Research progress on histone lactylation modification in ischemic stroke: mechanisms and therapeutic potential.

IF 1.5 4区 医学 Q4 NEUROSCIENCES
Wang Tingting, Chen Yushan, Wang Shuangshuang
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引用次数: 0

Abstract

Ischemic stroke (IS) is a leading cause of death and disability worldwide, with a complex pathogenesis involving neuroinflammation, oxidative stress, and disruption of the blood-brain barrier. Recent research has brought histone lactylation into focus as a novel epigenetic modification that plays a crucial role in IS. Under cerebral ischemia and hypoxia, lactate levels rise, providing an alternative energy source to support ischemic brain regions. Lactate also functions as a signaling molecule, regulating key processes such as neuroprotection, angiogenesis, and anti-inflammatory responses. This review synthesizes the current research on histone lactylation in IS, emphasizing its role in neuronal survival, inflammatory regulation, and blood-brain barrier integrity. A comprehensive literature review was conducted using databases such as PubMed, Scopus, and Web of Science, focusing on studies published from 2015 to 2023. Additionally, the review explores the potential of histone lactylation as a therapeutic target for post-stroke recovery. Histone lactylation can be targeted therapeutically through the use of specific inhibitors or enhancers of acetyltransferase and deacetylase enzymes, offering a promising strategy for modulating stroke-related cellular processes. By integrating recent findings, this review aims to provide new insights into ischemic stroke and promote the development of innovative therapeutic strategies.

缺血性脑卒中组蛋白乳酸化修饰的研究进展:机制和治疗潜力。
缺血性中风(IS)是世界范围内死亡和残疾的主要原因,其复杂的发病机制涉及神经炎症、氧化应激和血脑屏障的破坏。最近的研究将组蛋白乳酸化作为一种新的表观遗传修饰引起关注,在IS中起着至关重要的作用。在脑缺血和缺氧的情况下,乳酸水平升高,为脑缺血区域提供替代能量来源。乳酸也是一种信号分子,调节神经保护、血管生成和抗炎反应等关键过程。本文综述了IS中组蛋白乳酸化的最新研究,重点介绍了其在神经元存活、炎症调节和血脑屏障完整性中的作用。利用PubMed、Scopus和Web of Science等数据库进行了全面的文献综述,重点研究了2015年至2023年发表的研究。此外,该综述还探讨了组蛋白乳酸化作为卒中后康复治疗靶点的潜力。组蛋白乳酸化可以通过使用乙酰转移酶和去乙酰化酶的特异性抑制剂或增强剂进行靶向治疗,为调节中风相关的细胞过程提供了一种有前途的策略。通过对近期研究成果的整合,本文旨在为缺血性脑卒中的研究提供新的见解,并促进创新治疗策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.10
自引率
0.00%
发文量
132
审稿时长
2 months
期刊介绍: The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders.  The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.
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