International Journal of General Medicine最新文献

{"title":"Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review.","authors":"Dan-Dan Wang, Shi-Guang Ren, Rui Hu, Hui-Lan Zhai, Fen Xie, Lu Jiang, Wen-Lei Huang, Xue-Qin Li","doi":"10.2147/IJGM.S502142","DOIUrl":"https://doi.org/10.2147/IJGM.S502142","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the digestive tract, including Crohn's disease and ulcerative colitis. Fatigue is one of the common and important extraintestinal symptoms in IBD patients, which significantly affects the patient's ability to work, daily life, social activities, emotional state, and cognitive function. Although the impact of fatigue on patients' quality of life cannot be ignored, medical professionals still have limited knowledge of its concepts, assessment tools, influencing factors, and non-pharmacological interventions, which may lead to neglect and inadequate management of the symptoms. The purpose of this article is to review the definition and epidemiological characteristics of IBD-related fatigue and to discuss the application of four commonly used fatigue assessment tools in patients with IBD. In addition, we will analyze the multiple factors that affect fatigue in IBD patients from three levels: physiological, psychological, and sociodemographic. Finally, we will assess the effectiveness of different non-pharmacological interventions in alleviating fatigue in people with IBD and make corresponding clinical recommendations.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1403-1413"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Immune-Nutrition Inflammation Index for Predicting Coronary Slow Flow Phenomenon in Patients with Angina and No Obstructive Coronary Arteries.","authors":"Jiang Guo, Zhi-Zhen Xiang, Dan-Dan Ma","doi":"10.2147/IJGM.S516108","DOIUrl":"10.2147/IJGM.S516108","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammatory responses are involved in the initiation and development of the coronary slow flow phenomenon (CSFP). However, as a newly developed immuno-nutritional inflammation indicator, the global immune-nutrition inflammation index (GINI) has not been well elaborated for predicting CSFP in patients with angina and no obstructive coronary arteries (ANOCA).</p><p><strong>Methods: </strong>A total of 1422 individuals with ANOCA were consecutively included in this study, of whom 93 developed CSFP (CSFP group). We selected 186 (1:2 matched) age- and sex-matched patients with ANOCA and angiographically proven normal coronary blood flow as the controls (the control group). Multivariate logistic regression analysis was used to investigate predictors of CSFP in patients with ANOCA. The optimal cutoff values for GINI were calculated.</p><p><strong>Results: </strong>In total, 93 patients developed CSFP, including 29% (27) in one vessel, 28% (26) in two vessels, and 43% (40) in three vessels. Patients with CSFP had an elevated CRP level, white blood cell (WBC) count, neutrophil count, GINI, fasting blood glucose (FBG) level, and a lower lymphocyte count (P<0.05). Multivariate logistic analysis showed that the GINI and FBG levels were independent predictors of CSFP in patients with ANOCA. Moreover, we found that the more vessels affected by CSFP, the higher the GINI level. The receiver operating characteristic (ROC) showed that GINI had a better predictive value than indicators alone. When the GINI AISI was >84.1, the sensitivity and specificity were 88.2% and 58.7%, respectively [The Area Under the ROC curve (AUC): 0.774; 95% CI: 0.721-0.827; P < 0.001].</p><p><strong>Conclusion: </strong>Elevated GINI is a reliable predictor of CSFP in patients with ANOCA. Moreover, GINI had a superior predictive value compared to the indicators alone. As a newly developed inflammatory indicator, GINI can be used for further risk stratification of patients with ANOCA.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1325-1332"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio for Target Lesion Revascularization in Patients With Drug-Eluting Stent Implantation.","authors":"He Meng, Xiujun Zhou, Lushan Li, Yuanying Liu, Yujie Liu, Ying Zhang","doi":"10.2147/IJGM.S502386","DOIUrl":"10.2147/IJGM.S502386","url":null,"abstract":"<p><strong>Background: </strong>Severe in-stent restenosis (ISR) following the implantation of drug-eluting stent (DES) can lead to recurrent angina pectoris or even acute myocardial infarction, thereby necessitating target lesion revascularization (TLR). Prior studies have confirmed the correlation between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and ISR after DES implantation. The potential of MHR to predict TLR following DES implantation remains an area of ongoing research and may have significant clinical implications.