International Journal of General Medicine最新文献

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D-Dimer/Platelet Ratio Predicts in-Hospital Death in Patients with Acute Type a Aortic Dissection. D-Dimer/Platelet 比率可预测急性 a 型主动脉夹层患者的院内死亡。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S490858
Ani Zhao, Yanchun Peng, Baolin Luo, Yaqin Chen, Liangwan Chen, Yanjuan Lin
{"title":"D-Dimer/Platelet Ratio Predicts in-Hospital Death in Patients with Acute Type a Aortic Dissection.","authors":"Ani Zhao, Yanchun Peng, Baolin Luo, Yaqin Chen, Liangwan Chen, Yanjuan Lin","doi":"10.2147/IJGM.S490858","DOIUrl":"10.2147/IJGM.S490858","url":null,"abstract":"<p><strong>Purpose: </strong>Acute Type A aortic dissection (ATAAD) is a rare and life-threatening aortic disease. This study was aimed at the potential of the D-dimer to platelet count ratio (DPR) as a prognostic indicator of ATAAD.</p><p><strong>Patients and methods: </strong>This study retrospectively analyzed ATAAD patients who were admitted to the Department of Cardiac Surgery, Fujian Medical University Union Hospital from January 2022 to April 2023. Patients were divided into survival (n = 173) and death (n = 24) groups based on whether death occurred. The primary outcome was death, and the secondary outcome was adverse hospitalization, including new postoperative arrhythmias, acute renal insufficiency, acute liver insufficiency, pleural effusion, length of ICU stay, mechanical ventilation length, and length of stay. The logistic regression model was used to analyze the relationship between DPR and in-hospital death, and the receiver operating characteristic curve (ROC) was drawn to analyze the predictive value of DPR for in-hospital death of ATAAD patients.</p><p><strong>Results: </strong>Of the 197 patients included, 24 died, and the in-hospital mortality rate was 12.2%. There was a significant difference in diastolic blood pressure (<i>P</i> < 0.05). In terms of laboratory indexes, total bilirubin, direct bilirubin, indirect bilirubin, D-dimer, red blood cell volume distribution width, and DPR in the death group were higher than those in the survival group, with statistical significance (<i>P</i> < 0.05). Operation duration, hospital stay, ICU stay, mechanical ventilation time, and acute renal insufficiency in the death group were higher than those in the survival group (<i>P</i> < 0.05). Univariate analysis and multivariate analysis showed that DPR > 0.0305 ug/mL was an independent risk factor for death in ATAAD patients.</p><p><strong>Conclusion: </strong>Increased DPR is independently associated with in-hospital death in patients with ATAAD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5191-5202"},"PeriodicalIF":2.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Wright Blood Group Alleles and Genotypes in Malaria-Endemic Area in Southwestern Saudi Arabia. 沙特阿拉伯西南部疟疾流行地区赖特血型等位基因和基因型的调查。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-10 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S496346
Amr J Halawani, Saif Elden B Abdalla, Mahmoud M Habibullah, Ghalia Shamlan, Neil D Avent
{"title":"Investigation of Wright Blood Group Alleles and Genotypes in Malaria-Endemic Area in Southwestern Saudi Arabia.","authors":"Amr J Halawani, Saif Elden B Abdalla, Mahmoud M Habibullah, Ghalia Shamlan, Neil D Avent","doi":"10.2147/IJGM.S496346","DOIUrl":"10.2147/IJGM.S496346","url":null,"abstract":"<p><strong>Purpose: </strong>Inherited blood disorders as well as malaria are prevalent in southwestern Saudi Arabia. Patients with specific hemoglobinopathies may require frequent blood transfusions. Accordingly, alloimmunization may occur if donors and recipients are incompatible. Therefore, examination of various blood group antigens to provide compatible blood units is essential. Two alleles of the Diego (DI) blood group system, <i>DI*02.03</i> and <i>DI*02.04</i> encode the Wright antigens; Wr<sup>a</sup> and Wr<sup>b</sup>, respectively. Anti-Wr<sup>a</sup> may lead to alloimmunization during transfusion and pregnancy. Furthermore, the Wr<sup>b</sup> antigen may involve in interaction between protein receptors for <i>Plasmodium falciparum</i>. This study aimed to investigate the allele/genotype frequencies of the Wright blood groups in southwestern Saudi blood donors regarding the blood transfusion and assessed the population of Jazan Province for susceptibility of <i>Plasmodium falciparum</i> invasion.