International Journal of Neuroscience最新文献

Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-01-05 DOI: 10.1080/00207454.2024.2449382

Jin Zhu, Rui Gu, Fan Ji

{"title":"Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.","authors":"Jin Zhu, Rui Gu, Fan Ji","doi":"10.1080/00207454.2024.2449382","DOIUrl":"10.1080/00207454.2024.2449382","url":null,"abstract":"Purpose: To investigate the activity of default mode network (DMN), frontoparietal network (FPN) and cerebellar network (CN) in drug-resistant epilepsy (DRE) patients undergoing vagus nerve stimulation (VNS).Methods: Fifteen patients were recruited and underwent resting-state functional magnetic resonance imaging (fMRI) scans. Independent component analysis and paired sample t-tests were used to examine activity changes of DMN, FPN and CN before and after VNS.Results: Compared with preoperative patients, DMN exhibited decreased activity in left cuneus/precuneus, left median cingulate gyrus, left superior/middle occipital gyrus, right superior parietal gyrus, right precentral/postcentral gyrus, right rolandic operculum and right insula, while increased activity was observed in right supramarginal gyrus, left fusiform gyrus, right supplementary motor area, left amygdala, and right inferior frontal gyrus. FPN displayed decreased activity in left cuneus, left anterior cingulate gyrus, right precentral gyrus, left middle/inferior frontal gyrus, right middle frontal gyrus, left superior/middle temporal gyrus, left superior/middle occipital gyrus, and right superior parietal gyrus, but increased activity in right inferior temporal gyrus. CN showed decreased activity in left superior/middle frontal gyrus, right inferior frontal gyrus, left supplementary motor area, left precuneus, left postcentral gyrus, left middle occipital gyrus, right middle temporal gyrus, and left inferior cerebellum, while increased activity was detected in bilateral superior cerebellum and right fusiform gyrus.Conclusions: DMN, FPN and CN exhibited distinct changes in DRE patients following VNS. The suppression or activation of sensorimotor, language, memory and emotion-related regions may represent the underlying neurological mechanisms of VNS. However, the contrasting activity patterns between superior and inferior cerebellum require further investigation.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Long Non-coding RNA in Nerve Regeneration. 长非编码RNA在神经再生中的作用。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-01-01 Epub Date: 2023-11-20 DOI: 10.1080/00207454.2023.2280446

Jiaxi Qian, Maorong Jiang, Zihan Ding, Dandan Gu, Huiyuan Bai, Min Cai, Dengbing Yao

引用次数: 0

Harnessing the power of probiotics to enhance neuroplasticity for neurodevelopment and cognitive function in stunting: a comprehensive review. 利用益生菌增强发育迟缓患者神经发育和认知功能的神经可塑性:综述。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-01-01 Epub Date: 2023-11-21 DOI: 10.1080/00207454.2023.2283690

Khairun Nisa, Rizki Arisandi, Nurhadi Ibrahim, Hardian Hardian

{"title":"Harnessing the power of probiotics to enhance neuroplasticity for neurodevelopment and cognitive function in stunting: a comprehensive review.","authors":"Khairun Nisa, Rizki Arisandi, Nurhadi Ibrahim, Hardian Hardian","doi":"10.1080/00207454.2023.2283690","DOIUrl":"10.1080/00207454.2023.2283690","url":null,"abstract":"Background: Stunting become a global concern because it's not only affecting physical stature, but also affecting on neurodevelopment and cognitive function. These impacts are resulting in long-term consequences especially for human resources, such as poor-quality labor, decreased productivity due to decreasing of health quality, including immunity and cognitive aspect.Discussion: This comprehensive review found that based on many studies, there is an altered gut microbiota, or dysbiosis, in stunted children, causing the impairment of brain development through Microbiota-Gut Brain Axis (MGB Axis) mechanism. The administration of probiotics has been known affect MGBA by improving the physical and chemical gut barrier integrity, producing antimicrobial substance to inhibit pathogen, and recovering the healthy gut microbiota. Probiotics, along with healthy gut microbiota, produce SCFAs which have various positive impact on CNS, such as increase neurogenesis, support the development and function of microglia, reduce inflammatory signaling, improve the Blood Brain Barrier's (BBB's) integrity, produce neurotropic factors (e.g. BDNF, GDNF), and promote the formation of new synapse. Probiotics also could induce the production of IGF-1 by intestinal epithelial cells, which functioned as growth factor of multiple body tissues and resulted in improvement of linear growth as well as brain development.Conclusion: These properties of probiotics made it become the promising and feasible new treatment approach for stunting. But since most of the studies in this field are conducted in animal models, it is necessary to translate animal data into human models and do additional study to identify the numerous components in the MGB axis and the effect of probiotics on human.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"41-51"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p.

