International Journal of General Medicine最新文献

{"title":"Development and Validation of an Anoikis-Related Gene Signature for Prognostic Prediction in Cervical Cancer.","authors":"Silu Meng, Xiangqin Li, Jianwei Zhang, Xiaodong Cheng","doi":"10.2147/IJGM.S508059","DOIUrl":"10.2147/IJGM.S508059","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer still has high incidence and mortality rates worldwide. This study aimed to evaluate the prognostic value of anoikis-related genes (ARGs) and develop a risk scoring model for accurate survival prediction in cervical cancer patients.</p><p><strong>Methods: </strong>The expression profiles of cervical cancer tissue and survival data were downloaded from TCGA-CESC and CGCI-HTMCP-CC. We identified 83 ARGs significantly associated with patients' survival. Subsequently, we developed a risk-scoring model based on 10 key genes. We assessed the predictive performance of our model by survival analysis, ROC curve analysis, and a nomogram that incorporated clinical factors. Additionally, we validated the expression of Granzyme B (GZMB) by immunohistochemical staining. Furthermore, we compared the biological processes and pathway enrichment in high-risk and low-risk patient groups, using differential gene expression and functional enrichment analysis. Finally, we investigated the immune microenvironment of patients in both high-risk and low-risk groups.</p><p><strong>Results: </strong>Patients in the high-risk group had significantly poorer survival compared to those in the low-risk group. The immunohistochemical results suggested that GZMB was associated with the prognosis of cervical cancer patients. The risk scoring model showed high accuracy in predicting the prognosis of cervical cancer patients. Differential gene expression analysis revealed enriched pathways related to tumor invasion and metastasis in the high-risk group. Conversely, the low-risk group showed a strong association with the activation of immune response pathways.</p><p><strong>Conclusion: </strong>This study concluded that anoikis-related genes played a crucial role in determining the prognosis of individuals with cervical cancer. This discovery not only presented potential biomarkers but also provided valuable insights for informing treatment strategies. The risk scoring model may assist clinicians in better identifying high-risk patients and personalizing treatment plans.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2861-2879"},"PeriodicalIF":2.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Aerobic Exercise on Health Management in Older Patients with Hypertension: A Systematic Review of Randomized Controlled Trials from the Past Decade.","authors":"Bingxue Zhang, Hongjuan Hu, Ziyi Mi, Haidi Liu","doi":"10.2147/IJGM.S516371","DOIUrl":"10.2147/IJGM.S516371","url":null,"abstract":"<p><strong>Purpose: </strong>This study was based on the PICO framework to systematically evaluate the effects of aerobic exercise on key health management indicators such as blood pressure, heart rate and cardiorespiratory fitness in older hypertensive patients.</p><p><strong>Patients and methods: </strong>A systematic search of randomized controlled trials from four English language databases, Web of Science, PubMed, Cochrane, and Embase, and four Chinese language databases, CNKI, VIP, Wanfang, and Sinomed, was performed (April 2014 to April 2024). StataCorp Stata v.18.0 was used for data analysis. In a random-effects meta-analysis, continuous variables were represented by the mean difference, and each effect size was represented by a 95% confidence interval.</p><p><strong>Results: </strong>Nine randomized controlled trials with 484 participants were included. The meta-analysis revealed that compared with the control group, participants engaging in aerobic exercise significantly reduced systolic blood pressure (SMD = -0.93, 95% CI = -1.48 to -0.39, <i>P</i> =0.001), diastolic blood pressure (SMD = -0.48, 95% CI = -0.75 to -0.21, <i>P</i> =0.001), and heart rate (SMD = -1.78, 95% CI = -3.31 to -0.24, <i>P</i> =0.024), and improved cardiorespiratory health (SMD =0.71, 95% CI =0.24 to 1.18, <i>P</i> =0.003).</p><p><strong>Conclusion: </strong>Older patients with hypertension aged 60 years should engage in 120-150 minutes of low- to moderate-intensity aerobic exercise per week, maintaining 40-75% maximum HR or 40-60% VO₂max (20-30 minutes per day, 5 days per week, or 75-150 minutes of exercise only once or twice a week. However, it is crucial that individuals assess their own health conditions, make appropriate time adjustments, and gradually increase the duration and intensity of exercise. And central randomization with blinded assessment should be used in future randomized controlled trials to reduce implementation bias and measurement bias.