International Journal of Oral Science最新文献

Expert consensus on orthodontic treatment of patients with periodontal disease

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-03 DOI: 10.1038/s41368-025-00356-w

Wenjie Zhong, Chenchen Zhou, Yuanyuan Yin, Ge Feng, Zhihe Zhao, Yaping Pan, Yuxing Bai, Zuolin Jin, Yan Xu, Bing Fang, Yi Liu, Hong He, Faming Chen, Weiran Li, Shaohua Ge, Ang Li, Yi Ding, Lili Chen, Fuhua Yan, Jinlin Song

{"title":"Expert consensus on orthodontic treatment of patients with periodontal disease","authors":"Wenjie Zhong, Chenchen Zhou, Yuanyuan Yin, Ge Feng, Zhihe Zhao, Yaping Pan, Yuxing Bai, Zuolin Jin, Yan Xu, Bing Fang, Yi Liu, Hong He, Faming Chen, Weiran Li, Shaohua Ge, Ang Li, Yi Ding, Lili Chen, Fuhua Yan, Jinlin Song","doi":"10.1038/s41368-025-00356-w","DOIUrl":"https://doi.org/10.1038/s41368-025-00356-w","url":null,"abstract":"Patients with periodontal disease often require combined periodontal-orthodontic interventions to restore periodontal health, function, and aesthetics, ensuring both patient satisfaction and long-term stability. Managing these patients involving orthodontic tooth movement can be particularly challenging due to compromised periodontal soft and hard tissues, especially in severe cases. Therefore, close collaboration between orthodontists and periodontists for comprehensive diagnosis and sequential treatment, along with diligent patient compliance throughout the entire process, is crucial for achieving favorable treatment outcomes. Moreover, long-term orthodontic retention and periodontal follow-up are essential to sustain treatment success. This expert consensus, informed by the latest clinical research and practical experience, addresses clinical considerations for orthodontic treatment of periodontal patients, delineating indications, objectives, procedures, and principles with the aim of providing clear and practical guidance for clinical practitioners.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"32 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the mechanical and biological interplay in the periodontal ligament

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-02 DOI: 10.1038/s41368-025-00354-y

Xinyu Wen, Fang Pei, Ying Jin, Zhihe Zhao

引用次数: 0

Expert consensus on early orthodontic treatment of class III malocclusion

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-01 DOI: 10.1038/s41368-025-00357-9

Xin Zhou, Si Chen, Chenchen Zhou, Zuolin Jin, Hong He, Yuxing Bai, Weiran Li, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Bin Yan, Jiejun Shi, Jie Guo, Zhihua Li, Wensheng Ma, Yi Liu, Huang Li, Yanqin Lu, Liling Ren, Rui Zou, Linyu Xu, Jiangtian Hu, Xiuping Wu, Shuxia Cui, Lulu Xu, Xudong Wang, Songsong Zhu, Li Hu, Qingming Tang, Jinlin Song, Bing Fang, Lili Chen

{"title":"Expert consensus on early orthodontic treatment of class III malocclusion","authors":"Xin Zhou, Si Chen, Chenchen Zhou, Zuolin Jin, Hong He, Yuxing Bai, Weiran Li, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Bin Yan, Jiejun Shi, Jie Guo, Zhihua Li, Wensheng Ma, Yi Liu, Huang Li, Yanqin Lu, Liling Ren, Rui Zou, Linyu Xu, Jiangtian Hu, Xiuping Wu, Shuxia Cui, Lulu Xu, Xudong Wang, Songsong Zhu, Li Hu, Qingming Tang, Jinlin Song, Bing Fang, Lili Chen","doi":"10.1038/s41368-025-00357-9","DOIUrl":"https://doi.org/10.1038/s41368-025-00357-9","url":null,"abstract":"The prevalence of Class III malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore, early orthodontic treatment for Class III malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class III malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class III malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class III malocclusion through early orthodontic treatment.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"31 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on imaging diagnosis and analysis of early correction of childhood malocclusion

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-01 DOI: 10.1038/s41368-025-00351-1

Zitong Lin, Chenchen Zhou, Ziyang Hu, Zuyan Zhang, Yong Cheng, Bing Fang, Hong He, Hu Wang, Gang Li, Jun Guo, Weihua Guo, Xiaobing Li, Guangning Zheng, Zhimin Li, Donglin Zeng, Yan Liu, Yuehua Liu, Min Hu, Lunguo Xia, Jihong Zhao, Yaling Song, Huang Li, Jun Ji, Jinlin Song, Lili Chen, Tiemei Wang

