International Journal of Neuroscience最新文献

{"title":"Nomogram Combined Neuron-Specific Enolase and NIHSS for Prediction of Post Stroke Depression.","authors":"Chuming Yan, Wancheng Zheng, Tong Si, Liyuan Huang, Lulu Wen, Huixin Shen, Miao Qu","doi":"10.1080/00207454.2025.2488758","DOIUrl":"https://doi.org/10.1080/00207454.2025.2488758","url":null,"abstract":"<p><strong>Objective: </strong>The National Institutes of Health Stroke Scale (NIHSS) is a known risk factor for post-stroke depression (PSD). However, more objective indicators are needed. The role of neuron-specific enolase (NSE) in PSD development remains unclear. This study aimed to ascertain the correlation of NIHSS score and NSE with PSD risk, and establish a novel nomogram combining NSE and NIHSS for early PSD prediction.</p><p><strong>Methods: </strong>A total of 172 patients with acute ischemic stroke (AIS) were involved. Baseline clinical data including NSE and NIHSS were collected. At 3-month follow-up, patients were categorized into PSD and non-PSD groups. Logistic models and restricted cubic spline curve were used to investigate the correlation between NIHSS, NSE and PSD. A corresponding nomogram was formulated.</p><p><strong>Results: </strong>Among 172 patients with AIS, 63 (36.63%) were diagnosed with PSD, while 109 (63.37%) were non-PSD. The baseline NIHSS and NSE were positively correlated with the risk of 3-month PSD (<i>P</i> < 0.05). Multivariate logistic regression revealed that sex (OR= 2.168, 95% CI 1.038 ∼ 4.526), age (OR= 1.035, 95% CI 1.002 ∼ 1.070), NIHSS (OR= 1.164, 95% CI 1.022 ∼ 1.325) and NSE (OR= 1.180, 95% CI 1.037 ∼ 1.343) were independently associated with 3-month PSD (all <i>P</i> < 0.05). The nomogram constructed using sex, age, baseline NIHSS score and NSE showed good discrimination, calibration, and clinical utility.</p><p><strong>Conclusion: </strong>NSE is a valuable tool for early identification of PSD risk. A combined prediction model incorporating NIHSS and NSE has been established for the personalized prevention and intervention of PSD.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the application of virtual reality technology in patients with Duchenne muscular dystrophy.","authors":"Shuting Liu, Xiaokang Wang, Yahao Ren, Li Peng","doi":"10.1080/00207454.2025.2488768","DOIUrl":"https://doi.org/10.1080/00207454.2025.2488768","url":null,"abstract":"<p><p>Duchenne muscular dystrophy is a common hereditary muscular dystrophy, virtual reality technology as an emerging therapeutic method has been gradually applied to the rehabilitation treatment of Duchenne muscular dystrophy patients. This paper reviews the current management status of Duchenne muscular dystrophy patients, the application effect of virtual reality technology in the rehabilitation treatment of Duchenne muscular dystrophy patients, and points out the challenges faced by the application of virtual reality technology in the field of Duchenne muscular dystrophy, aiming to provide a basis for the care of muscular dystrophy patients.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbamazepine toxicity with concomitant levetiracetam therapy in patients with epilepsy.","authors":"Archana Mishra, Biswa Ranjan Mishra, Debadatta Mohapatra, Anand Srinivasan, Rituparna Maiti, Debasish Hota","doi":"10.1080/00207454.2025.2489701","DOIUrl":"https://doi.org/10.1080/00207454.2025.2489701","url":null,"abstract":"<p><strong>Aim: </strong>Drug interactions are crucial in understanding the efficacy and safety of co-administered antiepileptic drugs, which underscores the need for cautious prescribing and close monitoring of patients receiving multiple antiepileptics. This study aims to investigate drug interactions between carbamazepine(CBZ) and levetiracetam(LEV) and whether the CBZ toxicity is LEV drug-dose or dose-ratio-dependent(LEV:CBZ).</p><p><strong>Methods: </strong>The present record-based case-control study analyzed data from 158 patients. A univariate analysis was done to identify the association of various factors with toxic trough CBZ concentrations. Frequentist disproportionality analysis was done to determine a signal for the association between concomitant LEV administration and CBZ toxicity. Receiver operating characteristic (ROC) analysis was done to identify the LEV:CBZ dose ratio or LEV dose to differentiate between toxic and non-toxic CBZ concentrations.</p><p><strong>Results: </strong>The odds of developing manifestations of CBZ toxicity in CBZ + LEV versus CBZ group was 16.65(95%CI:3.52-78.70;p < 0.001). The univariate analysis showed no association between CBZ dose and toxic trough CBZ levels, while an association between LEV administration and toxic trough CBZ levels was evident. A reporting odds ratio(ROR) of 2.25(95%CI:1.07-4.72;p = 0.030) and a proportional reporting ratio (PRR) of 1.77(95%CI:1.07-2.94) was observed for toxic levels of CBZ with co-administration of LEV. A LEV: CBZ dose ratio of 1.86 was identified as a threshold for differentiating between toxic and non-toxic serum concentrations with an accuracy of 72.9%.</p><p><strong>Conclusions: </strong>There is a temporal association between LEV administration and toxic blood levels and toxic symptoms of CBZ. The chances of achieving toxic concentrations of CBZ are significantly higher when the dose strength of LEV is nearly double the dose of CBZ.