International Journal of Neuroscience最新文献

The best indices of anesthesia depth monitored by electroencephalogram in different age groups. 通过脑电图监测不同年龄组麻醉深度的最佳指标。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-11-20 DOI: 10.1080/00207454.2024.2432893

Feixiang Li, Bingqing Gong, Huaichen Sheng, Zichen Song, Yonghao Yu, Yongyan Yang

{"title":"The best indices of anesthesia depth monitored by electroencephalogram in different age groups.","authors":"Feixiang Li, Bingqing Gong, Huaichen Sheng, Zichen Song, Yonghao Yu, Yongyan Yang","doi":"10.1080/00207454.2024.2432893","DOIUrl":"https://doi.org/10.1080/00207454.2024.2432893","url":null,"abstract":"IntroductionCurrent electroencephalogram (EEG) indices for monitoring the depth of anesthesia have not been adjusted for age. This study aims to identify the most suitable EEG indices for monitoring anesthesia depth across different age groups.MethodIn here, we conducted a prospective observational trial to observe whether different EEG features in different age groups can detect anesthesia depth and compare their performance.ResultsIn Group 1, absolute θ had the highest prediction probability (Pk) value (0.78 ± 0.07), while relative γ had the lowest relative coefficient of variation (CV) value in states 1 (0.160), 2 (0.153), 3 (0.214), and 4 (0.144). In Group 2, absolute θ had the highest Pk value (0.81 ± 0.09), and relative γ had the lowest CV value in states 1 (0.159), 2 (0.178), 3 (0.140), and 4 (0.095). In Group 3, absolute δ had the highest Pk value (0.79 ± 0.08), with absolute slow wave having the lowest CV value in states 1 (0.196), 2 (0.258), 3 (0.295), and 4 (0.181). In Group 4, absolute δ had the highest Pk value (0.75 ± 0.10), and absolute slow wave had the lowest CV value in states 1 (0.176), 2 (0.192), 3 (0.185), and 4 (0.144).ConclusionsIn this study, we found that absolute θ and relative γ are the most suitable choices for young and middle-aged patients, while absolute δ and absolute slow wave are the most suitable choices for young elderly and elderly patients.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

40 Hz binaural beats entrainment enhances the mood and cognition of medical students. 40赫兹双耳节拍增强了医学生的情绪和认知能力。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-11-19 DOI: 10.1080/00207454.2024.2429495

Rubina Shakya, Piotr Suffczynski, Sachin Shrestha, Srijana Dangol, Prithuja Poudyal, Dil Islam Mansur

{"title":"40 Hz binaural beats entrainment enhances the mood and cognition of medical students.","authors":"Rubina Shakya, Piotr Suffczynski, Sachin Shrestha, Srijana Dangol, Prithuja Poudyal, Dil Islam Mansur","doi":"10.1080/00207454.2024.2429495","DOIUrl":"10.1080/00207454.2024.2429495","url":null,"abstract":"Background: Many medical students experience psychological distress from high academic demands, potentially harming their performance and mental health. Binaural beats (BB) stimulation, particularly gamma band entrainment, has been suggested to enhance neural communication, cognition, and reduce anxiety.Objective: This study aimed to determine whether 40 Hz BB could improve cognitive performance and mood in medical students.Method: Forty participants, selected based on the inclusion criteria of good health, normal hearing, and no mental illness were recruited considering factors such as all sessions availability and consent. Participants listened to BB for 15 min, three times a week, over three consecutive weeks. Electroencephalogram recordings confirmed that 40 Hz BB induced gamma neural oscillations in the brain. Emotional states were assessed using the 32-item Brunel Mood Scale (BRUMS) with ratings on a 5-point Likert scale, whereas cognitive function was measured with the Stroop's test, based on reaction time in milliseconds. Pre- and post-BB comparisons and gender-related differences were analyzed using paired and unpaired t-tests or appropriate non-parametric tests.Result: Listening to BB significantly reduced negative emotions (p < 0.001), enhanced positive emotions (p < 0.001), and facilitated improvements in cognitive performance. However, the effects of BB were gender-specific, with female students showing greater improvements in 'happiness' and 'calmness', (p < 0.001), while males experienced more pronounced enhancements in cognitive performance (p < 0.001). Additionally, time-dependent effects of BB were also observed.Conclusion: 40 Hz BB appears to be an effective tool for helping students manage their challenges calmly and more efficiently.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-11-13 DOI: 10.1080/00207454.2024.2410086