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2823-2838"},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KRT23 as a Potential Target for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): Evidence From Bioinformatics Analysis, Human Gene Polymorphism and Animal Experiments.","authors":"Yangmin Hao, Tao Zhang, Shaliyan Tuerxunmaimaiti, Ye Tian, Xinyu Wang, Zhiming Li, Liang Zhao, Lei Bai, Qu Chen, Cheng Li, Ayiguzhali Abulitipu, Rui Wang, Sheng Jiang, Guoli Du","doi":"10.2147/IJGM.S520326","DOIUrl":"10.2147/IJGM.S520326","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent in Xinjiang, with genetic factors influencing its pathogenesis. Keratin 23 (KRT23), a liver-enriched protein linked to metabolic regulation, remains understudied in MAFLD genetics.</p><p><strong>Objective: </strong>To investigate associations between KRT23 gene polymorphisms, expression, and MAFLD in Xinjiang.</p><p><strong>Methods: </strong>This study enrolled 1,795 MAFLD patients diagnosed via ultrasonography and metabolic criteria. KRT23 polymorphisms (rs72826004, rs2269859) were analyzed. GEO database screening identified MAFLD-related genes. KRT23 expression was assessed in human serum/liver tissues (ELISA, Western blot, qRT‒PCR, IHC) and murine models (high-fat diet-induced MAFLD and db/db mice).</p><p><strong>Results: </strong>Enrichment analysis identified 10 key MAFLD-associated genes, including KRT23. The rs72826004 TT genotype increased MAFLD risk (OR: 2.156, P=0.007), while rs2269859 TT conferred protection (OR: 0.306, P=0.002). MAFLD patients exhibited elevated KRT23 protein/mRNA levels in serum and liver versus controls. Murine models confirmed higher KRT23 expression in MAFLD and db/db mice compared to wild-type.</p><p><strong>Conclusion: </strong>KRT23 gene polymorphism was associated with the occurrence of MAFLD. The rs72826004 loci TT genotype may be a risk factor for MAFLD, whereas the rs2269859 loci TT genotype may be a protective factor against MAFLD. Higher KRT23 expression (protein and mRNA) is related to MAFLD. KRT23 is a potential target for the treatment of MAFLD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2807-2821"},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Vedolizumab with Glucocorticoids vs Infliximabin Severe Ulcerative Colitis: A Retrospective Study.","authors":"Chenfei Zhang, Xiaoling Huang, Mailidan Maimaitiniyazi, Tingwei Zhou","doi":"10.2147/IJGM.S525638","DOIUrl":"10.2147/IJGM.S525638","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of vedolizumab plus glucocorticoids versus infliximab in severe ulcerative colitis for optimized treatment selection.</p><p><strong>Methods: </strong>Patients admitted to the Department of Gastroenterology of Xinjiang Uygur Autonomous Region People's Hospital with confirmed diagnosis of ulcerative colitis from January 2020 to December 2022 were collected, and according to the biologics used, the patients were divided into Vedolizumab combined with glucocorticoids group (n = 23) and infliximab group (n = 23). Clinically relevant indicators of the patients were retrospectively analyzed.</p><p><strong>Results: </strong>The difference between the basic information of the two groups of patients before treatment was not significant (<i>p</i> > 0.05). WBC 30 weeks, ESR (6 weeks, 30 weeks), ALB 30 weeks, Hb (6 weeks, 14 weeks, 30 weeks) of the difference between the groups was statistically significant (<i>p</i> < 0.05). WBC, CRP, ESR, ALB, Hb were tested by ANOVA, the differences between groups were statistically significant (<i>p</i> < 0.05). Comparison of the incidence of various complications between the two groups of patients, the difference was not significant (<i>p</i> > 0.05). The clinical response rate, clinical remission rate and mucosal healing rate of the 2 groups were statistically analyzed in terms of treatment effects at weeks 6, 14 and 30, respectively. Comparison between the groups showed that the differences in clinical response rate at week 6, clinical remission rate and endoscopic remission rate at week 30 and at weeks 14 and 30 were not statistically significant (<i>p</i> > 0.05); at weeks 14 and 30, the clinical response rate of group A was better than that of group B, and the differences were statistically significant (<i>p</i> < 0.05). At week 14, the clinical remission rate of group A was better than that of group B, and the difference was statistically significant (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Vedolizumab and infliximab are effective for severe UC, but vedolizumab with glucocorticoids outperforms infliximab in clinical response, remission, and long-term outcomes.