International Journal of General Medicine最新文献

{"title":"Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients.","authors":"Libo Chen, Hui Rao, Nanhui Chen, Renyuan Li, Dan Chen, Huiming Jiang","doi":"10.2147/IJGM.S516768","DOIUrl":"https://doi.org/10.2147/IJGM.S516768","url":null,"abstract":"<p><strong>Objective: </strong>Inflammation and nutritional status are involved in the occurrence and progression of cancer. The purpose of this study was to investigate the relationship of nutritional status indices (geriatric nutritional risk index (GNRI), neutrophil to albumin ratio (NAR), prognostic nutritional index (PNI)), and comprehensive inflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) and bone metastasis of prostate cancer.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 888 prostate cancer patients treated in Meizhou People's Hospital from November 2017 to December 2022. Clinical characteristics were collected, including age, body mass index (BMI), bone metastasis, and GNRI, NAR, PNI, PIV, SII, and SIRI levels. The optimal cutoff values of these indices were calculated by receiver operating characteristic (ROC) curve, and the relationship between these indices and bone metastasis was analyzed.</p><p><strong>Results: </strong>There were 836 (94.1%) cases were ≥60 years old, indicating that the majority of prostate cancer patients were elderly men. There were 640 (72.1%) patients without bone metastasis and 248 (27.9%) patients with bone metastasis. The levels of GNRI and PNI in patients with bone metastasis were significantly lower than those without, while NAR, PIV, SII, and SIRI were not statistically significant. And the levels of GNRI and PNI in patients with multiple bone metastasis were significantly lower than those with single bone metastasis. When bone metastasis was taken as the endpoint of GNRI and PNI, the critical value of GNRI was 97.05 (sensitivity 55.2%, specificity 67.5%, area under the ROC curve (AUC) = 0.639), the PNI cutoff value was 44.925 (sensitivity 51.2%, specificity 67.2%, AUC = 0.634), and the AUC of GNRI plus PNI was 0.647.</p><p><strong>Conclusion: </strong>Prostate cancer is more common in older men; about a quarter of patients have bone metastasis. GNRI and PNI have predictive efficacy in bone metastasis and multiple bone metastasis of prostate cancer, but NAR, PIV, SII, and SIRI do not.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2703-2713"},"PeriodicalIF":2.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Experimental Validation of Prognostic Signature and Peroxisome-Related Key Genes in Clear Cell Renal Cell Carcinoma.","authors":"Congcong Fan, Yifei Li, Weizhi Zhang, Yining Wang, Yanzhen Li, Jianjian Zheng, Zhixian Yu, Yong Guo","doi":"10.2147/IJGM.S513102","DOIUrl":"https://doi.org/10.2147/IJGM.S513102","url":null,"abstract":"<p><strong>Introduction: </strong>Clear cell renal cell carcinoma (ccRCC) is a common urological malignant tumor. Dysregulated peroxisomes contribute to the progression of cancers. However, the prognostic significance of peroxisome-related genes (PGs) in ccRCC is still poorly understood.</p><p><strong>Methods: </strong>PGs were collected from MsigDB. Prognostic differentially expressed genes were filtered via differentially expression analysis and univariate Cox regression analysis. The construction of risk model was performed by the least absolute shrinkage selection operator Cox regression analysis. Subsequently, the clinical application of risk model in prognosis prediction, tumor microenvironment (TME) and drug sensitivity was comprehensively evaluated. The expression levels of genes were measured by qRT-PCR and immunohistochemistry. Finally, the role of the genes of this risk model in biological behaviors of RCC cells was further verified via CCK-8, transwell invasion and wound healing assay.</p><p><strong>Results: </strong>A risk model, including 9 PGs, was established. The risk model exhibited a robust and accurate performance in prognostic prediction across TCGA, GSE167573 and the local cohorts. Moreover, the risk model was closely correlated with clinical characteristics, TME and drug sensitivity. Silencing of the key genes attenuated the proliferation, migration, and invasion ability of RCC cells.