International Journal of Neuroscience最新文献

{"title":"Perampanel improves cognitive function in epilepsy by targeting AMPA receptor subunit GluR2-mediated endoplasmic reticulum stress and synaptic plasticity.","authors":"Xiaoqin Wang, Bin Lei, Yao Zhou, Foyang Fan, Liang Huang, Shuzhen Luo, Liping Zhang, Youfeng Zhou","doi":"10.1080/00207454.2026.2738702","DOIUrl":"10.1080/00207454.2026.2738702","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to explore the action mechanism of Perampanel (PER) in epilepsy treatment, particularly the associations with endoplasmic reticulum stress (ERS).</p><p><strong>Methods: </strong>Epilepsy mice model was induced by injecting kainic acid (KA) into hippocampus of mice, and KA-stimulated hippocampal neurons were used as <i>in vitro</i> cell model. Cognitive function of mice was evaluated by Novel Object Recognition and Morris Water maze tests. Hematoxylin-eosin and Nissl staining were conducted to observe neuron damage. Synaptic plasticity was evaluated by Golgi staining, immunofluorescence staining of microtubule-associated protein (MAP2) and synaptic function proteins expression. The 4-phenylbutyric acid (4-PBA) was used to inhibit ERS in cells.</p><p><strong>Results: </strong>PER treatment markedly ameliorated epileptic seizure behaviors, improved the spatial learning and memory functions, and hippocampal neuron injury of KA-induced epilepsy mice model. Moreover, KA-induced epilepsy mice showed reduced GluR2 expression, decreased dendritic spine density and expression of synaptic function proteins (SYP and PSD95) as well as elevated ERS-related proteins (GRP78, ATF4, CHOP, IRE1α and ATF6), while PER treatment could reverse such changes. Meanwhile, PER treatment could alleviate KA-induced neurotoxicity and synaptic plasticity deficits in hippocampal neurons. In terms of mechanism, GluR2 silencing reversed the protective effects of PER in KA-stimulated hippocampal neurons, and further inhibiting ERS using 4-PBA could offset the effects of GluR2 silencing.</p><p><strong>Conclusion: </strong>GluR2-mediated ERS may involve the improved effects of Perampanel in cognitive function of epilepsy patients by promoting synaptic plasticity.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link of oral microbiome diversity to stroke risk: evidence from the national cohort study in the United States.","authors":"Honghui Xu, Tingting Zhong, Jianyi Li","doi":"10.1080/00207454.2026.2736054","DOIUrl":"10.1080/00207454.2026.2736054","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether oral microbiome diversity and periodontal health are independently associated with stroke prevalence in a U.S. adult cohort, with implications for risk stratification in physical medicine and rehabilitation.</p><p><strong>Methods: </strong>We analyzed cross-sectional NHANES 2009-2012 data from 4,438 adults. Survey-weighted logistic regression estimated associations of stroke with oral microbiome β-diversity (unweighted UniFrac), α-diversity (Shannon and Simpson), and periodontal measures (probing depth, attachment loss, tooth count), adjusting for demographic, socioeconomic, behavioral, and cardiometabolic covariates.</p><p><strong>Results: </strong>In crude models, each 1-mm increase in probing depth (odds ratio [OR] 1.89, 95% CI 1.39-2.56) and attachment loss (OR 1.50, 95% CI 1.32-1.71) raised stroke odds; each additional tooth lowered them (OR 0.91, 95% CI 0.88-0.94). After stepwise adjustment, attachment loss (OR 1.23, 95% CI 1.04-1.46; P=0.017) and tooth count (OR 0.96, 95% CI 0.92-0.99; P=0.024) remained significant, whereas probing depth did not (OR 1.30, 95% CI 0.90-1.88; P=0.156), with a threshold near 1.46 mm. β-Diversity clusters did not differ after adjustment (global P=0.61), and neither α-diversity index was significant (Shannon fully adjusted OR 1.29, 95% CI 0.97-1.72; P=0.081). Periodontal associations were consistent across sex and age strata; null findings in younger participants reflected limited power.</p><p><strong>Conclusion: </strong>Attachment loss and tooth count were associated with stroke prevalence independently of traditional risk factors, whereas microbiome diversity indices were not. These measures may help refine risk assessment. The cross-sectional design precludes causal inference, and prospective cohorts with adjudicated outcomes and metagenomic profiling are needed.