引用次数: 0

Correction. 更正。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-11-13 DOI: 10.1080/00207454.2024.2410079

引用次数: 0

Genetic Determinants of Telomere Length and Risk of Aneurysmal Subarachnoid Hemorrhage: A Bidirectional Two-Sample Mendelian Randomization Study. 端粒长度的遗传决定因素与动脉瘤性蛛网膜下腔出血的风险：双向双样本孟德尔随机研究

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-11-11 DOI: 10.1080/00207454.2024.2414285

Xiangjia Qi, Liqian Gao, Lifeng Qi

{"title":"Genetic Determinants of Telomere Length and Risk of Aneurysmal Subarachnoid Hemorrhage: A Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Xiangjia Qi, Liqian Gao, Lifeng Qi","doi":"10.1080/00207454.2024.2414285","DOIUrl":"https://doi.org/10.1080/00207454.2024.2414285","url":null,"abstract":"Background: Our objective is to investigate the potential causal relationship between telomere length (TL) and aneurysmal subarachnoid hemorrhage (aSAH) and intracranial aneurysms (IAs) by conducting a bidirectional two-sample Mendelian Randomization (MR) study.Methods: We utilized publicly available summary data from genome-wide association studies (GWAS) for comprehensive analysis. Telomere length-associated data were sourced from the Epidemiology Unit (IEU) GWAS database (n = 472,174), while data pertaining to intracranial aneurysms were derived from a GWAS meta-analysis conducted by Bakker et al, encompassing aneurysmal subtypes including aSAH (n = 77,074), IAs (n = 79,429), and unruptured intracranial aneurysms (uIA) (n = 74,004), all sampled from European populations. The primary method for MR analysis employed was the Inverse Variance Weighted (IVW) method. Additionally, we conducted various sensitivity analyses to assess the heterogeneity and pleiotropy of study findings. Reverse MR analysis was employed to explore potential reverse causality.Results: In the forward MR analysis, the IVW method indicated a negative association between TL and aSAH (OR = 0.636, 95% CI: 0.459-0.883, p = 0.006) as well as IAs (OR = 0.670, 95% CI: 0.499-0.900, p = 0.0079). There was no evidence of heterogeneity or horizontal pleiotropy in the forward MR analysis. Reverse MR analysis did not reveal any causal relationship between aSAH, IAs, uIA and TL.Conclusions: In European populations, there exists a causal relationship between longer TL and reduced risks of aSAH and IAs Further research is warranted to elucidate the underlying mechanisms and the potential of TL as an intervention target for lowering the incidence of aSAH and IAs.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-22"},"PeriodicalIF":1.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation index in failure of delay functional independence after successful recanalization. 成功再通后未能延迟功能独立的炎症指数。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-10-30 DOI: 10.1080/00207454.2024.2414280

Mengke Zhang, Wenbo Zhao, Chuanjie Wu, Jiali Xu, Wenting Guo, Changhong Ren, Sijie Li, Xunming Ji

{"title":"Inflammation index in failure of delay functional independence after successful recanalization.","authors":"Mengke Zhang, Wenbo Zhao, Chuanjie Wu, Jiali Xu, Wenting Guo, Changhong Ren, Sijie Li, Xunming Ji","doi":"10.1080/00207454.2024.2414280","DOIUrl":"10.1080/00207454.2024.2414280","url":null,"abstract":"Background: Failure of delayed neurological improvement (fDNI) following successful recanalization is a prevalent clinical phenomenon in patients who have experienced acute ischemic stroke (AIS). An investigation into the potential link between markers of systemic inflammation such as platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index known as SII, and the occurrence of fDNI in patients received successful reperfusion was conducted.Methods: The study included patients diagnosed with AIS who underwent thrombectomy and experienced fDNI, as observed in a prospective study conducted from January 2017 to April 2020. In order to identify predictors of fDNI, we performed multivariable logistic regression and receiver operating characteristic (ROC) curve.Results: Eighty-four patients (23.86%) without early neurological improvement (ENI) experienced DNI, and 268 (76.14%) patients did not show DNI. After adjustment for potential confounders, NLR (adjust OR, 2.131; 95%CI, 1.066-4.259; p = 0.032) and SII (adjust OR, 1.065; 95%CI, 1.001-1.132, p = 0.045) exhibited independent reationship with fDNI independently in multivariate analysis. The areas under AUC of multivariable NLR and SII mode were 0.862 and 0.861, respectively.Conclusions: The immune-inflammatory biomarkers, including NLR and SII, exhibited associations with DNI in patients without ENI. Further investigations are warranted to elucidate the underlying mechanisms.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats. 恩格列净通过减轻氧化应激和脑源性神经营养因子的可能参与，改善糖尿病大鼠嗅球切除术诱发的抑郁症。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-10-25 DOI: 10.1080/00207454.2024.2414270

