International Journal of General Medicine最新文献

{"title":"Relationship Between MIC-1, VEGF, and TGF-β1 and Clinicopathologic Stage and Lymph Node Metastasis in Gastric Cancer.","authors":"Jianyun Sheng, Jieshi Wang, Tengda Ma, Peina He","doi":"10.2147/IJGM.S497572","DOIUrl":"10.2147/IJGM.S497572","url":null,"abstract":"<p><strong>Objective: </strong>This research investigated the relationship between serum macrophage inhibitory cytokine-1 (MIC-1), vascular endothelial growth factor (VEGF), and transforming growth factor-β1 (TGF-β1) levels and clinicopathologic features, lymph node metastasis (LNM), and prognosis of gastric cancer (GC) patients.</p><p><strong>Methods: </strong>The GC group (GC patients, 198 cases)) and healthy group (healthy people, 100 cases) were established. The relationship between serum MIC-1, VEGF, TGF-β1, and clinical and pathological features in GC patients was analyzed. GC patients were divided into a metastasis group (77 patients) and a non-metastasis group (121 patients) based on whether they had LNM. The factors influencing LNM in GC patients were identified. The predictive value of serum MIC-1, VEGF, and TGF-β1 for LNM in GC patients and the relationship between serum MIC-1, VEGF, TGF-β1 levels and prognosis were analyzed.</p><p><strong>Results: </strong>MIC-1, VEGF, and TGF-β1 were higher in GC. Serum MIC-1, VEGF, and TGF-β1 levels were higher in GC patients with tumor diameter ≥ 3 cm, T stage of T3 and T4, low/moderate differentiation, and LNM. Multivariate Logistic regression analysis showed that TNM stage, tumor differentiation, and serum MIC-1, VEGF, and TGF-β1 levels were risk factors for LNM in GC patients. The ROC results indicated that the combination of serum MIC-1, VEGF, and TGF-β1 had the highest AUC for predicting LNM in GV patients. The median survival time of patients with low serum MIC-1, VEGF, and TGF-β1 was higher than that of patients with high serum MIC-1, VEGF, and TGF-β1 (26.13 months vs 19.24 months, 27.06 months vs 20.18 months, and 24.20 months vs 20.08 months).</p><p><strong>Conclusion: </strong>The changes of serum MIC-1, VEGF and TGF-β1 levels are related to the clinicopathological characteristics of GC patients, and the elevated levels of these indices are independent risk factors affecting LNM and prognosis of GC patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"955-965"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Skeletal Muscle Mass and Different Pathological Types of Colorectal Polyp in Chinese Asymptomatic Population.","authors":"Wenya Li, Na Wang, Huajun Ye, Mengjun Chen","doi":"10.2147/IJGM.S503137","DOIUrl":"10.2147/IJGM.S503137","url":null,"abstract":"<p><strong>Background: </strong>Low relative muscle mass was identified to be related to ascending risk of pre-cancerous polyps (adenoma) in recent cohort study. Our study aimed to dig out the correlation between muscle mass and different pathological types of colorectal polyps in Chinese asymptomatic population.</p><p><strong>Methods: </strong>In all, 5923 adults were included. The effects of low skeletal muscle mass index (SMI) on colorectal polyp occurrence, including different pathological types, and the effects modification of age and BMI were analyzed using univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Lower SMI was connected with the lower occurrence of colorectal polyp (OR: 0.810, 95% CI: 0.683~0.960, p=0.015). Considering different pathological types of colorectal polyps, lower SMI was associated with lower occurrence of inflammatory polyp (OR: 0.633, 95% CI: 0.434~0.898, p=0.013), rather than conventional adenoma and serrated polyp (all p>0.05). Besides, SMI was positively related to the occurrence of 2 pathological types of colorectal polyp in males: inflammatory polyp (OR: 1.237, 95% CI: 1.058~1.444, p=0.007) and serrated polyp (OR: 1.288, 95% CI: 1.143~1.456, p<0.001). The interaction effect of BMI and SMI on occurrence of inflammatory polyp after adjusting age and smoking status was significant (p=0.015). For individuals with low SMI (compared with the normal SMI group), the incidence of inflammatory polyp was reduced from 8.95% to 3.50% in the low BMI quartile (Q1) in the adjusted model (OR of 0.332, 95% CI: 0.005-0.061, p<0.001). It was noticeable for males rather than females that individuals with colorectal polyps had higher levels of SMI (p=0.003). In addition, individuals with inflammatory polyps as well as serrated polyps possessed higher levels of SMI in males (all p<0.05).