International Journal of Neuroscience最新文献

{"title":"Evaluation of sarcopenia and phase angle in elderly patients with Parkinson's Disease.","authors":"Merve Yilmaz, Yasemin Atik-Altinok, Dilek Seyidoglu Yüksel, Ahmet Acarer, Devrim Bozkurt, Sumru Savas, Z Fulden Sarac, Fehmi Akcicek","doi":"10.1080/00207454.2024.2310180","DOIUrl":"10.1080/00207454.2024.2310180","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate sarcopenia and related factors and to determine the disease-specific phase angle (PhA) cut-off score in detecting sarcopenia in elderly patients with Parkinson's Disease (PD).</p><p><strong>Methods: </strong>This cross-sectional study was conducted with 89 participants. The Mini-Nutritional Assessment (MNA), the Eating Attitude Test-10 (EAT-10), the Physical Activity Scale for The Elderly (PASE) questionnaire and the Hoehn-Yahr scale have been used. Additionally, anthropometric measurements were performed. The diagnosis of sarcopenia was based on the new consensus published by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). PhA has been performed by Bioelectrical Impedance Analysis (BIA) with Tanita MC 780®.</p><p><strong>Results: </strong>The mean age was of the participants 68.9 ± 6.4 years, and 57.3% were male. The prevalence of sarcopenia was 12.3%. PhA, malnutrition, age, disease severity, low calf circumference (CC), low body mass index (BMI), the difference between the pre-diagnosis and current weight loss, dopaminergic treatment, and low PASE score were associated with sarcopenia. The cut-off value of the PhA in terms of the ability to identify sarcopenia was <4.5o with a sensitivity of 53.3% and a specificity of 93.2% (<i>p</i> = 0.001). When we grouped the PhA of the patients according to this cut-off score, it was seen that 14.6% of them were sarcopenic. Age, disease severity, PASE score and hand grip strength were significantly related to both sarcopenia and PhA.</p><p><strong>Conclusion: </strong>It is important to be aware of sarcopenia and related factors at an early stage in Parkinson's patients. Because of disease-related symptoms, it may be more appropriate to use a disease-specific PhA cut-off score in the definition of sarcopenia.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"488-495"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/00207454.2024.2306430","DOIUrl":"10.1080/00207454.2024.2306430","url":null,"abstract":"","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"434"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial lipoma: an incidental finding and a rare cause of secondary headache.","authors":"Faheem Arshad, Karthik Kulanthaivelu, Ravi Yadav","doi":"10.1080/00207454.2024.2302861","DOIUrl":"10.1080/00207454.2024.2302861","url":null,"abstract":"<p><strong>Aim of the study: </strong>Expand the differential diagnosis of secondary headache to include rare intracranial tumours, detected incidentally on brain imaging. Intracranial lipomas are rare congenital malformations, and are usually pericallosal asymptomatic midline lesions. However, some cases present with headache and seizures. Symptomatic intracranial lipomas are very rare and often detected incidentally on brain imaging.</p><p><strong>Methods: </strong>We present a 52-year-old woman referred to our tertiary centre with a history of hypothyroidism presented with headache for 2 years. She had generalised body pains for six months. Her headache was persistent despite being on medications. Physical and neurological examination was unremarkable. Her visual acuity and fundus examination were normal.</p><p><strong>Results: </strong>Her brain imaging revealed a lesion over the corpus callosum and in the interhemispheric fissure with signal attenuation on the fat suppression sequence, features suggestive of curvilinear pericallosal lipoma. Symptomatic treatment with analgesics and anti-inflammatory agents were slightly effective. It is debatable whether tumour removal is required, as the risks of surgical intervention far outweigh the potential benefits.</p><p><strong>Conclusion: </strong>Corpus callosal lipoma is a rare and unrecognised cause of secondary headache. It should be suspected in patients with an atypical headache without papilledema and who are unresponsive to analgesics. This may be the only presenting feature of intracranial lipomas rendering it even more difficult to suspect and diagnose, thus emphasising the importance of evaluating secondary headaches. Diagnosis is important because long-term follow-up may be required if patients develop new focal deficits, which may necessitate surgical intervention.