</p><p><strong>Conclusion: </strong>The novel peroxisome-related risk model holds promise as a prognostic tool for estimating the prognosis of ccRCC patients and provides insights into treatment strategies.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2687-2702"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Implementation of a Self-Management Intervention Program for Patients with Esophageal and Gastric Varices Secondary to Liver Cirrhosis Under Collaborative Care.","authors":"Ming Li, Xing-Er Xie, Xiangqing Qin, Tian Wu, Zhao-Lian Bian","doi":"10.2147/IJGM.S514019","DOIUrl":"https://doi.org/10.2147/IJGM.S514019","url":null,"abstract":"<p><strong>Objective: </strong>To design and evaluate a self-management intervention program tailored for patients undergoing endoscopic treatment for esophageal and gastric varices secondary to liver cirrhosis, implemented within a collaborative care framework.</p><p><strong>Methods: </strong>The control group received standard inpatient care and discharge instructions, whereas the intervention group participated in the newly developed collaborative care program. Key outcomes, including self-management proficiency, medication adherence, quality of life, rebleeding rates, and unplanned readmissions within a three-month period, were compared between the two groups. Subgroup analyses were conducted based on disease severity using Child-Pugh scores.</p><p><strong>Results: </strong>The intervention group demonstrated significantly higher scores in self-management proficiency compared to the control group (P < 0.05). Medication adherence was markedly better in the intervention group (P < 0.05), with a 95% adherence rate versus 76.92% in the control group. Quality of life assessments also revealed superior scores in the intervention group (P < 0.05). Additionally, the intervention group had significantly lower rates of unplanned readmissions (5.00% vs 20.51%, P < 0.05) and rebleeding (10.00% vs 30.77%, P < 0.05) compared to the control group. The 12-month survival rate was significantly higher in the intervention group (95.00% vs 79.49%, P < 0.05). Subgroup analyses indicated that patients with more advanced disease benefited the most from the intervention.</p><p><strong>Conclusion: </strong>The implementation of a self-management intervention program within a collaborative care framework significantly enhances self-management capabilities, medication adherence, and quality of life while reducing rebleeding rates, unplanned readmissions, and mortality in patients with esophageal and gastric varices secondary to liver cirrhosis. These findings underscore the importance of tailored self-management strategies, particularly for patients with advanced disease, and highlight the potential of collaborative care to address the complex needs of this population. This study provides a strong foundation for future research to optimize and scale similar interventions in diverse clinical settings.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2673-2686"},"PeriodicalIF":2.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of MTMR3 rs12537 at miR-181a Binding Site with Ischemic Stroke in Southern Chinese Han Population.","authors":"Linfa Chen, Shan Wei, Yutian Zhang, You Li, Zishan Li, Pengru Huang, Chun Xiao, Yusheng Zhang","doi":"10.2147/IJGM.S524033","DOIUrl":"https://doi.org/10.2147/IJGM.S524033","url":null,"abstract":"<p><strong>Background: </strong>Single nucleotide polymorphisms (SNPs) at microRNA (miRNA)--binding sites influence the development of ischemic stroke (IS) by affecting the expression of specific target genes. Myotubularin-related protein 3 (MTMR3), which is involved in autophagy, is directly targeted by miR-181a. This research examined the potential association between the SNP rs12537 in the miRNA-181a binding location within the 3' untranslated region (3'-UTR) of MTMR3 and the incidence and prognosis of IS.</p><p><strong>Methods: </strong>An improved multitemperature ligase detection reaction assay was used to perform genotyping analysis in two independent case-control datasets consisting of 1128 subjects with IS and 1140 healthy controls with matched ages.