International Journal of General Medicine最新文献

{"title":"Endoscopic Treatment and Outcome Analysis of Biliary Stricture After Orthotopic Liver Transplantation: A Single Center Retrospective Study.","authors":"Decai Kong, Xiaojing Zhang, Yangguang Yuan, Haoyu Duan, Junfeng Ye","doi":"10.2147/IJGM.S513603","DOIUrl":"10.2147/IJGM.S513603","url":null,"abstract":"<p><strong>Purpose: </strong>The incidence of biliary stricture (BS) after liver transplantation (LT) significantly increases the risks of retransplantation and mortality. Although various endoscopic treatment strategies are available, a consensus is lacking in certain aspects, and the impact of endoscopic treatment on overall survival has yet to be studied. This retrospective study aims to explore factors influencing the efficacy of initial endoscopic treatment for BS after deceased donor orthotopic liver transplantation (OLT) and to analyze outcomes.</p><p><strong>Patients and methods: </strong>This research conducted a retrospective analysis of 89 patients who developed BS after OLT at The First Hospital of Jilin University between 01/01/2014 and 01/01/2022. Patients were categorized into a successful group (59 patients) and a failed group (30 patients) based on the success or failure of initial endoscopic treatment. Risk factor analysis for initial endoscopic treatment failure in patients with BS after OLT was performed using univariate and multivariate logistic regression analysis. The survival analysis for patients with BS after OLT was conducted using Cox regression and Kaplan-Meier methods.</p><p><strong>Results: </strong>The failure rate of initial endoscopic treatment was 33.7%. Independent risk factors for failure included the proximal and distal bile duct angle≤145 (<i>OR</i>=16.667, 95% <i>CI</i>: 3.279-83.333, <i>P</i>=0.001), severe stricture (<i>OR</i>=9.009, 95% <i>CI</i>: 1.590-50.000, <i>P</i>=0.013), and non-anastomotic stricture (NABS) type (<i>OR</i>=20.049, 95% <i>CI</i>: 2.663-150.953, <i>P</i>=0.004). Furthermore, failed initial endoscopic treatment (<i>HR</i>=3.205, 95% <i>CI</i>: 1.350-7.634, <i>P</i>=0.008) emerged as an independent risk factor for mortality in patients with BS after OLT.</p><p><strong>Conclusion: </strong>Initial endoscopic treatment for BS in patients after OLT is effective, safe, and has a high success rate. However, patients with the proximal and distal bile duct angle≤145, NABS, and severe strictures exhibit poorer initial endoscopic treatment effect. Those whose initial endoscopic treatment fails demonstrate significantly worse prognoses.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5883-5895"},"PeriodicalIF":2.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Dynamic Nomogram for Sepsis-Associated Encephalopathy in Elderly ICU Patients with Sepsis: A Retrospective Cohort Study.","authors":"Simeng Zhu, Lianmin Ye, Jie Chen","doi":"10.2147/IJGM.S527691","DOIUrl":"10.2147/IJGM.S527691","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to develop and validate a nomogram for predicting sepsis-associated encephalopathy (SAE) in elderly patients with sepsis admitted to the intensive care unit (ICU).</p><p><strong>Methods: </strong>We conducted a retrospective study at the First Affiliated Hospital of Wenzhou Medical University. The least absolute shrinkage and selection operator (LASSO) regression was employed to identify characteristic predictors for SAE, and a nomogram was subsequently developed. The nomogram's performance was evaluated using receiver operating characteristic (ROC) curves, the concordance index (C-index), calibration curves, the Brier score, and decision curve analysis (DCA) to assess discrimination, calibration, and clinical utility. Internal validation was performed using the bootstrap resampling method.</p><p><strong>Results: </strong>A total of 231 elderly sepsis patients were included in the study, among whom 66 were diagnosed with SAE. The study identified invasive mechanical ventilation (IMV), platelet count, white blood cell (WBC) count, glucose levels, lactate levels, and calcium levels as significant risk factors for SAE. The nomogram demonstrated an area under the curve (AUC) of 0.81, outperforming other predictive factors. The corrected C-index, determined through 500 bootstrap validations, was 0.842. Additionally, the calibration curve indicated strong agreement between predicted outcomes and actual observations. The Brier score of the prediction model was 0.139. Finally, DCA revealed that the nomogram had high clinical applicability.</p><p><strong>Conclusion: </strong>The prediction nomogram and online website demonstrated strong predictive performance for the occurrence of SAE in elderly patients with sepsis, which made the evaluation process of SAE more convenient and efficient.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5977-5987"},"PeriodicalIF":2.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Diagnostic Value of Gastrointestinal Ultrasound Contrast Filling Method in Differentiating Gastric Tumors and Ulcers in the Elderly.","authors":"Yuanyuan Sun, Yujie Deng, Lin Sang, Qian Zhang","doi":"10.2147/IJGM.S534027","DOIUrl":"10.2147/IJGM.S534027","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the differential diagnostic value of the gastrointestinal ultrasound contrast filling method in distinguishing gastric tumors from gastric ulcers in elderly patients.