International Journal of Neuroscience最新文献

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The variability in nociceptive flexion reflex threshold measurement is mostly caused by probabilistic effects of the estimation algorithms: a simulation study. 痛觉屈曲反射阈值测量的变异性主要是由估计算法的概率效应引起的:一项模拟研究。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-09 DOI: 10.1080/00207454.2024.2312991
Carlo Jurth, Gregor Lichtner, Thomas Bienert, Falk von Dincklage
{"title":"The variability in nociceptive flexion reflex threshold measurement is mostly caused by probabilistic effects of the estimation algorithms: a simulation study.","authors":"Carlo Jurth, Gregor Lichtner, Thomas Bienert, Falk von Dincklage","doi":"10.1080/00207454.2024.2312991","DOIUrl":"10.1080/00207454.2024.2312991","url":null,"abstract":"<p><strong>Objectives: </strong>The nociceptive flexion reflex (NFR) and its threshold are frequently used to investigate spinal nociception in humans. Since this threshold (NFRT) is a probabilistic measure, specific algorithms are used for NFRT estimation based on the stochastic occurrence of reflexes at different stimulus intensities. We used a validated simulation model of the NFR to investigate the amount of NFRT measurement variability induced by different estimation algorithms in a steady setting of reduced external influences.</p><p><strong>Methods: </strong>We simulated the behavior of different estimation algorithms in subjects with an artificially steady baseline NFRT variability (standard deviation: 0 mA) or low baseline NFRT variability (standard deviation: 0.156 mA), equaling a quiet experimental setting. The obtained data were analyzed for NFRT measurement variability caused by the algorithms compared to the baseline variability reflecting other physiological influences.</p><p><strong>Results: </strong>The standard deviation of the NFRT estimated by the different algorithms ranged between 0.381 and 3.464 mA with 96.8% to 99.6% of the measurement variability attributed to the algorithm used. Out of the investigated algorithms the dynamic staircase algorithm was most precise.</p><p><strong>Conclusion: </strong>The NFRT measurement variability observed during quiet and steady experimental sessions is mostly caused by the properties of the estimation algorithms, due to the probabilistic nature of the reflex occurrence. Our results give reference for choosing the optimal estimation algorithm to improve measurement precision.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"553-562"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of empathy-like behaviour in nicotine-preferring rat lines. 研究尼古丁偏好大鼠品系的移情行为
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-02-12 DOI: 10.1080/00207454.2024.2312989
Sinem Demirel, Fulya Tuzcu, Nazan Uysal Harzadin, Sevim Kandiş, Servet Kızıldağ, Lütfiye Kanıt
{"title":"Examination of empathy-like behaviour in nicotine-preferring rat lines.","authors":"Sinem Demirel, Fulya Tuzcu, Nazan Uysal Harzadin, Sevim Kandiş, Servet Kızıldağ, Lütfiye Kanıt","doi":"10.1080/00207454.2024.2312989","DOIUrl":"10.1080/00207454.2024.2312989","url":null,"abstract":"<p><strong>Aim: </strong>Addiction is an important global health issue, impacting also addicts environment and society. Empathy plays crucial role in establishing successful social relationships and is a fundamental component of social life. The aim of this study is to investigate how nicotine preferring (NP) strain and oral forced nicotine administration affects empathy-like behaviour in rats, with gender differences.</p><p><strong>Materials and methods: </strong>Sprague-Dawley NP rats (10 males/10 females) and wild-type control rats (10 males/10 females) were used. Behavioural tests were administered to all rats before and after oral forced nicotine administration. The behavioural tests were completed in the fourth week of nicotine administration. Anxiety levels that could affect empathy-like behaviour were evaluated with open field, elevated plus maze tests and with blood cortisol levels. Oxytocin receptor and arginine vasopressin (AVP) levels, which have been shown to be related to empathy-like behaviour, were examined in the prefrontal cortex and amygdala regions using the enzyme-linked immunoassay method.</p><p><strong>Results: </strong>It was observed that males from the NP strain showed less empathy-like behaviour than all other groups, and nicotine administration did not cause a significant change in the results. Higher levels of locomotor activity (LA) were found in control females than in all other groups. Blood nicotine and corticosterone levels were higher in NP rats. No significant differences were found in AVP and oxytocin receptor levels in the prefrontal cortex and amygdala.Conclusions It was found that coming from an addicted strain particularly reduces empathy-like behaviour in males.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"544-552"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LncRNA PVT1 promotes neuroinflammation after intracerebral hemorrhage by regulating the miR-128-3p/TXNIP axis. LncRNA PVT1通过调控miR-128-3p/TXNIP轴促进脑内出血后的神经炎症。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-03-09 DOI: 10.1080/00207454.2024.2312998
