International Journal of Neuroscience最新文献

{"title":"Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma.","authors":"Xiangdi Xu, Jiahao Wang, Mingming Xue, Longkai Feng","doi":"10.1080/00207454.2026.2681886","DOIUrl":"10.1080/00207454.2026.2681886","url":null,"abstract":"<p><strong>Background: </strong>Glioma is a primary tumor derived from central nervous system glial cells. RNA binding motif protein 25 (RBM25) has been implicated in glioma progression, yet its underlying molecular mechanism remains incompletely understood.</p><p><strong>Methods: </strong>In this study, glioma-related datasets were retrieved from the Proteomic Data Commons (PDC) and Gene Expression Omnibus (GEO) databases. Core glioma-associated targets were screened using machine learning algorithms. Protein expression was assessed by Western blot, while migration, and invasion, cell cycle and apoptosis were analyzed by Transwell assay and flow cytometry. Chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assays were used to validate the interaction between transcription factors and genes.</p><p><strong>Results: </strong>Proteomic analysis revealed distinct differences between glioma and control groups, with differentially expressed proteins mainly enriched in mitochondrial energy metabolism, synaptic function, and neurodegenerative disease pathways. Transcriptomic profiles also exhibited significant alterations, with RBM25 and HSPA8 showing consistent changes at both protein and RNA levels. Multiple machine learning models identified RBM25, NKTR, MAP2K6, TRAPPC3, and HSPA8 as key genes associated with glioma, with RBM25 and NKTR showing strong relevance in model-based feature selection. RBM25 was upregulated in glioma and linked to neuronal signaling pathways, whereas HSPA8 and TRAPPC3 were downregulated. RBM25 knockdown suppressed glioma cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis.</p><p><strong>Conclusion: </strong>RBM25 contributes to glioma malignancy and may serve as a potential biomarker and therapeutic target for glioma.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1108-1121"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From imaging to molecular pathways: a comprehensive narrative review of the distinctive landscape of secretory meningioma.","authors":"Erfan Shahabinejad, Mahsa Kamali, Amirreza Shakoeizadeh, Zeinab Falakian, Aynaz Foroughi Eghbal, Seyyed Mohammad Alipour, Maria Krywyj, Jason P Sheehan, Qais Alrashidi, Hamid Borghei-Razavi","doi":"10.1080/00207454.2026.2681874","DOIUrl":"10.1080/00207454.2026.2681874","url":null,"abstract":"<p><strong>Background: </strong>Secretory meningioma (SM) is an uncommon variety of meningioma, representing about 1-3% of cases. Notwithstanding its benign classification, SM is frequently associated with excessive peritumoral brain edema (PTBE), resulting in considerable morbidity. This study examines the epidemiology, clinical presentation, imaging characteristics, histological features, immuno-histochemical profile and genetic landscape of SM, along with management methods and results.</p><p><strong>Materials and methods: </strong>We performed a structured search in PubMed, Scopus, and Web of Science up up to October 2025 using keywords including \"secretory meningioma\" \"meningioma\", \"peritumoral brain edema\", and related terms. Original and review articles in English were included. Relevant data were extracted and narratively synthesized covering clinical, radiological, pathological, and genetic features.</p><p><strong>Results: </strong>SM is defined by the presence of pseudopsammoma bodies, pronounced immunoreactivity for carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA), and a unique molecular profile featuring KLF4 K409Q and TRAF7 mutations. Radiologically, PTBE is characterized by fluid-attenuated inversion recovery (FLAIR) hyperintensity and increased apparent diffusion coefficient (ADC) values serves as critical diagnostic indicators. While surgical gross complete resection is the gold standard, significant postoperative tumor bed edema complicates perioperative treatment and may necessitate additional therapies.</p><p><strong>Conclusion: </strong>Identifying SM as a unique clinical entity is essential for diagnosis, prognosis and therapeutic approaches.