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-27 DOI: 10.1080/00207454.2024.2441120

Baoxi Shen, Ning Liu, Yiwu Dai

{"title":"Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p.","authors":"Baoxi Shen, Ning Liu, Yiwu Dai","doi":"10.1080/00207454.2024.2441120","DOIUrl":"10.1080/00207454.2024.2441120","url":null,"abstract":"Objective: To identify the molecular targets of mesenchymal stem cell (MSC)-derived exosomes in treating cerebral ischemia and elucidate their therapeutic mechanisms.Methods: We utilized a mouse model of middle cerebral artery occlusion and treated mice with umbilical cord mesenchymal stem cells derived exosomes. Proteomic analysis identified AAK1(AP2 associated kinase 1) as a key target protein. Functional studies confirmed that AAK1 modulates the NF-κB signaling pathway in ischemic stroke. MicroRNA profiling, bioinformatic prediction and cell experiments identified miR-664a-5p as the specific microRNA regulating AAK1 expression. Finally, we validated the therapeutic effects of umbilical cord mesenchymal stem cell-derived exosomes using engineered miR-664a-5p-deficient exosomes.Results: Our findings demonstrate that umbilical cord mesenchymal stem cells-derived exosomes exert neuroprotective effects in ischemic stroke by modulating the AAK1/NF-κB axis via miR-664a-5p.Conclusion: This study provides novel insights into the therapeutic mechanism of mesenchymal stem cell-derived exosomes in ischemic stroke, highlighting their potential for developing exosome-based therapies.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grade 4 astrocytoma vs. grade 4 glioblastoma: is there any clue in H&E?

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-26 DOI: 10.1080/00207454.2024.2441994

Cevriye Cansiz Ersöz, Havva Berber, Aylin Heper

{"title":"Grade 4 astrocytoma vs. grade 4 glioblastoma: is there any clue in H&E?","authors":"Cevriye Cansiz Ersöz, Havva Berber, Aylin Heper","doi":"10.1080/00207454.2024.2441994","DOIUrl":"10.1080/00207454.2024.2441994","url":null,"abstract":"Objective: Gliomas are the most common primary tumors of the central nervous system. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the CNS identifies IDH mutant astrocytomas grade 4 and IDH wild type glioblastomas grade 4 as distinct entities. This study aimed to identify morphological indicators that could predict IDH mutation status in grade 4 diffuse astrocytomas and grade 4 glioblastomas among fifty patients from two groups.Methods: Hematoxylin and eosin (H&E)-stained tumor slides were scanned using a digital scanner and further histopathological examinations were performed on digital images, with additional calculations and measurements.Results: The study showed that, IDH-wildtype glioblastomas and IDH-mutant grade 4 astrocytomas exhibit unique morphological features, particularly in relation to levels of necrosis, microvessel density, and the presence of \"C\" or \"Ring\" shape giant cells.Conclusion: Despite advancements in genomic biomarker technology, histology remains an essential tool for predicting patient outcomes. Therefore, pathologists must continue to investigate and document the morphological implications of molecular changes in CNS tumors.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic determinants of telomere length and risk of aneurysmal subarachnoid hemorrhage: a bidirectional two-sample mendelian randomization study. 端粒长度的遗传决定因素与动脉瘤性蛛网膜下腔出血的风险：双向双样本孟德尔随机研究

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-09 DOI: 10.1080/00207454.2024.2414285