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2839-2849"},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of CT-Based 3D Reconstruction in Analyzing Fracture Line Distribution in Postmenopausal Women with Osteoporotic Pelvic Fractures.","authors":"Chunming Si, Baolin Bai, Wei Cong, Lipeng Zhang, Ruisheng Guan","doi":"10.2147/IJGM.S506333","DOIUrl":"10.2147/IJGM.S506333","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the application value of CT-based 3D reconstruction in analyzing the distribution of pelvic fracture lines and to identify key factors, that affect fracture patterns in postmenopausal women with osteoporotic pelvic fractures.</p><p><strong>Methods: </strong>A total of 150 postmenopausal female patients with osteoporotic pelvic fractures who underwent CT scans in our radiology department from June 2022 to June 2023 were included. Subjects were divided into a normal group (n=60) and a pelvic fracture group (n=90). CT-based 3D reconstruction was used to analyze the distribution of fracture lines. The correlations between fracture lines and various factors were evaluated, such as age, bone mineral density (BMD) and body mass index (BMI).</p><p><strong>Results: </strong>The results showed a significant difference in BMD between the pelvic fracture group and the normal group. The average BMD in the pelvic fracture group was 0.763 ± 0.026 g/cm², which was significantly lower than 0.925 ± 0.051 g/cm² in the normal group (<i>P</i> < 0.001). This finding suggests that BMD plays an important role in the risk of pelvic fractures. 3D reconstruction revealed that fractures were more widespread in low BMD regions and fewer in high BMD regions, highlighting the correlation between lower BMD and higher fracture risk.</p><p><strong>Conclusion: </strong>CT-based 3D reconstruction enhances the assessment of pelvic fractures by providing a detailed evaluation of fracture line distribution. This study found that lower bone mineral density is a significant risk factor for pelvic fractures, with a direct correlation to the number and distribution of fracture lines.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2799-2806"},"PeriodicalIF":2.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Validation of Key Genes Involved in the Coupling of Mitochondria-Associated Endoplasmic Reticulum Membrane in Hemorrhoidal Disease.","authors":"Lihua Mao, Zhiying Rao, Yanru Wang, Jun Yang, Junmei He, Zhi Zheng, Lanyu Chen","doi":"10.2147/IJGM.S511281","DOIUrl":"10.2147/IJGM.S511281","url":null,"abstract":"<p><strong>Background: </strong>Hemorrhoidal disease (HD) is the most prevalent rectal disorder, with various cellular processes influenced by the mitochondria-associated endoplasmic reticulum membrane (MAM). Potential therapeutic mechanisms for HD may be associated with MAM. This study aims to identify key genes linked to MAM in HD and to provide novel therapeutic targets.</p><p><strong>Methods: </strong>Transcriptome data and MAM-related genes (MAM-RGs) were obtained from the Gene Expression Omnibus (GEO) database and relevant literature. Differential expression analysis and single-sample Gene Set Enrichment Analysis (ssGSEA) scores were initially employed to identify candidate genes. Key genes were further refined using Least Absolute Shrinkage and Selection Operator (LASSO) and Protein-Protein Interaction (PPI) networks. A nomogram based on these key genes was developed and assessed. Additionally, CIBERSORT algorithms were utilized to evaluate immune cell infiltration abundance, differences, and correlations in the samples. Finally, the expression of key genes was validated via reverse transcription-quantitative PCR (RT-qPCR).</p><p><strong>Results: </strong>Differential expression analysis identified 956 differentially expressed genes (DEGs), and ssGSEA identified 143 differentially expressed MAM-RGs. A total of 50 candidate genes were selected through their intersection. Machine learning identified two key genes, <i>MUC16</i> and <i>DEFA5</i>. A nomogram with strong predictive capability was constructed. Immune cell analysis revealed two types of differential immune cells-activated dendritic cells and plasma cells-where activated dendritic cells were more highly expressed in the case group, and plasma cells showed a strong positive correlation with <i>DEFA5</i>. Additionally, <i>MUC16</i> was significantly overexpressed in patients with HD, while <i>DEFA5</i> exhibited down-regulation compared to controls.