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1241-1257"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Bobath-based neurorehabilitation after mechanical thrombectomy for moderate-to-severe hemiparesis: preliminary findings from a propensity score-matched cohort study.","authors":"Jing Wang, Dong Hao, Yingzhi Lu","doi":"10.1080/00207454.2026.2682964","DOIUrl":"10.1080/00207454.2026.2682964","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate whether early Bobath-based neurorehabilitation improves motor and functional recovery in patients with acute ischemic stroke and moderate-to-severe hemiparesis after anterior-circulation mechanical thrombectomy.</p><p><strong>Methods: </strong>We conducted a single-center retrospective propensity score-matched cohort study comparing early Bobath-based neurorehabilitation with conventional rehabilitation in AIS patients with moderate-to-severe hemiparesis after anterior-circulation mechanical thrombectomy. Patients aged ≥18 years initiated rehabilitation within 30 days after the procedure, and complete discharge and follow-up data were required for inclusion in the matched cohort. The primary outcome was change in Fugl-Meyer Assessment (FMA) motor score from baseline to discharge. Secondary outcomes included Modified Barthel Index (MBI), Modified Ashworth Scale (MAS), modified Rankin Scale (mRS), quality of life, and safety outcomes during 12-month follow-up.</p><p><strong>Results: </strong>After matching, 206 patients (103 per group) were included. At discharge, the Bobath group showed greater improvement in motor function and daily living ability than the conventional group (adjusted mean difference: FMA 5.7 points, 95% CI 3.4-8.0; MBI 6.6 points, 95% CI 4.0-9.3; both <i>p</i> < 0.001). Improvements remained significant at 3 months but not at 12 months. Functional independence (mRS ≤2) at 3 months was more frequent in the Bobath group (82.5% vs 73.8%; <i>p</i> = 0.05). Complication rates were similar between groups.</p><p><strong>Conclusions: </strong>Early Bobath-based neurorehabilitation is associated with better short-term motor and functional recovery without increased adverse events after mechanical thrombectomy. The between-group differences attenuated by 12 months; therefore, further multicenter prospective studies are needed to confirm durability and long-term benefit.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1122-1133"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing an advanced deep learning-based MR image framework for brain stroke segmentation and classification with novel activation function.","authors":"J Jesila Mol, S Jancy","doi":"10.1080/00207454.2026.2685181","DOIUrl":"10.1080/00207454.2026.2685181","url":null,"abstract":"<p><strong>Aim: </strong>Stroke is considered as one of the most prevalent causes of death and disability for the humans, although it is preventable and treatable. Earlier stroke detection and treatment management helps in enhancing the clinical outcomes, thereby significantly minimizing the risk of disease. Thus, this work presents a sophisticated deep learning-based stroke prediction framework using the Magnetic Resonance Imaging (MRI) and provides specialized and flexible diagnostic guidance.</p><p><strong>Methods: </strong>The developed stroke detection system begins by collecting the required MR images in the benchmark sources. Further, the gathered MR images are fed to the stroke lesion segmentation using the developed Region Masked Attention-based Multi-Dilated Inception Unet++ (RMA-MIUnet++), which is accurately focus on stroke-affected regions. The segmented images are acquired as the outcomes from the proposed RMA-MIUnet++ model. These segmented images are further classified in the developed Efficient InceptionV3 with Novel Activation Function (EIV3-NAF)-based stroke classification model.</p><p><strong>Results: </strong>The experimental validation is performed on the developed system by comparing it with other conventional methods. When considering the batch size at 48, the accuracy of the proposed model for dataset 1 is 97% and dataset 2 is 93.26%.</p><p><strong>Conclusion: </strong>The results achieved by the developed EIV3-NAF model clearly show enriched performance in classifying the strokes.