International Journal of General Medicine最新文献

{"title":"A Review of Advances in Multimodal Treatment Strategies for Chronic Disorders of Consciousness Following Severe Traumatic Brain Injury.","authors":"Shuyan Liu, Xueqing Li, Shi Jiang, Dan Liu, Jinghua Wang","doi":"10.2147/IJGM.S502086","DOIUrl":"10.2147/IJGM.S502086","url":null,"abstract":"<p><strong>Background: </strong>Chronic disorders of consciousness (cDoC) resulting from severe traumatic brain injury (sTBI) are associated with significant challenges in treatment and recovery. This review explores multimodal interventions aimed at improving patient outcomes.</p><p><strong>Methods: </strong>A systematic review was conducted on peer-reviewed studies from PubMed and Google Scholar published between 2000 and 2023. The review included clinical trials, observational studies, and case series that assessed interventions for improving consciousness and cognitive function in patients with cDoC following sTBI. Interventions considered included pharmacological treatments, non-invasive neuromodulation, rehabilitation therapies, and traditional medicine approaches.</p><p><strong>Results: </strong>The review identifies several promising interventions. Hyperbaric oxygen therapy (HBOT), when combined with physical rehabilitation and non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), has shown positive effects on consciousness and cognitive recovery. Non-invasive neuromodulation techniques have been linked to improvements in cortical activity and consciousness, with taVNS emerging as a novel approach. Additionally, traditional Chinese medicine, particularly herbal therapies, has demonstrated complementary benefits when integrated with modern rehabilitation methods. Personalized treatment strategies based on clinical characteristics, biomarkers, and genetic data were found to enhance recovery. Notably, integrating these modalities into personalized care protocols has shown enhanced efficacy, suggesting that individualized approaches are critical for improving outcomes.</p><p><strong>Conclusion: </strong>Multimodal therapies show promise in enhancing recovery in cDoC patients after sTBI, but further research is needed to optimize treatment protocols and standardize clinical practices. The integration of traditional and modern therapies represents a potentially effective strategy for improving patient outcomes.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"771-786"},"PeriodicalIF":2.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Serum Homocysteine Levels With Various Types of Coronary Syndromes (CS) and In-Hospital Mortality - A Multicenter Study.","authors":"Himayat Ullah, Sarwat Huma, Lubna Naeem, Ghulam Yasin, Muhammad Ashraf, Nafisa Tahir, Mohammed Yunus, Hossam Shabana, Abdulrahman H Shalaby, Ahmed Ali Hassan Ali, Mohamed Elwan Mohamed Mahmoud, Elsayed Mohamed Elsayed Tayee, Ahmed Farag Abd Elkader Elbwab, Ahmed Mohamed Ewis Alhawy, Ahmed Ahmed Mohamed Abotaha, Mahmoud Ezzat Abdelraouf, Mohammed S Imam, Hossam Aladl Aladl Aladl, Taiseer Ahmed Shawky, Ashraf Mohammed Said, Mahmoud Saeed Mahmoud, Kazem Mohamed Tayee, Reda Fakhry Mohamed, Ali Hosni Farahat, Mohammad Mossaad Abd Allah Alsayyad, Hesham El Sayed Lashin, Hani Ismail Hamed, Hazem Sayed Ahmed Sayed Ayoub, Ayman Mohamed Salem Ahmed Nafie","doi":"10.2147/IJGM.S500973","DOIUrl":"10.2147/IJGM.S500973","url":null,"abstract":"<p><strong>Purpose: </strong>Coronary artery disease (CAD), clinically manifested as coronary syndrome (CS), is the leading cause of death and a significant contributor to morbidity worldwide. Elevated serum homocysteine levels have been associated with an increased risk of cardiovascular diseases, including CAD. Despite extensive research, the relationship between serum homocysteine and coronary syndromes with related short-term mortality is still under-studied. The main objective of this study is to evaluate the correlation between serum homocysteine levels and various types of CS, as well as in-hospital mortality in these patients.</p><p><strong>Patients and methods: </strong>This multicenter study included 381 CS patients from Afghanistan, Egypt, and Pakistan tertiary care hospitals. The relation of serum homocysteine levels with different types of CS as well as with in-hospital mortality was measured and analyzed using inferential statistics (ANOVA, Kruskal-Wallis test, Tukey's post-hoc, Pearson correlation, etc.) and regression analysis (Binary regression).