</p><p><strong>Conclusion: </strong>This study identifies <i>MUC16</i> and <i>DEFA5</i> as key genes associated with HD and MAM and presents a predictive nomogram with high accuracy. These findings provide novel insights into the mechanisms and potential treatment targets for HD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2781-2798"},"PeriodicalIF":2.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Pathogenic Characteristics of Benign and Malignant Thyroid Nodules Undergoing Ultrasonography for Health Checkup Population.","authors":"Zhifeng Yao, Weihong Zhou, Zhixiang Shen, Qingxia Li","doi":"10.2147/IJGM.S517851","DOIUrl":"10.2147/IJGM.S517851","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the epidemiological and pathogenic characteristics of benign and malignant thyroid nodules undergoing ultrasonography for health checkup population and evaluate the value of ultrasonography in early detection of thyroid cancer.</p><p><strong>Methods: </strong>The thyroid nodules ultrasonic characteristics of 70430 examinees in different ages and genders were retrospectively analyzed according to the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS). The high-risk thyroid nodules pathological results were compared with ultrasonic C-TIRADS to analyze the value of ultrasonography in early detection of thyroid cancer.</p><p><strong>Results: </strong>The total thyroid nodules prevalence was 47.64%. Females had a significantly higher prevalence of thyroid nodules than males (52.10% vs 43.48%; <i>P</i> < 0.01), and thyroid nodules prevalence was gradually increased with age (<i>P</i> for trend < 0.01). Thyroid nodules were mainly multiple, unilateral lobe, maximum diameter < 1cm and solid nodules. The distribution of thyroid nodules in different genders was different in number, location, maximum diameter, echo characteristics and C-TIRADS (<i>P</i> < 0.01). The distribution of C-TIRADS in different ages was statistically different (<i>P</i> < 0.01). The thyroid nodules prevalence of C-TIRADS 2, 3, 4A, 4B, 4C, and 5 were 12.88%, 32.04%, 2.33%, 0.36%, 0.02% and 0.009%, respectively (<i>P</i> < 0.01). A total of 436 examinees were definitely diagnosed, of which 323 were benign and 113 were malignant, and the difference in the prevalence of malignancies among different C-TIRADS was statistically significant (<i>P</i> < 0.01). Well-differentiated papillary thyroid cancer accounted for 86.73% and most were early stage cancer and micro-carcinoma. The sensitivity, specificity and accuracy of ultrasonic C-TIRADS diagnosis of thyroid cancer were 84.07%, 97.41%, and 97.39%, respectively.</p><p><strong>Conclusion: </strong>Age and gender are closely related to thyroid nodules prevalence. Ultrasonography based on C-TIRADS has certain value in detecting thyroid nodules and screening early thyroid cancer.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2769-2779"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dual Role and Therapeutic Implications of the Wnt/β-Catenin Pathway in Diabetic Kidney Disease.","authors":"Yilinuer Adeerjiang, Xiao-Xue Gan, Wen-Ting Li, Qin-Tian Li, Yi-Qi Jiang, Xia Zhu, Chen-Ming Hu, Pan-Xia Wang, Sheng Jiang","doi":"10.2147/IJGM.S524138","DOIUrl":"10.2147/IJGM.S524138","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD), a major microvascular complication of diabetes, affects 30-40% of patients and is the leading cause of end-stage renal disease. The Wnt/β-catenin signaling pathway plays a dual role in DKD pathogenesis: its moderate activation protects against hyperglycemia-induced mesangial apoptosis, while chronic overactivation exacerbates renal fibrosis, podocyte injury, and tubular dysfunction. This review synthesizes current evidence on the pathway's context-dependent mechanisms. Emerging therapeutic strategies-including small-molecule inhibitors (eg, Dickkopf-1), monoclonal antibodies, and natural compounds like curcumin and Salvia miltiorrhiza extracts-show preclinical promise in modulating Wnt/β-catenin activity. However, clinical translation faces challenges such as pathway redundancy, off-target effects, and the need for precise dosing to balance protective and injurious outcomes. Recent advances in biomarker discovery (eg, urinary β-catenin) and ongoing clinical trials highlight the pathway's potential as a therapeutic target. Future research must prioritize patient stratification, combination therapies (eg, Wnt inhibitors + RAAS blockers), and mechanistic studies to address unresolved controversies in Wnt signaling dynamics. This work underscores the therapeutic implications of targeting Wnt/β-catenin in DKD while advocating for a nuanced approach to harness its protective roles.