International Journal of Neuroscience最新文献

Single-nucleus RNA sequencing of rostral ventromedial medulla in mice with trigeminal neuralgia. 三叉神经痛小鼠喙侧腹内侧髓质单核RNA测序。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-06 DOI: 10.1080/00207454.2025.2499863

Xia Zhang, Liuhanhui Guo, Jingyan Lyu, Xinrui Li, Yucheng Hao, Yanli Zhang, Xiaofeng Bai

{"title":"Single-nucleus RNA sequencing of rostral ventromedial medulla in mice with trigeminal neuralgia.","authors":"Xia Zhang, Liuhanhui Guo, Jingyan Lyu, Xinrui Li, Yucheng Hao, Yanli Zhang, Xiaofeng Bai","doi":"10.1080/00207454.2025.2499863","DOIUrl":"https://doi.org/10.1080/00207454.2025.2499863","url":null,"abstract":"Aim: To investigate the transcriptional changes and cell interactions following trigeminal neuralgia (TN) in different cell types in rostral ventromedial medulla (RVM).Methods: In this study, trigeminal neuropathic pain was induced in mice by ligating the left infraorbital nerve. Ten days after nerve ligation, we performed single-nucleus RNA sequencing of the RVM cells from the Sham and TN groups.Results: We identified neurons, astrocytes, microglial cells, oligodendrocytes, oligodendrocyte progenitor cells, Purkinje cells, neuroblasts, endothelial cells and fibroblasts in RVM tissue. After analyzing the cell-type-specific transcriptional changes in the RVM following nerve ligation, we found that the number of neurons and Purkinje cells in the RVM increased. Furthermore, the differentially expressed genes (DEGs) in neurons and astrocytes between the two groups was identified. The downregulated DEGs in neurons were significantly enriched in GABAergic synapse (such as Gabrg3 and Gabra2). The upregulated DEGs in neurons were enriched in glutamatergic synapse and voltage-gated ion channels. The downregulated DEGs in astrocytes involved in regulation of the postsynaptic membrane and synaptic membrane were enriched. Notably, the CellChat analysis highlights the Slit2-Robo 1/2 signaling pathway as a key route of communication between neurons and astrocytes after nerve ligation.Conclusions: This study analyzed cell-type-specific transcriptional responses to pain, and identified the possible key genes involved in TN. We inferred cell-state-specific communication in various cell types. Our findings provide potential targets, such as Slit2-Robo 1/2, Gabrg3, Gabra2, Grm4, Grik2, Cadps2 and Camk4 on therapeutic strategies for neuropathic or orofacial pain.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dorsal root ganglion-pulsed neuromodulation radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients. 背根神经节脉冲神经调控射频治疗对慢性脊柱源性疼痛有显著的临床疗效，能明显改善患者的症状和睡眠质量。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-03-18 DOI: 10.1080/00207454.2024.2312985

Peiguo Zhang, Xifang Wei, Jianzhang Jia

{"title":"Dorsal root ganglion-pulsed neuromodulation radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients.","authors":"Peiguo Zhang, Xifang Wei, Jianzhang Jia","doi":"10.1080/00207454.2024.2312985","DOIUrl":"10.1080/00207454.2024.2312985","url":null,"abstract":"Background: Chronic spinal-origin pain poses a substantial clinical challenge, prompting the investigation of novel treatment modalities. This study aims to evaluate the potential application of spinal nerve dorsal root ganglion (DRG) radiofrequency treatment in addressing chronic spinal-origin pain.Methods: The study encompassed patients undergoing treatment for chronic spinal-origin pain, with a particular focus on those experiencing pain localized in specific regions. Inclusion criteria comprised patients with conditions such as a herniated intervertebral disc or foraminal stenosis leading to compression of descending or exiting nerve roots, accompanied by reported radicular pain in the lower limb.Results: There was no significant difference in comparability between the two groups (p > 0.05). The clinical effective rate in the study group was significantly higher than that in the control group (p < 0.05). The VAS scores of the study group at 2 weeks and 1 month after treatment were significantly lower than those of the control group (p < 0.05). The PSQI index of the study group after treatment was significantly lower than that of the control group (p < 0.05). There was no significant difference in the incidence of complications between the two groups (p > 0.05).Conclusion: Spinal nerve DRG radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients. The occurrence of complications is relatively low, and it can be reduced through strict operational standards and preoperative and postoperative management. However, caution should be exercised in its widespread application, but it is worthy of broad clinical use.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"524-532"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of static balance performance in 4-stage balance test in the healthy older adults. 健康老年人在四阶段平衡测试中的静态平衡表现特征。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-12 DOI: 10.1080/00207454.2024.2312992

