International Journal of Neuroscience最新文献_第3页

Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels. 介入封堵疗法对合并有卵圆孔孔隙的隐源性中风年轻患者的疗效及其对血清纤维蛋白原和 D-Dimer 水平的影响

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-01-04 DOI: 10.1080/00207454.2023.2298714

Kai Yu, Yaoru Li, Ce Wang, Jinguo Fu, Yaping Hu, Lei Wang, Jun Zhang

{"title":"Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels.","authors":"Kai Yu, Yaoru Li, Ce Wang, Jinguo Fu, Yaping Hu, Lei Wang, Jun Zhang","doi":"10.1080/00207454.2023.2298714","DOIUrl":"10.1080/00207454.2023.2298714","url":null,"abstract":"Objective: To explore the efficacy of interventional closure therapy in young patients with cryptogenic stroke and coexisting patent foramen ovale and analyze its impact on serum fibrinogen and D-dimer levels.Methods: All subjects in this study were young stroke patients with PFO. After excluding patients who did not meet the inclusion criteria, they were registered and divided into two groups based on the treatment method: the closure group and the medical group.Results: There were no significant differences in basic clinical data between the two groups, indicating comparability (p > 0.05). The closure group showed better heart function after treatment compared to the medical group, with significant differences (p < 0.05). Headache symptoms in the closure group were less severe than those in the medical group after treatment, with significant differences (p < 0.05). Laboratory indicators in the closure group were better than those in the medical group after treatment, with significant differences (p < 0.05). Serum fibrinogen and D-dimer levels in the closure group were lower than those in the medical group after treatment, with significant differences (p < 0.05).Conclusion: Interventional closure therapy demonstrated positive effects on young patients with cryptogenic stroke and coexisting PFO, showing improvements in heart function, headache symptoms, and blood coagulation parameters. While the study suggests potential benefits, cautious interpretation is warranted, given the observational study design. Further research with a larger sample size and long-term follow-up is needed to validate these findings.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"272-279"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganshuang granule plays a pharmacological role in anti-alcoholic and anti-hangover via regulating alcohol metabolism and affecting neurotransmitters. 甘双颗粒通过调节酒精代谢和影响神经递质，在抗酒精和抗宿醉方面发挥药理作用。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-02-08 DOI: 10.1080/00207454.2023.2300734

Qiannan Li, Yinghui Lu, Jinfeng Shang, Qi Song, Jiakang Jiao, Lei Bi, Tingyue Jiang, Xin Liu

{"title":"Ganshuang granule plays a pharmacological role in anti-alcoholic and anti-hangover via regulating alcohol metabolism and affecting neurotransmitters.","authors":"Qiannan Li, Yinghui Lu, Jinfeng Shang, Qi Song, Jiakang Jiao, Lei Bi, Tingyue Jiang, Xin Liu","doi":"10.1080/00207454.2023.2300734","DOIUrl":"10.1080/00207454.2023.2300734","url":null,"abstract":"Background: To explore the effect of Ganshuang granule on anti-alcoholic and anti-hangover and its potential mechanism.Methods: SPF SD rats' drunken model and SPF Kunming mice's hangover model were used as models.Results: Ganshuang granule could significantly reduce sleep time, the time to climb in mice, and significantly prolong the tolerance time and shorten sleep time in rats (p < 0.05). The blood ethanol concentration of rats in each administration group was lower than that in the model group at each time point (p < 0.05). Compared with the control group, the activities of ADH and ALDH in the liver of the model group were significantly decreased (p < 0.05); the content of DA and 5-HT in the striatum of the model group was significantly increased (p < 0.05); and the activity of AchE in the hippocampus was significantly decreased (p < 0.05). The above processes could be improved and regulated in the drug administration group. Compared with the control group, there was no significant difference between ADH and ALDH in the serum of the model group (p > 0.05). However, the activities of ADH and ALDH in the liver of drunk rats could be upregulated by Ganshuang granule (p < 0.05).Conclusion: Ganshuang granule has the pharmacological effects of anti-alcoholic and anti-hangover, which is related to regulating the activities of ADH and ALDH in the liver, the contents of DA and 5-HT in striatum, and the activity of AchE in the hippocampus.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"345-357"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of early clinical interventions for children with global developmental delay. 对全球发育迟缓儿童进行早期临床干预的效果。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-02-01 DOI: 10.1080/00207454.2023.2298715