</p><p><strong>Results: </strong>The distribution frequencies of the T allele (<i>p</i> = 5.2×10^-4) of SNP rs12537 in MTMR3 were elevated significantly in IS patients as compared to healthy controls. Further categorization based on IS subtypes revealed that individuals carrying the variation T allele were linked with a higher risk of suffering large-artery (<i>p</i> = 1.2×10^-3) and small-artery (<i>p</i> = 7.0×10^-4) atherosclerotic stroke subtypes. The T allele of rs12537 was shown to be linked to both moderate and severe stroke (NIHSS ≥ 6) (<i>p</i> = 0.011), as well as a poor short-term outcome (<i>p</i> = 0.016) of IS. A significant correlation was also found between the rs12537 T allele mutation and a decrease in MTMR3 (<i>p</i> = 0.019), as well as an elevated miR-181a (<i>p</i> = 0.021) and LC3B (<i>p</i> = 0.026) in individuals with IS.</p><p><strong>Conclusion: </strong>This study identified a novel role for the rs12537 variant in influencing IS susceptibility and prognosis, potentially by modulating MTMR3 expression and leading to increased autophagy.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2659-2672"},"PeriodicalIF":2.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Doses of Oliceridine Combined with Propofol for Painless Hysteroscopy: A Prospective Dose-Finding Study.","authors":"Liangliang Gao, Aiping Tan, Zehui Wang, Lei Wei, Xingshuang Wang","doi":"10.2147/IJGM.S523428","DOIUrl":"https://doi.org/10.2147/IJGM.S523428","url":null,"abstract":"<p><strong>Background: </strong>The combination of oliceridine with propofol represents a new option for complete intravenous anesthesia in painless hysteroscopy. The purpose of this study was to determine the 95% effective dose (ED95) and the median effective dose (ED50) of oliceridine when combined with propofol for painless hysteroscopy.</p><p><strong>Methods: </strong>A total of 29 patients, aged between 18 and 60 years and classified as American Society of Anesthesiologists (ASA) I-II, were initially recruited for hysteroscopy. Subsequently, 26 of these patients were included in the final analysis. Before surgery, an intravenous dose of 0.02 mg/kg oliceridine, with a dose gradient of 0.002 mg/kg, was administered using Dixon's up-and-down method. Two minutes later, 2 mg/kg of propofol was administered. The oliceridine dosage for the following patient was increased by 0.002 mg/kg if the hysteroscopy failed (defined as poor cervical dilatation, problematic hysteroscopic placement, or a Ramsay Sedation Scale (RSS) score < 5 or any movement and frowning by the patient within 5 minutes). In contrast, the dosage was decreased by 0.002 mg/kg. At least seven crossovers had to occur before the test was stopped. The ED50 and ED95 of oliceridine in combination with propofol for hysteroscopy were determined using the probit analysis method.</p><p><strong>Results: </strong>The ED50 and ED95 of oliceridine with 95% CI were 0.0192 (0.0183-0.0216) mg/kg and 0.0237 (0.0214-0.0415) mg/kg, respectively. No patients experienced significant adverse effects.</p><p><strong>Conclusion: </strong>The study determined that the ED50 and ED95 of oliceridine in combination with propofol for painless hysteroscopy are 0.0192 mg/kg and 0.0237 mg/kg, respectively. Oliceridine at 0.0237 mg/kg provides safe and effective anesthesia when combined with propofol.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2651-2657"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A Cross-Sectional Evaluation of Knowledge of Medicine Safety and Frequency of Reading Medication Leaflets and Its Predictors - Insights From Saudi Adults in Riyadh, Saudi Arabia [Corrigendum].","authors":"","doi":"10.2147/IJGM.S540080","DOIUrl":"https://doi.org/10.2147/IJGM.S540080","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/IJGM.S446041.].</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2649-2650"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of High Tumor-Stroma Ratio with Prostate Cancer Progression: Insights from Clinical and Genomic Data.","authors":"Wenbo Xu, Qian Niu, Kun Zhao, Haozhi Zhao, Long Zhang, Wenxuan Li, Hong Yan, Zhilong Dong","doi":"10.2147/IJGM.S515066","DOIUrl":"10.2147/IJGM.S515066","url":null,"abstract":"<p><strong>Background: </strong>Tumor stroma ratio (TSR) is a prognostic factor in various cancers, but its role in prostate adenocarcinoma (PRAD) remains unclear. This study investigates TSR's prognostic value in PRAD using clinicopathological data, bulk/single-cell RNA sequencing to explore tumor-stroma interactions and identify therapeutic targets.