</p><p><strong>Materials and methods: </strong>One-hundred-fifty Saudi blood donors were enrolled to this study. DNA was extracted from the blood samples. Primer pairs were designed to capture a single nucleotide variation that distinguishes the Wright alleles. Polymerase chain reaction (PCR) was conducted and followed by standard sequencing.</p><p><strong>Results: </strong>Among the 150 genotyped samples, the only observed allele was <i>DI*02.04</i> (n = 150, 100%). Accordingly, the genotype prevalence of <i>DI*02.04/DI*02.04</i> was accounted for (n = 150, 100%).</p><p><strong>Conclusion: </strong>This study demonstrated the allele frequencies of <i>DI*02.03</i> and <i>DI*02.04</i> of the DI blood group system in Saudi blood donors. The <i>DI*02.04</i> allele was the only allele that was observed. Furthermore, the prevalence of the genotypes was determined and the only observed genotype was <i>DI*02.04/DI*02.04</i>. Interestingly, this study indicates that the Saudi Arabian population living in Jazan Province may be more susceptible to <i>Plasmodium falciparum</i> invasion. Moreover, adding the Wright alleles for the transfusion screening panel is not recommended.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5175-5180"},"PeriodicalIF":2.1,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitude of Healthcare Providers Towards Care of People with Disabilities, in Hail Region, Saudi Arabia. 沙特阿拉伯海尔地区医疗服务提供者对残疾人护理的态度。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S488916
Khalil A Saleh, Gamil Ghaleb Alrubaiee, Talal Ali Hussein Alqalah, Mokhtar Abdu Almoliky, Habib Alrashedi, Sameer A Alkubati, Waled A M Ahmed
{"title":"Attitude of Healthcare Providers Towards Care of People with Disabilities, in Hail Region, Saudi Arabia.","authors":"Khalil A Saleh, Gamil Ghaleb Alrubaiee, Talal Ali Hussein Alqalah, Mokhtar Abdu Almoliky, Habib Alrashedi, Sameer A Alkubati, Waled A M Ahmed","doi":"10.2147/IJGM.S488916","DOIUrl":"10.2147/IJGM.S488916","url":null,"abstract":"<p><strong>Background: </strong>Disability, whether congenital or acquired, poses significant challenges that affect individuals' physical, mental, psychological, and social functioning. This study aimed to examine the attitudes of healthcare providers in Hai'l City towards people with disabilities.</p><p><strong>Methods: </strong>A cross-sectional design was used, involving 321 healthcare providers from the Hai'l region, employing the Scale of Attitudes towards Disabled Persons (SADP) for data collection. The data were collected through an online survey and analyzed using SPSS 26.</p><p><strong>Results: </strong>The results indicated a generally positive attitude of healthcare providers towards people with disabilities, with mean scores exceeding 89 across various groups. Older providers (over 35 years old) exhibited the highest positivity rate (92.57), although differences in age, sex, educational level, years of experience, and professional role were not statistically significant. Master's degree holders had the highest average score (93.52), but the differences remained statistically insignificant.</p><p><strong>Conclusion: </strong>The study concludes that while healthcare providers generally have positive attitudes towards people with disabilities, there is a critical need for comprehensive training programs to enhance the quality of care provided. Future research should extend to other regions and employ qualitative methods to gain deeper insights into healthcare providers' attitudes toward and experiences with people with disabilities.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5181-5190"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Early Treatment Effectiveness in Bell's Palsy Using Machine Learning: A Focus on Corticosteroids and Antivirals. 利用机器学习预测贝尔氏麻痹症的早期治疗效果:聚焦皮质类固醇和抗病毒药物。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S488418
Jheng-Ting Luo, Yung-Chun Hung, Gina Jinna Chen, Yu-Shiang Lin