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on a consecutive series of 474 patients undergoing DES implantation and follow-up coronary angiography between December 1, 2014 and December 1, 2022. The patients were categorized into two distinct groups according to their exposure to TLR. To assess the predictive performance of the MHR with respect to TLR, we utilized multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The study revealed a significant elevation in the MHR value within the TLR group compared to the non-TLR group (12.34 vs 8.97; P < 0.001). MHR was identified as an independent predictor of TLR (Odds Ratio [OR] = 1.162; 95% Confidence Interval [CI]: 1.102-1.225). The area under the curve (AUC) was found to be 0.712 (95% CI: 0.664-0.759). When the MHR exceeded 10.98, the specificity for predicting TLR was 75.8%, and the sensitivity was 58.0%. When the MHR was incorporated into the predictive model comprising established risk factors, there was a notable improvement in the AUC, from 0.689 to 0.749 (P < 0.001). Additionally, there was a significant categorical net reclassification improvement (NRI) of 0.183 (P < 0.001) and an integrated discrimination improvement (IDI) of 0.074 (P < 0.001).</p><p><strong>Conclusion: </strong>The MHR functions as a predictor for TLR subsequent to DES implantation. Incorporating MHR into the predictive model improves the model's accuracy, indicating its potential value for clinical application.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1383-1391"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Radiomics-Based Model for Prediction of Lymph Node Metastasis in Cervical Cancer.","authors":"Zhenjie Shi, Longlong Lu","doi":"10.2147/IJGM.S491986","DOIUrl":"10.2147/IJGM.S491986","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains a major cause of mortality among women globally, with lymph node metastasis (LNM) being a critical determinant of patient prognosis.</p><p><strong>Methods: </strong>In this study, MRI scans from 153 cervical cancer patients between January 2018 and January 2024 were analyzed. The patients were assigned to two groups: 103 in the training cohort; 49 in the validation cohort. Radiomic features were extracted from T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) maps. The ITK-SNAP software enabled three-dimensional manual segmentation of the tumor regions in cervical cancer to identify regions of interest (ROIs). The collected data was divided for the training and validation of the Support Vector Machine (SVM) model.</p><p><strong>Results: </strong>The combined T2WI and ADC-based radiomics model exhibited robust diagnostic capabilities, achieving an area under the curve (AUC) of 0.804 (95% CI [0.712-0.890]) in the training cohort and an AUC of 0.811 (95% CI [0.721-0.902]) in the validation cohort. The nomogram that includes radiomic features, International Federation of Gynecology and Obstetrics (FIGO) stage, and LNM has a C-index of 0.895 (95% CI [0.821-0.962]) in the training cohort and a C-index of 0.916 (95% CI [0.825-0.987]) in the validation cohort. The C-statistics are all above 0.80, and the predicted variables are nearly aligned with the 45-degree line, consistent with the results shown in the calibration plot. This indicates that our model demonstrates good discrimination ability and satisfactory calibration.</p><p><strong>Conclusion: </strong>The MRI radiomics model, leveraging T2WI combined with ADC maps, offers an effective method for predicting LNM in cervical cancer patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1371-1381"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Impact Factors and Efficacy of N-Butylphthalide (NBP) on Functional Outcomes Following Mechanical Thrombectomy in Stroke Patients.","authors":"Xinxing Wang, Doudou Shi, Yali Liu, Yifan Liu","doi":"10.2147/IJGM.S506806","DOIUrl":"10.2147/IJGM.S506806","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke was a major cause of mortality and disability worldwide. Mechanical thrombectomy (MT) has improved acute ischemic stroke treatment by restoring blood flow in large vessel occlusions. Yet, reperfusion injury remains a challenge, necessitating adjunctive neuroprotective strategies to enhance recovery. N-butylphthalide (NBP), with its anti-inflammatory and antioxidative properties, may improve functional outcomes post-MT.