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of antiplatelet drugs combined with Argatroban in treating acute ischemic stroke and its impact on patients' coagulation function and neurological function: a preliminary trial.","authors":"Meng Sun, Guoyi Li, Yingge Du, Jiwei Cheng, Qiaoyan Zhu, Zhizhen Shi","doi":"10.1080/00207454.2024.2303370","DOIUrl":"10.1080/00207454.2024.2303370","url":null,"abstract":"<p><p>This retrospective study analyzed the efficacy of combined antiplatelet therapy with Argatroban in treating acute ischemic stroke (AIS) and its impact on patients' coagulation and neurological functions. Clinical data of 113 AIS patients admitted between January 2021 and January 2023 were retrospectively analyzed. Patients were divided into control (<i>n</i> = 56) and observation (<i>n</i> = 57) groups based on treatment interventions. The control group patients were treated with antiplatelet drugs, while the observation group patients received combination therapy with apatinib on the basis of the control group treatment. Compared to the control group, the observation group demonstrated higher clinical efficacy, improved coagulation parameters, reduced stroke severity (measured by NIHSS), enhanced daily living abilities (BI scores), and lowered inflammatory and neural injury markers post-treatment. Adverse reaction incidence was similar between groups. Combining Argatroban with antiplatelet drugs in AIS management showed superior efficacy without increasing adverse effects, suggesting its potential for clinical application.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"405-412"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on \"estimated intracranial pressure in glaucoma patients and its correlation with disease severity\".","authors":"Dipen Kumar, David Fleischman","doi":"10.1080/00207454.2024.2302867","DOIUrl":"10.1080/00207454.2024.2302867","url":null,"abstract":"","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"392-393"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.","authors":"Zidan Gao, Zhuoma Danzhen, Junyu Zhu, Yao Li, Zhu Xu, Lan Chu","doi":"10.1080/00207454.2024.2304081","DOIUrl":"10.1080/00207454.2024.2304081","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to explore the possible relationship between the serum vitamin D level and olfactory impairment in a population of multiple sclerosis (MS) patients in Guizhou, China.</p><p><strong>Methods: </strong>We included 25 patients with MS and 18 healthy controls (HCs) who were recruited from the Affiliated Hospital of Guizhou Medical University from February 2021 to September 2021. The University of Pennsylvania Smell Identification Test (UPSIT) was used to test the patients' sense of smell, and the level of serum 25-hydroxyethylene polyprotein D was measured.</p><p><strong>Results: </strong>Serum vitamin D levels and UPSIT scores were significantly different between the MS group and the control group (both <i>p</i> < 0.001). Moreover, a significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients (<i>r</i> = 0.537, <i>p</i> = 0.021).</p><p><strong>Conclusions: </strong>The serum vitamin D level may be involved in the regulation of olfactory dysfunction in MS patients in Guizhou, China.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"420-427"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Solitaire AB stent thrombectomy with tirofiban and butylphthalide on neurological function and inflammatory factors in acute cerebral infarction patients.","authors":"Le Bao, Ying Liu, Long Chen, Fei Wang, Yuzhi Zhu, Shuang Liang, Youbin Wang, Hetai Quan, Pengfei Li","doi":"10.1080/00207454.2024.2309464","DOIUrl":"10.1080/00207454.2024.2309464","url":null,"abstract":"<p><strong>Background: </strong>Acute cerebral infarction profoundly affects patients' neurological function and quality of life. This study explores the impact of Solitaire AB stent thrombectomy, combined with tirofiban and butylphthalide, on neurological function and inflammatory factors in patients with acute cerebral infarction.</p><p><strong>Methods: </strong>Seventy-three eligible patients treated between 2021 and 2023 were divided into a control group (Solitaire AB stent thrombectomy) and a treatment group (Solitaire AB stent thrombectomy with tirofiban and butylphthalide). Postoperative neurological function scores and inflammatory factor levels were analyzed.</p><p><strong>Results: </strong>The treatment group demonstrated a higher clinical effective rate, lower National Institutes of Health Stroke Scale scores at one day and seven days and higher Mini-Mental State Examination and Montreal Cognitive Assessment scores post-treatment. Inflammatory factor levels (Neuron Specific Enolase (NSE), S100-β, TNF-α and IL-6) were lower in the treatment group. No significant differences in adverse outcomes were observed.</p><p><strong>Conclusion: </strong>Solitaire AB stent thrombectomy with tirofiban and butylphthalide shows superior efficacy, improving neurological function and inflammatory factors without increasing adverse outcomes. This offers valuable insights for clinical treatment of acute cerebral infarction.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"445-454"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of endovascular interventional embolization and microsurgical clipping for ruptured cerebral aneurysms: impact on patient outcomes.","authors":"Min Li, Zhihua Tian, Xiaohong Ru, Jianbo Shen, Guiping Chen, Zhibin Duan, Jie Cui","doi":"10.1080/00207454.2024.2303369","DOIUrl":"10.1080/00207454.2024.2303369","url":null,"abstract":"<p><strong>Objective: </strong>To compare the therapeutic efficacy of endovascular interventional embolization and microsurgical clipping in patients with ruptured cerebral aneurysms and investigate their subsequent influence on inflammatory indices, neurological function, prognosis, and recovery.