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a machine learning-based prediction model for postoperative delirium after glioma surgery.","authors":"Jingjing Li, Nini Xiao","doi":"10.1080/00207454.2026.2736052","DOIUrl":"10.1080/00207454.2026.2736052","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium after glioma surgery is difficult to predict because risk information evolves throughout the perioperative period. We developed and internally validated a temporally structured machine-learning framework for early risk stratification.</p><p><strong>Methods: </strong>This single-centre retrospective study included adults who underwent resection of pathologically confirmed glioma between December 2021 and December 2025. Predictors were classified according to their temporal availability. A perioperative reference model included variables available by the end of surgery, whereas the primary fixed 24-h postoperative landmark model additionally incorporated ICU admission status ascertained by the 24-h landmark. Feature selection was performed in the training cohort using clinical review, correlation analysis, and LASSO regression. Six machine-learning algorithms were evaluated for discrimination, calibration, classification performance, clinical utility using decision-curve analysis, and model interpretability using SHAP.</p><p><strong>Results: </strong>Among 316 eligible patients, 221 were assigned to the training cohort and 95 to the internal validation cohort. Postoperative delirium occurred in 44 and 19 patients, respectively. The perioperative model retained six predictors: age, ASA III-IV status, tumour size, neutrophil-to-lymphocyte ratio, albumin, and intraoperative blood loss. ICU admission was interpreted as an early postoperative predictive marker rather than a causal risk factor. XGBoost achieved the highest numerical validation AUC (0.895) and the lowest Brier score (0.134), with an accuracy of 0.832, sensitivity of 0.842, specificity of 0.829, and F1-score of 0.667. Paired DeLong testing showed that XGBoost had significantly higher discrimination than logistic regression, whereas differences from the other machine-learning models were not statistically significant. SHAP analysis identified clinically interpretable contributions from perioperative and early postoperative predictors.</p><p><strong>Conclusion: </strong>A temporally structured machine-learning framework showed promising internal validation performance for early POD risk stratification after glioma surgery. External multicentre validation and prospective evaluation are required before clinical implementation.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the remodeling of the microglial communication network and the role of CADM1 in vascular dementia based on single-nucleus transcriptomics.","authors":"Jiani Hao, Song Luo, Li Li, Juanjuan Xu","doi":"10.1080/00207454.2026.2733278","DOIUrl":"10.1080/00207454.2026.2733278","url":null,"abstract":"<p><strong>Introduction: </strong>Vascular dementia (VaD) is characterized by neurovascular unit dysfunction and neuroinflammation. However, the molecular regulators linking microglial activation to remodeling of intercellular communication remain incompletely understood.</p><p><strong>Methods: </strong>The human postmortem single-nucleus RNA-sequencing dataset GSE282111 was analyzed using Seurat-based dimensionality reduction and clustering, differential-expression analysis, CellChat, and functional enrichment. Candidate genes associated with microglial polarization were screened. An oxygen-glucose deprivation (OGD) model in murine BV2 microglial cells combined with CADM1 knockdown was used for <i>in vitro</i> validation of microglial marker expression and TNF-pathway components.</p><p><strong>Results: </strong>Six major brain cell populations were identified, and cell-type proportions differed between control and VaD samples. CADM1, CYTIP, and MSR1 were identified as candidate genes associated with microglial polarization and were upregulated in VaD. CellChat analysis indicated remodeling of microglia-centered communication, including altered SPP1 and TGFβ signaling. In the OGD model, CADM1 silencing reduced CD16 expression and TNF-pathway components while increasing CD206 expression, indicating that CADM1 modulates microglial activation-related marker patterns and inflammatory signaling under ischemic stress.