provide potential routes for developing novel anti-OSF therapeutics.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"20 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment GenAI 从拉曼成像合成组织病理学图像，用于术中舌鳞状细胞癌评估

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-01-26 DOI: 10.1038/s41368-025-00346-y

Bing Yan, Zhining Wen, Lili Xue, Tianyi Wang, Zhichao Liu, Wulin Long, Yi Li, Runyu Jing

{"title":"GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment","authors":"Bing Yan, Zhining Wen, Lili Xue, Tianyi Wang, Zhichao Liu, Wulin Long, Yi Li, Runyu Jing","doi":"10.1038/s41368-025-00346-y","DOIUrl":"https://doi.org/10.1038/s41368-025-00346-y","url":null,"abstract":"The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis. This method utilizes Raman imaging to swiftly and non-invasively capture tissue Raman images, which are then transformed into hematoxylin-eosin (H&E)-stained histopathological images using an AI generative model for histopathological diagnosis. The generated H&E-stained images clearly illustrate the tissue’s pathological conditions. Independently reviewed by three pathologists, the overall diagnostic accuracy for distinguishing between tumor tissue and normal muscle tissue reaches 86.7%. Notably, it outperforms current clinical practices, especially in TSCC with positive lymph node metastasis or moderately differentiated grades. This advancement highlights the potential of AI-enhanced Raman imaging to significantly improve intraoperative assessments and surgical margin evaluations, promising a versatile diagnostic tool beyond TSCC.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"45 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of aging on neutrophil functions and the contribution to periodontitis 衰老对中性粒细胞功能的影响及对牙周炎的贡献

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-01-16 DOI: 10.1038/s41368-024-00332-w

Zi Wang, Anish Saxena, Wenbo Yan, Silvia M. Uriarte, Rafael Siqueira, Xin Li

{"title":"The impact of aging on neutrophil functions and the contribution to periodontitis","authors":"Zi Wang, Anish Saxena, Wenbo Yan, Silvia M. Uriarte, Rafael Siqueira, Xin Li","doi":"10.1038/s41368-024-00332-w","DOIUrl":"https://doi.org/10.1038/s41368-024-00332-w","url":null,"abstract":"The increasing aging population and aging-associated diseases have become a global issue for decades. People over 65 show an increased prevalence and greater severity of periodontitis, which poses threats to overall health. Studies have demonstrated a significant association between aging and the dysfunction of neutrophils, critical cells in the early stages of periodontitis, and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion. Neutrophils differentiate and mature in the bone marrow before entering the circulation; during an infection, they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens. Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues. The impacts of aging on neutrophils’ chemotaxis, anti-microbial function, cell activation, and lifespan result in impaired neutrophil functions and excessive neutrophil activation, which could influence periodontitis course. We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses. We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging. This review could help us better understand the pathogenesis of periodontitis, which could offer novel therapeutic targets for periodontitis.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"49 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy 用于 CT 成像和光热疗法的舌鳞癌靶向 Au-HN-1 纳米系统

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-01-14 DOI: 10.1038/s41368-024-00343-7

Ming Hao, Xingchen Li, Xinxin Zhang, Boqiang Tao, He Shi, Jianing Wu, Yuyang Li, Xiang Li, Shuangji Li, Han Wu, Jingcheng Xiang, Dongxu Wang, Weiwei Liu, Guoqing Wang

{"title":"Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy","authors":"Ming Hao, Xingchen Li, Xinxin Zhang, Boqiang Tao, He Shi, Jianing Wu, Yuyang Li, Xiang Li, Shuangji Li, Han Wu, Jingcheng Xiang, Dongxu Wang, Weiwei Liu, Guoqing Wang","doi":"10.1038/s41368-024-00343-7","DOIUrl":"https://doi.org/10.1038/s41368-024-00343-7","url":null,"abstract":"Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy. Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC. However, inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy (PTT). This study modified gold nanodots (AuNDs) with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT. The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuNDs. The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC. Moreover, owing to its stable long-term fluorescence and high X-ray attenuation coefficient, the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC, rendering it useful for early tumor detection and accurate delineation of surgical margins. In conclusion, Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"43 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration. 粘附和可注射水凝胶微球用于nrf2介导的牙周骨再生。

IF 10.8 1区医学

International Journal of Oral Science Pub Date : 2025-01-10 DOI: 10.1038/s41368-024-00340-w

Yu Wang, Shanshan Jin, Yaru Guo, Yilong Lu, Xuliang Deng

{"title":"Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration.","authors":"Yu Wang, Shanshan Jin, Yaru Guo, Yilong Lu, Xuliang Deng","doi":"10.1038/s41368-024-00340-w","DOIUrl":"10.1038/s41368-024-00340-w","url":null,"abstract":"Regenerating periodontal bone defect surrounding periodontal tissue is crucial for orthodontic or dental implant treatment. The declined osteogenic ability of periodontal ligament stem cells (PDLSCs) induced by inflammation stimulus contributes to reduced capacity to regenerate periodontal bone, which brings about a huge challenge for treating periodontitis. Here, inspired by the adhesive property of mussels, we have created adhesive and mineralized hydrogel microspheres loaded with traditional compound cordycepin (MMS-CY). MMS-CY could adhere to the surface of alveolar bone, then promote the migration capacity of PDLSCs and thus recruit them to inflammatory periodontal tissues. Furthermore, MMS-CY rescued the impaired osteogenesis and ligament-forming capacity of PDLSCs, which were suppressed by the inflammation stimulus. Moreover, MMS-CY also displayed the excellent inhibitory effect on the osteoclastic activity. Mechanistically, MMS-CY inhibited the premature senescence induced by the inflammation stimulus through the nuclear factor erythroid 2-related factor (NRF2) pathway and reducing the DNA injury. Utilizing in vivo rat periodontitis model, MMS-CY was demonstrated to enhance the periodontal bone regeneration by improving osteogenesis and inhibiting the osteoclastic activity. Altogether, our study indicated that the multi-pronged approach is promising to promote the periodontal bone regeneration in periodontitis condition by reducing the inflammation-induced stem cell senescence and maintaining bone homeostasis.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"17 1","pages":"7"},"PeriodicalIF":10.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis 专家一致同意牙髓切开术治疗成熟恒牙伴牙髓炎

