International Journal of Neuroscience最新文献_第3页

Proteomic analysis of baicalin intervention on protein expression and modification in the hippocampus of Alzheimer's disease model rat. 黄芩苷干预阿尔茨海默病模型大鼠海马蛋白质表达和修饰的蛋白质组学分析

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-07-01 Epub Date: 2024-09-01 DOI: 10.1080/00207454.2024.2332963

Jiwei Zhao, Fan Lu, Hongli Yu, Jingwei Cao, Zhiqiang Su, Jingkun Zhao

{"title":"Proteomic analysis of baicalin intervention on protein expression and modification in the hippocampus of Alzheimer's disease model rat.","authors":"Jiwei Zhao, Fan Lu, Hongli Yu, Jingwei Cao, Zhiqiang Su, Jingkun Zhao","doi":"10.1080/00207454.2024.2332963","DOIUrl":"10.1080/00207454.2024.2332963","url":null,"abstract":"Objective: We aimed to explore the treatment effect and therapeutic mechanisms of baicalin in Alzheimer's disease (AD).Methods: The AD rat model was established by intracerebroventricular injection of Aβ1-40, with rats in the baicalin group receiving baicalin intraventricular injections. Morris Water Maze and Hematoxylin-eosin (H&E) Staining were employed to detect the successful model construction and baicalin treatment effect. The proteins extracted from the hippocampus were subjected to proteomics analysis. Bioinformatics technology was employed for differential protein screening, functional classification, and enrichment. Western Blot was employed to validate the expressions of differentially expressed proteins (DEPs) and the protein modification alternations.Results: Water maze test confirmed the successful AD model construction and baicalin can improve learning and memory abilities. A total of 26 DEPs associated with 28 Gene Ontology (GO) functions were identified in the model and 32 DEPs were obtained between the baicalin group and the model. Bioinformatics analysis demonstrated that AD occurrence resulted in neuronal dysfunction and was associated with immune responses. The baicalin therapeutic effect on AD may be associated with metabolic processes, vitamin response, angiogenesis regulation, and fatty acid response. Immunoglobulin heavy constant mu (Ighm) and Immunoglobulin G2a (IgG2a) exhibited significant increases in AD and baicalin attenuated their expressions, while Fatty acid desaturase 1 (Fads1) exhibited a significantly diminished expression and baicalin could reverse the trend. Succinylation detection exhibited the differentially expressed at 35 kD between the model and baicalin group.Conclusion: Baicalin intervention may ameliorate cognitive impairment in AD rats by modulating the expressions of proteins and the succinylation modifications.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"797-806"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the characteristics of retrograde trans-synaptic degeneration from retinal ganglion cells loss in patients with homonymous hemianopia caused by acquired cerebral lesions. 探讨获得性脑损伤致同名性偏盲患者视网膜神经节细胞丢失的逆行性跨突触变性特征。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-22 DOI: 10.1080/00207454.2025.2520029

Fei Wang, Hongtao Zhang, Shanshan Cao, Huanfen Zhou, Quangang Xu, Shihui Wei, Chunxia Peng

{"title":"Exploring the characteristics of retrograde trans-synaptic degeneration from retinal ganglion cells loss in patients with homonymous hemianopia caused by acquired cerebral lesions.","authors":"Fei Wang, Hongtao Zhang, Shanshan Cao, Huanfen Zhou, Quangang Xu, Shihui Wei, Chunxia Peng","doi":"10.1080/00207454.2025.2520029","DOIUrl":"10.1080/00207454.2025.2520029","url":null,"abstract":"Aim: The existence of retrograde trans-synaptic degeneration (RTD) had been a controversial due to no structural continuity of two neurons in human. The study aimed to detect the macular retinal ganglion cell layer (mRGCL) loss in homonymous hemianopia (HH) patients caused by acquired cerebral lesions using optical coherence tomography (OCT) to explore RTD characteristics.Methods: A total of 40 HH patients (80 eyes) were enrolled this study. All the patients underwent OCT examination to evaluate the peripapillary retinal nerve fiber layer (pRFNL) and mRGCL loss. Their VF defects (mean deviations [MDs]) were assessed by Humphrey Perimeter.Results: pRNFL and mRGCL thicknesses in HH patients reduced markedly compared to that in healthy eyes. Temporal mRGCL thicknesses in ipsilateral eyes reduced 4.77 ± 7.98 μm (p = 0.002) in contrast to their contralateral eyes. Nasal mRGCL thickness in contralateral eyes reduced 5.75 ± 10.44 μm (p = 0.004), compared to their ipsilateral eyes. Additionally, trauma (p = 0.08) and tumor (p = 0.030) cerebral lesions caused more pRNFL loss than that of cerebrovascular diseases. VF defects (MD) had linear correlations to mRGCL thicknesses in nasal hemisphere in contralateral eyes (r = 0.397, p = 0.0404). The mRGCL and pRNFL loss occurred as early as 2-3 months after cerebral lesions occurred and progressed over time.Conclusion: RTD caused by acquired cerebral lesions were objectively detected by OCT and its characteristics were consistent to anatomic features of visual pathway. The mRGCL loss due to RTD correlated to VF defects and trauma and tumors caused greater injuries in pRNFL. Visual pathway could be an ideal model and OCT is a useful tool for RTD.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional, comparative study of health-related quality of life across the adult lifespan in multiple sclerosis. 多发性硬化症患者成年后健康相关生活质量的横断面比较研究。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-03-13 DOI: 10.1080/00207454.2024.2327404