</p><p><strong>Conclusion: </strong>CADM1 emerges as a candidate regulator associated with microglial activation and TNF signaling in VaD. These exploratory findings support further investigation of the CADM1-TNF axis; however, independent clinical cohorts, chronic <i>in vivo</i> VaD models, and additional gain-of-function or rescue studies are required before diagnostic or therapeutic relevance can be established.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of robot-assisted physiotherapy on motor and cognitive recovery in individuals with hemiparetic stroke: a pilot randomized controlled trial.","authors":"Fatma Kübra Çekok, Ayşenur Gökşen, Nurel Bellur, Ali Mutlu","doi":"10.1080/00207454.2026.2733273","DOIUrl":"10.1080/00207454.2026.2733273","url":null,"abstract":"<p><strong>Aim: </strong>Stroke often leads to persistent motor and cognitive impairments, which can significantly limit functional independence. This study aimed to investigate the effects of a robot-assisted physiotherapy program on motor and cognitive outcomes in individuals with hemiparetic stroke.</p><p><strong>Methods: </strong>Twenty individuals with hemiparetic stroke were randomly assigned to an experimental group (EG, <i>n</i> = 10), receiving robot-assisted physiotherapy (THERA-Trainer-based training) combined with Bobath exercises, or a control group (CG, <i>n</i> = 10), receiving patient-specific Bobath exercises alone. The Mini-Mental State Examination (MMSE) was administered at baseline to assess cognitive status. Outcome measures included the Digit Span Forward (DSF), Digit Span Backward (DSB), Frenchay Arm Test, Fugl-Meyer Assessment-Upper Extremity (FMA-UE), Fugl-Meyer Assessment-Lower Extremity (FMA-LE), Mini-Balance Evaluation Systems Test (Mini-BESTest), Timed Up and Go (TUG), Timed Up and Go Cognitive (TUG-C), and Five Times Sit-to-Stand (5STS). Oxygen saturation (SpO₂) and heart rate (HR) were monitored at baseline, at the end of the 5STS, and 1 min after the test.</p><p><strong>Results: </strong>The EG demonstrated significantly greater improvements in both cognitive performance and upper and lower limb motor function compared to the CG (<i>p</i> < 0.05). In addition, the EG showed superior improvements in TUG (<i>p</i> = 0.001) and TUG-C (<i>p</i> < 0.001), enhanced post-test SpO₂ recovery (<i>p</i> = 0.011), and reduced baseline HR (<i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>These findings suggest that integrating robot-assisted physiotherapy into standard rehabilitation may provide clinically meaningful benefits in individuals with subacute stroke. The combined approach appears to enhance both motor and cognitive recovery, supporting improved functional independence.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sericin improves diabetic cognitive impairment in rats by inhibiting TXNIP/NLRP3 neuroinflammation through SIRT1.","authors":"Dan Yi, Xiya Lang, Jinyue Li, Haichen Cui, Yixin Ye, Yiyi Ling, Yuanzhao Zhou, Shuijing Chen, Yafei Wang, Pingjing Wen","doi":"10.1080/00207454.2026.2690429","DOIUrl":"10.1080/00207454.2026.2690429","url":null,"abstract":"<p><p>This study aimed to examine the effects of sericin on diabetic cognitive impairment (DCI) in rats based on neuroinflammation. SD rats were first fed with a high sugar and high fat diet for 4 weeks, and then injected with 50 mg/kg streptozotocin intraperitoneally to establish a diabetic model. The diabetic rats were randomly divided into 3 groups and treated with distilled water (<i>n</i> = 10), 500 mg/kg (<i>n</i> = 10) or 1000 mg/kg (<i>n</i> = 20) sericin, respectively, by gavage once a day for 8 weeks. Before the end of the trial, 10 rats in the 1000 mg/kg sericin group were injected with 10 μg EX527, a Sirtuin-1 (SIRT1) inhibitor, into the lateral ventricles once every other day for 5 times. Treated with sericin significantly reduced fasting blood glucose and improved DCI in rats. Sericin significantly inhibited neuroinflammation and microglial activation, reduced the expression of NOD-like receptor protein 3 (NLRP3) and thioredoxin-interacting protein (TXNIP) proteins, and reduced cell apoptosis, while increasing the expression of SIRT1 protein in the hippocampus of diabetic rats. After inhibiting SIRT1 with EX527, the above effect of sericin on DCI rats was weakened. These results indicated that sericin may block DCI progression in rats by inhibiting TXNIP/NLRP3 neuroinflammation and neuronal apoptosis through SIRT1.