Sachin P Borikar, Gaurav V Chitode, Deepali N Tapre, Deepak K Lokwani, Shirish P Jain

{"title":"Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats.","authors":"Sachin P Borikar, Gaurav V Chitode, Deepali N Tapre, Deepak K Lokwani, Shirish P Jain","doi":"10.1080/00207454.2024.2414270","DOIUrl":"10.1080/00207454.2024.2414270","url":null,"abstract":"Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has recently reported to prevent the depression in chronic animal model. The present study aimed to explore the antidepressant potential of empagliflozin using a neuroinflammation-mediated depression involving the olfactory bulbectomy (OBX) model in diabetic rats. A low dose of streptozotocin was injected to induce diabetes in all group of animals. Following the confirmation of hyperglycemia, OBX surgery was performed. Post-surgery, the drug treatments were administered orally for 14 consecutive days. The study evaluated the effects of daily oral administration of empagliflozin at doses of 5 and 10 mg/kg, alongside metformin (200 mg/kg) and clomipramine (50 mg/kg), on OBX-induced behavioral depression in rats. Separate sham and vehicle control groups were also maintained. Behavioral parameters in open field, forced swim test, elevated plus maze and splash test were recorded on 28th day. Results showed that empagliflozin, at the higher dose, significantly enhanced behavioral outcomes, evidenced by increased distance travelled, greater open arm entries, and reduced immobility, alongside a notable reduction in grooming time. Moreover, empagliflozin significantly restored the antioxidants level specifically Glutathione (GSH) and Catalase (CAT) in OBX insulted rat brain and decreased Lipid peroxidase (LPO). Notably, molecular docking study demonstrated a good binding affinity of empagliflozin for Brain-Derived Neurotrophic Factor (BDNF), suggesting that its antidepressant effects may be mediated through the modulation of the BDNF pathway. These findings support the potential therapeutic application of empagliflozin for depression, particularly in cases associated with neuroinflammation and oxidative stress.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between TNF-α & IL-6 level changes and remission from depression with duloxetine treatment. TNF-α和IL-6水平变化与度洛西汀治疗抑郁症缓解之间的关系

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-10-18 DOI: 10.1080/00207454.2024.2414279

Eriko Suzuki, Akitsugu Sueki, Hitoshi Takahashi, Jun Ishigooka, Katsuji Nishimura

{"title":"Association between TNF-α & IL-6 level changes and remission from depression with duloxetine treatment.","authors":"Eriko Suzuki, Akitsugu Sueki, Hitoshi Takahashi, Jun Ishigooka, Katsuji Nishimura","doi":"10.1080/00207454.2024.2414279","DOIUrl":"10.1080/00207454.2024.2414279","url":null,"abstract":"Purpose/aim of the study: The pathophysiology of major depressive disorder (MDD) involves multiple factors, including inflammatory processes. This study investigated the relationship between changes in the levels of cytokines and remission in patients with MDD following duloxetine treatment.Materials and methods: MDD patients were administered duloxetine for 16 weeks. Clinical evaluation and immunological monitoring were performed every 4 weeks.Results: Our results indicated that changes in serum levels of TNF-α and IL-6 were associated with remission following duloxetine treatment in MDD patients. There was a slight increase in TNF-α levels in the first four weeks following duloxetine treatment, which correlated significantly with patients who were in remission. Furthermore, patients in remission exhibited an initial increase in IL-6 levels in the first four weeks, followed by a decrease at 16 weeks.Conclusions: These results suggest an important relationship between changes in cytokine levels and remission in patients with major depression after duloxetine treatment.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion tensor imaging with tractography in surgical resection of brainstem cavernous malformations: a systematic review and meta-analysis. 脑干海绵畸形手术切除术中的弥散张量成像与束成像：系统综述与荟萃分析。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-10-01 Epub Date: 2023-05-25 DOI: 10.1080/00207454.2023.2214696