Trinh L T Huynh, Corey D Feasel, Brenda Jeng, Robert W Motl

{"title":"Cross-sectional, comparative study of health-related quality of life across the adult lifespan in multiple sclerosis.","authors":"Trinh L T Huynh, Corey D Feasel, Brenda Jeng, Robert W Motl","doi":"10.1080/00207454.2024.2327404","DOIUrl":"10.1080/00207454.2024.2327404","url":null,"abstract":"Purpose: This study examines the independent and interactive effects of age and multiple sclerosis (MS) on health-related quality of life (HRQOL).Materials and methods: The sample included persons with MS (n = 207) and healthy controls (HCs; n = 99) divided into three age groups (young, middle-aged, and older adults) who completed a battery of questionnaires, including the 36-item Short-Form Health Survey (SF-36) as a measure of HRQOL. The SF-36 yielded scores for the Physical Component Summary (PCS) (i.e. physical HRQOL) and Mental Component Summary (MCS) (i.e. mental HRQOL). The data were analyzed using two-way MANOVA.Results: There was no interaction between age and disease status on HRQOL, but there were significant main effects of age and disease status on HRQOL. HRQOL was significantly lower in participants with MS than HCs, regardless of age. Physical HRQOL was lower, whereas mental HRQOL was higher across age groups.Conclusion: The findings suggest that future research should develop behavioral and rehabilitation approaches that are applicable for improving HRQOL across the lifespan in persons with MS, particularly for physical HRQOL in older adults with MS.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"718-725"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-03-19 DOI: 10.1080/00207454.2024.2327405

Hande Gazeteci Tekin, Pınar Edem

{"title":"DHDDS-related disease; biallelic missense novel variant causing major severity with an early-onset epilepsy and hyperkinetic movement disorder.","authors":"Hande Gazeteci Tekin, Pınar Edem","doi":"10.1080/00207454.2024.2327405","DOIUrl":"10.1080/00207454.2024.2327405","url":null,"abstract":"Background: Dehydrodolichyl diphosphate synthase complex is encoded by DHDDS. De novo mutations in this gene are associated with epilepsy, movement disorders, intellectual and motor disabilities. The clinical picture is commonly identified in children and shows variations in terms of age of onset, severity, seizure types, and types of dyskinesia.Case: we present a case with a infantile- onset epilepsy and severe global developmental delay, caused by a novel, de novo homozygous variant (c.425C > T, p.Thr142Met) in DHDDS. Clinical improvement was achieved with valproate and tetrabenazine treatments in the 2-year-old male patient with drug-resistant epilepsy, hyperkinetic movement disorder and myoclonus.Conclusion: Despite being rare, DHDDS-related diseases should be considered in patients with movement disorders, seizures and global developmental delay in infancy in differential diagnosis of patients resembling neuronal ceroid lipofuscinosis or progressive myoclonic epilepsies.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"726-730"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review and Meta-Analysis of Drug Eluting Stents for Safety and Efficacy in Intracranial Atherosclerotic Disease. 药物洗脱支架对颅内动脉粥样硬化性疾病安全性和有效性的系统回顾和荟萃分析。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-02-19 DOI: 10.1080/00207454.2024.2313013