</p><p><strong>Methods: </strong>The two groups were compared in terms of surgery duration, hospital stay, Hunt-Hess classification, and inflammatory indices before and after the surgery, as well as National Institutes of Health Stroke Scale (NIHSS), Baethel Index (BI), and one-year prognosis of patients affected.</p><p><strong>Results: </strong>The surgery duration and hospital stay of the intervention group were (116.27 ± 12.32) min and (19.82 ± 2.26) d, respectively, and those of the clipping group was (173.87 ± 10.39) min and (24.11 ± 2.33) d, respectively (both <i>p</i> < 0.05). Neither the intervention nor the microscopic approach had a significant impact on the severity of the patients' conditions in terms of Hunt-Hess classification (<i>p</i> > 0.05). In the intervention group, CRP was changed to (5.31 ± 1.22) mg/L and PCT decreased to (1.17 ± 0.39) μg/L after the surgery, while the corresponding values in clipping group were (9.78 ± 2.35) mg/L and (2.75 ± 0.81) μg/L (<i>p</i> > 0.05). After surgery, both groups' NIHSS scores declined dramatically, with the intervention group scoring lower than the microscopy group (6.81 ± 1.22 vs 8.72 ± 1.27) (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The findings of this study support the potential advantages of endovascular interventional embolization (coiling) over microsurgical clipping for the management of ruptured cerebral aneurysms. These advantages include shorter surgical duration, reduced hospital stay, lower inflammatory response, improved neurological and functional outcomes, and better long-term prognosis.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"397-404"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis of circRNA networks in postoperative cognitive dysfunction.","authors":"Jian Tang, Yanhong Tang, Peimin Lin, Jie Zheng, Zhengfen Li, Ying Zhang","doi":"10.1080/00207454.2024.2309473","DOIUrl":"10.1080/00207454.2024.2309473","url":null,"abstract":"<p><strong>Objective: </strong>In the quest to decipher the molecular intricacies of Postoperative Cognitive Dysfunction (POCD), this study focused on circular RNA (circRNA) and their regulatory networks.</p><p><strong>Materials and methods: </strong>Analyzing the Gene Expression Omnibus Series (GSE) 147277 dataset, we pinpointed 10 differentially expressed circRNAs linked to POCD.</p><p><strong>Results: </strong>The ensuing competing endogenous RNA (ceRNA) network, featuring pivotal players like Homo sapiens(hsa)_circ_0003424 and hsa-miR-193b-5p, provided a comprehensive understanding of the molecular players at play in POCD.</p><p><strong>Conclusion: </strong>Additionally, the Protein-Protein Interaction (PPI) network spotlighted 10 core Hub genes, including phosphatase and tensin homolog (PTEN) and signal transducer and activator of transcription 3(STAT3), shedding light on potential therapeutic targets.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"455-487"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of atorvastatin calcium plus clopidogrel in the treatment of patients with transient ischemic attacks and its effect on blood lipids and platelets.","authors":"Maocheng Bian, Fei Zhong, Jian Wan","doi":"10.1080/00207454.2024.2303373","DOIUrl":"10.1080/00207454.2024.2303373","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical effect of atorvastatin calcium combined with clopidogrel in the treatment of patients with transient ischemic attacks (TIAs) and its effect on blood lipids and platelets.</p><p><strong>Methods: </strong>Low-density lipoprotein cholesterol (LDL-C)], platelet-related parameters [prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count (PLT)], incidence of cerebral infarction, and adverse reactions.</p><p><strong>Results: </strong>The clinical outcomes of the experimental group patients were significantly better than those of the control group patients (<i>p</i> < 0.05). The experimental group exhibited notably lower levels of TG, TC, and LDL-C compared to the control group (<i>p</i> < 0.05). Platelet-related indices-PT, APTT, and PLT-showed no significant differences between groups before and after treatment (<i>p</i> > 0.05). The incidence of cerebral infarction was notably lower in the experimental group (<i>p</i> < 0.005), while the occurrence of adverse reactions showed no significant difference between groups (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Atorvastatin calcium combined with clopidogrel demonstrates a positive impact on individuals with TIAs by significantly lowering levels of LDL, total cholesterol, and triglycerides. However, it is noteworthy that platelet-related indices did not exhibit significant differences between the experimental and control groups. While the observed improvements in blood lipids are attributed to the effects of atorvastatin, the combination with clopidogrel did not show a substantial influence on platelet-related parameters. Thus, the overall therapeutic impact, particularly on platelet-related indices, may require further investigation and clarification. Despite these nuances, our findings suggest potential benefits in reducing the risk of adverse reactions and cerebral infarction, supporting the consideration of this approach for wider clinical use.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"413-419"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}