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"388-391"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying hub genes and dysregulated pathways in Duchenne muscular dystrophy.","authors":"Jianzeng Xin, Sheng Liu","doi":"10.1080/00207454.2024.2302551","DOIUrl":"10.1080/00207454.2024.2302551","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to identify the hub genes and dysregulated pathways in the progression of duchenne muscular dystrophy (DMD) and to unveil detailedly the cellular and molecular mechanisms associated with DMD for developing efficacious treatments in the future.</p><p><strong>Material and methods: </strong>Three mRNA microarray datasets (GSE13608, GSE38417 and GSE109178) were downloaded from Gene Expression Omnibus (GEO). The differentially expressed genes (DEGs) between DMD and normal tissues were obtained via R package. Function enrichment analyses were implemented respectively using DAVID online database. The network analysis of protein-protein interaction network (PPI) was conducted using String. Cytoscape and String were used to analyse modules and screen hub genes. The expression of the identified hub genes was confirmed in mdx mice through using qRT-PCR.</p><p><strong>Results: </strong>In total, 519 DEGs were identified, consisting of 393 upregulated genes and 126 downregulated genes. The enriched functions and pathways of the DEGs mainly involve extracellular matrix organization, collagen fibril organization, interferon-gamma-mediated signaling pathway, muscle contraction, endoplasmic reticulum lumen, MHC class II receptor activity, phagosome, graft-versus-host disease, cardiomyocytes, calcium signaling pathway. Twelve hub genes were discovered and biological process analysis proved that these genes were mainly enriched cell cycle, cell division. The result of qRT-PCR suggested that increase in expression of CD44, ECT2, TYMS, MAGEL2, HLA-DMA, SERPINH1, TNNT2 was confirmed in mdx mice and the downregulation of ASB2 and LEPREL1 was also observed.</p><p><strong>Conclusion: </strong>In conclusion, DEGs and hub genes identified in the current research help us probe the molecular mechanisms underlying the pathogenesis and progression of DMD, and provide candidate targets for diagnosis and treatment of DMD.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"375-387"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability, asymmetry and bilateral coordination of gait during single- and dual-task walking of patients with cerebral small vessel disease.","authors":"Hongyang Xie, Cuiqiao Xia, Hongyi Zhao, Zhenxi Xia, Nan Zhang, Yonghua Huang","doi":"10.1080/00207454.2024.2309454","DOIUrl":"10.1080/00207454.2024.2309454","url":null,"abstract":"<p><strong>Objective: </strong>We investigated coefficient of variation (CV), gait asymmetry (GA) and phase coordination index (PCI) in cerebral small vessel disease (CSVD) patients during single-task walking (STW) and dual-task walking (DTW) and explored the relationship between above parameters with disease severity and cognitive function.</p><p><strong>Methods: </strong>This cross-sectional study collected cognitive function indices and gait parameters from 23 healthy controls and 94 patients with CSVD during STW and DTW. According to the Fazekas scales, the severity of CSVD valued by white matter hyperintensity (WMH) were divided into control, mild, moderate, severe and control group. MRIs were analyzed for WMHs, CMB, lacunes, etc.</p><p><strong>Results: </strong>The control group showed lower PCI than CSVD patients during STW; no differences were detected among the disease severity groups. During DTW, all four groups exhibited significant differences in PCI and CV. For the moderate and severe groups, coordination and variation significantly differed between the two walking methods. There were correlations between the PCI and GA in the moderate and severe groups (<i>R</i> = 0.376, <i>R</i> = 0.573 during DTW; <i>R</i> = 0.414, <i>R</i> = 0.643 during STW) and no correlations in the control group and mild CSVD group.</p><p><strong>Conclusion: </strong>PCI and CV may be vital for detecting the symptoms in the early stage of CSVD disease. We also verified that the PCI could become the bridge across the cognition and motor disorder in CSVD, which was helpful for evaluating clinical symptoms comprehensively.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"435-444"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Déjerine-Roussy syndrome presenting with atypical involuntary movements.","authors":"Ramesh Krishnan, Dinesh Mohan Chaudhari, Pushpendra Nath Renjen, Anjali Mishra, Priyal, Shisher Pandey","doi":"10.1080/00207454.2024.2302870","DOIUrl":"10.1080/00207454.2024.2302870","url":null,"abstract":"<p><strong>Background: </strong>The Déjerine-Roussy syndrome is caused by a stroke in the posterior lateral nuclei of the thalamus. It has a 17 to 18% prevalence after a stroke involving the inferior lateral thalamus.