International Journal of Oral Science最新文献

Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis 专家对放化疗所致口腔黏膜炎防治的共识

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-07-15 DOI: 10.1038/s41368-025-00382-8

Juan Xia, Xiaoan Tao, Qinchao Hu, Wei Luo, Xiuzhen Tong, Gang Zhou, Hongmei Zhou, Hong Hua, Guoyao Tang, Tong Wu, Qianming Chen, Yuan Fan, Xiaobing Guan, Hongwei Liu, Chaosu Hu, Yongmei Zhou, Xuemin Shen, Lan Wu, Xin Zeng, Qing Liu, Renchuan Tao, Yuan He, Yang Cai, Wenmei Wang, Ying Zhang, Yingfang Wu, Minhai Nie, Xin Jin, Xiufeng Wei, Yongzhan Nie, Changqing Yuan, Bin Cheng

{"title":"Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis","authors":"Juan Xia, Xiaoan Tao, Qinchao Hu, Wei Luo, Xiuzhen Tong, Gang Zhou, Hongmei Zhou, Hong Hua, Guoyao Tang, Tong Wu, Qianming Chen, Yuan Fan, Xiaobing Guan, Hongwei Liu, Chaosu Hu, Yongmei Zhou, Xuemin Shen, Lan Wu, Xin Zeng, Qing Liu, Renchuan Tao, Yuan He, Yang Cai, Wenmei Wang, Ying Zhang, Yingfang Wu, Minhai Nie, Xin Jin, Xiufeng Wei, Yongzhan Nie, Changqing Yuan, Bin Cheng","doi":"10.1038/s41368-025-00382-8","DOIUrl":"https://doi.org/10.1038/s41368-025-00382-8","url":null,"abstract":"Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy. Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment. To date, differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties, which has increased the uncertainty of treatment effects. On the basis of current research evidence, this expert consensus outlines risk factors, clinical manifestations, clinical grading, ancillary examinations, diagnostic basis, prevention and treatment strategies and efficacy indicators for OM. In addition to strategies such as basic oral care, anti-inflammatory and analgesic agents, anti-infective agents, pro-healing agents, and photobiotherapy recommended in previous guidelines, we also emphasize the role of traditional Chinese medicine in OM prevention and treatment. This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention, diagnosis, and treatment, standardizing clinical practice, reducing OM occurrence, promoting healing, and improving the quality of life of patients.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"23 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation. 作者更正：成纤维细胞衍生的C3通过巨噬细胞M1极化和破骨细胞分化促进实验性牙周炎的进展。

IF 10.8 1区医学

International Journal of Oral Science Pub Date : 2025-07-02 DOI: 10.1038/s41368-025-00383-7

Feilong Ren, Shize Zheng, Huanyu Luo, Xiaoyi Yu, Xianjing Li, Shaoyi Song, Wenhuan Bu, Hongchen Sun

引用次数: 0

Correction: Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition. 更正：鉴定一种参与宿主小rna介导的生长抑制的梭杆菌rna结合蛋白。

IF 10.8 1区医学

International Journal of Oral Science Pub Date : 2025-06-25 DOI: 10.1038/s41368-025-00389-1

Pu-Ting Dong, Mengdi Yang, Jie Hu, Lujia Cen, Peng Zhou, Difei Xu, Peng Xiong, Jiahe Li, Xuesong He

引用次数: 0

Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-19 DOI: 10.1038/s41368-025-00379-3

Shiwen Zhang, Rui Sheng, Zhen Fan, Fang Wang, Ping Di, Junyu Shi, Duohong Zou, Dehua Li, Yufeng Zhang, Zhuofan Chen, Guoli Yang, Wei Geng, Lin Wang, Jian Zhang, Yuanding Huang, Baohong Zhao, Chunbo Tang, Dong Wu, Shulan Xu, Cheng Yang, Yongbin Mou, Jiacai He, Xingmei Yang, Zhen Tan, Xiaoxiao Cai, Jiang Chen, Hongchang Lai, Zuolin Wang, Quan Yuan