</p><p><strong>Conclusion: </strong>Generally, especially in Chinese asymptomatic males, low SMI kept independent effect on the presence of inflammatory polyp and serrated polyp, rather than conventional adenoma.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"927-938"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Myocardial Injury/Infarction in Patients with Stable or Unstable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention: The Effects of Preoperative Lipid Management.","authors":"Xuefeng Chen, Wenlou Bai, Peng Qi, Yantao Zhang, Wenjing Yao, Yi Dang","doi":"10.2147/IJGM.S508529","DOIUrl":"10.2147/IJGM.S508529","url":null,"abstract":"<p><strong>Background: </strong>Identifying the risk factors for perioperative myocardial injury/infarction (PMI) is critical to prevent postoperative adverse cardiovascular events. However, whether reducing the preoperative LDL-C can mitigate the risk of PMI remains unclear. We therefore investigated the effect of the preoperative LDL-C level in patients with stable angina pectoris (SAP) or unstable angina pectoris (UAP) on perioperative myocardial injury/infarction (PMI) after elective percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>Patients with SAP or UAP who received PCI from January 2021 to June 2023 at one of the two institutions (Hebei Provincial People's Hospital, Handan Central Hospital) were reviewed. The occurrence of PMI was determined based on the elevation of cardiac troponin I (cTnI) after the operation. The preoperative low density lipoprotein cholesterol (LDL-C) level was divided into three grades: low, <1.4 mmol/L; medium, 1.4-1.8 mmol/L; high, >1.8 mmol/L. The relationship between PMI and preoperative LDL-C was analyzed.</p><p><strong>Results: </strong>Of all 308 included patients, 226 did not have PMI and 82 experienced PMI. Positive correlation was found both between PMI and preoperative LDL-C level (r = 0.322, <i>P</i> < 0.05) and between PMI and preoperative LDL-C grade (r = 0.189, <i>P</i> < 0.05). According to the multivariate logistic regression analysis, the preoperative LDL-C grade (Medium vs Low, <i>OR</i>=3.994, <i>P</i> < 0.05; High vs Medium, <i>OR</i>=6.140, <i>P</i> < 0.05) and the number of stents implanted during PCI were independent risk factors for PMI (<i>OR</i>=1.940; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>For SAP and UAP patients, decreasing LDL-C to <1.4 mmol/L before elective PCI can reduce the incidence of PMI after the operation. We strongly recommend the practice of sufficiently reducing LDL-C level below 1.4 for patients with SAP or UAP who receive elective PCI.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"939-945"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of Fatigue in Patients with Chronic Heart Failure: Latent Categories and Influencing Factors.","authors":"Xianxian Yang, Wenjun Wang, Yue Xu, Weiting Guo, Yufang Guo","doi":"10.2147/IJGM.S522314","DOIUrl":"10.2147/IJGM.S522314","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to analyze the latent categories of fatigue in patients with chronic heart failure (CHF), explore their characteristic differences, and identify the associated influencing factors.</p><p><strong>Methods: </strong>This cross-sectional study included 289 patients with CHF who were enrolled at 2 tertiary-level hospitals in Shandong, China, from August to December 2023. The convenience sampling method was used to collect data. Furthermore, the level of fatigue, insomnia, anxiety, depression, and social support were evaluated using the Chinese version of the Multidimensional Fatigue Inventory-20, Insomnia Severity Index, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, and Multidimensional Scale of Perceived Social Support. Latent profile analysis was performed to elucidate the latent categories of fatigue in the patients. In addition, the risk factors associated with the different categories were assessed using multiple logistic regression analyses.