</p><p><strong>Methods: </strong>Two PRAD cohorts (The Cancer Genome Atlas cohort, TCGA; Lanzhou University Second Hospital, LUSH) were analyzed for TSR associations with clinicopathological features and biochemical recurrence (BCR). TSR was assessed via digital image analysis and expert pathologist review. Publicly available bulk/single-cell RNA sequencing data were analyzed to identify TSR-associated genes and predict drug targets, pathways, and immunotherapy responses. Quantitative real-time PCR validated mRNA expression. In vitro assays assessed cell proliferation, growth, and migration, while in vivo xenograft assays validated BGN's role in promoting tumorigenesis.</p><p><strong>Results: </strong>TSR significantly correlated with clinicopathological features (age, Gleason score, stage, seminal vesicle invasion, BCR) in both TCGA (n = 453) and LUSH (n = 320) cohorts. High TSR independently predicted BCR in multivariable Cox regression. High TSR was associated with copy number variations, differentially expressed miRNAs/transcription factors, and metabolic pathways. Predicted anti-cancer drug targets, like Ki8751, showed potential benefit in high-TSR patients. High TSR may correlate with poor immunotherapy response. Notably, downregulation of BGN in cancer-associated fibroblasts (CAFs) significantly suppressed cell proliferation, migration, and invasion in vitro, and in vivo xenograft assays confirmed that BGN downregulation inhibited tumor growth.</p><p><strong>Conclusion: </strong>This study highlights TSR's prognostic significance in prostate cancer and its association with adverse clinical outcomes and complex tumor-stroma interactions, identifying BGN, a stromal cell-related gene, as a potential therapeutic target for CAFs. However, these findings are limited by the retrospective design, necessitating prospective validation.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2599-2618"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer.","authors":"Shaoyu Wang, Qiaomei Zheng, Lihong Chen","doi":"10.2147/IJGM.S523878","DOIUrl":"10.2147/IJGM.S523878","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer (OC), a common fatal malignancy in women, has a poor prognosis. RNA modifications are associated with the development of OC. In this study, we aimed to identify and verify RNA modifications-related prognostic genes in OC by integrating bulk and single-cell RNA sequencing (scRNA-seq) data.</p><p><strong>Methods: </strong>Transcriptome data came from public databases and RNA modifications-related genes (RMRGs) were obtained from literature. Candidate genes were identified by intersecting RMRGs with differentially expressed genes (DEGs) in OC patients. Prognostic genes were gained via machine learning techniques, particularly LASSO regression. A risk model was built to predict the prognosis. OC patients were divided into high-risk and low-risk groups according to risk score. Subsequent analyses covered enrichment analysis, immune microenvironment, mutation analysis, and chemotherapeutic drug sensitivity. In addition, scRNA-seq data was assessed for key cells and gene expression in them. Finally, RT-qPCR was applied to identify the expression of prognostic genes.</p><p><strong>Results: </strong><i>LSM4, SNRPC, ZC3H13, LSM2, WTAP, DCP2, PUS7</i>, and <i>TUT1</i> were selected as prognostic genes. The risk model exhibited excellent predictive abilities. Seventeen pathways were enriched like calcium signaling pathway, 7 differential immune cells were identified like regulatory T cells and plasmacytoid dendritic cells, and <i>TP53</i> had highest mutation rate. Half-maximal inhibitory concentrations (IC50) values of 47 drugs like paclitaxel differed between two risk groups. The prognostic genes were distributed mainly in fibroblast cells, epithelial cells and endothelial cells. During fibroblast cells differentiation, expression of prognostic genes fluctuated to varying degrees. The RT-qPCR demonstrated that the expression of <i>LSM2, LSM4, PUS7, SNRPC</i>, and <i>TUT1</i> were upregulated in OC, while <i>DCP2, WTAP</i>, and <i>ZC3H13</i> were downregulated.