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1159-1183"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing stroke recovery: the role of upper limb rehabilitation robot-assisted training.","authors":"Dengxuan Wu, Li Li, Chengbing Fang, Xiangru Luo","doi":"10.1080/00207454.2026.2681879","DOIUrl":"10.1080/00207454.2026.2681879","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the clinical value of upper limb rehabilitation robot-assisted training in stroke patients.</p><p><strong>Methods: </strong>A total of 101 stroke patients were assigned to either conventional rehabilitation plus robot-assisted upper limb training (<i>n</i> = 50) or conventional rehabilitation alone (<i>n</i> = 51). The Fugl-Meyer Assessment of the Upper Extremity (FMA-UE), Modified Ashworth Scale for Upper Extremity (MAS-UE), Action Research Arm Test (ARAT), Functional Independence Measure (FIM) and quality-of-life outcomes were assessed. Oxygenated haemoglobin (HbO₂) levels in the affected primary motor cortex (M1), premotor cortex (PMC) and supplementary motor area (SMA) were measured.</p><p><strong>Results: </strong>After treatment, both groups showed improvements in FMA-UE, MAS-UE, ARAT and FIM scores, with no significant difference between the groups. Quality of life improved in both groups; however, the study group had significantly higher post-treatment scores in the environmental, physical, social and psychological domains than the control group (<i>p</i> = 0.000). After treatment, HbO₂ levels in the affected M1, PMC and SMA increased in both groups, with the study group showing higher levels (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Upper limb rehabilitation robot-assisted training improved quality of life and cortical activation in stroke patients but showed no additional benefit in motor function compared with conventional rehabilitation.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1101-1107"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A voyage on computer aided intelligent algorithms for the segmentation of brain tissues for neurodisorder diagnosis.","authors":"Kumar Subbiah Pillai Neelakanta Pillai, Nor Asilah Wati Abdul Hamid, Dafik Dafik, Sunder Ramasamy, Siva Shankar Subramanian, Arun Sundaram, Kannadhasan Suriyan","doi":"10.1080/00207454.2026.2680936","DOIUrl":"10.1080/00207454.2026.2680936","url":null,"abstract":"<p><p>Neurodisorders pose a considerable burden to global health, frequently requiring early treatment and diagnosis to avoid irreversible cognitive and motor impairments. Segmentation of brain tissue is an essential task in neurodiagnostics due to its inability to accurately separate grey matter, white matter and cerebrospinal fluid within imaging modalities like MRI and CT. This article reviews the progress of brain tissue segmentation techniques from manual and semi-automated approaches to sophisticated machine learning and deep learning algorithms. It discusses how these contemporary methodologies enhance segmentation quality, address difficult anatomical variation and optimize diagnostic accuracy in diseases like Alzheimer's, multiple sclerosis, traumatic brain injury and stroke. This research work compares supervised, unsupervised and deep learning paradigms on the basis of their advantages, disadvantages and potential use in clinical settings. In addition, it presents hybrid and ensemble methods that blend conventional and AI-based approaches to mitigate obstacles such as data heterogeneity, annotation limitations and interpretability. This survey details the revolutionizing potential of machine learning in neuroimaging and ultimately seeks to facilitate early diagnosis, treatment planning and individualized healthcare provision for neurological diseases.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1208-1230"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic glycyrrhizin attenuates sevoflurane-surgery-induced recognition memory deficit and neuroinflammation in middle-aged mice via HMGB1-TLR4 pathway modulation.","authors":"Han Yang, Yuqiang Liu, Fan Zhang, Yonghan Jiang, Niannian Shuai, Xiongjuan Li, Lifei Xiao, Zhiheng Liu, Shiyuan Xu","doi":"10.1080/00207454.2026.2676624","DOIUrl":"10.1080/00207454.2026.2676624","url":null,"abstract":"<p><strong>Background: </strong>Perioperative neurocognitive disorders (PNDs) encompass delayed neurocognitive recovery (dNCR; ≤30 days) and postoperative neurocognitive disorder (NCD; >30 days). While the HMGB1-TLR4/NF-κB axis drives acute neuroinflammation, temporal dynamics beyond the acute phase and distinct contributions of HMGB1 versus TLR4 to dNCR-to-NCD transition remain elusive. This study investigated whether glycyrrhizin attenuates sevoflurane-surgery-induced recognition memory deficit <i>via</i> HMGB1-TLR4 modulation.