</p><p><strong>Results: </strong>The average fatigue score was 62.45 ± 13.55. The potential fatigue profile of CHF was divided into three categories: low fatigue group C1 (18.6%), moderate fatigue group C2 (47.4%), and high fatigue group C3 (34.0%). Multiple logistic regression analysis showed that C3 patients with CHF were mainly characterized by lower ejection fraction (<i>OR</i> = 0.01, <i>p</i> = 0.008), insomnia (<i>OR</i> = 1.19, <i>p</i> = 0.005), and anxiety (<i>OR</i> = 1.20, <i>p</i> = 0.034). C2 patients indicated lower ejection fraction (<i>OR</i> = 0.04, <i>p</i> = 0.040), and C1 patients had higher social support (<i>OR</i> = 0.91, <i>p</i> < 0.001; <i>OR</i> = 0.93, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study indicated that CHF patients had significantly heterogeneous levels of fatigue. Therefore, it is recommended that medical staff could adopt more precise interventions according to different category characteristics to improve the outcomes of patients with CHF.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"857-866"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application Value of Novel Inflammatory Indicators in Response to Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis.","authors":"Siqi Liu, Yongli Pang, Xiaoxi Wang, Ruihang Lin, Siqing Tunala","doi":"10.2147/IJGM.S493132","DOIUrl":"10.2147/IJGM.S493132","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the application value of novel inflammation indicators such as the lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with primary biliary cholangitis (PBC) undergoing ursodeoxycholic acid (UDCA) treatment. We plan to further seek simple and convenient methods to assess the response of patients to UDCA treatment.</p><p><strong>Methods: </strong>We recorded routine blood tests, liver function, and vitamin D (VD) levels of PBC patients and healthy controls visiting the hospital between October 2022 and October 2023. LMR, NLR, and PLR were calculated, and differences between the two groups were analyzed. PBC patients were divided into good response and poor response groups according to the Paris I criteria, and differences in laboratory tests between the two groups were analyzed. The predictive value of novel inflammation indicators in UDCA treatment response was further analyzed using ROC analysis.</p><p><strong>Results: </strong>LMR and VD levels were significantly lower in the PBC group compared to the control group (<i>P</i>=0.000, <i>P</i>=0.000). In PBC patients, the good response group had higher LMR than the poor response group (<i>P</i>=0.001) and lower NLR than the poor response group (<i>P</i>=0.015). The areas under the ROC curve for LMR and NLR were 0.682±0.049 and 0.630±0.052, respectively. There was a significant negative correlation between PLR and VD in PBC patients (<i>r</i>=-0.252, <i>P</i>=0.005).</p><p><strong>Conclusion: </strong>Low LMR and high NLR may indicate poor treatment response. And PLR also have certain predictive values for treatment response.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"897-905"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of NLR and PLR in the Diagnosis of Rheumatoid Arthritis Combined with Interstitial Lung Disease and Assessment of Treatment Effect: A Retrospective Cohort Study.","authors":"Peng Cui, Tao Cheng, Huichun Yan, Dong Xu, Guohua Ren, Shangmin Ma","doi":"10.2147/IJGM.S509546","DOIUrl":"10.2147/IJGM.S509546","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective cohort study investigated the value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in the diagnosis and treatment of rheumatoid arthritis complicated with interstitial lung disease (RA-ILD).</p><p><strong>Methods: </strong>A total of 163 patients with newly diagnosed rheumatoid arthritis (RA) were enrolled, with 122 patients in the RA group and 41 patients in the RA-ILD group. The mean age of the RA group was 63.84 ± 8.53 years, with a male-to-female ratio of 14:47. The RA-ILD group had a mean age of 66.29 ± 12.72 years, with a male-to-female ratio of 13:28. During the 2-year follow-up period, 10 patients in the RA group developed interstitial lung disease (ILD).</p><p><strong>Results: </strong>NLR and PLR were significantly higher in RA-ILD group than in RA group (p < 0.05). The optimal critical values of NLR and PLR for the diagnosis of RA-ILD were 3.15 and 152.62, the area under ROC curve was 0.615 and 0.61, the sensitivity was 72%, 62%, and the specificity was 54% and 64%. NLR and PLR were significantly increased after ILD during follow-up in RA patients but decreased after ILD in the predicted percentage of vital capacity (VC%), forced vital capacity (FVC%), forced expiratory volume in the first second (FEV1%) and carbon monoxide dispersion (DLcoSB%) (p < 0.05). Moreover, NLR and PLR decreased after treatment. While VC%, FVC%, FEV1%, and DLcoSB% increased after treatment (p < 0.05). NLR was negatively correlated with FVC% and DLcoSB% both before and after treatment. PLR was also significantly negatively correlated with FVC% and DLcoSB% before and after treatment (p < 0.05).