{"title":"Predicting Early Treatment Effectiveness in Bell's Palsy Using Machine Learning: A Focus on Corticosteroids and Antivirals.","authors":"Jheng-Ting Luo, Yung-Chun Hung, Gina Jinna Chen, Yu-Shiang Lin","doi":"10.2147/IJGM.S488418","DOIUrl":"10.2147/IJGM.S488418","url":null,"abstract":"<p><strong>Purpose: </strong>Facial nerve paralysis, particularly Bell's palsy, manifests as a rapid onset of unilateral facial weakness or paralysis. Despite most patients recovering within three to six months, a significant proportion experience poor recovery. This study utilized six machine learning models to investigate the effectiveness of early treatment in Bell's palsy.</p><p><strong>Patients and methods: </strong>We applied data from 17 hospitals in Scotland to predict treatment outcomes. Patients were randomized into four groups: Prednisolone (corticosteroids), Acyclovir (antivirals), both, and placebo. Outcomes, defined as full resolution of symptoms, were assessed using the House-Brackmann scale at 3 and 9 months post-treatment. We employed six different machine learning models to predict recovery outcomes and evaluated model performance using AUC, precision, recall, and F1-score.</p><p><strong>Results: </strong>Among 493 patients, 72.6% recovered after three months and 89.5% after nine months. Logistic regression demonstrated the highest predictive performance for both 3-month (<i>AUC</i> = 0.751) and 9-month recovery (<i>AUC</i> = 0.720). Additionally, several models achieved Precision levels exceeding 0.9. We further employed the best-performing logistic regression for feature ranking, indicating that the patient's age and prednisolone administration are the most significant predictors of recovery.</p><p><strong>Conclusion: </strong>The results highlight the potential of machine learning models in predicting the effectiveness of early treatment. This study conducted a comprehensive comparison of six different machine learning models, with the logistic regression showing the highest predictive performance for both 3-month and 9-month recovery. Additionally, feature ranking using logistic regression supported the importance of Prednisolone in treatment. Notably, our findings revealed the significance of age in prognosis evaluation for the first time. This suggests that future research should further develop age-specific prognostic models, enabling clinicians to tailor individualized treatment strategies more effectively. This previously unrecognized discovery provides a foundation for prognostic analysis in Bell's palsy patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5163-5174"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Vitamin D Deficiency is Associated with Mortality Risk in Critically Ill Patients with Acute Kidney Injury. 严重缺乏维生素 D 与急性肾损伤重症患者的死亡风险有关。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S477114
Beili Shen, Bianling Liu, Yanhui Wang, Rui Wang, Dongfeng Gu
{"title":"Severe Vitamin D Deficiency is Associated with Mortality Risk in Critically Ill Patients with Acute Kidney Injury.","authors":"Beili Shen, Bianling Liu, Yanhui Wang, Rui Wang, Dongfeng Gu","doi":"10.2147/IJGM.S477114","DOIUrl":"10.2147/IJGM.S477114","url":null,"abstract":"<p><strong>Purpose: </strong>Deficiency in vitamin D is associated with adverse outcomes in several health conditions. However, the specific impact of vitamin D levels on mortality in acute kidney injury (AKI) patients remains inadequately explored. This study aims to investigate the association between serum vitamin D concentrations and mortality risk in critically ill patients diagnosed with AKI. We hypothesize that severe vitamin D deficiency is associated with an increased risk of 90-day all-cause mortality in these patients.</p><p><strong>Patients and methods: </strong>This study retrospectively enrolled 259 adult AKI patients admitted to the intensive care unit (ICU) at The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital) between July 2021 and June 2023. Based on 25-hydroxyvitamin D (25-OHD) levels, they were categorized into 4 groups: severe deficiency (<10 ng/mL), deficiency (10-20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (>30 ng/mL). Multivariate survival analysis using Cox's regression model was used to analyze the impact of vitamin D concentrations on the 90-day all-cause mortality risk after controlling for potential confounders.</p><p><strong>Results: </strong>The 90-day all-cause mortality rate was the highest in patients with severe deficiency (50.8%), followed by those with deficiency (35.0%), insufficiency (23.9%), and sufficiency (12.2%). Multivariate Cox regression showed that compared with sufficiency, severe deficiency (HR=3.34, 95% CI: 1.14-9.77; <i>P</i>=0.03) was independently associated with a higher risk of 90-day all-cause mortality, but deficiency and insufficiency were not significantly associated with 90-day all-cause mortality risk.</p><p><strong>Conclusion: </strong>Severe vitamin D deficiency (<10 ng/mL) significantly increases the risk of mortality in AKI patients, underlining the need for monitoring and potentially supplementing vitamin D in this population.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5153-5162"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decongestant Effect of "Coldamaris Akut", a Carrageenan- and Sorbitol-Containing Nasal Spray in Seasonal Allergic Rhinitis. 含卡拉胶和山梨醇的鼻腔喷雾剂 "Coldamaris Akut "对季节性过敏性鼻炎的减充血作用