Anand A Dharia, Stefano H Byer, Kevin Le, Xi Chen, Nihil Abraham, Suzanne Hunt, Michael G Abraham

{"title":"A Systematic Review and Meta-Analysis of Drug Eluting Stents for Safety and Efficacy in Intracranial Atherosclerotic Disease.","authors":"Anand A Dharia, Stefano H Byer, Kevin Le, Xi Chen, Nihil Abraham, Suzanne Hunt, Michael G Abraham","doi":"10.1080/00207454.2024.2313013","DOIUrl":"10.1080/00207454.2024.2313013","url":null,"abstract":"Background: Advancements in arterial stenting technology have challenged prior notions favoring medical management for intracranial atherosclerotic disease (ICAD). Where previous conclusions were drawn from bare metal stent (BMS) technology, recent studies suggest drug-eluting stents (DES) are favorable due to their anti-proliferative effect, which reduces vascular remodeling.Methods: We conducted a systematic review and meta-analysis of the literature prior to August 2023 reviewing all reports of ICAD treated with DES. Our target outcomes were incidence of any stroke, transient ischemic attack (TIA), or death within 30 days (postprocedural complications), ischemic stroke in the territory of the qualifying artery beyond 30 days (long-term complications), radiographically detected in-stent restenosis rate (ISR), and symptomatic ISR during follow-up. A subgroup analysis further stratified preprocedural mean stenosis above and below 70% into severe and moderate cohorts, respectively.Results: PubMed, Web of Science, Cochrane and EMBASE query identified 527 candidate articles, from which 14 studies met inclusion criteria for a total of 607 patients and 640 ICAD lesions. Incidence of postprocedural complications was 7.3% (95% CI 3.9-11.7%) with subgroup analysis demonstrating significantly higher incidence in the severely stenotic group [9.0% (95% CI 4.7-14.5%)] than the moderately stenotic group [3.0% (95% CI 0.7-6.8%)]. Long-term complications were 1.2% (95% CI 0.4-2.3%). Radiographic ISR was 3.5% (95% CI 1.4-6.3%) and symptomatic ISR was 0.3% (95% CI 0.0-1.5%).Conclusions: Our systematic review and meta-analysis suggest that DES can effectively reduce the risk of ISR and may be a viable treatment modality to reduce long-term complications in refractory ICAD patients.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"607-617"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Daiwenjiu ointment on the treatment of cervical spondylosis with nerve root type caused by cold dampness obstruction. 戴温灸膏治疗寒湿阻滞型神经根型颈椎病的疗效观察

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-04-30 DOI: 10.1080/00207454.2024.2324026

Xinnian Guo, Suotang Kou, Bai Yang, Wenjun Zhu, Junfeng Zhang

{"title":"Efficacy of Daiwenjiu ointment on the treatment of cervical spondylosis with nerve root type caused by cold dampness obstruction.","authors":"Xinnian Guo, Suotang Kou, Bai Yang, Wenjun Zhu, Junfeng Zhang","doi":"10.1080/00207454.2024.2324026","DOIUrl":"10.1080/00207454.2024.2324026","url":null,"abstract":"Objective: This study aimed to assess the clinical efficacy of Daiwenjiu ointment in the treatment of cervical spondylosis with cold dampness obstruction nerve root type.Methods: A retrospective analysis was conducted on a cohort of 110 patients diagnosed with cervical spondylotic radiculopathy. Based on the treatment method, the patients were divided into two groups. The control group received electroacupuncture treatment, while the observation group received a combination of Daiwenjiu ointment and electroacupuncture treatment. The outcome measures included Japanese Orthopedic Association (JOA) scores for cervical spine function, Simplified McGill Pain Questionnaire (SF-MPQ) scores, and changes in serum inflammatory factors TNF-α and IL-1β.Results: Following treatment, the JOA score in the observation group increased from 9.45 ± 1.35 to 14.82 ± 1.29 after treatment, indicating better recovery of cervical spine function compared to the control group (p < 0.001). The SF-MPQ score in the observation group decreased to 18.25 ± 3.80 after treatment, while it remained at 30.20 ± 4.30 in the control group. This difference between the groups was statistically significant (p < 0.001). Furthermore, the observation group demonstrated a significant decrease in serum levels of TNF-α and IL-1β after treatment compared to the control group (p < 0.001).Conclusion: Daiwenjiu ointment exhibits significant therapeutic effects in patients with cold dampness obstruction nerve root type cervical spondylosis. It effectively improves cervical function, reduces pain, and downregulates inflammatory cytokine levels.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"665-672"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of biofeedback intervention on neurological characteristics of children with attention deficit hyperactivity disorder. 生物反馈干预对注意力缺陷多动障碍儿童神经特征的影响。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-03-11 DOI: 10.1080/00207454.2024.2325029