</p><p><strong>Conclusion: </strong>When NLR and PLR increase, we should be alert to the possibility of RA complicated with ILD, which can be used as an evaluation index of the treatment effect of RA-ILD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"867-880"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Improved-EFI Score: A Multi-Omics-Based Novel Efficacy Predictive Tool for Predicting the Natural Fertility of Endometriosis Patients.","authors":"Qiumin He, Chongyuan Zhang, Yao Hu, Jinfang Deng, Shuirong Zhang","doi":"10.2147/IJGM.S512359","DOIUrl":"10.2147/IJGM.S512359","url":null,"abstract":"<p><strong>Objective: </strong>Infertility caused by endometriosis (EM) directly affects the possibility of pregnancy in women of gestational age. This study aims to establish a prediction model to accurately predict the natural pregnancy outcome of patients with EM, providing valuable information for clinical decision-making.</p><p><strong>Methods: </strong>We retrospectively selected a total of 496 patients who underwent their first laparoscopic surgery for infertility at the Obstetrics and Gynecology Department of Jingzhou Central Hospital from January 2016 to June 2023. An improved endometriosis fertility index (EFI) predictive model was created based on ultrasound radiomics and urinary proteomics gathered during the patient's initial admission, using two machine learning algorithms. The predictive model was evaluated for C-index, calibration, and clinical applicability through receiver working characteristic curve, decision curve analysis.</p><p><strong>Results: </strong>The improved EFI prediction model nomogram, based on five ultrasound radiomics parameters and three urine proteomics, had AUC values of 0.921 (95% CI: 0.864-0.978) and 0.909 (95% CI: 0.852-0.966) in the training and validation sets, respectively, while the traditional EFI prediction model had AUC values of 0.889 (95% CI: 0.832-0.946) and 0.873 (95% CI: 0.816-0.930) in the training and validation sets, respectively. Additionally, the nomogram exhibited better discrimination ability and achieved an overall better benefit against threshold probability than the EFI model and decision tree in the decision curve analysis (DCA).</p><p><strong>Conclusion: </strong>The combined ultrasound radiomics-urine proteomics model was better able to predict natural pregnancy-associated patients with EM compared to the classical EFI score. This can help clinicians better predict an individual patient's risk of natural pregnancy following a first-ever laparoscopic surgery and facilitate earlier diagnosis and treatment.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"881-895"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discoid Domain Receptors Signaling in Macrophages-Mediated Diseases.","authors":"Yaohui Ma, Hang Gong, Long Cheng, Dekui Zhang","doi":"10.2147/IJGM.S487093","DOIUrl":"10.2147/IJGM.S487093","url":null,"abstract":"<p><p>Macrophages, as a crucial component of the body's immune system, play a vital role in the onset, progression, and outcome of diseases. Discoidin domain receptors (DDRs), important members of the novel receptor tyrosine kinase superfamily, exhibit unique functions in macrophage physiology. Through interactions with the extracellular matrix, DDRs activate signaling pathways such as p38 MAPK and NF-κB, regulating macrophage adhesion, migration, and secretory functions, thereby influencing their behavior in diseases. Recent studies have indicated a direct correlation between DDRs and the progression of various diseases, including inflammation, cancer, and fibrosis. However, there remain numerous knowledge gaps regarding the specific mechanisms by which DDRs function in macrophage-mediated diseases. This article provides an in-depth summary of the regulatory mechanisms of DDRs on macrophages, detailing their modulatory roles in various diseases through macrophages and their underlying mechanisms. The aim is to offer new insights into biomedical therapies targeting DDRs and the development of novel drugs.