</p><p><strong>Conclusion: </strong>We constructed an RNA modifications-related prognostic signature that can effectively predict clinical outcomes and therapeutic responses in patients with OC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2629-2647"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Effectiveness of Ustekinumab in Crohn's Disease: Results from a Real-World Retrospective Multicenter Study in China.","authors":"Xiuli Zhu, Xiaoli Fang, Qiaomin Wang, Ming Li, Kaiguang Zhang, Li Xie, Xiaoping Niu, Song Wang","doi":"10.2147/IJGM.S520984","DOIUrl":"10.2147/IJGM.S520984","url":null,"abstract":"<p><strong>Background: </strong>There are few data on ustekinumab treatment for Crohn's disease (CD) in a Chinese population. Our study is a real-world retrospective multicenter study aimed at exploring the effectiveness of ustekinumab in CD patients and comparing the effectiveness of first line and second line treatments.</p><p><strong>Methods: </strong>Laboratory indicators, CD activity index (CDAI) and simple endoscopic score for CD (SES-CD) scores of patients at the 8th, 16th and 24th weeks of treatment were collected, and the clinical remission rate, clinical response rate, endoscopic remission rate and endoscopic response rate were calculated, and the patients were divided into first line group and second line group for comparison.</p><p><strong>Results: </strong>A total of 102 patients were treated with ustekinumab, and 56 patients with a clinical data integrity rate greater than 70% were ultimately included. The clinical remission rate of the patients gradually increased at the 8th, 16th and 24th weeks of treatment, which were 34 cases (60.7%), 37 cases (66.1%) and 49 cases (87.5%), respectively. The clinical response rates for 8th, 16th and 24th weeks were 38 (67.8%), 42 (0.75%) and 51 (91.1%), respectively, and the endoscopic remission rate was 4% (2/50) at the 24th week. The clinical response rates of the first line group were higher than those of the second line group at the 16th and 24th weeks, with statistically significant differences. The clinical response time of patients receiving first line or second line treatment with ustekinumab was different, and the first line treatment group achieved clinical response more quickly.</p><p><strong>Conclusion: </strong>Ustekinumab is effective in the short-term treatment of CD patients in China, with first line treatment superior to second line treatment and faster than second line treatment.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2589-2597"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Macular Microstructural Changes with Disease Staging and Visual Acuity in Diabetic Retinopathy.","authors":"Wenhua Zhang, Feng Zhang, Yezhen Yang, Jiamin Cao, Ziyi Zhu","doi":"10.2147/IJGM.S516938","DOIUrl":"10.2147/IJGM.S516938","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the changes in macular microvascular structure at different stages of diabetic retinopathy (DR) and the correlation between macular ischemia and visual acuity.</p><p><strong>Patients and methods: </strong>A prospective cross-sectional study was conducted. A total of 173 patients with DR were enrolled and divided into three groups according to DR stage. The control group consisted of 29 gender and age matched healthy individuals. Macular perfusion indexes were measured by optical coherence tomography angiography (OCTA) and compared.</p><p><strong>Results: </strong>The p-values of central foveal thickness (CFT), focal avascular zone (FAZ) area, and vessel density were less than 0.05 in DR patients and healthy individuals. As the severity of DR increased, there was a corresponding decline in visual acuity, the logMAR best corrected visual acuity (BCVA) was 0.40±0.30 in mild-moderate NPDR, then worsened to 0.48 ± 0.30 (p=0.059) in severe NPDR and further to 0.60 ± 0.34 (p=0.043) in PDR. Superficial capillary plexus (SCP) vessel density correlated negatively with logMAR BCVA (p<0.001, R=-0.267), whereas the severity of DR correlated positively with logMAR BCVA (p<0.001, R=0.199). And increased DR stage was associated with significant reductions in foveal density at 300 μm (FD-300 μm; p=0.004) and deep capillary plexus (DCP) vessel density (p=0.009).</p><p><strong>Conclusion: </strong>Macular perfusion status decreases as DR progresses. Early changes of macular microvascular structure in different capillary plexus may indicate progression of DR severity and affect visual acuity.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2619-2628"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}