{"title":"Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery","authors":"Shiwen Zhang, Rui Sheng, Zhen Fan, Fang Wang, Ping Di, Junyu Shi, Duohong Zou, Dehua Li, Yufeng Zhang, Zhuofan Chen, Guoli Yang, Wei Geng, Lin Wang, Jian Zhang, Yuanding Huang, Baohong Zhao, Chunbo Tang, Dong Wu, Shulan Xu, Cheng Yang, Yongbin Mou, Jiacai He, Xingmei Yang, Zhen Tan, Xiaoxiao Cai, Jiang Chen, Hongchang Lai, Zuolin Wang, Quan Yuan","doi":"10.1038/s41368-025-00379-3","DOIUrl":"https://doi.org/10.1038/s41368-025-00379-3","url":null,"abstract":"Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health. Currently, several surgical techniques have been validated for their effectiveness in increasing PIKM. However, the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques, variations in clinical scenarios, and anatomical differences. Therefore, clear guidelines and considerations for PIKM augmentation are needed. This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery. It aims to establish a standardized framework for assessing, planning, and executing PIKM augmentation procedures, with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"19 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation methods of exosomes derived from dental stem cells 牙干细胞外泌体的分离方法

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-16 DOI: 10.1038/s41368-025-00370-y

Paras Ahmad, Nathan Estrin, Nima Farshidfar, Yufeng Zhang, Richard J. Miron

{"title":"Isolation methods of exosomes derived from dental stem cells","authors":"Paras Ahmad, Nathan Estrin, Nima Farshidfar, Yufeng Zhang, Richard J. Miron","doi":"10.1038/s41368-025-00370-y","DOIUrl":"https://doi.org/10.1038/s41368-025-00370-y","url":null,"abstract":"Mesenchymal stem cells are highly regarded for their potential in tissue repair and regenerative medicine due to their multipotency and self-renewal abilities. Recently, mesenchymal stem cells have been redefined as “medical signaling cells,” with their primary biological effects mediated through exosome secretion. These exosomes, which contain lipids, proteins, RNA, and metabolites, are crucial in regulating various biological processes and enhancing regenerative therapies. Exosomes replicate the effects of their parent cells while offering benefits such as reduced side effects, low immunogenicity, excellent biocompatibility, and high drug-loading capacity. Dental stem cells, including those from apical papilla, gingiva, dental pulp, and other sources, are key contributors to exosome-mediated regenerative effects, such as tumor cell apoptosis, neuroprotection, angiogenesis, osteogenesis, and immune modulation. Despite their promise, clinical application of exosomes is limited by challenges in isolation techniques. Current methods face issues of complexity, inefficiency, and insufficient purity, hindering detailed analysis. Recent advancements, such as micro-electromechanical systems, alternating current electroosmosis, and serum-free three-dimensional cell cultures, have improved exosome isolation efficacy. This review synthesizes nearly 200 studies on dental stem cell-derived exosomes, highlighting their potential in treating a wide range of conditions, including periodontal diseases, cancer, neurodegenerative disorders, diabetes, and more. Optimized isolation methods offer a path forward for overcoming current limitations and advancing the clinical use of exosome-based therapies.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"12 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet methyltransferase-like protein 4-mediated mitochondrial DNA metabolic disorder exacerbates oral mucosal immunopathology in hypoxia 血小板甲基转移酶样蛋白4介导的线粒体DNA代谢紊乱加剧了缺氧的口腔黏膜免疫病理

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-12 DOI: 10.1038/s41368-025-00373-9

Yina Zhu, Meichen Wan, Yutong Fu, Junting Gu, Zhaoyang Ren, Yun Wang, Kehui Xu, Jing Li, Manjiang Xie, Kai Jiao, Franklin Tay, Lina Niu