</p><p><strong>Methods: </strong>This retrospective study analyzed 120 ischemic stroke patients treated with MT at a single institution from December 2020 to December 2022. Patients were divided into a routine care group (n = 56) and an NBP treatment group (n = 64). Baseline characteristics, comorbidities, and biochemical profiles were assessed. Functional outcomes were measured by the modified Rankin Scale (mRS) at 90 days. Statistical analysis included correlation and logistic regression to identify factors influencing recovery.</p><p><strong>Results: </strong>Among the NBP group, a significantly higher percentage achieved favorable mRS scores (0-2) compared to the routine care group (62.50% vs 37.50%, P = 0.006). Smoking (OR 0.320, P = 0.021), diabetes (OR 0.246, P = 0.022), and elevated hs-CRP levels (OR 0.407, P = 0.004) were identified as negative predictors of functional recovery. Conversely, NBP treatment significantly improved outcomes (OR 3.248, P = 0.008).</p><p><strong>Conclusion: </strong>The study supports the potential of NBP as an effective adjunctive therapy in improving recovery following MT in ischemic stroke patients. Modifiable factors such as smoking and diabetes, along with elevated hs-CRP, negatively influence outcomes, highlighting the importance of comprehensive management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1311-1324"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cell Crisis and Excess Histopathological Features During the Development and Progression of <i>H. pylori</i> Infection in the Gastric Mucosa.","authors":"Su-Nan Wang, Yang-Kun Wang, Ping Li, Ling-Chao Kong, Wei-Yi Deng, Bo Jiang, Ying-Ying Li","doi":"10.2147/IJGM.S474925","DOIUrl":"10.2147/IJGM.S474925","url":null,"abstract":"<p><strong>Objective: </strong>To investigate immune cell crisis and excess histopathological features during the development and progression of <i>H. pylori</i> infection in the gastric mucosa.</p><p><strong>Methods: </strong>One thousand two hundred and seventy-six cases of <i>H. pylori</i> infection were examined by endoscopic biopsy and endoscopic submucosal dissection (ESD) resection. The relationship between epithelial cells and immune cells and the pathological features of immune cell dysfunction and excess tissue were observed. The 1276 cases of mucosal biopsy of <i>H. pylori</i> infection and ESD resection were included. Among them, 39 were ESD excision and 1237 were gastric mucosal biopsy specimens. Among them, there were 896 cases of antrum infection, 274 cases of stomach body infection, and 106 cases of infection in antrum and body of stomach. Three to five pieces of mucosal tissue were extracted from each site. There were 789 males (61.8%) and 454 females (35.6%). There were 724 cases (56.7%) with age ≤60 and 552 cases (43.3%) with age >60.</p><p><strong>Results: </strong>During the occurrence and development of <i>H. pylori</i> infection, there were not only spider-like vacuolar degeneration of surface epithelial cells, compensatory cervical mucous cell proliferation, proliferation disorder of stem cells in proliferating areas, and neoplastic proliferation of gastric mucosal epithelial cells, but also morphological changes of immune cells in the process of occurrence and development of <i>H. pylori</i> infection. First, neutrophils that rapidly respond and attack the infection; however, neutrophils quickly display functional deficiencies, forming mucosal erosion and micro-abscesses. Then, it enters a phase of immune cell crisis. The immune defense is adjusted. The rapid proliferation of lymphocytes leads to the formation of lymphocyte immunity and the formation of lymphocyte follicle-like structures. In this stage, the lesions are wide and deep, the duration is long, and the number of patients is large. Persistent <i>H. pylori infection</i> can result in abnormal proliferation and transformation of gastric mucosal epithelial cells and immune cells and gastric adenocarcinoma and MALT lymphoma.</p><p><strong>Conclusion: </strong>Understanding the immune cell crisis and excess histopathological features during the occurrence and development of <i>H. pylori</i> infection is important for controlling the occurrence and development of gastric cancer and lymphoid system tumors via immune intervention.