Fanyong Gong, Yiting Wei
{"title":"LncRNA PVT1 promotes neuroinflammation after intracerebral hemorrhage by regulating the miR-128-3p/TXNIP axis.","authors":"Fanyong Gong, Yiting Wei","doi":"10.1080/00207454.2024.2312998","DOIUrl":"10.1080/00207454.2024.2312998","url":null,"abstract":"<p><strong>Objective: </strong>Intracerebral hemorrhage (ICH) has significant morbidity and mortality. TXNIP and the competing endogenous RNA (ceRNA) regulatory mechanism involved in long non-coding RNA (lncRNA) play roles in ICH. We probed the upstream microRNAs (miRNAs)/lncRNAs that regulated TXNIP expression in the ceRNA mechanism.</p><p><strong>Methods: </strong>ICH mouse model was established, and ICH secondary injury was simulated in BV2 microglia by hemin treatment. TXNIP was silenced 48 h before ICH modeling. The ICH mouse brain water content (BWC) and brain lesion volume after ICH were recorded. Neuronal apoptosis and neurological deficits were evaluated by double staining of NeuN and TUNEL/modified Garcia/corner turn/forelimb placement tests. Iba1 + microglia number and tumor necrosis factor-α (TNF-α)/interleukin-1β (IL-1β)/IL-10/TXNIP/PVT1/miR-128-3p levels were assessed by immunohistochemistry, Western blot, ELISA, and RT-qPCR. Cell viability/death of BV2 cells conditioned medium-treated neuron HT22 cells were assessed by CCK-8/LDH assays. miRNA that had a targeted binding relationship with TXNIP was screened. The targeted bindings of miR-128-3p to TXNIP/PVT1 to miR-128-3p were verified by dual-luciferase reporter gene assay.</p><p><strong>Results: </strong>TXNIP knockdown reduced post-ICH microglial activation/release of pro-inflammatory factors/brain edema/brain lesion volume/neurological deficits in mice and increased releases of anti-inflammatory factors. TXNIP/PVT1 knockdown inhibited hemin-induced inflammatory responses in BV2 cells and protected <i>in vitro</i> co-cultured HT22 cells. PVT1 was a sponge of miR-128-3p to repress TXNIP expression. miR-128-3p knockdown diminished PVT1 knockdown-inhibited hemin-induced BV2 cell inflammatory responses/neurotoxicity.</p><p><strong>Conclusions: </strong>PVT1 silencing reduced hemin-induced neuroinflammation and had a protective effect on neurons by increasing the targeted inhibition of TXNIP by miR-128-3p.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"573-587"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UCMSCs-derived exosomal SLIT2 alleviates ischemic stroke through the β-catenin/TCF4/USP20 signaling pathway. ucmscs衍生的外泌体SLIT2通过β-catenin/TCF4/USP20信号通路缓解缺血性卒中。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-30 DOI: 10.1080/00207454.2025.2497936
Rongjun Xiao, Qingsong Wang, Jun Peng, Xiqi Hu, Min Chen, Ying Xia
{"title":"UCMSCs-derived exosomal SLIT2 alleviates ischemic stroke through the β-catenin/TCF4/USP20 signaling pathway.","authors":"Rongjun Xiao, Qingsong Wang, Jun Peng, Xiqi Hu, Min Chen, Ying Xia","doi":"10.1080/00207454.2025.2497936","DOIUrl":"https://doi.org/10.1080/00207454.2025.2497936","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke (IS) is a disease that causes necrosis of brain tissues by inadequate blood supply to the brain. Umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UCMSCs-Exo) have been reported to alleviate IS, and slit guidance ligand 2 (SLIT2) could promote neurological repair after IS. The aim of this research was to explore the potential mechanism of UCMSCs-derived exosomal SLIT2 on IS progression.</p><p><strong>Methods: </strong>The middle cerebral artery occlusion (MCAO) rat and oxygen glucose deprivation/reperfusion (OGD/R)-induced cellular models were established, and then treated with UCMSCs-Exo. Cell viability and apoptosis were explored by cell counting kit-8 (CCK-8) assay and flow cytometry, respectively. The expressions of ubiquitin specific peptidase 20 (USP20) and related apoptotic proteins were determined using Western blot. Immunofluorescence and immunohistochemistry were performed to evaluate the effect of SLIT2 on β-catenin nuclear translocation. The association between transcription factor 4 (TCF4) and <i>USP20</i> promoter was investigated by chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assys.