{"title":"Platelet methyltransferase-like protein 4-mediated mitochondrial DNA metabolic disorder exacerbates oral mucosal immunopathology in hypoxia","authors":"Yina Zhu, Meichen Wan, Yutong Fu, Junting Gu, Zhaoyang Ren, Yun Wang, Kehui Xu, Jing Li, Manjiang Xie, Kai Jiao, Franklin Tay, Lina Niu","doi":"10.1038/s41368-025-00373-9","DOIUrl":"https://doi.org/10.1038/s41368-025-00373-9","url":null,"abstract":"Hypoxemia is a common pathological state characterized by low oxygen saturation in the blood. This condition compromises mucosal barrier integrity particularly in the gut and oral cavity. However, the mechanisms underlying this association remain unclear. This study used periodontitis as a model to investigate the role of platelet activation in oral mucosal immunopathology under hypoxic conditions. Hypoxia upregulated methyltransferase-like protein 4 (METTL4) expression in platelets, resulting in N6-methyladenine modification of mitochondrial DNA (mtDNA). This modification impaired mitochondrial transcriptional factor A-dependent cytosolic mtDNA degradation, leading to cytosolic mtDNA accumulation. Excess cytosolic mt-DNA aberrantly activated the cGAS-STING pathway in platelets. This resulted in excessive platelet activation and neutrophil extracellular trap formation that ultimately exacerbated periodontitis. Targeting platelet METTL4 and its downstream pathways offers a potential strategy for managing oral mucosa immunopathology. Further research is needed to examine its broader implications for mucosal inflammation under hypoxic conditions.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"5 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition 一种参与宿主小rna介导生长抑制的梭杆菌rna结合蛋白的鉴定

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-11 DOI: 10.1038/s41368-025-00378-4

Puting Dong, Mengdi Yang, Jie Hu, Lujia Cen, Peng Zhou, Difei Xu, Peng Xiong, Jiahe Li, Xuesong He

{"title":"Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition","authors":"Puting Dong, Mengdi Yang, Jie Hu, Lujia Cen, Peng Zhou, Difei Xu, Peng Xiong, Jiahe Li, Xuesong He","doi":"10.1038/s41368-025-00378-4","DOIUrl":"https://doi.org/10.1038/s41368-025-00378-4","url":null,"abstract":"Host-derived small RNAs are emerging as critical regulators in the dynamic interactions between host tissues and the microbiome, with implications for microbial pathogenesis and host defense. Among these, transfer RNA-derived small RNAs (tsRNAs) have garnered attention for their roles in modulating microbial behavior. However, the bacterial factors mediating tsRNA interaction and functionality remain poorly understood. In this study, using RNA affinity pull-down assay in combination with mass spectrometry, we identified a putative membrane-bound protein, annotated as P-type ATPase transporter (PtaT) in Fusobacterium nucleatum (Fn), which binds Fn-targeting tsRNAs in a sequence-specific manner. Through targeted mutagenesis and phenotypic characterization, we showed that in both the Fn type strain and a clinical tumor isolate, deletion of ptaT led to reduced tsRNA intake and enhanced resistance to tsRNA-induced growth inhibition. Global RNA sequencing and label-free Raman spectroscopy revealed the phenotypic differences between Fn wild type and PtaT-deficient mutant, highlighting the functional significance of PtaT in purine and pyrimidine metabolism. Furthermore, AlphaFold 3 prediction provides evidence supporting the specific binding between PtaT and Fn-targeting tsRNA. By uncovering the first RNA-binding protein in Fn implicated in growth modulation through interactions with host-derived small RNAs (sRNAs), our study offers new insights into sRNA-mediated host-pathogen interplay within the context of microbiome-host interactions.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"217 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice 琥珀酸通过琥珀酸受体1依赖机制调节老年小鼠口腔生态失调和炎症

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-10 DOI: 10.1038/s41368-025-00376-6

Fangxi Xu, Yuqi Guo, Scott C. Thomas, Anish Saxena, Samantha Hwang, Mridula Vardhan, Xin Li