</p><p><strong>Results: </strong>Among 381 patients from both genders, 160 were from Pakistan, 130 from Egypt, and 91 from Afghanistan. There was no significant difference in baseline characteristics, like age, gender, homocysteine level, CS type, and mortality, among the three countries (<i>p</i> > 0.05). The one-way ANOVA, the Kruskal Wallis Test, and Tukey's post hoc test showed a significant difference among different CS groups based on serum homocysteine levels, and Pearson correlation showed a strong correlation between serum homocysteine and CS (r = 0.4). Binary regression analysis showed a 10.5% increase in in-hospital mortality for each 1 µmol/L increase in homocysteine levels.</p><p><strong>Conclusion: </strong>Serum homocysteine could serve as a valuable biomarker and mortality predictor in CS patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"725-732"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Dynamics of Respiratory Viruses in Hospitalized Children of Fuzhou: Insights Into the Impact of COVID-19 Pandemic Control Measures.","authors":"Kunhai Wu, Huifang Huang, Lufei Chen, Yanan Wu","doi":"10.2147/IJGM.S511995","DOIUrl":"10.2147/IJGM.S511995","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the prevalence of common respiratory viruses among children with acute respiratory infections in Fuzhou from 2017 to 2023, considering the varying Corona Virus Disease 2019 (COVID-19) epidemic control measures in place.</p><p><strong>Patients and methods: </strong>This study retrospectively analyzed the detection of respiratory viruses in children diagnosed with acute respiratory infections at a tertiary hospital in Fuzhou during the study period. The analysis covers three distinct phases: Phase I (2017-2019), Phase II (2020-2022), and Phase III (2023). The subjects of this study included adenovirus (ADV), influenza A virus (Flu A), influenza B virus (Flu B), parainfluenza virus types 1, 2, and 3 (PIV-1, PIV-2, PIV-3), and respiratory syncytial virus (RSV).</p><p><strong>Results: </strong>A total of 24,838 throat swab samples were collected, resulting in an overall positive detection rate of 17.87% (4439/24,838). The positive detection rates of respiratory viruses among hospitalized children in Phases I, II, and III were 18.51%, 18.27%, and 15.90%, respectively, demonstrating a statistically significant decreasing trend over the years (P < 0.001). Among the detected viruses, RSV, PIV-3, and Flu A were the most prevalent. RSV infections was most common in children under six years of age. Seasonal trends for Flu A, PIV-3, and RSV varied throughout the outbreak; specifically, the detection rate of Flu A increased during March and April in 2023, while RSV detection rebounded sharply from April to June. The incidence of mixed respiratory virus infections was 0.40% (100/24,838), the most common being PIV-3 and RSV.</p><p><strong>Conclusion: </strong>Using COVID-19 safety rules has helped stop the spread of some viruses in kids. But these rules have not made much difference in how often RSV and PIV-3 viruses show up.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"759-770"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Clinical Application of Rh Blood Group Bank in the East China Region.","authors":"Yiming Jin, Xiaoyan Fu, Shuhong Xie, Zhen Liu, Zihao Xu, Mingyuan Wang, Yihan Wang, Rong Lu, Lingling Wang","doi":"10.2147/IJGM.S505147","DOIUrl":"10.2147/IJGM.S505147","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.</p><p><strong>Patients and methods: </strong>A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. An automated blood type analyzer was used to determine Rh phenotypes, which were then applied clinically for ABO and Rh blood type-matching in transfusions.</p><p><strong>Results: </strong>Analysis of 28672 RhD-positive donors identified 13 RhD variants and eight Rh phenotypes, with the most common being CCee (42.69%) and CcEe (35.27%). Antigen frequencies were e (92.07%), C (87.85%), c (56.75%), and E (47.65%). Among 307 RhD-negative donors, seven Rh phenotypes were identified, with ccee (60.26%) and Ccee (29.32%) being the predominant ones. Antigen frequencies were e (99.67%), c (96.09%), C (34.53%), and E (6.84%). These findings supported 1834 ABO- and Rh- blood type-matching transfusions, but no significant difference was observed between ABO-compatible and dual-system compatible transfusions (<i>p</i> > 0.05). Additionally, it was found that there are significant differences compared to populations from India and other regions (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>In this region of East China, the prevalence of RhD variants among voluntary blood donors was 0.045%. The predominant Rh phenotypes were CCDee and CcDEe, with the highest frequencies observed for the e and C antigens. And the frequency of Rh phenotypes in this region differs from related studies in other areas. It is essential to strengthen the establishment of a rare blood type database in East China to provide data support for clinical compatible blood transfusion.