</p><p><strong>Results: </strong>In the OGD/R-induced cell model, UCMSCs-derived exosomal SLIT2 increased cell viability, decreased apoptosis and promoted β-catenin nuclear translocation. Besides, β-catenin agonist (SKL2001) facilitated USP20 transcription by promoting TCF4 binding to <i>USP20</i> promoter. Finally, TCF4 upregulated USP20 and inhibited OGD/R-induced cell damage. In the MCAO rat model, UCMSCs-derived exosomal SLIT2 mitigated IS by promoting β-catenin nuclear translocation, which activated the TCF4/USP20 pathway to inhibit apoptosis.</p><p><strong>Conclusion: </strong>UCMSCs-derived exosomal SLIT2 activated TCF4 by promoting β-catenin nuclear translocation, which transcriptionally upregulated USP20 expression, thereby attenuating OGD/R-induced neuroncell damage and ultimately leading to inhibition of IS progression.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. Piezo1是神经系统疾病的致病基因和治疗靶点。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-28 DOI: 10.1080/00207454.2025.2496819
Hui Wang, Zhixian Gou, Shunrui Chen, Liqun Lu
{"title":"Piezo1 is a pathogenic gene and therapeutic target for neurological diseases.","authors":"Hui Wang, Zhixian Gou, Shunrui Chen, Liqun Lu","doi":"10.1080/00207454.2025.2496819","DOIUrl":"https://doi.org/10.1080/00207454.2025.2496819","url":null,"abstract":"<p><p>Piezo1 is a ubiquitously expressed non-selective cation channel protein found across various species. It possesses the ability to detect and respond to external mechanical forces, converting mechanical cues into intracellular bioelectrical events, thereby facilitating the propagation of electrochemical signals. Within the nervous system, Piezo1 is integral to synaptogenesis and myelination, modulation of pro-inflammatory mediators, neuropathic pain, cognitive processes, angiogenesis, and the regulation of cerebral hemodynamics, consequently impacting the pathogenesis and progression of neurological disorders. This review meticulously summarizes and synthesizes existing literature to provide an exhaustive overview of Piezo1's roles and mechanisms in a spectrum of neurological diseases, including neurodegenerative disorders, cerebrovascular accidents, traumatic brain injuries, gliomas, multiple sclerosis, and epilepsy. Additionally, it explores the potential therapeutic applications of targeting Piezo1. The discussion also encompasses the current research limitations, the imperative need for future investigations, and prospective strategies. Our analysis indicates that Piezo1 is a susceptibility gene for neurological conditions, and its expression inhibition may confer therapeutic benefits. In summary, this comprehensive review offers novel insights into the involvement of Piezo1 in neurological diseases and establishes a theoretical groundwork for the future development of Piezo1-targeted therapeutic interventions.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Passive mapping of hand motor cortex across altered states of consciousness. 意识改变状态下手部运动皮层的被动映射。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-26 DOI: 10.1080/00207454.2025.2496821
Yusheng Tong, Zhen Fan, Xiang Zou, Qi Yue, Zehan Wu, Liang Chen
{"title":"Passive mapping of hand motor cortex across altered states of consciousness.","authors":"Yusheng Tong, Zhen Fan, Xiang Zou, Qi Yue, Zehan Wu, Liang Chen","doi":"10.1080/00207454.2025.2496821","DOIUrl":"https://doi.org/10.1080/00207454.2025.2496821","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the ability of median nerve stimulation (MNS)-induced high gamma band (HGB) activity in mapping the hand motor cortex at different states of consciousness.</p><p><strong>Methods: </strong>Five patients undergoing awake craniotomy were recruited. MNS-induced electrocorticographic signals were recorded from awake to anesthetic states, with the loss of consciousness (LOC) session divided into three stages (LOC1, LOC2, and LOC3) based on conscious level. HGB signals were analyzed to localize hand motor cortex. Linear models were applied to analyze HGB dynamics during LOC.