</p><p><strong>Methods: </strong>We reported a case of a 65-year-old, diabetic and hypertensive male who presented with sudden onset of superficial hemianesthesia, allodynia, severe and paroxysmal pain on the right side of the body with choreoathetoid movements in the upperN limb, along with slured speech, and unsteadiness while walking.</p><p><strong>Conclusions: </strong>It is characterized by superficial hemianesthesia, allodynia, severe paroxysmal pain, and choreoathetoid movements in the limbs on the paralyzed side. A posterior lateral thalamic lesion can present with ataxia hemiparesis contralateral to the side of the lesion.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"394-396"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical study on the researches about the application of neurotechnology in education.","authors":"Javad Alipoor, Hatef Pourrashidi","doi":"10.1080/00207454.2024.2311231","DOIUrl":"10.1080/00207454.2024.2311231","url":null,"abstract":"<p><strong>Introduction: </strong>The education and pedagogy have been adopted with the development of technology in order to achieve efficient consequences and the new methods in neuroscience and neurotechnology have influenced the educational systems and the classrooms. A great number of researches have been projected in this field to demonstrate the advantages and desirable effects of neurotechnology in education and the classrooms. These researches are examinable in terms of considering both advantages and disadvantages of technology.</p><p><strong>Objects: </strong>The aim of this study is to demonstrate the advantages and undesirable effects of neurotechnology in education and the classrooms.</p><p><strong>Methods: </strong>This article surveys the fourteen recent researches about using neurotechnology in education and the classrooms in the framework of critical theory to discuss the adverse and undesired effects of neurotechnology as well as their neglected aspects in education and the classrooms.</p><p><strong>Findings: </strong>The findings illuminate that crucial disadvantages of neurotechnology are neglected in using computerbased tools in education and the classrooms and their side effects on the participants in the process of learning.</p><p><strong>Conclusions: </strong>The new methods in neuroscience and neurotechnology have influenced the educational systems and the classrooms. A considerable number of researches have been projected in this field that all try to demonstrate the advantages and desirable effects of neurotechnology in education and the classrooms, but they consciously or unconsciously neglect the immoral and unscrupulous effects of such technologies.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"496-503"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.","authors":"Yuxin Pu, Yiyong Xu, Zushun Zhuo, Huizhong Xiao, Xinyi Xu","doi":"10.1080/00207454.2025.2478825","DOIUrl":"10.1080/00207454.2025.2478825","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to assess the ameliorative effects of naringin (NR) on cognitive impairment in schizophrenia(SZ) from multiple perspectives using behavioral, histopathological and molecular biological approaches.</p><p><strong>Materials and methods: </strong>SZ models were established in rats <i>via</i> acute intraperitoneal injection of MK-801 in all groups except the control group, which received saline. Cognitive function was assessed using the Morris water maze test 21 days after prophylactic NR administration. Subsequently, Serum interleukin-6 (IL-6) and homocysteine (HCY) levels were quantified using enzyme-linked immunosorbent assay (ELISA), and hippocampal neuronal and synaptic structures were observed <i>via</i> microscopy. Molecular detection was performed using real-time reverse transcription polymerase chain reaction (RT-qPCR) and western blotting (WB) to assess the expression levels of molecules related to the microRNA-25-3p/salt inducible kinase 1/CREB regulated transcription coactivator 2/cAMP responsive element binding protein 1 (miR-25-3p/SIK1/CRTC2/CREB1) pathway, thereby elucidating the mechanism by which NR ameliorates cognitive impairment in SZ.</p><p><strong>Results: </strong>NR was found to mitigate cognitive decline in learning and memory induced by MK-801. It lowered serum levels of IL-6 and HCY, reduced neuronal damage in the CA1 region of the hippocampus, increased the thickness of postsynaptic dense material, decreased the distance between synaptic gaps, decreased the expression of SIK1, and elevated the expression of miR-25-3p, CRTC2 and CREB1 in the hippocampus.