Cai Zhang, Xiaoxuan Zhou, Nanfei Hu, Lin Xu

{"title":"Effect of biofeedback intervention on neurological characteristics of children with attention deficit hyperactivity disorder.","authors":"Cai Zhang, Xiaoxuan Zhou, Nanfei Hu, Lin Xu","doi":"10.1080/00207454.2024.2325029","DOIUrl":"10.1080/00207454.2024.2325029","url":null,"abstract":"Objective: To evaluate the effects of biofeedback intervention on the neurological characteristics of children with attention deficit hyperactivity disorder (ADHD).Methods: 150 children aged 6-12 years with ADHD were divided into two groups according to the treatment method. The atomoxetine group received atomoxetine drug treatment, and the combined treatment group received EEG biofeedback therapy. Continuous performance test (CPT), SNAP-IV and WFIRS-P were used to assess attention and behavior, and functional magnetic resonance imaging (fMRI) was used to observe changes in brain activity.Results: The response time, error times, error response rate and attention fluctuation index of CPT in the combined treatment group were significantly lower than those in the atomoxetine group (p < 0.05), and the correct response rate was higher than that in the atomoxetine group (p < 0.05). After intervention, SNAP-IV and WFIRS-P scores in the combined treatment group were significantly lower than those in the atomoxetine group (p < 0.001). fMRI results showed that the activity of the prefrontal, parietal, amygdala and hippocampus in the combined treatment group was significantly higher than that in the atomoxetine group (p < 0.001).Conclusion: Biofeedback intervention can significantly improve the attention and behavior of ADHD children and positively regulate the neural activity in related brain areas on the basis of drug treatment, suggesting that biofeedback therapy can be considered as a potential effective nondrug treatment option for ADHD children.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"684-691"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Processing speed and executive functioning in relation to off-topic verbosity among young adults and older adults. 年轻人和老年人的处理速度和执行功能与离题口头禅的关系。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-04-01 DOI: 10.1080/00207454.2024.2327401

Michael D Barnett, Leah N Smith, Allyson M Coldiron

{"title":"Processing speed and executive functioning in relation to off-topic verbosity among young adults and older adults.","authors":"Michael D Barnett, Leah N Smith, Allyson M Coldiron","doi":"10.1080/00207454.2024.2327401","DOIUrl":"10.1080/00207454.2024.2327401","url":null,"abstract":"Purpose: Off-topic verbosity (OTV) is a tendency towards excessive, off-topic speech and has been linked with age-related deficits in executive functioning, particularly inhibition. However, there are numerous disagreements within the literature on what constitutes OTV, and there is a further lack of investigation into alternative cognitive explanations for the link between inhibition and OTV. The purpose of this study was to investigate the speech characteristics of OTV in young and older adults as well as to examine whether variations in OTV are better explained by diminished executive functioning or processing speed, as measured by the D-KEFS Stroop test.Methods: Young adults (n = 65; age 18-28) and older adults (n = 85; age 60-98) completed the D-KEFS Color-Word Interference Test and provided verbal samples of autobiographical episodic and procedural speech. These speech samples were rated on three facets of OTV: tangentiality, egocentrism and quantity of speech.Results: Procedural autobiographical speech was found to best measure age cohort variations in OTV, and higher OTV was associated with poorer Stroop test performance in older adults but not in young adults. In fact, young adults only displayed associations between poorer Stroop performance and a reduction in speech quantity. Finally, processing speed deficits were more associated with increased OTV in older adults than executive functioning.Conclusion: These results provide support for links between age-related cognitive decline and OTV, but the results suggest that processing speed may be more implicated than executive functioning.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"701-708"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAD⁺ affects differentially expressed genes-MBOAT2-SLC25A21-SOX6 in experimental autoimmune encephalomyelitis model. NAD+ 影响实验性自身免疫性脑脊髓炎模型中的差异表达基因--MBOAT2-SLC25A21-SOX6。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-02-07 DOI: 10.1080/00207454.2024.2313022