Xiangjia Qi, Liqian Gao, Lifeng Qi

{"title":"Genetic determinants of telomere length and risk of aneurysmal subarachnoid hemorrhage: a bidirectional two-sample mendelian randomization study.","authors":"Xiangjia Qi, Liqian Gao, Lifeng Qi","doi":"10.1080/00207454.2024.2414285","DOIUrl":"10.1080/00207454.2024.2414285","url":null,"abstract":"Background: Our objective is to investigate the potential causal relationship between telomere length (TL) and aneurysmal subarachnoid hemorrhage (aSAH) and intracranial aneurysms (IAs) by conducting a bidirectional two-sample Mendelian Randomization (MR) study.Methods: We utilized publicly available summary data from genome-wide association studies (GWAS) for comprehensive analysis. Telomere length-associated data were sourced from the Epidemiology Unit (IEU) GWAS database (n = 472,174), while data pertaining to intracranial aneurysms were derived from a GWAS meta-analysis conducted by Bakker et al. encompassing aneurysmal subtypes including aSAH (n = 77,074), IAs (n = 79,429), and unruptured intracranial aneurysms (uIA) (n = 74,004), all sampled from European populations. The primary method for MR analysis employed was the Inverse Variance Weighted (IVW) method. Additionally, we conducted various sensitivity analyses to assess the heterogeneity and pleiotropy of study findings. Reverse MR analysis was employed to explore potential reverse causality.Results: In the forward MR analysis, the IVW method indicated a negative association between TL and aSAH (OR = 0.636, 95% CI: 0.459-0.883, p = 0.006) as well as IAs (OR = 0.670, 95% CI: 0.499-0.900, p = 0.0079). There was no evidence of heterogeneity or horizontal pleiotropy in the forward MR analysis. Reverse MR analysis did not reveal any causal relationship between aSAH, IAs, uIA and TL.Conclusions: In European populations, there exists a causal relationship between longer TL and reduced risks of aSAH and IAs Further research is warranted to elucidate the underlying mechanisms and the potential of TL as an intervention target for lowering the incidence of aSAH and IAs.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of auraptene and 17-β estradiol on traumatic brain injury treatment: oxidant/antioxidant status, inflammatory cytokines and pathology. Auaptene和17-β雌二醇在创伤性脑损伤治疗中的协同作用：氧化剂/抗氧化剂状态、炎性细胞因子和病理学。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-01 Epub Date: 2023-10-19 DOI: 10.1080/00207454.2023.2269478

Zakieh Keshavarzi, Sedigheh Amiresmaili, Masoud Nazari, Elham Jafari, Mohadeseh Chahkandi, Rakesh K Sindhu

{"title":"Synergistic effects of auraptene and 17-β estradiol on traumatic brain injury treatment: oxidant/antioxidant status, inflammatory cytokines and pathology.","authors":"Zakieh Keshavarzi, Sedigheh Amiresmaili, Masoud Nazari, Elham Jafari, Mohadeseh Chahkandi, Rakesh K Sindhu","doi":"10.1080/00207454.2023.2269478","DOIUrl":"10.1080/00207454.2023.2269478","url":null,"abstract":"Objective: Despite significant advances that have been made in the treatment of traumatic brain injury (TBI), it remains a global health issue. This study aimed to investigate the synergistic effects of 17-β estradiol (E2) and auraptene (AUR) on TBI treatment.Methods: In total, 70 adult male Wistar rats were divided randomly into ten main groups: Sham, TBI, TBI + DMSO, TBI + AUR (4 mg/kg), TBI + AUR (8 mg/kg), TBI + AUR (25 mg/kg), TBI + E2 group, TBI + AUR (4 mg/kg) + E2 group, TBI + AUR (8 mg/kg) + E2 group and TBI + AUR (25 mg/kg) + E2 group. Diffuse TBI was caused by the Marmarou process in male rats. The brain's tissues were harvested to check the parameters of oxidative stress and levels of inflammatory cytokine.Results: The finding revealed that TBI induced a significant increase in brain edema, pro-inflammatory cytokines and oxidant levels [MDA and NO], and also a decrease in the brain's antioxidant biomarkers [GPx, SOD]. We also found that E2 and AUR (25 mg/kg) significantly preserved the levels of these biomarkers. The combination of AUR concentrations and E2 showed that this treatment efficiently preserved the levels of these biomarkers. Furthermore, the combination of E2 and AUR (25 mg/kg) c could cause the most effective synergistic interaction.Conclusion: AUR could act synergistically with E2 to treat brain injury complications.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1477-1489"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent subcutaneous metastasis of a convexity meningioma: a case report and literature review. 凸面脑膜瘤复发性皮下转移：一例报告和文献复习。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-01 Epub Date: 2023-11-07 DOI: 10.1080/00207454.2023.2279499