</p><p><strong>Conclusion: </strong>NR may protect neurons in the CA1 region of the hippocampus and enhance synaptic plasticity by regulating the miR-25-3p/SIK1/CRTC2/CREB1 signaling pathway, thereby promoting cognitive improvement.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroprotective effects of Piracetam on cisplatin-induced cognitive decline.","authors":"Maha Elbeltagy, Bann Khraisat, Lujain AlZoubi, Leen Hmoud, Ahmad AlJeady, Mohammed Yousef, Ahmed Salman","doi":"10.1080/00207454.2023.2300733","DOIUrl":"10.1080/00207454.2023.2300733","url":null,"abstract":"<p><strong>Aim: </strong>This work explores the effect of Cisplatin-a chemotherapeutic agent known to cause deterioration in cognitive function in cancer patients, and spatial memory in mice. It also investigates the potential neuroprotective effects of Piracetam, which is a nootropic drug recognized for improving cognitive ability.</p><p><strong>Materials and methods: </strong>The study incorporates four groups of mice receiving varied medication regimens, with memory tested using the Novel Location Recognition (NLR) method.</p><p><strong>Results: </strong>The findings from our study revealed that memory decline and a suppression of cellular proliferation were observed in adult male mice subjected to Cisplatin treatment; furthermore, a decline in antioxidant efficacy within the hippocampal dentate gyrus was evident. Moreover, analysis of treatment effects on the animals' weight revealed that the Cisplatin and Piracetam group exhibited the most significant weight loss during drug administration. Despite the significant weight loss, the simultaneous use of Cisplatin and Piracetam demonstrated a notable improvement in memory and an augmentation of hippocampal proliferation and antioxidant effect.</p><p><strong>Limitations: </strong>It is important to note that our study was hampered by budget limits, a lack of additional animals, and mice's low tolerance for protracted treatment.</p><p><strong>Conclusions: </strong>Should the outcomes of Piracetam observed in this investigation be applicable to patients, it might offer a relatively straightforward approach to mitigate the cognitive impacts endured by cancer survivors following exposure to chemotherapy. Future research will be needed to study Piracetam's effect on mice with brain cancer after Cisplatin treatment in order to extrapolate the results onto cancer patients.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"337-344"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of butylphthalide on cerebral vascular circulation, coagulation function, and neurological function in patients with acute severe ischemic stroke following intravenous thrombolysis: a preliminary study.","authors":"Yu Li, Hui Wang, Jiansen Zhao, Lei Xia, Kaiju Xiong, Huaping Zhong","doi":"10.1080/00207454.2023.2301424","DOIUrl":"10.1080/00207454.2023.2301424","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of Butylphthalide on cerebral vascular circulation, coagulation function, and neurological function in patients with acute severe ischemic stroke following intravenous thrombolysis.</p><p><strong>Methods: </strong>Clinical efficacy, cerebral vascular circulation indicators [anterior cerebral artery (ACA), middle cerebral artery (MCA), vertebral artery (VA) blood flow velocity], coagulation function indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB)], neurological function indicators [Activities of Daily Living (ADL) score.</p><p><strong>Results: </strong>The total effective rate of treatment in the control group was 76.47%, while in the observation group, it was 96.08%, with the observation group showing a significantly higher total effective rate than the control group (<i>p</i> < 0.05). Before treatment, there was no significant difference in ACA, MCA, and VA blood flow velocity between the two groups (<i>p</i> > 0.05). However, after treatment, the ACA, MCA, and VA blood flow velocity in the observation group were significantly higher than those in the control group (<i>p</i> < 0.05). Before treatment, there was no significant difference in PT, APTT, TT, and FIB levels between the two groups (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>In patients with acute severe ischemic stroke undergoing intravenous thrombolysis, the addition of Butylphthalide to the treatment regimen yields favorable clinical outcomes. Compared to Alteplase alone, the addition of Butylphthalide further improves cerebral vascular circulation and coagulation function, promoting the recovery and reconstruction of neurological function in patients. Importantly, the addition of Butylphthalide does not increase the risk of adverse reactions, making it a safe and ideal option for clinical application.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"367-374"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}