Xu Zeng, Kexue Zhang, Ming Liang, Bin Yu, Peng Zhang, Arshad Mehmood, Hongtian Zhang

{"title":"NAD+ affects differentially expressed genes-MBOAT2-SLC25A21-SOX6 in experimental autoimmune encephalomyelitis model.","authors":"Xu Zeng, Kexue Zhang, Ming Liang, Bin Yu, Peng Zhang, Arshad Mehmood, Hongtian Zhang","doi":"10.1080/00207454.2024.2313022","DOIUrl":"10.1080/00207454.2024.2313022","url":null,"abstract":"Background: Nicotinamide adenine dinucleotide (NAD+) plays a key role in neuroinflammation and neurodegeneration and provides anti-inflammatory and neuroprotective effects in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).Aim: In this study, we aimed to investigate whether NAD+ affects differentially expressed genes (DEGs) in splenocytes of EAE mice to reveal candidate genes for the pathogenesis of MS.Methods: The EAE model was used to perform an intervention on NAD+ to investigate its potential as a protective agent in inflammation and demyelination. Transcriptome analysis of nerve tissue was carried out to gain better insights into NAD+ function. Effects of NAD+ on DEGs in the splenocytes of EAE mice were investigated to determine its anti-inflammatory effect.Results: NAD+ in EAE mice showed the clinical score was significantly improved (EAE 3.190 ± 0.473 vs. NAD+ 2.049 ± 0.715). DEGs (MBOAT2, SLC25A21, and SOX6) between the EAE and the EAE + NAD+ groups showed that SOX6 was significantly improved after NAD+ treatment compared with the EAE group, and other indicators were improved but did not reach statistical significance. NAD+ exhibited clinical scores in EAE mice, and key inflammation was ameliorated in EAE mice spleen after NAD+ intervention, while transcriptome analysis between EAE and EAE + NAD+ groups showed several DEGs in the underlying mechanism.Conclusion: NAD+ on DEGs attenuates disease severity in EAE. Transcriptome analysis on nerve tissue reveals several protein targets in the underlying mechanisms. However, NAD+ does not significantly improve DEGs in the splenocytes of the EAE model.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"618-625"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of SCN2A single nucleotide polymorphisms with Parkinson's disease: evidence from a case-control study. SCN2A单核苷酸多态性与帕金森病的关联：来自病例对照研究的证据

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-06-01 DOI: 10.1080/00207454.2025.2501651

Teng Li, Jingxin Wang, Gan Gao, Benzhang Tao, Qishuai Yu, Shiying Huang, Yanyang Zhang, Pei Zhang

{"title":"Association of SCN2A single nucleotide polymorphisms with Parkinson's disease: evidence from a case-control study.","authors":"Teng Li, Jingxin Wang, Gan Gao, Benzhang Tao, Qishuai Yu, Shiying Huang, Yanyang Zhang, Pei Zhang","doi":"10.1080/00207454.2025.2501651","DOIUrl":"10.1080/00207454.2025.2501651","url":null,"abstract":"Background: A growing body of strong evidence shows that voltage-gated sodium channels genes play key roles in the development of sporadic Parkinson's disease (sPD). However, little data have been reported on the association between single nucleotide polymorphisms (SNPs) and sPD. This study aimed to investigate the association between SCN2A gene polymorphisms and sPD.Methods: 267 patients with sPD and 267 healthy controls were included in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of SCN2A in the serum of patients and healthy individuals.Results: The distribution of the G allele of rs2304016 or the A allele of rs17183814 in SCN2A was significantly higher in patients with sPD (p = 0.001). In subtype analysis, the frequency of the rs2304016 AG heterozygote significantly differed between the early onset PD (EOPD) and late-onset PD (LOPD) groups (p < 0.001). The frequency of the rs17183814 AG heterozygote was significantly higher in the male patients (p = 0.002). Furthermore, we found that the level of SCN2A mRNA transcription in the serum of sPD patients was significantly lower than that in the control group (p < 0.05). The serum expression level of SCN2A in patients with the AA genotype at rs17183814 was lower (p < 0.05).Conclusions: This study demonstrated a significant association between SNPs and the expression of SCN2A with sPD. These findings contribute to a better understanding of the role of SCN2A and SCN2A SNPs in sPD.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0