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"717-724"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Serum NLRP3 in Spontaneous Intracerebral Hemorrhage.","authors":"Yong Cai, Yijun Ma, Chao Tang, Wei Li, Xuan Lv, Zhijie Xie, Jun Wang","doi":"10.2147/IJGM.S507518","DOIUrl":"10.2147/IJGM.S507518","url":null,"abstract":"<p><strong>Background: </strong>Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is involved in secondary brain injury after acute intracerebral hemorrhage (ICH). The objective of this study was to determine its ability to predict early neurological deterioration (END) and 3-month neurological outcome after ICH.</p><p><strong>Methods: </strong>In this prospective cohort study, serum NLRP3 levels were measured in 128 patients with sICH and 100 healthy controls. National institute of health stroke scale (NIHSS) scores and hematoma volumes were recorded. Post-ICH END and 3-month poor outcome (modified Rankin Scale (mRS) scores of 3-6) were documented. The results were assessed using multivariate analysis.</p><p><strong>Results: </strong>Serum NLRP3 levels in sICH patients increased significantly as compared to controls (P<0.001). Serum NLRP3 levels were independently correlated with hematoma volumes (β=0.046; 95% confidence interval (CI), 0.020-0.072; P=0.001) and NIHSS scores (β=0.071; 95% CI, 0.004-0.139; P=0.039), independently forecasted END (OR=1.268; 95% CI, 0.892-1.801; P=0.036) and poor prognosis at post-ICH 3 months (OR=1.448; 95% CI, 1.006-2.085; P=0.046), and were predictive of them with areas under receiver operating characteristic curve at 0.788 (95% CI, 0.706-0.855) and 0.805 (95% CI, 0.725-0.870) separately. Serum NLRP3 levels, along with the two independent predictors, that are NIHSS scores and hematoma volumes, are combined to establish prediction models of END and poor prognosis. The models worked well by applying a series of statistical methods.</p><p><strong>Conclusion: </strong>Increased serum NLRP3 levels after ICH are independently associated with bleeding severity, END and adverse outcomes of patients, meaning that serum NLRP3 may be a potential prognostic biomarker of sICH.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"745-757"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine Blood Tests as Predictive Tools for Differentiating Follicular Thyroid Carcinoma From Follicular Adenoma.","authors":"Jiaxi Wang, Jingwei Wang, Hanqing Liu, Chuang Chen","doi":"10.2147/IJGM.S502626","DOIUrl":"10.2147/IJGM.S502626","url":null,"abstract":"<p><strong>Background: </strong>Thyroid cancer is the most common endocrine malignancy, with an increasing incidence rate, particularly among adolescents. Follicular thyroid carcinoma (FTC), though less common than papillary thyroid carcinoma (PTC), presents greater diagnostic challenges, especially when differentiating from follicular adenoma (FA). Current diagnostic methods lack specificity, underscoring the need for a simple, cost-effective predictive model for FTC.This study aimed to develop a predictive scoring system based on routine blood biomarkers to distinguish between FTC and FA, facilitating early diagnosis and treatment.</p><p><strong>Methods: </strong>A retrospective, single-center case-control study was conducted on patients diagnosed with FTC and FA at Renmin Hospital of Wuhan University from 2016 to 2022. Patients' demographic, clinicopathological characteristics, and preoperative blood biomarker data were analyzed. Statistical tests, including chi-square, t-tests, and Mann-Whitney <i>U</i>-tests, were used to compare biomarkers. Significant variables were included in univariate and multivariate logistic regression analyses, leading to the development of a scoring system. The model's performance was assessed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The study included 23 patients with FA and 26 patients with FTC. Seven blood biomarkers showed significant differences between the groups: ALB, DBIL, TBIL, LYM#, MCHC, RDW-SD, and WBC. Multivariate logistic regression identified ALB and WBC as key predictors, forming a scoring model (Score = 0.54 × ALB - 1.10 × WBC). The model exhibited strong predictive performance (AUC = 0.839), with sensitivity and specificity of 0.808 and 0.826, respectively.