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"907-926"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Deregulated MicroRNAs in Immune Cells of Sjögren's Disease.","authors":"Qimao Han, Lijuan Gao, Lu Chen","doi":"10.2147/IJGM.S504780","DOIUrl":"10.2147/IJGM.S504780","url":null,"abstract":"<p><p>The 2024 Nobel Prize in Physiology or Medicine, awarded for the discovery of microRNAs (miRNAs) as essential regulators of gene expression, has spotlighted their pivotal roles in disease processes, including autoimmune conditions such as Sjögren's disease (SD). SD is a chronic autoimmune disease marked by lymphocytic infiltration of exocrine glands, resulting in significant glandular dysfunction and diverse systemic effects. Recent research has revealed that miRNAs play crucial roles in SD pathogenesis, orchestrating immune cell activity, epithelial cell integrity, and the regulation of inflammatory pathways. Dysregulation of specific miRNAs is associated with exacerbated immune responses, glandular damage, epithelial cell dysfunction, and sustained inflammation, positioning these small RNA molecules as central players in disease progression. This review synthesizes current findings on the roles of miRNAs in SD, highlighting how certain miRNAs contribute to immune dysregulation, epithelial dysfunction, and disease chronicity. Additionally, we explore the potential of miRNAs as biomarkers for disease activity, reflecting both immune and epithelial health, and as novel therapeutic targets. By consolidating recent advancements, we aim to offer a comprehensive perspective on the involvement of miRNAs in SD and to underscore the potential for miRNA-based strategies to transform the diagnosis, management, and treatment of SD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"847-855"},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effects of Traditional Chinese Medicine + Azithromycin in the Treatment of Mycoplasma Pneumonia.","authors":"Guan Zhang, Qian Li, Jing Zhang","doi":"10.2147/IJGM.S495993","DOIUrl":"10.2147/IJGM.S495993","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical effect of Traditional Chinese Medicine (TCM) plus azithromycin in the treatment of Mycoplasma pneumonia (MP).</p><p><strong>Methods: </strong>This was a retrospective study including the clinical data of 119 patients with MP treated at Taihe County Hospital of Traditional Chinese Medicine from April 2021 to November 2023. According to treatment records, 58 cases were treated with conventional therapy and azithromycin (azithromycin group), and 61 cases were treated with conventional therapy, azithromycin, and Xiaoxianxiong decoction and Weijing decoction and acupoint application (TCM + azithromycin group). The treatment outcomes, levels of inflammatory status indicators before and after treatment, respiratory function status, and incidence of adverse reactions were analyzed between the two groups.</p><p><strong>Results: </strong>The overall effective rate of TCM + azithromycin group was significantly higher than that of azithromycin group (<i>P</i><0.05). After treatment, the serum C-reactive protein (CRP), procalcitonin (PCT), and white blood cell count (WBC) levels in both groups significantly decreased compared to before treatment, and the TCM + azithromycin group was significantly lower than the azithromycin group (<i>P</i><0.05). After treatment, partial pressure of carbon dioxide (PaCO₂) in both groups significantly decreased compared to before treatment, while oxygen partial pressure (PaO₂) and oxygenation index (OI) significantly increased compared to before treatment; Moreover, the TCM + azithromycin group had significantly lower PaCO₂ and higher PaO₂ and OI than the azithromycin group (<i>P</i><0.05). There was no significant difference in the incidence of adverse reactions between the two groups (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>Compared with treatment with azithromycin alone, intervention with TCM + azithromycin can significantly improve the respiratory function of patients with MP, reduce the degree of inflammatory response, and enhance the overall treatment effect without increasing the incidence of adverse reactions.</p><p><strong>Core tip: </strong>This study indicates that intervention with traditional Chinese medicine and azithromycin can significantly improve the respiratory function of MP patients, reduce the degree of inflammatory response, improve overall treatment efficacy, and is safe.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"825-833"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}