</p><p><strong>Methods: </strong>Eight-month-old male C57BL/6J mice underwent right common carotid artery dissection under prolonged sevoflurane anesthesia (3%, 2 h) with or without glycyrrhizin pretreatment (30 mg/kg, i.p.; <i>n</i> = 15/group for batch 1, <i>n</i> = 7/group for batch 2). Cognitive function was assessed <i>via</i> open field, novel object recognition, Y-maze, and Morris water maze. Hippocampal neuroinflammation , HMGB1-TLR4-NF-κB signaling, synaptic proteins , and Nissl staining were evaluated at postoperative days 7 and 20.</p><p><strong>Results: </strong>Prolonged sevoflurane exposure combined with surgery induced recognition memory impairment and reduced platform crossings, both attenuated by glycyrrhizin. While peripheral IL-6 normalized by day 7, hippocampal cytokines (IL-6, IL-1β, TNF-α) and glial activation persisted through day 20. HMGB1 was elevated at day 7 but normalized by day 20, whereas TLR4/NF-κB remained elevated at both time points; glycyrrhizin suppressed this cascade. Synaptic proteins were reduced and CA3/dentate gyrus exhibited Nissl staining reductions at days 7 and 20, protected by glycyrrhizin, whereas CA1 showed no significant alterations.</p><p><strong>Conclusions: </strong>These findings demonstrate temporal dissociation between HMGB1 normalization and sustained TLR4/NF-κB activation following sevoflurane-surgery in middle-aged mice. Prophylactic glycyrrhizin attenuates recognition memory deficits and suppresses hippocampal neuroinflammation, though mechanistic inferences remain speculative and require rigorous validation.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1081-1100"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of traumatic intracerebral hemorrhage associated metabolites using untargeted metabolomics.","authors":"Wei Wang, Wei Zheng, Xiaohui Lu","doi":"10.1080/00207454.2026.2687854","DOIUrl":"10.1080/00207454.2026.2687854","url":null,"abstract":"<p><p>Traumatic intracerebral hemorrhage (TICH) is a severe neurological emergency whose metabolic mechanisms remain largely unresolved. This study used serum metabolomics analysis to compare the metabolic profiles of TICH patients (<i>n</i> = 10) with non-TICH controls (<i>n</i> = 10). LC-MS/MS analysis identified a total of 3183 metabolites. The relative abundances of benzene and its derivatives, organic acids and their derivatives were significantly increased in the serum of ICH patients, while fatty acid, glycerophospholipid, and sphingomyelin metabolites were generally decreased. Multidimensional statistical methods were used to screen for significantly differentially expressed metabolites. Metabolite regulatory networks revealed the potential roles of amino acid metabolism, lipid metabolism (GP/SP/FA), and aromatic compounds (benzenes) in regulating TICH metabolism. Enrichment analysis revealed that these metabolites were highly enriched in lipid metabolism, amino acid metabolism, and neural signaling pathways, and were significantly associated with inflammatory drug pathways. The differentially expressed metabolites were further mapped to the Human Metabolite Database (HMDB) and subjected to metabolic-disease association analysis, suggesting that these metabolites may be closely related to the pathogenesis of TICH. ROC analysis demonstrated good diagnostic performance of five key metabolites in both discovery and validation cohorts (AUC > 0.70), with hypoxanthine and L-histidine showing the highest accuracy (AUC > 0.93). Correlation analysis indicated that key metabolites were associated with hematoma volume, NIHSS and GCS scores. <i>In vitro</i> experiments further confirmed that, under conditions of neuronal injury, the changes in these metabolites exhibit consistency. This study provides a theoretical basis for the development of potential biomarkers and precise intervention strategies.