A neuroeconomic theory of obsessive-compulsive disorder.

IF 1.5 4区 医学 Q4 NEUROSCIENCES
Anıl Şafak Kaçar, Ahmed A Moustafa, Mubashir Hassan, Mustafa Zeki, Fuat Balcı
{"title":"A neuroeconomic theory of obsessive-compulsive disorder.","authors":"Anıl Şafak Kaçar, Ahmed A Moustafa, Mubashir Hassan, Mustafa Zeki, Fuat Balcı","doi":"10.1080/00207454.2025.2529226","DOIUrl":null,"url":null,"abstract":"<p><p>While there are many studies on the neural bases of obsessive-compulsive disorder (OCD), there is a dire need for a neurocomputational framework to explain its symptoms. To this end, we use the Expected Value of Control (EVC) theory to conceptualize the information processing deficits underlying OCD. Specifically, we argue that when experiencing obsessions, weak cognitive control is favored due to the affective cost of disregarding anxiety-provoking obsessions (akin to ignoring a fire alarm). This affective cost leads to the overvaluation of the cost of cognitive control (deeming it expensive), favoring automatic responses in the form of compulsions. We also exercise other ways by which OCD symptoms can be explained within the same theoretical framework. We ground our EVC-based neuroeconomic account in different neural systems implicated in OCD, including the orbitofrontal cortex, dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex, and basal ganglia, which refer to different EVC constituents. Finally, we argue that input from the bed nucleus of the stria terminalis to dACC introduces the key affective cost information to the estimation of EVC.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":1.5000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00207454.2025.2529226","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

While there are many studies on the neural bases of obsessive-compulsive disorder (OCD), there is a dire need for a neurocomputational framework to explain its symptoms. To this end, we use the Expected Value of Control (EVC) theory to conceptualize the information processing deficits underlying OCD. Specifically, we argue that when experiencing obsessions, weak cognitive control is favored due to the affective cost of disregarding anxiety-provoking obsessions (akin to ignoring a fire alarm). This affective cost leads to the overvaluation of the cost of cognitive control (deeming it expensive), favoring automatic responses in the form of compulsions. We also exercise other ways by which OCD symptoms can be explained within the same theoretical framework. We ground our EVC-based neuroeconomic account in different neural systems implicated in OCD, including the orbitofrontal cortex, dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex, and basal ganglia, which refer to different EVC constituents. Finally, we argue that input from the bed nucleus of the stria terminalis to dACC introduces the key affective cost information to the estimation of EVC.

强迫症的神经经济学理论。
虽然有许多关于强迫症(OCD)的神经基础的研究,但迫切需要一个神经计算框架来解释其症状。为此,我们使用控制期望值(EVC)理论(Shenhav et al., 2013)来概念化强迫症背后的信息处理缺陷。具体来说,我们认为,当经历强迫时,由于忽视引起焦虑的强迫(类似于忽视火灾警报)的情感机会成本,弱认知控制更受青睐。这种情感成本导致了对认知控制成本的高估(认为它很昂贵),倾向于强迫形式的自动反应。我们也在同样的理论框架内运用其他方法来解释强迫症症状。我们将基于EVC的神经经济学理论建立在与强迫症有关的不同神经系统的基础上,包括眶额皮质、背前扣带皮层(dACC)、背外侧前额叶皮质和基底神经节,它们涉及不同的EVC成分。最后,我们认为从终纹床核到dACC的输入为EVC的估计引入了关键的情感代价信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.10
自引率
0.00%
发文量
132
审稿时长
2 months
期刊介绍: The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders.  The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信