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-01-07 DOI: 10.1038/s41368-024-00333-9

Lu Zhang, Chen Lin, Zhuo Chen, Lin Yue, Qing Yu, Benxiang Hou, Junqi Ling, Jingping Liang, Xi Wei, Wenxia Chen, Lihong Qiu, Jiyao Li, Yumei Niu, Zhengmei Lin, Lei Cheng, Wenxi He, Xiaoyan Wang, Dingming Huang, Zhengwei Huang, Weidong Niu, Qi Zhang, Chen Zhang, Deqin Yang, Jinhua Yu, Jin Zhao, Yihuai Pan, Jingzhi Ma, Shuli Deng, Xiaoli Xie, Xiuping Meng, Jian Yang, Xuedong Zhou, Zhi Chen

{"title":"Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis","authors":"Lu Zhang, Chen Lin, Zhuo Chen, Lin Yue, Qing Yu, Benxiang Hou, Junqi Ling, Jingping Liang, Xi Wei, Wenxia Chen, Lihong Qiu, Jiyao Li, Yumei Niu, Zhengmei Lin, Lei Cheng, Wenxi He, Xiaoyan Wang, Dingming Huang, Zhengwei Huang, Weidong Niu, Qi Zhang, Chen Zhang, Deqin Yang, Jinhua Yu, Jin Zhao, Yihuai Pan, Jingzhi Ma, Shuli Deng, Xiaoli Xie, Xiuping Meng, Jian Yang, Xuedong Zhou, Zhi Chen","doi":"10.1038/s41368-024-00333-9","DOIUrl":"https://doi.org/10.1038/s41368-024-00333-9","url":null,"abstract":"Pulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes. Pulpotomy is categorized into partial pulpotomy (PP), the removal of a partial segment of the coronal pulp tissue, and full pulpotomy (FP), the removal of whole coronal pulp, which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth. Procedural decisions for the amount of pulp tissue removal or retention depend on the diagnostic of pulp vitality, the overall treatment plan, the patient’s general health status, and pulp inflammation reassessment during operation. This statement represents the consensus of an expert committee convened by the Society of Cariology and Endodontics, Chinese Stomatological Association. It addresses the current evidence to support the application of pulpotomy as a potential alternative to root canal treatment (RCT) on mature permanent teeth with pulpitis from a biological basis, the development of capping biomaterial, and the diagnostic considerations to evidence-based medicine. This expert statement intends to provide a clinical protocol of pulpotomy, which facilitates practitioners in choosing the optimal procedure and increasing their confidence in this rapidly evolving field.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"21 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain 交感神经与感觉神经局部串扰对颞下颌关节骨关节炎疼痛的影响

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-01-07 DOI: 10.1038/s41368-024-00336-6

Zhangyu Ma, Qianqian Wan, Wenpin Qin, Wen Qin, Janfei Yan, Yina Zhu, Yuzhu Wang, Yuxuan Ma, Meichen Wan, Xiaoxiao Han, Haoyan Zhao, Yuxuan Hou, Franklin R. Tay, Lina Niu, Kai Jiao

{"title":"Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain","authors":"Zhangyu Ma, Qianqian Wan, Wenpin Qin, Wen Qin, Janfei Yan, Yina Zhu, Yuzhu Wang, Yuxuan Ma, Meichen Wan, Xiaoxiao Han, Haoyan Zhao, Yuxuan Hou, Franklin R. Tay, Lina Niu, Kai Jiao","doi":"10.1038/s41368-024-00336-6","DOIUrl":"https://doi.org/10.1038/s41368-024-00336-6","url":null,"abstract":"Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechanism mediating pain remains unclear. To investigate the underlying mechanism of TMJ-OA pain, an abnormal joint loading model was used to induce TMJ-OA pain. We found that during the development of TMJ-OA, the increased innervation of sympathetic nerve of subchondral bone precedes that of sensory nerves. Furthermore, these two types of nerves are spatially closely associated. Additionally, it was discovered that activation of sympathetic neural signals promotes osteoarthritic pain in mice, whereas blocking these signals effectively alleviates pain. In vitro experiments also confirmed that norepinephrine released by sympathetic neurons promotes the activation and axonal growth of sensory neurons. Moreover, we also discovered that through releasing norepinephrine, regional sympathetic nerves of subchondral bone were found to regulate growth and activation of local sensory nerves synergistically with other pain regulators. This study identified the role of regional sympathetic nerves in mediating pain in TMJ-OA. It sheds light on a new mechanism of abnormal innervation at the osteochondral junction and the regional crosstalk between peripheral nerves, providing a potential target for treating TMJ-OA pain.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"35 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0