</p><p><strong>Conclusion: </strong>The study developed a novel predictive model using routine blood biomarkers, offering a non-invasive, cost-effective tool for differentiating between FTC and FA. The model has significant clinical potential, providing a feasible alternative to conventional diagnostic techniques. Further multicenter studies and mechanistic investigations are warranted to validate and refine the model, enhancing its utility in clinical practice.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"733-744"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling.","authors":"Chenlu Wang, Zhaojin Lu, Guangpeng She, Kaining Chen, Huazhong Zhou, Xueli Zhan, Hongyan Yu, Lei Pi, Liandong Zuo, Di Che","doi":"10.2147/IJGM.S487632","DOIUrl":"10.2147/IJGM.S487632","url":null,"abstract":"<p><strong>Purpose: </strong>Recurrent abortion(RA) is a prevalent adverse pregnancy event. Exosomes, secreted by various body fluids, are known to play a role in disease diagnosis and serve as biomarkers through intercellular communication. This study aims to analyze single exosomes in patients with recurrent abortion to identify new biomarkers that may significantly contribute to recurrent abortion, providing new directions for its treatment.</p><p><strong>Patients and methods: </strong>A total of 244 serum exosomes were collected, including 216 patients with recurrent abortion of varying outcomes and 28 normal pregnancies. We performed the proximity barcoding assay (PBA) to analyze single exosome surface proteins, which allowed us to identify individual exosomes related to the development of RA as well as the major subpopulations of exosomes. After PBA treatment, samples were analyzed for single exosomes, and exosomes from each group were compared using volcano plots, dot plots, and ROC curves.</p><p><strong>Results: </strong>By intersecting all significantly differentially expressed genes obtained from comparisons between the normal pregnancy control group and the recurrent abortion group, including the RA before abortion, RA after abortion, and RA non-pregnancy groups, we identified seven shared differential genes: FN1, APIPOQ, CDH13, DSG1, CLDN4, CD36, and ULBP3. Among these, FN1 was the most significantly differentially expressed gene in exosomes, with FN1 | log2 (fold change) |>1.5 and an AUC of 0.7414. In addition, exosome subpopulation analyses showed that cluster 11 accounted for the largest proportion of the total 16 subpopulations, and FN1 was the marker with the highest concentration of cluster 11.</p><p><strong>Conclusion: </strong>Single-exosome profiling and exosome subpopulations of RA by PBA yielded significant differential gene FN1, which provides new possibilities for diagnostic screening of RA.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"691-702"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohort Study.","authors":"Ning Yan, Peng Wu, Baozhen Zhu, Ali Ma, Xin Wang, Xinrui Hai, Xueping Ma, Hao Jiang, Shaobin Yang","doi":"10.2147/IJGM.S509816","DOIUrl":"10.2147/IJGM.S509816","url":null,"abstract":"<p><strong>Background: </strong>The relationship between mitral regurgitation (MR) and long-term outcomes in Chinese patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remains scarce. This study aimed to elucidate the connection between MR and long-term clinical outcomes following AMI treated with PCI.</p><p><strong>Methods: </strong>In this retrospective study 6940 patients who were diagnosed with AMI were consecutively enrolled from General Hospital of Ningxia Medical University (2014-2019). The included AMI patients were divided into no MR, mild MR and moderate/serve MR according to MR occurred. All patients were clinically followed for 3-year to collect major adverse cardiac and cerebrovascular events (MACCEs), comprising all-cause death, nonfatal myocardial infarction (MI), rehospitalization for angina, rehospitalization for heart failure (RHF), and stroke. Cox regression models were employed to analyze the association between MR and 3-year clinical outcomes after adjusting for various confounding factors.</p><p><strong>Results: </strong>Among the 6940 patients, 2871 (41.35%) exhibited no MR, 3681 (53.04%) had mild MR, and 388 (5.59%) had moderate/severe MR. The cumulative 3-year incidence of MACCEs was 19.21% overall, with rates of 15.26%, 20.37%, and 37.37% in the no MR, mild MR, and moderate/severe MR groups, respectively (log-rank <i>p</i> < 0.001). Kaplan-Meier survival curves of MR with all-cause death and RHF were also plotted (log-rank <i>p < 0.001</i>). After controlling confounding variables completely, we found that moderate/severe MR compared to none MR was found to be significantly associated with 3-year MACCEs [hazard ratio (HR) = 1.83; 95% confidence interval (CI) = 1.21-2.77; <i>p = 0.0042</i>], all-cause mortality (HR = 3.11; 95% CI = 1.75-5.50; <i>p=0.001</i>) and RHF (HR = 1.69; 95% CI = 1.09-2.62; <i>p=</i>0.019) through Cox proportional hazards regression models.