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S476707
Nicole Unger-Manhart, Martina Morokutti-Kurz, Petra Zieglmayer, Antonella Russo, Cornelia Siegl, Marielle König-Schuster, Christiane Koller, Philipp Graf, Christine Graf, Patrick Lemell, Markus Savli, René Zieglmayer, Hanna Dellago, Eva Prieschl-Grassauer
{"title":"Decongestant Effect of \"Coldamaris Akut\", a Carrageenan- and Sorbitol-Containing Nasal Spray in Seasonal Allergic Rhinitis.","authors":"Nicole Unger-Manhart, Martina Morokutti-Kurz, Petra Zieglmayer, Antonella Russo, Cornelia Siegl, Marielle König-Schuster, Christiane Koller, Philipp Graf, Christine Graf, Patrick Lemell, Markus Savli, René Zieglmayer, Hanna Dellago, Eva Prieschl-Grassauer","doi":"10.2147/IJGM.S476707","DOIUrl":"https://doi.org/10.2147/IJGM.S476707","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a hyperosmolar, barrier-forming nasal spray based on carrageenan and sorbitol, and to demonstrate its decongestant effect in the context of allergic rhinitis (AR).</p><p><strong>Methods: </strong>The efficacy of the nasal spray components was tested in vitro by barrier function, virus replication inhibition, and water absorption assays. The decongestant effectiveness was assessed in a randomized, controlled, crossover environmental chamber trial, where participants with a history of seasonal grass pollen AR were exposed to grass pollen allergens under controlled conditions. Forty-one adults were randomized to receive either carrageenan- and sorbitol-containing nasal spray (CS) or saline solution (SS). After 1 week, participants repeated the exposure with the treatment they had not received before. The primary efficacy endpoint was the mean change in nasal congestion symptom score (NCSS). Secondary efficacy endpoints were nasal airflow, nasal secretion, total nasal symptom score (TNSS), total ocular symptom score (TOSS) and total respiratory symptom score (TRSS).</p><p><strong>Results: </strong>Preclinical assays demonstrated barrier-building, virus-blocking, and water-withdrawing properties of the CS components. In the clinical study, there was no significant difference in mean NCSS change from pre- to post-treatment between CS and SS. However, nasal airflow increased over time after treatment with CS, while it declined after SS, leading to a growing difference in airflow between CS and SS (p = 0.04 at 6:00 h). Mean nasal secretion over 2-6 h was reduced by ~25% after CS (p = 0.003) compared to pre-treatment, while it was reduced by only ~16% after SS (p = 0.137). No significant differences in TNSS, TOSS and TRSS were observed between CS and SS.</p><p><strong>Conclusion: </strong>CS improves nasal airflow and reduces nasal secretion in adults with AR. We propose CS as a safe and effective adjuvant to baseline pharmacological treatments.</p><p><strong>Trial registration: </strong>NCT04532762.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5105-5121"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice. 区分良性和恶性阻塞性黄疸的综合指数
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S485004
Hao Peng, Jixue Li, Xiaoru Zhou, Zhewen Nong, Ruiying Zhang, Pei Lu, Shasha Ye, Liping Lei, Chuang Qin, Jiangfa Li
{"title":"A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice.","authors":"Hao Peng, Jixue Li, Xiaoru Zhou, Zhewen Nong, Ruiying Zhang, Pei Lu, Shasha Ye, Liping Lei, Chuang Qin, Jiangfa Li","doi":"10.2147/IJGM.S485004","DOIUrl":"10.2147/IJGM.S485004","url":null,"abstract":"<p><strong>Objective: </strong>To explore a more effective and practical comprehensive index for differentiating benign from malignant obstructive jaundice by analyzing the clinical data of patients with benign obstructive jaundice (BJ) group and malignant obstructive jaundice (MJ) group.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 339 patients with obstructive jaundice. The cases were divided into two data sets: training cohort and validation cohort. The cases were divided into two groups: malignant and benign obstructive jaundice group. Logistic regression analysis was used to build a prediction model for judging the nature of obstructive jaundice, and the prediction model was verified using the validation cohort.