Tiantian Wang, Liuxin Yang, Xuan Li, Panpan Su, Dianhuai Meng

{"title":"Characteristics of static balance performance in 4-stage balance test in the healthy older adults.","authors":"Tiantian Wang, Liuxin Yang, Xuan Li, Panpan Su, Dianhuai Meng","doi":"10.1080/00207454.2024.2312992","DOIUrl":"10.1080/00207454.2024.2312992","url":null,"abstract":"Background: The 4-Stage Balance test is one of the most commonly used tests to assess balance for older adults. Although it is generally accepted that the four positions (including side-by-side (SBSS), semi-tandem (STS), tandem (TS), and single-leg stance (SLS)) in this test are progressively more difficult, there are no studies comparing the balance parameters of the four positions in older adults to prove this result. The purpose of this study is to determine the difficulty of 4 positions in the 4-Stage Balance test and the effect of the dominant and non-dominant lower extremities on static balance among healthy older adults.Methods: A total of 115 community-dwelling healthy older adults were included. The postural parameters (including sway range standard deviation (SR), velocity of body sway (V), total sway area (TSA) and sway perimeter (TSP) of the center of pressure) were measured during 8 static postures (including SBSS, left STS, right STS, left TS, right TS, left SLS, right SLS and comfortable stance (CS)). Repeated measures ANOVA was used to analyze the postural parameters in 8 static postures.Results: The static balance stability of the five stances in older adults can be ranked in the following sequence: CS > SBSS/STS > TS > SLS. Moreover, changing foot placement in STS, TS and SLS tasks has no influence on stability. This study has been registered in China Clinical Trial Registry (ChiCTR2200065803).Conclusions: Our findings suggest that it is feasible to simplify the 4-Stage Balance test to a 3-Stage Balance test in the older adults.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"563-569"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Algorithmic assessment reveals functional implications of GABRD gene variants linked to idiopathic generalized epilepsy. 算法评估揭示了与特发性全身性癫痫有关的 GABRD 基因变异的功能影响。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-09 DOI: 10.1080/00207454.2024.2312987

Ayla Arslan

{"title":"Algorithmic assessment reveals functional implications of GABRD gene variants linked to idiopathic generalized epilepsy.","authors":"Ayla Arslan","doi":"10.1080/00207454.2024.2312987","DOIUrl":"10.1080/00207454.2024.2312987","url":null,"abstract":"Objective: The primary objective of this study is to address the challenge posed by the increasing number of variants of unknown clinical significance (VUS) within the GABRD gene, which encodes the δ subunit of γ-Aminobutyric acid type A receptors. The focus is on predicting the most pathogenic GABRD VUS to enhance precision medicine and improve our understanding of relevant pathophysiology.Methods: The study employs a combination of in silico algorithms to analyze 82 variants of unknown clinical significance of GABRD gene sourced from the ClinVar database. Initially, separate algorithms based on sequence homology are utilized to assess this variant set. Subsequently, consensus variants predicted as pathogenic undergo further evaluation through a web server employing an algorithm based on structural homology. The resulting 11 variants are then validated using in silico tools that assess variant effects based on genetic and molecular data. The evaluation includes consideration of disease association and protein stability due to amino acid substitutions.Results: The study identifies specific variants (L111R, R114C, D123N, G150S, and L243P) in the coding region of the GABRD gene, which are predicted as deleterious by multiple algorithms. These variants are evolutionarily conserved, mapped onto the extracellular domain of the δ subunit, and associated with idiopathic generalized epilepsy.Conclusions: The findings suggest structural or functional consequences that lead to pathogenicity, offering valuable insights for wet-lab experimentation. Besides, the findings contribute to the validation of clinically significant genetic variants in the GABRD gene, which is critical for epilepsy precision medicine.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"533-543"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital myasthenic syndromes in two male siblings born to healthy consanguineous parents: a case report. 父母血缘关系健康的两对男性兄弟姐妹的先天性肌无力综合征：病例报告。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-05 DOI: 10.1080/00207454.2024.2313010

Marzyeh Alipour, Mohsen Moeini, Masumeh Panahi, Khalil Khashei Varnamkhasti

引用次数: 0

Comprehensive and integrated management of basilar impression, platybasia and cranio-vertebral junction abnormality- a case report. 基底凹陷、扁桃体和颅椎交界处畸形的全面综合治疗--病例报告。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-03-04 DOI: 10.1080/00207454.2024.2311234