</p><p><strong>Conclusion: </strong>MR significantly predicted 3-year clinical outcomes in AMI patients undergoing PCI, highlighting the need for physicians to prioritize MR assessment in clinical practice.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"703-715"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis.","authors":"Lingling Zhu, Linglin Tian, Suxia Li, Lijuan Huo","doi":"10.2147/IJGM.S481323","DOIUrl":"10.2147/IJGM.S481323","url":null,"abstract":"<p><strong>Purpose: </strong>There is limited research on the correlation between blood lipid levels and severe ulcerative colitis, and this article helps to reveal the relationship between the two. This study aimed to explore the relationship between blood lipid levels and disease activity, and to evaluate the early predictive value of blood lipid levels for severe ulcerative colitis (UC).</p><p><strong>Patients and methods: </strong>Here, we analyzed blood lipid indicators of 210 patients with UC and 210 healthy individuals who visited the hospital between August 2018 and August 2022. We divided the patients with UC into non-severe and severe groups, analyzed the relationship between blood lipid levels and severe UC, and evaluated the early predictive value of blood lipid indicators for severe UC.</p><p><strong>Results: </strong>Compared with healthy individuals, patients with UC had lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and non-HDL-C levels (P<0.05). Patients with severe versus non-severe UC had decreased TC, HDL-C, LDL-C, and non-HDL-C levels (P<0.05). The combined detection of TC level and erythrocyte sedimentation rate (ESR) predicted a working characteristic receiver operating characteristic curve area of 0.768 (0.694-0.841) in patients with severe UC, which had good early predictive value with a sensitivity of 77.0% and specificity of 66.7%.</p><p><strong>Conclusion: </strong>TC, HDL-C, LDL-C, and non-HDL-C levels were decreased in patients with severe UC. Combined TC levels and ESRs had good early predictive value for severe UC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"671-680"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study.","authors":"Xinli Zhang, Wennan Wang, Ye Li, Xiaoning Liu, Liangzhu Zhang, Zhenyu Cheng, Mingyan Liu, Yu Wang, Lin Fu, Jin Yang","doi":"10.2147/IJGM.S500848","DOIUrl":"10.2147/IJGM.S500848","url":null,"abstract":"<p><strong>Background: </strong>Irisin is the cleaved form of fibronectin type III domain-containing protein 5 (FNDC5), which can confer antioxidant and anti-inflammatory effects. Several studies have revealed that irisin can alleviate lung injury and affect the pathology of coronavirus disease 2019 (COVID-19). The aim of this study was to assess the relationships of serum irisin with the severity and prognosis of COVID-19.</p><p><strong>Methods: </strong>A total of 328 COVID-19 patients were recruited. Peripheral blood samples were collected. The level of serum irisin was determined by ELISA. The associations of serum irisin with COVID-19 severity and prognosis were evaluated through linear and logistic regression models on the basis of a prospective cohort study.</p><p><strong>Results: </strong>Serum irisin levels were lower in severe patients than in mild patients. The level of serum irisin was gradually decreased with the worsening of COVID-19. Spearman correlation analysis revealed that serum irisin concentration was inversely correlated with several clinical characteristics. Moreover, linear and logistic regression analyses revealed that serum irisin concentration was negatively correlated with the severity score. Interestingly, chronic heart and kidney diseases significantly affected the associations between serum irisin and severity scores. The results of the follow-up study suggested that the level of serum irisin upon admission was reduced in patients who died within one month of hospitalization. A lower serum irisin level at admission increased the risk of death within one month.</p><p><strong>Conclusion: </strong>Serum irisin levels at admission were negatively correlated with disease severity and prognosis, suggesting that irisin is involved in the pathological process of COVID-19. Serum irisin may be used as a biomarker for diagnostic and prognostic assessment of COVID-19.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"659-670"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}