Fang Li, Jinfu Tian, Fangfang Yuan, Weidong Zhao, Huijun Chen, Jie Hao, Fangfei Cheng, Shunyi Song

{"title":"Efficacy of early clinical interventions for children with global developmental delay.","authors":"Fang Li, Jinfu Tian, Fangfang Yuan, Weidong Zhao, Huijun Chen, Jie Hao, Fangfei Cheng, Shunyi Song","doi":"10.1080/00207454.2023.2298715","DOIUrl":"10.1080/00207454.2023.2298715","url":null,"abstract":"Objective: To evaluate the efficacy of early clinical interventions for children with global developmental delay.Methods: A total of 127 initial subjects with GDD met the complete inclusion criteria. Seven cases were excluded due to withdrawal or refusal for follow-up. Eventually, the remaining 120 children were divided into two groups based on different treatment regimens: an experimental group and a control group. Ninety children received individualized treatment in the experimental group, while 30 children, due to various reasons, did not receive inpatient treatment and only underwent home-based intervention therapy in the control group. The developmental progress under different intervention methods was compared, and their clinical effectiveness was analyzed.Results: Both groups of patients showed no significant differences in general characteristics such as gender and age (p > 0.05), demonstrating comparability. The initial comparison of developmental quotient scores in all patients before treatment revealed no significant differences. Post-treatment, there was improvement observed in both groups. However, children in the experimental group exhibited significantly higher scores in gross motor skills, fine motor skills, adaptability, language, and personal-social skills compared to those in the control group (p < 0.05). Additionally, the clinical effective rate in the experimental group was notably higher than that in the control group (p < 0.05).Conclusion: The combined use of acupuncture with home-based intervention therapy demonstrates favorable therapeutic outcomes in young children with comprehensive developmental delays. This approach has the potential to enhance gross motor skills, fine motor skills, cognition, language, and overall intellectual development in affected children.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"280-286"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraine-like headache in subjects with isolated Lambl's excrescences: a case series and literature review. 孤立性兰博尔氏赘生物患者的偏头痛样头痛：病例系列和文献综述。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-01-08 DOI: 10.1080/00207454.2023.2300357

Wei Xie, Xiaoguang Wang, Ruibing Li, Zhihua Jia, Shuai Miao, Yang Liu, Chunxiao Yang, Chenhao Li, He Zhao, Shengyuan Yu, Ruozhuo Liu

{"title":"Migraine-like headache in subjects with isolated Lambl's excrescences: a case series and literature review.","authors":"Wei Xie, Xiaoguang Wang, Ruibing Li, Zhihua Jia, Shuai Miao, Yang Liu, Chunxiao Yang, Chenhao Li, He Zhao, Shengyuan Yu, Ruozhuo Liu","doi":"10.1080/00207454.2023.2300357","DOIUrl":"10.1080/00207454.2023.2300357","url":null,"abstract":"Aim: Lambl's excrescences are mobile, thin, fibrinous connective tissue strands typically found on left-sided cardiac values. Migraine is positively associated with structural cardiac anomalies. However, it remains unclear whether Lambl's excrescences are associated with migraine.Methods: Retrospective review of 182 inpatients with Lambl's excrescences confirmed by transesophageal echocardiogram in Chinese PLA General Hospital since January 2010. Among them, those with isolated Lambl's excrescences presented with migraine-like headache were included. We collected information on the demographics and clinical profiles of all participants, and performed follow-up visits.Results: A total of 8 patients presented with migraine-like headache among 15 patients with isolated Lambl's excrescences. They included 2 men and 6 women, with an average age of 44.63 ± 12.24 years. Among these patients, 3 had visual aura, and 6 manifested infarct-like lesions on magnetic resonance imaging, of which 2 developed lesions after first visit. During follow-up, 4 patients suffering from intervention for Lambl's excrescences dramatically reduced headache recurrence compared to the other 4 patients only receiving migraine preventive medications.Conclusions: This study supports the hypothesis that microemboli from isolated Lambl's excrescences could cause migraine-like headache. And intervention for Lambl's excrescences may be crucial for preventing headache recurrence.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"304-312"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Na⁺/Ca²⁺ exchangers was enhanced following pre-treatment of olive leaf extract and olive oil in animal model of ischemic stroke. 对缺血性中风动物模型进行橄榄叶提取物和橄榄油预处理后，Na+/Ca2+ 交换体的表达得到增强。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-01-08 DOI: 10.1080/00207454.2023.2300732