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1345-1357"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate Dehydrogenase Indicates Development From Fulminant Myocarditis to Chronic Persistent Myocarditis: A Multicenter Retrospective Cohort Study in China.","authors":"Qu Zhao, Zeping Li, Dao Wen Wang, Fan Li, Li Zhang, Jiangang Jiang","doi":"10.2147/IJGM.S509291","DOIUrl":"10.2147/IJGM.S509291","url":null,"abstract":"<p><strong>Background: </strong>Fulminant myocarditis (FM) is a critical manifestation of myocarditis. However, the clinical features and risk factors associated with its adverse outcomes are not fully understood. Given the high mortality and potential for long-term complications, it is crucial to identify factors that could predict the progression of FM to chronic persistent myocarditis. We hypothesize some clinical or laboratory markers may be predictive of this progression. This study aims to identify clinical factors that may help predict the progress of FM to chronic persistent myocarditis.</p><p><strong>Methods: </strong>A total of 82 patients with FM treated based on Chinese protocol were included. Kaplan-Meier curve and regression analysis were used to determine the clinical features and prognostic predictors of chronic persistent myocarditis in patients with 24 months of follow-up.</p><p><strong>Results: </strong>Chronic persistent myocarditis was observed in 20 patients during the follow-up. ROC curve showed that the critical value for chronic persistent myocarditis caused by lactate dehydrogenase (LDH) was 577.00U/L (sensitivity 75.0%, specificity 74.2%). Time from onset to admission over 6 days and LDH > 577.00U/L were identified as risk factors for chronic persistent myocarditis in patients with FM in both univariate and multivariate cox analysis. The hazard ratio and 95% Confidence intervals were 3.35 (1.32-8.50) (p = 0.011) and 6.11 (2.02-18.48) (<i>p</i> < 0.001), respectively. The per standard deviation of increment in LDH was associated with the 55% (1.55, 1.11-2.18) in HR and 95% CI of the occurrence of chronic persistent myocarditis.</p><p><strong>Conclusion: </strong>About 24.4% of the patients with FM treated based on the life support measures proposed in the consensus of Chinese Society of Cardiology have been observed chronic persistent myocarditis. Time from onset to admission over 6 days and LDH levels >577.00 U/L at admission may serve as risk factors for the progression from FM to chronic persistent myocarditis.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1333-1344"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean Systemic Filling Pressure Was Associated with 28-Day Mortality in Patients with Constrictive Pericarditis After Pericardial Stripping: A Retrospective Cohort Study.","authors":"Rongping Chen, Wei Du","doi":"10.2147/IJGM.S500503","DOIUrl":"10.2147/IJGM.S500503","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to explore changes in the venous return system in patients with Constrictive pericarditis (CP) after pericardial stripping and examine their value in predicting mortality.</p><p><strong>Methods: </strong>An 8-year single-center retrospective cohort study including patients with CP after pericardial stripping surgery. Hemodynamic parameters were analyzed in 90 patients at 11 time points including before and after surgery and every 4 to 9 hours in the first 48 hours in the ICU (pre-operation, post-operation, 0h, t1, t2, t3, 24h, t4, t5, t6, 48h).</p><p><strong>Results: </strong>Mean systemic filling pressure (Pmsf) were significantly higher in patients who died (non-survival group) than survivors (<i>P</i> = 0.016, respectively). Pmsf at 24h, APACHE II score, and SOFA score were evaluated as predictors of 28-day mortality. APACHE II combined with Pmsf at 24h had the highest prediction (AUC 0.807; 95% confidence interval, 0.671-0.941; <i>P</i> = 0.003).</p><p><strong>Discussion: </strong>In conclusion, Pmsf at 24h can be used as a valid indicator for prognostic assessment in patients with constrictive pericarditis admitted after pericardial stripping. Pmsf at 24h improves the performance of APACHE II scores in predicting 28-day mortality. Closely monitoring of Pmsf in patients after pericardial debridement may provide guidance for clinical management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1359-1369"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Patterns Associated With Heat Retention in Blood Vessel Syndrome (HRBVS) in Coronary Heart Disease: A Cross-Sectional Study.","authors":"Jiale Zhang, Hongxuan Tong, Lijie Jiang, Jingqing Hu","doi":"10.2147/IJGM.S510507","DOIUrl":"10.2147/IJGM.S510507","url":null,"abstract":"<p><strong>Background: </strong>Western dietary patterns are well-established risk factors for coronary heart disease (CHD); however, the potential role of Traditional Chinese Medicine (TCM) dietary theory in exacerbating specific TCM syndromes among CHD patients remains a significant knowledge gap. To address this gap, our study aimed to investigate the relationship between dietary patterns, encompassing diet tastes and eating habits, and the occurrence of Heart-Related Blood Vessel Syndromes (HRBVS) in Chinese patients with CHD.