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1308-1320"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic paravertebral nerve block combined with general anesthesia for patients undergoing minimally invasive vertebroplasty: effects on pain and lumbar function.","authors":"Dan Luo, Xuan Zhang, Xiao Cheng, Hu Cheng","doi":"10.1080/00207454.2026.2694669","DOIUrl":"10.1080/00207454.2026.2694669","url":null,"abstract":"<p><strong>Objective: </strong>This work was conducted to evaluate the effects of thoracic paravertebral nerve block (TPVB) combined with general anesthesia (GA) on pain and lumbar function in patients undergoing minimally invasive vertebroplasty.</p><p><strong>Methods: </strong>One hundred patients scheduled for minimally invasive vertebroplasty were randomly allocated to a GA group (GA alone, <i>n</i> = 50) or a TPVB + GA group (TPVB combined with GA, <i>n</i> = 50). Mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively (T₀), at puncture (T₁), at bone cement injection (T₂), and at the end of surgery (T₃). Operative time, intraoperative blood loss, and anesthetic consumption were compared. Pain was assessed using the visual analogue scale (VAS) on postoperative days 1, 3, and 7. Lumbar function was evaluated using the Oswestry Disability Index (ODI) preoperatively, 1 week postoperatively, and 1 month postoperatively. Adverse events were also recorded.</p><p><strong>Results: </strong>Significant group, time, and interaction effects were observed for MAP, HR, VAS, and ODI (all <i>p</i> < 0.05). Compared with the GA group, the TPVB + GA group showed lower MAP and HR at T₁-T₃, reduced blood loss and anesthetic use, lower VAS scores, improved ODI scores, and fewer adverse events (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>TPVB combined with GA stabilizes perioperative hemodynamics, alleviates pain, and promotes recovery of lumbar function.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1344-1351"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated multi-omics and machine learning identify OGDHL as a key regulator of glioblastoma progression and antitumor immunity via glutamine metabolism and histone lactylation.","authors":"Xindong Shi, Xiao Hu, Ziyan Shi, Fang Chen","doi":"10.1080/00207454.2026.2705220","DOIUrl":"10.1080/00207454.2026.2705220","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma (GBM) has an extremely poor prognosis, and its malignant progression is closely associated with glutamine metabolic reprogramming and immune evasion; however, the key regulatory networks remain unclear.</p><p><strong>Methods: </strong>This study integrated bioinformatics data and identified key proteins through weighted gene co-expression network analysis (WGCNA), screening for differentially expressed proteins (DEPs), and machine learning algorithms. The functions and molecular mechanisms were validated using <i>in vitro</i> cell experiments and <i>in vivo</i> mouse models.</p><p><strong>Results: </strong>Oxoglutarate dehydrogenase L (OGDHL) was identified as the key protein in GBM. It was down-regulated in both GBM and low-grade glioma (LGG) tissues and was correlated with immune cell infiltration. OGDHL overexpression inhibited GBM cell proliferation and reduced glutamate, α-ketoglutarate (α-KG), lactate production, and programmed death-ligand 1 (PD-L1) expression, while promoting apoptosis. OGDHL overexpression enhanced CD8⁺ T cell-mediated cytotoxicity and interferon-γ (IFN-γ) secretion. Mechanistically, OGDHL overexpression suppressed histone H3 lysine 18 lactylation (H3K18la) enrichment, reduced luciferase activity, and inhibited PD-L1 expression in GBM cells, effects that were rescued by exogenous lactate supplementation. <i>In vivo</i>, OGDHL up-regulation inhibited tumor growth, reduced glutamate and lactate production, and decreased Ki-67- and PD-L1-positive cells, while increasing OGDHL-positive cells.</p><p><strong>Conclusion: </strong>OGDHL exerts a tumor-suppressive function in GBM by regulating glutamine metabolism and histone lactylation-mediated PD-L1 expression, representing a potential new target for immunometabolic therapy.