Evaluating the role of Ginkgo biloba extract in the secondary prevention of acute ischemic stroke with cerebral microbleeds by quantitative susceptibility mapping (QSM).

IF 1.5 4区 医学 Q4 NEUROSCIENCES
International Journal of Neuroscience Pub Date : 2025-09-01 Epub Date: 2023-10-20 DOI:10.1080/00207454.2023.2268264
Wenting Lan, Xin Wu, Yuefei Wu, Hui Zhang
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引用次数: 0

Abstract

Background: EGb 761, a standardized dry extract of Ginkgo biloba leaves, has certain anti-inflammatory and thrombotic effects and can be used to treat cerebrovascular diseases.

Methods: A total of 49 patients were randomly assigned to the Aspirin group (24 cases in Controlled group) and the Aspirin + Ginkgo biloba group (25 cases in Treatment group). The quantitative magnetic sensitivity and venous oxygen saturation of cerebral microbleeds were analyzed at admission, discharge, and after follow-up for 3 and 6 months.

Results: The demographic details age, gender, and admission to NIHSS were not significantly different between the two groups (p < 0.05). Quantitative susceptibility mapping (QSM) showed that the magnetic sensitivity of patients in both groups remained stable after 3 and 6 months of follow-up, while the venous oxygen saturation of the Treatment group increased. The venous oxygen saturation at 3 and 6 months of follow-up was negatively correlated with the modified mRS grade score.

Conclusions: QSM can be used as a quantitative follow-up tool in monitoring both oxygen saturation and Magnetic susceptibility of microbleeds noninvasively in ischemic stroke patients with cerebral microbleeds. EGB combined with Aspirin can improve blood oxygen saturation in those patients and this effect is particularly significant in the long-term efficacy of secondary prevention.

通过定量易感性图谱(QSM)评估银杏叶提取物在脑微出血急性缺血性卒中二级预防中的作用。
背景银杏叶标准化干提取物EGb761具有一定的抗炎和血栓形成作用,可用于治疗脑血管疾病。方法:将49例患者随机分为阿司匹林组(对照组24例)和阿司匹林组 + 银杏组(治疗组25例)。在入院、出院和随访3个月和6个月后,分析脑微出血的定量磁敏度和静脉血氧饱和度。结果:两组患者的人口学特征年龄、性别和NIHSS入院率差异无统计学意义(P 结论:QSM可作为一种定量随访工具,无创监测脑微出血缺血性脑卒中患者微出血的血氧饱和度和磁化率。EGB联合阿司匹林可以改善这些患者的血氧饱和度,这种效果在二次预防的长期疗效中尤为显著。
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来源期刊
CiteScore
5.10
自引率
0.00%
发文量
132
审稿时长
2 months
期刊介绍: The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders.  The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.
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