引用次数: 0

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-04-01 DOI: 10.1038/s41368-025-00359-7

Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan

{"title":"Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription","authors":"Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan","doi":"10.1038/s41368-025-00359-7","DOIUrl":"https://doi.org/10.1038/s41368-025-00359-7","url":null,"abstract":"Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application. Numerous evidences support macrophages as the key immune cells during bone remodeling. Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2; R26GFP lineage tracing system. Fluorescence staining, flow cytometry analysis, and western blot determined the significantly enhanced expression of binding immunoglobulin protein (BiP) and emphasized the activation of sensor activating transcription factor 6 (ATF6) in macrophages. Then, we verified that macrophage specific ATF6 deletion (ATF6f/f; CX3CR1CreERT2 mice) decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy. In contrast, macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement. In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6. At the mechanism level, RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfα promotor and augmenting its transcription. Additionally, molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element (ERSE). Taken together, ATF6 may aggravate orthodontic bone remodeling by promoting Tnfα transcription in macrophages, suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"58 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-03-28 DOI: 10.1038/s41368-025-00358-8

Yuantong Liu, Shujin Li, Shuo Wang, Qichao Yang, Zhizhong Wu, Mengjie Zhang, Lei Chen, Zhijun Sun

引用次数: 0

Abnormal collagen deposition mediated by cartilage oligomeric matrix protein in the pathogenesis of oral submucous fibrosis

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-03-27 DOI: 10.1038/s41368-025-00355-x

Yafei Xiong, Xuechun Li, Bincan Sun, Jie Zhang, Xiaoshan Wu, Feng Guo

{"title":"Abnormal collagen deposition mediated by cartilage oligomeric matrix protein in the pathogenesis of oral submucous fibrosis","authors":"Yafei Xiong, Xuechun Li, Bincan Sun, Jie Zhang, Xiaoshan Wu, Feng Guo","doi":"10.1038/s41368-025-00355-x","DOIUrl":"https://doi.org/10.1038/s41368-025-00355-x","url":null,"abstract":"Abnormal accumulation of collagen fibrils is a hallmark feature of oral submucous fibrosis (OSF). However, the precise characteristics and underlying mechanisms remain unclear, impeding the advancement of potential therapeutic approaches. Here, we observed that collagen I, the main component of the extracellular matrix, first accumulated in the lamina propria and subsequently in the submucosa of OSF specimens as the disease progressed. Using RNA-seq and Immunofluorescence in OSF specimens, we screened the cartilage oligomeric matrix protein (COMP) responsible for the abnormal collagen accumulation. Genetic COMP deficiency reduced arecoline-stimulated collagen I deposition significantly in vivo. In comparison, both COMP and collagen I were upregulated under arecoline stimulation in wild-type mice. Human oral buccal mucosal fibroblasts (hBMFs) also exhibited increased secretion of COMP and collagen I after stimulation in vitro. COMP knockdown in hBMFs downregulates arecoline-stimulated collagen I secretion. We further demonstrated that hBMFs present heterogeneous responses to arecoline stimulation, of which COMP-positive fibroblasts secrete more collagen I. Since COMP is a molecular bridge with Fibril-associated collagens with Interrupted Triple helices (FACIT) in the collagen network, we further screened and identified collagen XIV, a FACIT member, co-localizing with both COMP and collagen I. Collagen XIV expression increased under arecoline stimulation in wild-type mice, whereas it was hardly expressed in the Comp-/- mice, even with under stimulation. In summary, we found that COMP may mediates abnormal collagen I deposition by functions with collagen XIV during the progression of OSF, suggesting its potential to be targeted in treating OSF.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"88 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-03-26 DOI: 10.1038/s41368-025-00353-z

Meijun Hu, Zhipeng Fan

{"title":"Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells","authors":"Meijun Hu, Zhipeng Fan","doi":"10.1038/s41368-025-00353-z","DOIUrl":"https://doi.org/10.1038/s41368-025-00353-z","url":null,"abstract":"Dental mesenchymal stem cells (DMSCs) are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability. The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques. These methods can influence the cellular microenvironment, activate disparate signaling pathways, and induce different biological effects. “Epigenetic regulation” refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences, such as histone methylation. Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages. The most important sites of histone methylation in tooth organization were found to be H3K4, H3K9, and H3K27. Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites, generating distinct chromatin structures associated with specific downstream transcriptional states. Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications. A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation. Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4, H3K9, and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments. This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"61 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren’s syndrome

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-03-19 DOI: 10.1038/s41368-025-00349-9