Mohammed Maan Al-Salihi, Maryam Sabah Al-Jebur, Yazen Al-Salihi, Ram Saha, Mhran Malek Daie, Md Moshiur Rahman, Ali Ayyad

{"title":"Diffusion tensor imaging with tractography in surgical resection of brainstem cavernous malformations: a systematic review and meta-analysis.","authors":"Mohammed Maan Al-Salihi, Maryam Sabah Al-Jebur, Yazen Al-Salihi, Ram Saha, Mhran Malek Daie, Md Moshiur Rahman, Ali Ayyad","doi":"10.1080/00207454.2023.2214696","DOIUrl":"10.1080/00207454.2023.2214696","url":null,"abstract":"Brainstem cavernous malformations are benign subset of cerebral cavernous malformations, which need a special intervention owing to being vital and complex. The diffusion tensor imaging technique, a well-recognized neuroimaging tool, can visualize the white matter tracts and their surroundings and provide promising surgical outcomes. This systematic review and meta-analysis evaluated the effect of preoperative diffusion tensor imaging in patients undergoing surgical resection of brainstem cavernous malformations. Five databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, were searched using a comprehensive search strategy to find any article matching our inclusion criteria. We used Comprehensive Meta-Analysis (CMA) software to analyze the collected data, get the evidence, and report the results as event rate (ER), with their 95% confidence interval (CI). Twenty-eight studies involving 467 patients matched our criteria and 19 studies entered the analysis. Our analysis showed that, in patients undergoing surgical resection of brainstem cavernous malformations assisted by preoperative diffusion tensor imaging, 82.21% achieved total resection. About 12.4% of patients achieved partial resection, 65.65% improved, 8.07% worsened, 25.04% showed no change, 3.59% experienced postoperative re-bleeding, and 0.87% died. The utilization of preoperative diffusion tensor imaging significantly increased the proportion of improved patients and decreased the proportion of worsened patients. However, further controlled research is needed to draw a definite conclusion about the usefulness of its role.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1075-1097"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with disease relapse rate in the Neuromyelitis optica spectrum disorder. 神经脊髓炎视网膜谱系障碍疾病复发率的相关因素。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-10-01 Epub Date: 2023-07-26 DOI: 10.1080/00207454.2023.2238245

Hai-Yun Li, Cai-San Cui, Hui-Min Yang, Wen-Jing Jiang, Xiang-Dong Yang

{"title":"Factors associated with disease relapse rate in the Neuromyelitis optica spectrum disorder.","authors":"Hai-Yun Li, Cai-San Cui, Hui-Min Yang, Wen-Jing Jiang, Xiang-Dong Yang","doi":"10.1080/00207454.2023.2238245","DOIUrl":"10.1080/00207454.2023.2238245","url":null,"abstract":"Background and objectives: Neuromyelitis optica spectrum disorder (NMOSD) is a group of demyelinating diseases of the nervous system with high relapse rate and high disability rate without treatment, and we aimed to explore the influencing factors related to the recurrence of NMOSD and provide basis for clinical treatment in this study.Methods: Referring to the diagnostic criteria for NMOSD issued in 2015, 259 patients were enrolled. Clinical information, cerebrospinal fluid (CSF) and serum analysis results, brain and spinal cord magnetic resonance imaging (MRI) findings, treatment details, and prognosis were all recorded.Results: 176 (68.00%) participants were found to be AQP4 Ab-positive in serum or CSF, and the relapse rate was 36.67% (95/259). These 259 individuals were separated into two groups: non-release (n = 164) and relapse (n = 95). In terms of EDSS scores at onset, EDSS score after treatment, lesion location, serum creatinine (Cr) and treatment strategy, there were statistical differences between the two groups. Multivariable logistic regression analyses revealed five predictors for recurrence of NMOSD patients within two years: EDSS scores at onset, transverse myelitis, brain/brainstem, Cr, and Rituximab/immunosuppressants.Conclusion: It is essential to explore the risk factors related to recurrence and prevent them to reduce the risk of disability and improve the prognosis, and the recurrence rate of NMOSD may be affected by several factors.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1114-1119"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0