Sepideh Khaksar, Mohammadreza Bigdeli, Raziyeh Mohammadi

{"title":"Expression of Na+/Ca2+ exchangers was enhanced following pre-treatment of olive leaf extract and olive oil in animal model of ischemic stroke.","authors":"Sepideh Khaksar, Mohammadreza Bigdeli, Raziyeh Mohammadi","doi":"10.1080/00207454.2023.2300732","DOIUrl":"10.1080/00207454.2023.2300732","url":null,"abstract":"Background: Neuroprotective role of olive and its natural products can introduce them as alternative candidates for the management of neurodegenerative diseases including stroke. The present study was designed to evaluate whether pretreatment of olive oil and leaf extract can attenuate the most important destructive processes in cerebral ischemia called excitotoxicity.Material and methods: The male rats were categorized into control, virgin olive oil (OVV), MCAO, MCAO + OVV (with doses of 0.25, 0.50 and 0.75 ml/kg as treatment groups), olive leaf extract, MCAO + olive leaf extract (with doses 50, 75 and 100 mg/kg as treatment groups) groups. Rats of treatment groups received gastric gavage with olive oil or leaf extract for 30 consecutive days. After pretreatment, the intraluminal filament technique was used to block middle cerebral artery (MCA) transiently. Neurological deficits, infarct volume and expression of Na+/Ca2+ exchangers (NCX1, NCX2 and NCX3) proteins were measured.Results: The results revealed that olive oil at doses of 0.50 and 0.75 ml/kg reduced the infarction and neurological score and upregulated NCXs expression in rat brain. In addition, olive leaf extract at doses of 75 and 100 mg/kg attenuated the infarction and neurological score and enhanced NCXs expression in rat brain.Conclusion: These findings support the view that olive oil and leaf extract play the neuroprotective role in cerebral ischemia due to the upregulation of NCXs protein expression.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"322-336"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic study of electroacupuncture preconditioning in alleviating myocardial ischemia-reperfusion injury in rats: involvement of mTOR/ROS signaling pathway to inhibit ferroptosis. 电针预处理缓解大鼠心肌缺血再灌注损伤的机制研究：mTOR/ROS信号通路抑制铁蛋白沉积的机制研究

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-02-06 DOI: 10.1080/00207454.2023.2299315

Yan Xiao, Liang Ding

{"title":"Mechanistic study of electroacupuncture preconditioning in alleviating myocardial ischemia-reperfusion injury in rats: involvement of mTOR/ROS signaling pathway to inhibit ferroptosis.","authors":"Yan Xiao, Liang Ding","doi":"10.1080/00207454.2023.2299315","DOIUrl":"10.1080/00207454.2023.2299315","url":null,"abstract":"Purpose: The objective of this study was to investigate the mechanism of electroacupuncture pretreatment in reducing myocardial ischemia-reperfusion injury in rats.Materials and methods: The comparison of HR among the different groups did not yield statistically significant differences (p > 0.05). Additionally, the trend of HR change at different time points within each group was not statistically significant (p > 0.05). In contrast, the comparison of SBP among the different groups showed statistically significant differences (p < 0.05). Furthermore, the trend of SBP change at different time points within each group exhibited significant differences (p < 0.05).Results: Compared to the Sham group, rats in the I/R group and EA control group showed a significant decrease in EF, FS, SOD, p-mTOR/mTOR, GPX4, and FTH1, and an increase in CK-MB, cTnI, LDH, iron, ROS, MDA, ACSL4, and NCOA4 (p < 0.05). Compared to EA control group, rats in the EA group exhibited a significant increase in EF, FS, SOD, p-mTOR/mTOR, GPX4, and FTH1, and a decrease in CK-MB, cTnI, LDH, iron, ROS, MDA, ACSL4, and NCOA4 (p < 0.05). Compared to the EA group, rats in the EA + RAP group showed a significant decrease in EF, FS, SOD, p-mTOR/mTOR, GPX4, and FTH1, and an increase in CK-MB, cTnI, LDH, iron, ROS, MDA, ACSL4, and NCOA4 (p < 0.05).Conclusions: Electroacupuncture preconditioning confers protective effects against myocardial ischemia-reperfusion injury in rats. Its mechanism may involve the activation of the mTOR/ROS signaling pathway by electroacupuncture to inhibit ferroptosis.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"287-295"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: a novel CYP27A1 gene variant in a patient with cerebrotendinous xanthomatosis with unusual clinical findings. 病例报告：临床表现异常的脑膜黄瘤病患者的新型 CYP27A1 基因变异。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-01-12 DOI: 10.1080/00207454.2023.2300735