Nikhil Pantbalekundri, Anjalee Chiwane, Harshita Reddy, Manjit Kothari

{"title":"Comprehensive and integrated management of basilar impression, platybasia and cranio-vertebral junction abnormality- a case report.","authors":"Nikhil Pantbalekundri, Anjalee Chiwane, Harshita Reddy, Manjit Kothari","doi":"10.1080/00207454.2024.2311234","DOIUrl":"10.1080/00207454.2024.2311234","url":null,"abstract":"Aim: To report a case of anomalous development of base of skull (platybasia, Basilar invagination and C1-C2 vertebral fusion); and emphasize nonsurgical management in inoperable cases that can improve quality of life of the patient.Materials and methods: The case is reported as a descriptive study of a 17-year-old female who presented to a rural teaching tertiary care hospital in Wardha, Maharashtra, India; with chief complaints of weakness in all four limbs since 10 years of age.Result and conclusion: Platybasia is a developmental defect of the occipital bone and upper cervical spine resulting from anomalous development. The mechanism of such anomalies is not known; however, the most accepted theory includes abnormal basi-occiput development. The pressure effects may present signs similar to progressive spastic paralysis, cerebellar symptoms, or cranial nerve palsy, in addition to musculoskeletal symptoms. It is, therefore, crucial for physicians and radiologists to be familiar with clinical manifestations and radiological findings. In the following case of a patient with base of skull anomalies, surgical intervention in view of progressive worsening of motor symptoms was advised, however, the guardians declined the same due to high risk involved. Due to financial constraints, genetic studies were unaffordable, and a lack of awareness regarding the disease hampered the guardians from making a decision on the definite management of the disease. Besides radical neurosurgery, intensive physiotherapy can prove vital in significantly improving the quality of life for the patient.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"515-520"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visuospatial processing can be disrupted in healthcare workers during the COVID-19 pandemic. 在 COVID-19 大流行期间，医护人员的视觉空间处理能力会受到干扰。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-08 DOI: 10.1080/00207454.2024.2312995

Ali Nouraeinejad

引用次数: 0

Children rely more profoundly on the visual system to control their posture than adults. 与成人相比，儿童更依赖视觉系统来控制自己的姿势。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-05 DOI: 10.1080/00207454.2024.2312981

Ali Nouraeinejad

引用次数: 0

Postural tremor and sexual chromosome aneuploidies: case report and review of literature. 姿势性震颤和性染色体非整倍体：病例报告和文献综述。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-06 DOI: 10.1080/00207454.2024.2313009

Juan Alcalá Torres, Sara Llamas-Velasco, Carlos Santos Martín, Antonio Méndez Guerrero

引用次数: 0

The variability in nociceptive flexion reflex threshold measurement is mostly caused by probabilistic effects of the estimation algorithms: a simulation study. 痛觉屈曲反射阈值测量的变异性主要是由估计算法的概率效应引起的：一项模拟研究。

IF 1.7 4区医学

International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-09 DOI: 10.1080/00207454.2024.2312991

Carlo Jurth, Gregor Lichtner, Thomas Bienert, Falk von Dincklage

{"title":"The variability in nociceptive flexion reflex threshold measurement is mostly caused by probabilistic effects of the estimation algorithms: a simulation study.","authors":"Carlo Jurth, Gregor Lichtner, Thomas Bienert, Falk von Dincklage","doi":"10.1080/00207454.2024.2312991","DOIUrl":"10.1080/00207454.2024.2312991","url":null,"abstract":"Objectives: The nociceptive flexion reflex (NFR) and its threshold are frequently used to investigate spinal nociception in humans. Since this threshold (NFRT) is a probabilistic measure, specific algorithms are used for NFRT estimation based on the stochastic occurrence of reflexes at different stimulus intensities. We used a validated simulation model of the NFR to investigate the amount of NFRT measurement variability induced by different estimation algorithms in a steady setting of reduced external influences.Methods: We simulated the behavior of different estimation algorithms in subjects with an artificially steady baseline NFRT variability (standard deviation: 0 mA) or low baseline NFRT variability (standard deviation: 0.156 mA), equaling a quiet experimental setting. The obtained data were analyzed for NFRT measurement variability caused by the algorithms compared to the baseline variability reflecting other physiological influences.Results: The standard deviation of the NFRT estimated by the different algorithms ranged between 0.381 and 3.464 mA with 96.8% to 99.6% of the measurement variability attributed to the algorithm used. Out of the investigated algorithms the dynamic staircase algorithm was most precise.Conclusion: The NFRT measurement variability observed during quiet and steady experimental sessions is mostly caused by the properties of the estimation algorithms, due to the probabilistic nature of the reflex occurrence. Our results give reference for choosing the optimal estimation algorithm to improve measurement precision.","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"553-562"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0