</p><p><strong>Results: </strong>The sensitivity of hand motor cortex mapping based on HGB average envelope at short-latency period was 100%, 96.67%±3.33%, 83.47%±8.19%, and 82.22%±11.44% for the awake, LOC1, LOC2 and LOC3 stages. The sensitivity for HGB average envelope at long-latency period was 92.67%±4.52%, 90.85%±4.13%, 72.27%±17.07%, and 40.53%±12.82% across the same stages. The sensitivity based on HGB average power at short-latency period decreased from 100% in awake stage to 72.83%±12.95%, 48.11%±15.95%, and 21.12%±5.70% across LOC stages. The sensitivity for HGB average power at long-latency period dropped from 92.67%±4.52% in awake stage to 70.94%±10.79%, 58.37%±17.49%, and 25.71%±14.95% in the subsequent LOC stages. The slope coefficient of the simple linear model for long-latency average envelope was significantly smaller than that for short-latency. In the linear mixed effects model, the Condition × Sliding Window estimate coefficient was -0.794.</p><p><strong>Conclusion: </strong>In awake state, HGB average envelope and average power both effectively localized hand motor cortex. With declining consciousness, the mapping ability of average power significantly deteriorated, while the mapping ability of short-latency average envelope remained relatively stable.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early neurological bedside rehabilitation intervention on the recovery of activities of daily living in stroke patients. 早期神经床边康复干预对脑卒中患者日常生活活动恢复的影响。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-17 DOI: 10.1080/00207454.2025.2490692
Kaiqi Huang, Ying Li, Xizhen Jie, Cui Liu, Huijuan Jie
{"title":"Early neurological bedside rehabilitation intervention on the recovery of activities of daily living in stroke patients.","authors":"Kaiqi Huang, Ying Li, Xizhen Jie, Cui Liu, Huijuan Jie","doi":"10.1080/00207454.2025.2490692","DOIUrl":"https://doi.org/10.1080/00207454.2025.2490692","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a common neurological disorder that leads to severe functional impairments and reduced quality of life. Early bedside rehabilitation plays a crucial role in recovery, but research on its effectiveness is limited.</p><p><strong>Methods: </strong>This study aimed to assess the impact of early bedside rehabilitation on stroke patients. A total of 150 patients were randomly assigned to an intervention group (<i>n</i> = 75) and a control group (<i>n</i> = 75). The intervention group received physical therapy, occupational therapy, and speech therapy within 48 h of stroke onset. The control group received standard care. Assessments included activities of daily living (ADL), motor function, cognitive function, and quality of life.</p><p><strong>Results: </strong>The intervention group showed significantly better outcomes in ADL, motor function, cognitive function, and quality of life compared to the control group. The intervention group had higher Barthel Index, modified Rankin Scale, Fugl-Meyer Assessment, Montreal Cognitive Assessment (MoCA), and Stroke-Specific Quality of Life Scale (SS-QOL) scores (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Early bedside rehabilitation in the neurology department significantly improves stroke patients' recovery, including ADL, motor function, cognitive function, and quality of life. These findings highlight the importance of early rehabilitation and a comprehensive, multidisciplinary approach in stroke care, which can improve recovery outcomes and overall quality of care.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomogram combined neuron-specific enolase and NIHSS for prediction of post stroke depression. 神经元特异性烯醇化酶与NIHSS的Nomogram联合预测脑卒中后抑郁。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-12 DOI: 10.1080/00207454.2025.2488758
Chuming Yan, Wancheng Zheng, Tong Si, Liyuan Huang, Lulu Wen, Huixin Shen, Miao Qu
{"title":"Nomogram combined neuron-specific enolase and NIHSS for prediction of post stroke depression.","authors":"Chuming Yan, Wancheng Zheng, Tong Si, Liyuan Huang, Lulu Wen, Huixin Shen, Miao Qu","doi":"10.1080/00207454.2025.2488758","DOIUrl":"10.1080/00207454.2025.2488758","url":null,"abstract":"<p><strong>Objective: </strong>The National Institutes of Health Stroke Scale (NIHSS) is a known risk factor for post-stroke depression (PSD). However, more objective indicators are needed. The role of neuron-specific enolase (NSE) in PSD development remains unclear. This study aimed to ascertain the correlation of NIHSS score and NSE with PSD risk, and establish a novel nomogram combining NSE and NIHSS for early PSD prediction.</p><p><strong>Methods: </strong>A total of 172 patients with acute ischemic stroke (AIS) were involved. Baseline clinical data including NSE and NIHSS were collected. At 3-month follow-up, patients were categorized into PSD and non-PSD groups. Logistic models and restricted cubic spline curve were used to investigate the correlation between NIHSS, NSE and PSD. A corresponding nomogram was formulated.