</p><p><strong>Results: </strong>Multivariate analysis revealed that CEA, TBIL, and NLR were independent factors in malignant obstructive jaundice. A comprehensive index for differentiating benign from malignant obstructive jaundice was established based on these indicators. The sensitivity, specificity, and receiver operating characteristic curve of this model for differentiating benign from malignant obstructive jaundice were 79.57%, 93.26%, and 0.920, respectively.</p><p><strong>Conclusion: </strong>The prediction model based on the comprehensive index of CEA, TBIL, and NLR has a higher accuracy in differentiating malignant obstructive jaundice.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5143-5151"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological Analysis of Thyroid Nodules with Taller-Than-Wide Shape in Adults. 成人甲状腺高大结节的组织病理学分析
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S473731
Xi-Yue Yang, Li-Fang Huang, Yue-Jian Han, Xiao-Xin Cen, Zong-Xin Tao
{"title":"Histopathological Analysis of Thyroid Nodules with Taller-Than-Wide Shape in Adults.","authors":"Xi-Yue Yang, Li-Fang Huang, Yue-Jian Han, Xiao-Xin Cen, Zong-Xin Tao","doi":"10.2147/IJGM.S473731","DOIUrl":"https://doi.org/10.2147/IJGM.S473731","url":null,"abstract":"<p><strong>Background: </strong>The ultrasound examination (USE) feature of taller-than-wide (TTW) shape is highly specific but low sensitive in diagnosis of thyroid carcinoma. Relationships between other USE malignant features (such as irregular margin, ill-defined, markedly hypoechoic, and microcalcification) with histopathological features have been well investigated, while studies about the histopathologic features of TTW shape are rare.</p><p><strong>Aim: </strong>The present study aimed to investigate the histopathological features of thyroid nodules with TTW shapes.</p><p><strong>Methods: </strong>A total of 85 thyroid nodules with TTW were selected from 1680 consecutive patients who underwent thyroid resection. USE features of the nodules, including size, location, boundary, margin, composition, echogenicity, and calcification, were recorded according to the China Thyroid Imaging Reporting and Data System (C-TIRADS). Hypoechoic lesions were further categorized as mild, moderate or markedly hypoechoic lesions. The histological features of the specimens were evaluated according to the arrangement of follicular cells, presence of papillary structures or psammoma bodies, degree of fibrosis, and amount of lymphoid infiltration. Differences in the USE and histological features between benign and malignant nodules were compared.</p><p><strong>Results: </strong>Among the 85 nodules, 72 (84.71%) were malignant, and 13 (15.29%) were benign. Only echogenicity showed a statistically significant difference between benign and malignant nodules (<i>P</i>=0.003). Apart from microfoci, papillary structures, and psammoma bodies, the degree of fibrosis was also significantly different between benign and malignant tumors (all <i>P</i><0.05). Regression analysis showed a trend of decreasing nodule echogenicity with increasing fibrosis frequency (odds ratio [OR] = 4.500).</p><p><strong>Conclusion: </strong>Extensive fibrosis is the most common histopathological feature of thyroid cancer and corresponds to hypoechogenicity in USE. TTW-shaped thyroid nodules are highly suggestive of malignancy, especially those with moderate or markedly hypoechogenicity.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5123-5131"},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis. 外周血炎症指数与腔隙性肺结核之间的关系
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S483185
Xiaoshan He, Hongbiao Hou, Yuting Jiang, Xiaohuan Huang