Anis Hachicha, Khalil Ghedira, Asma Bouhoula, Sofiene Bouali, Alia Zehani

引用次数: 0

tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial. tDCS在改善慢性脑卒中后的临床参数和神经可塑性生物标志物方面没有增加足下垂刺激器和步态训练的效果：随机对照试验。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-01 Epub Date: 2023-10-26 DOI: 10.1080/00207454.2023.2272041

Maira Jaqueline da Cunha, Gilson Pires Dorneles, Alessandra Peres, Simone Maurer, Keli Horn, Aline Souza Pagnussat

{"title":"tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial.","authors":"Maira Jaqueline da Cunha, Gilson Pires Dorneles, Alessandra Peres, Simone Maurer, Keli Horn, Aline Souza Pagnussat","doi":"10.1080/00207454.2023.2272041","DOIUrl":"10.1080/00207454.2023.2272041","url":null,"abstract":"Background: Transcranial direct current stimulation (tDCS) and foot drop stimulators (FDS) are widely used for stroke rehabilitation. However, no study has investigated if tDCS could boost the effects of FDS and gait training in improving clinical parameters and neuroplasticity biomarkers of chronic post-stroke subjects.Objective: To investigate the effects of combining tDCS and FDS on motor impairment, functional mobility, and brain-derived neurotrophic factor (BDNF) serum levels. Also, to evaluate the effects of this protocol on the insulin-like growth factor-1 (IGF-1), insulin growth factor-binding proteins-3 (IGFBP-3), interleukin (IL) 6 and 10, and tumor necrosis factor-α (TNF-α) levels.Methods: Thirty-two chronic post-stroke individuals were randomized to tDCS plus FDS or sham tDCS plus FDS groups. Both groups underwent ten gait training sessions for two weeks using a FDS device and real or sham tDCS. Blood samples and clinical data were acquired before and after the intervention. Motor impairment was assessed by the Fugl-Meyer Assessment and functional mobility using the Timed up and Go test.Results: Both groups improved the motor impairment and functional mobility and increased the BDNF levels. Both groups also increased the IL-10 and decreased the cortisol, IL-6, and TNF-α levels. No difference was observed between groups.Conclusion: tDCS did not add effect to FDS and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke individuals. Only FDS and gait training might be enough for people with chronic stroke to modify some clinical parameters and neuroplasticity biomarkers.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1518-1527"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated intracranial hypertension without cerebral venous sinus thrombosis in APLA syndrome: an unique association. APLA综合征中无脑静脉窦血栓形成的孤立性颅内高压：一种独特的相关性。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2024-12-01 Epub Date: 2023-10-30 DOI: 10.1080/00207454.2023.2273764

Camelia Porey, Binaya Kumar Jaiswal

{"title":"Isolated intracranial hypertension without cerebral venous sinus thrombosis in APLA syndrome: an unique association.","authors":"Camelia Porey, Binaya Kumar Jaiswal","doi":"10.1080/00207454.2023.2273764","DOIUrl":"10.1080/00207454.2023.2273764","url":null,"abstract":"Background: Antiphospholipid antibody (APLA) syndrome is an autoimmune disorder predisposing to thrombotic complications affecting CNS either by arterial vaso occlusion or venous thrombosis. Cerebral venous sinus thrombosis (CVST) secondarily produces raised intracranial pressure (ICP). However intracranial hypertension without evidence of CVST is rare entity.Case presentation: We present two cases of elevated ICP with absence of identifiable CVST. Case 1, a 28-year-old female presented with a 2 months history of headache followed by bilateral vision loss. Cerebrospinal fluid (CSF) opening pressure and fundoscopy along with Contrast Magnetic resonance imaging (MRI) was suggestive of Idiopathic intracranial hypertension (IIH) and patient improved with acetazolamide. 5 months later she presented with acute onset right sided hemiparesis. MRI showed acute left Middle cerebral artery (MCA) territory infarct with normal contrast Magnetic resonance venography (MRV). Anti-cardiolipin and Beta 2 glycoprotein (both IgG and IgM) titres were elevated. Case 2, a 23-year-old female presented with headache and diplopia of 2 months duration. Based on CSF, fundoscopy and contrast MRI brain was diagnosed as IIH and she too responded to diuretics. 2 years later she presented with recurrence of headache and APLA profile showed elevated beta 2 glycoprotein IgG and IgA.Conclusion: This is an important non thrombotic complication of APLA syndrome and requires further large-scale study for insight into the pathogenesis and early recognition to avoid future complications.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1547-1550"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0