Francisco A Tama Viteri, David Cotán Marín, Francisco A Tama Sánchez, Marcia A Tama Sánchez

{"title":"Case Report: a novel CYP27A1 gene variant in a patient with cerebrotendinous xanthomatosis with unusual clinical findings.","authors":"Francisco A Tama Viteri, David Cotán Marín, Francisco A Tama Sánchez, Marcia A Tama Sánchez","doi":"10.1080/00207454.2023.2300735","DOIUrl":"10.1080/00207454.2023.2300735","url":null,"abstract":"Purpose/aim of the study: Cerebrotendinous xanthomatosis is a disease with important clinical and molecular heterogeneity. CYP27A1 gene was described as the cause of these defects, with more than 50 mutations involved in the disease. The objective of this study was to carry out a genetic study and a clinical description of a patient with unusual clinical manifestation of the disease.Materials and methods: DNA sequencing was used for the evaluation of CYP27A1 exon sequences and their intron/exon boundaries. Copy number variants were calculated using a method based on depth of sequencing coverage. In addition, the potential effects of the missense variants were analyzed, and an in-silico protein modeling tool was used. Finally, a patient case description was performed in order to evaluate patient phenotype according to genetic results.Results: Patient clinical features indicate the possible presence of a disease milder phenotype. When analyzing the CYP27A1 gene, patient presents a pathogenic variant (p.Arg474Trp) and a variant of unknown significance (p.Met130Ile) that causes a slight modification of the protein functional structure. This variant in homozygosis or double or compound heterozygosis together with other biallelic pathological mutations may be the cause of the clinical phenotype observed in the reported patient.Conclusions: Clinical manifestations of cerebrotendinous xanthomatosis are heterogeneous, and sometimes wrongly suggest the presence of other diseases. Some patients seem to present an \"incomplete\" phenotype, which could be redefined as a variant of the disease with further studies. The evaluation of new mutations allows for earlier diagnosis and greater effectiveness in its treatment.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"358-366"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats. 急性和慢性甲醛暴露对雌雄大鼠学习和记忆的影响

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-01-08 DOI: 10.1080/00207454.2023.2300728

Didem Dönmez Aydin, Oğuz Taşkınalp, Enis Uluçam, Hakan Karadağ, Gülnur Kızılay Özfidan, Ruhan Topuz, Onur Ersoy

{"title":"The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats.","authors":"Didem Dönmez Aydin, Oğuz Taşkınalp, Enis Uluçam, Hakan Karadağ, Gülnur Kızılay Özfidan, Ruhan Topuz, Onur Ersoy","doi":"10.1080/00207454.2023.2300728","DOIUrl":"10.1080/00207454.2023.2300728","url":null,"abstract":"Aim: Formaldehyde is a chemical that lies behind the various systemical failures in organism. Many products that people use contain formaldehyde. Owing to its tissue fixative properties, scientists who work in life sciences are exposed to this substance more than others. Several studies have shown that formaldehyde affects the CA1 and CA3 regions of the hippocampus, which play crucial roles in memory consolidation. In this study, we aimed to investigate anxiety levels and indicate the short and long term effects of formaldehyde and sex-related differences by exposing formaldehyde to male and female rats.Materials and methods: Formaldehyde (10 mg/kg) was administered intraperitoneally for 7 days for acute exposure and 30 days for chronic exposure. Cognitive assessment was performed using fear conditioning, elevated plus maze, and Morris water maze tests. TUNEL staining was used to identify apoptosis in the brains obtained after decapitation.Results: Exposure to intraperitoneal formaldehyde does not impair learning and memory in acute and chronic periods and has no effect on depression or anxiety. After acute exposure, apoptosis was observed in the hippocampal CA1 and CA3 regions in males. When the cognitive test results were examined, no differences were found between the experimental and control groups. There was also no significant difference between males and females.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"313-321"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive and clinical dimensions of structural and functional insula alterations in patients with depression: a resting-state fMRI study. 抑郁症患者脑岛结构和功能改变的认知和临床维度：静息状态fMRI研究。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-02-12 DOI: 10.1080/00207454.2024.2446908