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2757-2768"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Serum D-Dimer, NLR, and CRP/ALB in Patients with Acute Ischemic Stroke.","authors":"Guo-Biao Luo, Di-Li Yan, Chao-Liu Luo, Sha-Sha Jiang, Zong-Jun Wang, Xiao-Song Li","doi":"10.2147/IJGM.S516037","DOIUrl":"10.2147/IJGM.S516037","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the association between serum D-dimer (D-D), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein to albumin ratio (CRP/ALB), and the prognosis of intravenous thrombolysis in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>Ninety AIS patients admitted from June 2021 to October 2023 were included and divided into poor prognosis (29 cases) and good prognosis groups (61 cases) based on 90-day follow-up modified Rankin Scale (mRS) scores. Binary logistic regression identified prognostic factors, while ROC analysis evaluated the predictive efficacy of D-D, NLR, and CRP/ALB. Correlations among these markers were also analyzed.</p><p><strong>Results: </strong>Binary logistic regression showed that age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR were significant prognostic risk factors (P < 0.05). ROC analysis yielded AUC values of 0.683 for D-D, 0.769 for NLR, and 0.728 for CRP/ALB, with combined AUC reaching 0.803. Sensitivity and specificity were 96.6%/39.3% for D-D, 100.0%/68.9% for NLR, and 100.0%/45.9% for CRP/ALB. Spearman correlation analysis revealed positive correlations among D-D, NLR, and CRP/ALB (r = 0.367, 0.482, 0.462, p < 0.05).</p><p><strong>Conclusion: </strong>Age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR are significant prognostic factors for intravenous thrombolysis in AIS patients. D-D, NLR, and CRP/ALB are effective indicators for predicting prognosis, with combined prediction showing greater efficacy.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2749-2756"},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of the Role of Metabolic Features in Osteoporosis: A Multi-Omics Analysis.","authors":"Shengjia Chang, Weiwei Tao, Pengwen Shi, Huashan Wu, Hongjun Liu, Junjie Xu, Jianghua Chen, Jianfei Zhu","doi":"10.2147/IJGM.S515717","DOIUrl":"10.2147/IJGM.S515717","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to comprehensively explore the metabolic features related to the pathogenesis of osteoporosis (OP) through multi-omics analysis strategy.</p><p><strong>Patients and methods: </strong>Gene expression profiles of OP patients (GSE56815) were downloaded from GEO, and metabolism-related genes (MRGs) were extracted. Plasma samples from 45 OP patients and 18 healthy controls (CON) were collected for metabolomics. We predicted miRNA and transcription factors (TFs) regulating the expression of MRGs on public databases ENCORI and JASPAR, and analyzed the expression levels of target miRNAs using miRNA sequencing of femoral tissues from 7 samples (OP:CON=4:3). Three machine learning algorithms were used to evaluate the diagnostic potential of metabolic signatures for OP.</p><p><strong>Results: </strong>A total of 402 significantly differentially expressed MRGs (DEMRGs) were identified in the transcriptome, and these DEMRGs were enriched in 11 metabolic pathways (<i>P</i><0.05). Metabolomics identified 119 differential plasma metabolites, enriched in 5 metabolic pathways (<i>P</i><0.05). Purine metabolism, Tryptophan metabolism, and Tyrosine metabolism were identified as key metabolic pathways and were significantly enriched in DEMRGs. Femoral miRNA sequencing found 124 differentially expressed miRNAs, with 23 regulating key metabolic pathway gene expression (<i>P</i><0.05). Additionally, 13 differentially expressed TFs were predicted to regulate the expression levels of these 23 miRNAs. Finally, three MRGs and one plasma metabolite were selected based on the machine learning algorithm, with AUC of 0.782, 0.714, 0.772 and 0.836, respectively. The diagnostic performance of these metabolic features was better than that of traditional bone metabolism biochemical markers.</p><p><strong>Conclusion: </strong>This multi-omics study comprehensively explores the metabolic landscape in OP progression, highlighting the central role of metabolic features in the disease. The constructed multi-omics regulatory network aids in understanding the molecular mechanisms of metabolic features in OP progression.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2727-2739"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}