{"title":"Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice","authors":"Fangxi Xu, Yuqi Guo, Scott C. Thomas, Anish Saxena, Samantha Hwang, Mridula Vardhan, Xin Li","doi":"10.1038/s41368-025-00376-6","DOIUrl":"https://doi.org/10.1038/s41368-025-00376-6","url":null,"abstract":"Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation. This study examines the role of succinate, a key metabolite produced and utilized by cells of both host and microbes, and its receptor, succinate receptor 1 (SUCNR1), in age-related oral dysbiosis and inflammation. We examined young and aged wild-type (WT) and SUCNR1 knockout (KO) mice for this analysis. Our findings revealed significant aging-associated alveolar bone loss and succinate elevation in aged WT mice, along with notable changes in the oral microbiome. Conversely, aged KO mice showed reduced bone loss, lower succinate levels, less inflammation, and better-maintained microbial function. These results suggest that SUCNR1 is crucial in influencing aging-related succinate elevation, oral dysbiosis, and inflammation. Analysis of gene families and pathways in the oral microbiome demonstrated distinct aging-related changes between WT and KO mice, with the functional potential being preserved in the KO-aged group. This study underscores the importance of succinate elevation and signaling through SUCNR1 in regulating inflammation, alveolar bone loss, and shifts in the oral microbiome, offering potential targets for therapeutic interventions in age-related oral health issues.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"1 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on management of instrument separation in root canal therapy 专家对根管治疗中器械分离处理的共识

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-09 DOI: 10.1038/s41368-025-00372-w

Yi Fan, Yuan Gao, Xiangzhu Wang, Bing Fan, Zhi Chen, Qing Yu, Ming Xue, Xiaoyan Wang, Zhengwei Huang, Deqin Yang, Zhengmei Lin, Yihuai Pan, Jin Zhao, Jinhua Yu, Zhuo Chen, Sijing Xie, He Yuan, Kehua Que, Shuang Pan, Xiaojing Huang, Jun Luo, Xiuping Meng, Jin Zhang, Yi Du, Lei Zhang, Hong Li, Wenxia Chen, Jiayuan Wu, Xin Xu, Jing Zou, Jiyao Li, Dingming Huang, Lei Cheng, Tiemei Wang, Benxiang Hou, Xuedong Zhou

{"title":"Expert consensus on management of instrument separation in root canal therapy","authors":"Yi Fan, Yuan Gao, Xiangzhu Wang, Bing Fan, Zhi Chen, Qing Yu, Ming Xue, Xiaoyan Wang, Zhengwei Huang, Deqin Yang, Zhengmei Lin, Yihuai Pan, Jin Zhao, Jinhua Yu, Zhuo Chen, Sijing Xie, He Yuan, Kehua Que, Shuang Pan, Xiaojing Huang, Jun Luo, Xiuping Meng, Jin Zhang, Yi Du, Lei Zhang, Hong Li, Wenxia Chen, Jiayuan Wu, Xin Xu, Jing Zou, Jiyao Li, Dingming Huang, Lei Cheng, Tiemei Wang, Benxiang Hou, Xuedong Zhou","doi":"10.1038/s41368-025-00372-w","DOIUrl":"https://doi.org/10.1038/s41368-025-00372-w","url":null,"abstract":"Instrument separation is a critical complication during root canal therapy, impacting treatment success and long-term tooth preservation. The etiology of instrument separation is multifactorial, involving the intricate anatomy of the root canal system, instrument-related factors, and instrumentation techniques. Instrument separation can hinder thorough cleaning, shaping, and obturation of the root canal, posing challenges to successful treatment outcomes. Although retrieval of separated instrument is often feasible, it carries risks including perforation, excessive removal of tooth structure and root fractures. Effective management of separated instruments requires a comprehensive understanding of the contributing factors, meticulous preoperative assessment, and precise evaluation of the retrieval difficulty. The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes. The current manuscript provides a framework for understanding the causes, risk factors, and clinical management principles of instrument separation. By integrating effective strategies, endodontists can enhance decision-making, improve endodontic treatment success and ensure the preservation of natural dentition.","PeriodicalId":14191,"journal":{"name":"International Journal of Oral Science","volume":"171 1","pages":""},"PeriodicalIF":14.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The research progress on periodontitis by the National Natural Science Foundation of China 国家自然科学基金对牙周炎的研究进展

IF 14.9 1区医学

International Journal of Oral Science Pub Date : 2025-06-03 DOI: 10.1038/s41368-025-00371-x

Liang Xie, Qian Chen, Hao Xu, Cui Li, Jiayu Lu, Yuangui Zhu

引用次数: 0