Xiangdi Mao, Haibing Li, Sainan Min, Jiazeng Su, Pan Wei, Yan Zhang, Qihua He, Liling Wu, Guangyan Yu, Xin Cong

{"title":"Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren’s syndrome","authors":"Xiangdi Mao, Haibing Li, Sainan Min, Jiazeng Su, Pan Wei, Yan Zhang, Qihua He, Liling Wu, Guangyan Yu, Xin Cong","doi":"10.1038/s41368-025-00349-9","DOIUrl":"https://doi.org/10.1038/s41368-025-00349-9","url":null,"abstract":"Tricellulin, a key tricellular tight junction (TJ) protein, is essential for maintaining the barrier integrity of acinar epithelia against macromolecular passage in salivary glands. This study aims to explore the role and regulatory mechanism of tricellulin in the development of salivary gland hypofunction in Sjögren’s syndrome (SS). Employing a multifaceted approach involving patient biopsies, non-obese diabetic (NOD) mice as a SS model, salivary gland acinar cell-specific tricellulin conditional knockout (TricCKO) mice, and IFN-γ-stimulated salivary gland epithelial cells, we investigated the role of tricellulin in SS-related hyposalivation. Our data revealed diminished levels of tricellulin in salivary glands of SS patients. Similarly, NOD mice displayed a reduction in tricellulin expression from the onset of the disease, concomitant with hyposecretion and an increase in salivary albumin content. Consistent with these findings, TricCKO mice exhibited both hyposecretion and leakage of macromolecular tracers when compared to control animals. Mechanistically, the JAK/STAT1/miR-145 axis was identified as mediating the IFN-γ-induced downregulation of tricellulin. Treatment with AT1001, a TJ sealer, ameliorated epithelial barrier dysfunction, restored tricellulin expression, and consequently alleviated hyposalivation in NOD mice. Importantly, treatment with miR-145 antagomir to specifically recover the expression of tricellulin in NOD mice significantly alleviated hyposalivation and macromolecular leakage. Collectively, we identified that tricellulin deficiency in salivary glands contributed to hyposalivation in SS. Our findings highlight tricellulin as a potential therapeutic target for hyposecretion, particularly in the context of reinforcing epithelial barrier function through preventing leakage of macromolecules in salivary glands.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"17 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-03-13 DOI: 10.1038/s41368-025-00347-x

Xige Zhao, Xiaoyu Zheng, Yijia Wang, Jing Chen, Xiaotong Wang, Xia Peng, Dong Yuan, Ying Liu, Zhiwei Wang, Juan Du

{"title":"Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring","authors":"Xige Zhao, Xiaoyu Zheng, Yijia Wang, Jing Chen, Xiaotong Wang, Xia Peng, Dong Yuan, Ying Liu, Zhiwei Wang, Juan Du","doi":"10.1038/s41368-025-00347-x","DOIUrl":"https://doi.org/10.1038/s41368-025-00347-x","url":null,"abstract":"Periodontal disease is a risk factor for many systemic diseases such as Alzheimer’s disease and adverse pregnancy outcomes. Cleft palate (CP), the most common congenital craniofacial defect, has a multifaceted etiology influenced by complex genetic and environmental risk factors such as maternal bacterial or virus infection. A prior case-control study revealed a surprisingly strong association between maternal periodontal disease and CP in offspring. However, the precise relationship remains unclear. In this study, the relationship between maternal oral pathogen and CP in offspring was studied by sonicated P. gingivalis injected intravenously and orally into pregnant mice. We investigated an obvious increasing CP (12.5%) in sonicated P. gingivalis group which had inhibited osteogenesis in mesenchyme and blocked efferocytosis in epithelium. Then glycolysis and H4K12 lactylation (H4K12la) were detected to elevate in both mouse embryonic palatal mesenchyme (MEPM) cells and macrophages under P. gingivalis exposure which further promoted the transcription of metallopeptidase domain17 (ADAM17), subsequently mediated the shedding of transforming growth factor-beta receptor 1 (TGFBR1) in MEPM cells and mer tyrosine kinase (MerTK) in macrophages and resulted in the suppression of efferocytosis and osteogenesis in palate, eventually caused abnormalities in palate fusion and ossification. The abnormal efferocytosis also led to a predominance of M1 macrophages, which indirectly inhibited palatal osteogenesis via extracellular vesicles. Furthermore, pharmacological ADAM17 inhibition could ameliorate the abnormality of P. gingivalis-induced abnormal palate development. Therefore, our study extends the knowledge of how maternal oral pathogen affects fetal palate development and provides a novel perspective to understand the pathogenesis of CP.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"49 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0