</p><p><strong>Results: </strong>Among 172 patients with AIS, 63 (36.63%) were diagnosed with PSD, while 109 (63.37%) were non-PSD. The baseline NIHSS and NSE were positively correlated with the risk of 3-month PSD (<i>P</i> < 0.05). Multivariate logistic regression revealed that sex (OR= 2.168, 95% CI 1.038 ∼ 4.526), age (OR= 1.035, 95% CI 1.002 ∼ 1.070), NIHSS (OR= 1.164, 95% CI 1.022 ∼ 1.325) and NSE (OR= 1.180, 95% CI 1.037 ∼ 1.343) were independently associated with 3-month PSD (all <i>P</i> < 0.05). The nomogram constructed using sex, age, baseline NIHSS score and NSE showed good discrimination, calibration, and clinical utility.</p><p><strong>Conclusion: </strong>NSE is a valuable tool for early identification of PSD risk. A combined prediction model incorporating NIHSS and NSE has been established for the personalized prevention and intervention of PSD.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbamazepine toxicity with concomitant levetiracetam therapy in patients with epilepsy. 卡马西平联合左乙拉西坦治疗癫痫患者的毒性。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-10 DOI: 10.1080/00207454.2025.2489701
Archana Mishra, Biswa Ranjan Mishra, Debadatta Mohapatra, Anand Srinivasan, Rituparna Maiti, Debasish Hota
{"title":"Carbamazepine toxicity with concomitant levetiracetam therapy in patients with epilepsy.","authors":"Archana Mishra, Biswa Ranjan Mishra, Debadatta Mohapatra, Anand Srinivasan, Rituparna Maiti, Debasish Hota","doi":"10.1080/00207454.2025.2489701","DOIUrl":"10.1080/00207454.2025.2489701","url":null,"abstract":"<p><strong>Aim: </strong>Drug interactions are crucial in understanding the efficacy and safety of co-administered antiepileptic drugs. This study aims to investigate drug interactions between carbamazepine (CBZ) and levetiracetam (LEV) and the factors associated with CBZ toxicity.</p><p><strong>Methods: </strong>The present record-based case-control study analyzed data from 158 patients. A univariate analysis was done to identify the association of various factors with toxic trough CBZ concentrations. Frequentist disproportionality analysis was done to determine a signal for the association between concomitant LEV administration and CBZ toxicity. Receiver operating characteristic (ROC) analysis was done to identify the LEV:CBZ dose ratio to differentiate between toxic and non-toxic CBZ concentrations.</p><p><strong>Results: </strong>The odds of developing manifestations of CBZ toxicity in CBZ + LEV <i>versus</i> CBZ group were 16.65 (95% confidence interval [CI]: 3.52-78.70; <i>p</i> < 0.001). The univariate analysis showed no association between CBZ dose and toxic trough CBZ levels, while an association between LEV administration and toxic trough CBZ levels was evident. A reporting odds ratio (ROR) of 2.25 (95% CI: 1.07-4.72; <i>p</i> = 0.030) and proportional reporting ratio (PRR) of 1.77(95% CI: 1.07-2.94) was observed for toxic levels of CBZ with co-administration of LEV.</p><p><strong>A lev: </strong>CBZ dose ratio of 1.86 was identified as a threshold for differentiating between toxic and non-toxic serum concentrations with an accuracy of 72.9%.</p><p><strong>Conclusions: </strong>There is a temporal association between LEV administration and toxic blood levels and toxic symptoms of CBZ, the chances of which significantly higher when the dose ratio of LEV:CBZ is 1.86.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the application of virtual reality technology in patients with Duchenne muscular dystrophy. 虚拟现实技术在杜氏肌营养不良患者中的应用研究进展。
IF 1.7 4区 医学
International Journal of Neuroscience Pub Date : 2025-04-09 DOI: 10.1080/00207454.2025.2488768
Shuting Liu, Xiaokang Wang, Yahao Ren, Li Peng
{"title":"Research progress on the application of virtual reality technology in patients with Duchenne muscular dystrophy.","authors":"Shuting Liu, Xiaokang Wang, Yahao Ren, Li Peng","doi":"10.1080/00207454.2025.2488768","DOIUrl":"10.1080/00207454.2025.2488768","url":null,"abstract":"<p><p>Duchenne muscular dystrophy is a common hereditary muscular dystrophy, virtual reality technology as an emerging therapeutic method has been gradually applied to the rehabilitation treatment of Duchenne muscular dystrophy patients. This paper reviews the current management status of Duchenne muscular dystrophy patients, the application effect of virtual reality technology in the rehabilitation treatment of Duchenne muscular dystrophy patients, and points out the challenges faced by the application of virtual reality technology in the field of Duchenne muscular dystrophy, aiming to provide a basis for the care of muscular dystrophy patients.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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