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1369-1387"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of cryopreserved autologous bone flaps versus titanium plates for cranioplasty: a retrospective comparative study.","authors":"Junqiang Tao, Zhenxin Wang, Chuwei Lin, Shanshan Dong","doi":"10.1080/00207454.2026.2691274","DOIUrl":"10.1080/00207454.2026.2691274","url":null,"abstract":"<p><strong>Aim: </strong>To compare the clinical efficacy and safety of cryopreserved autologous bone flaps versus titanium plates for cranioplasty in patients with cranial defects.</p><p><strong>Methods: </strong>Sixty patients with cranial defects admitted to our hospital from January 2021 to June 2024 were retrospectively selected. They were assigned to the autologous bone group (<i>n</i> = 30, cranioplasty with cryopreserved autologous bone flaps) and the titanium plate group (<i>n</i> = 30, cranioplasty with titanium plates) according to the reconstruction material. The perioperative indicators, outcome for cranioplasty, neurological function recovery, incidence of complications, and treatment costs were compared between the two groups.</p><p><strong>Results: </strong>The autologous bone group exhibited significantly better outcomes for cranioplasty at 3 and 6 months postoperatively than the titanium plate group (<i>p</i> < 0.05). At 6 months postoperatively, the autologous bone group exhibited significantly higher NIHSS scores than the titanium plate group (<i>p</i> < 0.05). The intracranial pressure levels were significantly lower at all postoperative time points in the autologous bone group than in the titanium plate group (<i>p</i> < 0.05). The autologous bone group demonstrated faster recovery of inflammatory indicators, lower overall incidence of complications (6.67% vs. 30.00%) (<i>χ</i>²=4.588, <i>p</i> = 0.032), and lower hospitalization costs and material expenses than the titanium plate group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Cryopreservation of autologous bone flaps for cranioplasty is associated with improved bone healing, better neurological recovery, reduced complication rates, and lower medical costs. However, these observational findings require further validation through prospective randomized controlled trials. Nevertheless, the current evidence supports the potential clinical application of this technique when feasible.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1321-1329"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of serum albumin, high-density lipoprotein cholesterol, and systemic immune-inflammation index for short-term prognosis in acute cerebral infarction after intravenous recombinant tissue plasminogen activator.","authors":"Zhimin Wang, Feng Li, Dandan Chi","doi":"10.1080/00207454.2026.2706608","DOIUrl":"10.1080/00207454.2026.2706608","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the influences of serum albumin (ALB), high-density lipoprotein cholesterol (HDL-C), combined with systemic immune-inflammation index (SII), on short-term prognosis in patients with acute cerebral infarction (ACI) receiving intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA).</p><p><strong>Background: </strong>ACI is a leading cause of disability with high recurrence rates, posing significant public health challenges.</p><p><strong>Methods: </strong>A total of 301 patients with ACI receiving rt-PA were divided into poor (<i>n</i> = 103) and good (<i>n</i> = 198) prognosis groups based on 3-month post-discharge modified Rankin Scale (mRS) scores. Correlations of serum ALB, HDL-C, and SII with admission National Institutes of Health Stroke Scale (NIHSS) and 3-month post-discharge mRS scores, influencing factors, and predictive value were analyzed using Spearman, logistic regression, and Receiver Operating Characteristic (ROC) curve analyses.</p><p><strong>Results: </strong>Serum ALB, HDL-C, and SII correlated with admission NIHSS scores and 3-month post-discharge mRS scores and were independent influencing factors for poor short-term prognosis. The areas under the curves for predicting unfavorable short-term prognosis were 0.680 (ALB), 0.633 (HDL-C), 0.705 (SII), and 0.767 (combination). The combined model had higher predictive efficacy than any single indicator. Reduced ALB and HDL-C and elevated SII were associated with an increased risk of poor short-term prognosis.</p><p><strong>Conclusion: </strong>ALB, HDL-C, and SII effectively predict short-term prognosis in patients with ACI after rt-PA thrombolysis, facilitating early risk stratification.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1388-1399"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}