{"title":"Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis.","authors":"Xiaoshan He, Hongbiao Hou, Yuting Jiang, Xiaohuan Huang","doi":"10.2147/IJGM.S483185","DOIUrl":"https://doi.org/10.2147/IJGM.S483185","url":null,"abstract":"<p><strong>Objective: </strong>To explore inflammation markers of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI) in the differential diagnosis of cavitary pulmonary tuberculosis (PTB) from non-cavitary PTB.</p><p><strong>Methods: </strong>This retrospective study included 1233 patients with PTB, 518 patients were diagnosed with cavitary PTB as case group, while 715 patients which diagnosed with non-cavitary PTB were selected as control group. The clinical data of patients was collected and the levels of inflammation indices were measured. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnosis and analysis of selected indices. Logistic regression analysis was performed to evaluate the factors associated with cavitary PTB.</p><p><strong>Results: </strong>The CRP, NLR, MLR, PLR, SII, and SIRI in the case group were significantly higher than those in the controls (all <i>p</i><0.001). When cavitary PTB was taken as the endpoint, the optimal diagnostic thresholds of CRP was 35.365 (area under the ROC curve (AUC)=0.601), NLR was 5.740 (AUC=0.595), MLR was 0.525 (AUC=0.577), PLR was 198.255 (AUC=0.602), SII was 1252.045 (AUC=0.628), and SIRI was 2.095 (AUC=0.605), respectively. Logistic regression analysis showed that gender, CRP, PLR, and SIRI were the independent risk factors for cavitary PTB. The sensitivity of the combination of the three indices (CRP+PLR, CRP+SIRI, PLR+SIRI, and CRP+PLR+SIRI) were higher than those of the CRP, PLR, and SIRI.</p><p><strong>Conclusion: </strong>CRP, PLR, and SIRI levels were associated with an increased likelihood of cavitary PTB. The combined detection of CRP, PLR, and SIRI is promising as a screening marker and may be useful for ruling out PTB with cavitary.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5133-5142"},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration of Serum MLKL Levels and Their Association with Severity and Clinical Outcomes in Human Severe Traumatic Brain Injury: A Prospective Cohort Study. 人类严重创伤性脑损伤中血清 MLKL 水平的变化及其与严重程度和临床结果的关系:一项前瞻性队列研究
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI: 10.2147/IJGM.S485153
Yidong Jin, Han Zhang, Min Zhou, Shaojun Zhang, Mi Guo
{"title":"Alteration of Serum MLKL Levels and Their Association with Severity and Clinical Outcomes in Human Severe Traumatic Brain Injury: A Prospective Cohort Study.","authors":"Yidong Jin, Han Zhang, Min Zhou, Shaojun Zhang, Mi Guo","doi":"10.2147/IJGM.S485153","DOIUrl":"https://doi.org/10.2147/IJGM.S485153","url":null,"abstract":"<p><strong>Background: </strong>Mixed lineage kinase domain-like protein (MLKL), which modulates necroptosis, has been implicated in pathophysiological processes following acute brain injury. Here, serum MLKL was quantified to determine its prognostic significance in severe traumatic brain injury (sTBI).</p><p><strong>Methods: </strong>This prospective cohort study enrolled 155 patients with sTBI and 155 healthy volunteers. The severity metrics included the Glasgow Coma Scale (GCS) score and Rotterdam computed tomography (CT) classification. The extended Glasgow outcome scale (GOSE) at posttraumatic 180 days was considered as a prognostic parameter, with a score of 1-4 as indicating poor prognosis. Univariate and subsequent multivariate analyses were used for independent factorial investigation.</p><p><strong>Results: </strong>Compared to controls, patients displayed profoundly elevated serum MLKL levels. In the framework of restricted cubic spline analysis, serum MLKL levels were linearly correlated with the likelihood of mortality, overall survival, and poor prognosis. Serum MLKL levels were not only independently correlated with GCS, Rotterdam CT scores and GOSE scores, but were also independently predictive of death, overall survival, and poor prognosis. Subgroup analysis showed that serum MLKL levels exhibited negligible interactions with age, sex, hypertension, diabetes, smoking habits, and alcohol consumption to distinguish the possibility of death, overall survival, and poor prognosis. Within the context of receiver operating characteristic curve analysis, serum MLKL levels had strong discrimination effectiveness for death and poor prognosis and, in contrast to GCS and Rotterdam CT scores, were considered to have equivalent predictive ability.</p><p><strong>Conclusion: </strong>Extreme elevation of serum MLKL levels is intimately related to trauma severity, death, and neurological outcomes, suggesting that serum MLKL may act as a potential predictor for facilitating severity stratification and prognosis prediction of sTBI.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5069-5084"},"PeriodicalIF":2.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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