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1194-1207"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148225279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic role of admission neutrophil-to-lymphocyte ratio in acute ischemic stroke: a systematic review and updated meta-analysis of 31,835 patients.","authors":"Haneen Sabet, Abdallah Abbas, Dina Essam Abo-Elnour, Mohammed Tarek Hasan, Ahmed Elshahat, Ahmed Samir, Moaz Elsayed Abouelmagd, Ahmed Mostafa Amin, Ahmed Mansour, Hadir Mustafa Mohamed, Rana Ahmed Youssef, Ahmed Elmashad, Iman Moeini Naghani, Sauson Soldozy, Basant Lashin, Amr Elshahat, Mostafa Meshref, Mohamed Elfil, Gurmeen Kaur, Chirag D Gandhi, Fawaz Al-Mufti","doi":"10.1080/00207454.2026.2687853","DOIUrl":"10.1080/00207454.2026.2687853","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association of admission neutrophil-to-lymphocyte ratio (NLR) with functional outcomes, intracranial hemorrhage (ICH), and mortality in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>We searched PubMed, Scopus, Web of Science, Cochrane CENTRAL, and Embase from inception until December 17, 2024. Studies examining admission NLR as a predictor for functional outcomes, ICH, and mortality in AIS patients were included. A meta-analysis was performed using pooled odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analyses were conducted based on treatment modality, time of measurement, hemorrhage type, and ethnicity. Heterogeneity was assessed using I² statistics, and publication bias was evaluated using Egger's test.</p><p><strong>Results: </strong>Sixty observational studies (31,853 patients), including 59 cohort studies and one cross-sectional study, were included. Higher admission NLR was significantly associated with unfavorable functional outcomes (OR: 1.10, 95% CI: [1.07, 1.14]), ICH (OR: 1.06, 95% CI: [1.03, 1.09]), and mortality (OR: 1.06, 95% CI: [1.04, 1.08]). Subgroup analysis indicated that NLR was associated with poor outcomes in AIS patients receiving mechanical thrombectomy and intravenous thrombolysis.</p><p><strong>Conclusion: </strong>Admission NLR is significantly associated with unfavorable functional outcomes, ICH, and mortality in AIS patients. Its predictive value remained evident in the MT and Asian subgroups; however, the association with unfavorable functional outcomes was not significant in the non-Asian subgroup, and the association with mortality in the IVT subgroup was also not significant. Given its accessibility and cost-effectiveness, NLR holds promise as a routine biomarker for stroke prognosis.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1271-1294"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of decompressive craniectomy on long-term functional outcomes in patients with severe acquired brain injury: a systematic review and meta-analysis.","authors":"Lingling Guo, Jinchao Zhao","doi":"10.1080/00207454.2026.2673871","DOIUrl":"10.1080/00207454.2026.2673871","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy of decompressive craniectomy (DC) on long-term functional outcomes in patients with severe acquired brain injury (ABI) through systematic review and meta-analysis.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of studies from 2010 to 2025. Nine studies (5 RCTs and 4 cohorts) with 3866 patients were included after quality assessment. Analysis was performed using RevMan 5.4.</p><p><strong>Results: </strong>DC significantly improved functional outcomes at 12 months (OR = 3.63, 95% CI: 1.45-9.10) and reduced 12-month mortality (OR = 0.44, 95% CI: 0.21-0.90), despite high heterogeneity for mortality. No significant benefit was found for 6-month functional outcomes or complication rates. Subgroup analyses indicated that the survival benefit was more pronounced in Asian populations, and functional improvement was significant for both traumatic and non-TBI patients.</p><p><strong>Conclusions: </strong>DC provides significant long-term benefits for functional outcomes and survival in severe ABI patients, without increasing short-term complications. Its efficacy varies by ethnicity and etiology, suggesting a need for personalized treatment decisions.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1231-1240"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}