</p><p><strong>Methods: </strong>Data from 4428 patients with CHD were collected, including 2,973 stable angina pectoris (SAP) cases, 614 acute coronary syndrome (ACS) cases, and 841 heart failure (HF) cases. The Coronary Heart Disease HRBVS Scale and the Patient Self-Assessment of Dietary Habits Scale were used. Logistic regression analysis and a backward stepwise regression strategy were employed to identify dietary factors affecting HRBVS.</p><p><strong>Results: </strong>Individuals with a preference for salty, greasy, and spicy foods and those with irregular eating habits were more likely to experience HRBVS. Good dietary habits and regular meal timing were associated with a lower incidence of HRBVS. In the multivariate regression analysis, individuals who preferred spicy, greasy, and cold foods and those who kipped or had no breakfast had a higher risk of HRBVS. Conversely, individuals with good dietary habits had a lower risk of HRBVS.</p><p><strong>Conclusion: </strong>HRBVS in patients with coronary heart disease is closely related to dietary habits. Positive dietary interventions may play a significant role in improving HRBVS and enhancing prognosis. Identifying and intervening in these dietary factors may improve the overall prognosis in patients with coronary heart disease.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (NCT02967718).</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1283-1294"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia.","authors":"Xiaoling Huang, Lihua Huang, Shicai Zhao, Lingyan Yuan, Xing Wang, Guanghua Tang, Kaifen Yuan, Min Xiao","doi":"10.2147/IJGM.S501744","DOIUrl":"10.2147/IJGM.S501744","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognostic value of hematological indices derived from routine blood tests in assessing 30-day mortality risk among elderly patients with bacterial pneumonia at the time of admission.</p><p><strong>Methods: </strong>This study was conducted in the Second Affiliated Hospital of Kunming Medical University. A total of 292 elderly patients with bacterial pneumonia were enrolled. A total of 292 elderly patients diagnosed with bacterial pneumonia were classified into two groups: the survival group (n= 256) and the mortality group (n=36). Following a Propensity Score Matching at a 1:1 ratio, differences in clinical data between the two groups were analyzed using the chi-square test and Mann-Whitney <i>U</i>-test. Furthermore, Spearman correlation analysis was employed to explore the relationships among the variables. The Receiver Operating Characteristic (ROC) curve was used to evaluate the predictive value of each index for 30-day mortality in elderly patients with bacterial pneumonia. Subsequently, pivotal risk indices were identified through multivariate logistic regression and Kaplan-Meier survival curves were constructed to illustrate the survival outcomes.</p><p><strong>Results: </strong>NLR, SII, SIRI and NMLR in the death group were significantly higher than those in the survival group (14.64 vs 5.47, 2621.05 vs 1308.01, 5.58 vs 2.36, 15.05 vs 5.75) (all P<0.05). And it was positively correlated with IL-6, PCT and hsCRP (all P<0.05). The ROC curve showed that the AUC of NLR, SII, SIRI and NMLR were 0.777,0.705,0.673 and 0.775 respectively. Multivariate Logistic regression analysis showed that NLR and PCT were the main risk indicators. When NLR≥15.46 (OR 18.44), SII≥2295.02 (OR 6.25), SIRI≥2.49 (OR 4.38) and NMLR≥15.72 (OR 17.00), the 30-day mortality of elderly patients with bacterial pneumonia was significantly increased.</p><p><strong>Conclusion: </strong>In elderly patients with community-acquired bacterial pneumonia, increased NLR, SII, SIRI and NMLR can predict 30-day mortality to a certain extent, but further multicenter studies are needed to verify.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1295-1309"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}