Feng Yan, Siyan Zan, Jiahua Xu, Shaokun Zhao, Zhiren Wang, Fude Yang

{"title":"Cognitive and clinical dimensions of structural and functional insula alterations in patients with depression: a resting-state fMRI study.","authors":"Feng Yan, Siyan Zan, Jiahua Xu, Shaokun Zhao, Zhiren Wang, Fude Yang","doi":"10.1080/00207454.2024.2446908","DOIUrl":"10.1080/00207454.2024.2446908","url":null,"abstract":"Aim: Depression is characterized by pervasive cognitive and emotional disturbances, yet the neural mechanisms underlying these deficits remain incompletely understood. Method: This study utilized multimodal neuroimaging, including resting-state functional MRI and structural T1-weighted imaging, alongside the MATRICS Consensus Cognitive Battery (MCCB) and the Hamilton Depression Rating Scale (HAMD), to delineate the structural and functional alterations in the insula in first-episode, medication-naïve patients with depression. Result: Compared to matched healthy controls, patients with depression exhibited significant reductions in gray matter density in the left insula, which were robustly associated with impairments in reasoning and problem-solving abilities. Mediation analyses revealed that insular gray matter density mediated the relationship between depressive symptom severity and cognitive deficits, emphasizing the insula's critical role in linking emotional and cognitive dysfunctions. Furthermore, functional connectivity analyses identified disrupted insula-medial prefrontal cortex circuits, highlighting their contribution to the pathophysiology of depression. Conclusion: These findings underscore the insula's dual role as a structural and functional hub in depression, advancing our understanding of the neural substrates of cognitive dysfunction and informing potential targets for intervention.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relations between immune cells and cerebral hemorrhage: a bidirectional Mendelian randomization study. 免疫细胞与脑出血之间的因果关系：一项双向孟德尔随机研究。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-02-11 DOI: 10.1080/00207454.2025.2457042

Zhimin Wu, Qiqi Wang, Zuojun Xiong

{"title":"Causal relations between immune cells and cerebral hemorrhage: a bidirectional Mendelian randomization study.","authors":"Zhimin Wu, Qiqi Wang, Zuojun Xiong","doi":"10.1080/00207454.2025.2457042","DOIUrl":"10.1080/00207454.2025.2457042","url":null,"abstract":"Background: Previous studies have shown that an increased number of immune cells is closely associated with the onset and course changes of intracerebral hemorrhage, but the exact causal relationship has not been clarified. The aim of this study was to investigate the causal relationship between immune cells and intracerebral hemorrhage by a two-way Mendelian randomization method.Methods: Two sets of SNPs were used as instrumental variables and two-way Mendelian randomization analyses were performed and leave-one-out method were used to assess the validity and heterogeneity of the included genetic variation instruments. The level of multiplicity and heterogeneity of the included genetic variance instruments was assessed.Results: The results showed a clear causal relationship between three immune cells and intracerebral hemorrhage, and no heterogeneity between SNPs related to intracerebral hemorrhage, while scatterplot and funnel plot confirmed that the causality was less likely to be biased; MR-Egger results suggested that no genetic pleiotropy was found. Leave-one-out analysis was applied to suggest that the MR analysis results for a single SNP were robust; meanwhile, Meta-analysis was applied to combine the two intracerebral hemorrhage datasets, and the analysis results suggested that in the fixed-effects model and random-effects model, the immunocyte CD66b on Granulocytic Myeloid-Derived Suppressor Cells and other three immune cells were significantly causally associated with intracerebral hemorrhage, while the heterogeneity test suggested that there was no significant difference between the different datasets.Conclusions: The present study found a significant causal relationship between specific immune cell phenotypes and intracerebral hemorrhage by Mendelian randomization analysis.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0