</p><p><strong>Methods: </strong>We retrospectively analyzed 274 elderly patients diagnosed with gastric diseases between January 2022 and October 2024, confirmed by endoscopic pathology as gastric tumors (n=82) or gastric ulcers (n=192). All underwent gastrointestinal ultrasound contrast filling. Differences in conventional ultrasound features (internal echo, calcification, morphology, classification) and contrast-enhanced ultrasound parameters [enhancement intensity (EI), time to peak (TTP), area under curve (AUC), arrival time (AT)] were compared. Spearman correlation assessed parameter-tumor relationships. ROC curves evaluated diagnostic performance.</p><p><strong>Results: </strong>The tumor group showed higher rates of low internal echo, calcification, irregular morphology, and type II classification than the ulcer group (P<0.05). EI, TTP, AUC, and AT were significantly elevated in tumors (P<0.05), correlating positively with tumor occurrence (r=0.524-0.597, P<0.05). ROC analysis yielded an AUC of 0.947, with sensitivity 96.72% and specificity 98.91%.</p><p><strong>Conclusion: </strong>Gastrointestinal ultrasound contrast filling effectively demonstrates both conventional and enhancement features of gastric lesions in the elderly, providing high sensitivity and specificity for differentiating gastric tumors from gastric ulcers.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5939-5947"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Six-Gene Mitochondrial Signature Predicts Prognosis in Dedifferentiated Thyroid Cancer.","authors":"Chenghui Lu, Xufu Wang","doi":"10.2147/IJGM.S548720","DOIUrl":"10.2147/IJGM.S548720","url":null,"abstract":"<p><strong>Background: </strong>Dedifferentiated thyroid cancer (DDTC) is a highly malignant, infiltrative neoplasm. Studies confirm mitochondrial (MD) dysfunction links to DDTC's aggressiveness and treatment resistance via regulating energy metabolism reprogramming, exacerbating oxidative stress, and mediating apoptotic resistance. This study explored the role of MD related genes (MDRGs) in DDTC prognosis to inform prognostic evaluation and targeted therapy.</p><p><strong>Methods: </strong>In this study, DDTC prognostic genes were identified through integrated analyses, including differential analysis, weighted gene co-expression network analysis (WGCNA), univariate Cox regression, and machine Learning. Subsequently, risk model and nomogram were constructed. Functional enrichment analysis explored prognosis-related pathways, while immune infiltration analysis revealed distinct immune cell infiltration patterns between high- and low-risk groups. Additionally, drug sensitivity analysis and drug prediction identified potential therapeutic targets for DDTC. Finally, prognostic gene expression was validated using quantitative real-time polymerase chain reaction (qRT-PCR).</p><p><strong>Results: </strong>A total of 6 MDRGs were obtained. Both risk model and nomogram demonstrated robust predictive performance. Furthermore, high-risk group was closely associated with DDTC prognosis, particularly involving pathways such as cytokine receptor interaction and biological processes like cytokine activity, which were related to immune regulation and emerged as critical drivers of DDTC progression. The 4 immune cells between the high- and low-risk groups were markedly different, such as activated CD4 memory T cells and plasma cells. Drug sensitivity analysis indicated that 40 and 27 medications sensitive to high- and low-risk groups, respectively. A total of 41 drugs were predicted to have potential therapeutic effects, including omarigliptin, bepridil and bortezomib. Finally, qRT-PCR validation demonstrated that SLC26A4, KCNQ1, PMAIP1, DPP4, and NOX4 had expression trends consistent with public database results.</p><p><strong>Conclusion: </strong>This study identified 6 MDRGs (SLC26A4, SLC25A37, KCNQ1, PMAIP1, DPP4 and NOX4) associated with the prognosis of DDTC, providing valuable scientific insights and references for the targeted therapy and patient stratification of DDTC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5897-5916"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Transfer Timing on Day-6 Blastocyst Pregnancy Outcomes in HRT Cycles of 2021-2024.","authors":"Chenyang Huang, Jun Xing, Qingqing Shi, Xiaoyue Shen, Yuan Yan, Yue Jiang","doi":"10.2147/IJGM.S544906","DOIUrl":"10.2147/IJGM.S544906","url":null,"abstract":"<p><strong>Background: </strong>The achievement of a healthy live birth from a singleton pregnancy has become the primary objective of modern Assisted Reproductive Technology (ART). Consequently, the effective utilization of a single blastocyst is of paramount importance. However, the optimal approach to improving clinical pregnancy rates for Day-6 (D6) blastocysts in the hormonal replacement therapy frozen embryo transfer (HRT-FET) cycle remains unclear.</p><p><strong>Methods: </strong>This study retrospectively analyzed 990 D6 single blastocyst HRT-FET cycles conducted at the Reproductive Medicine Center of Nanjing Drum tower Hospital from January 2021 to April 2024. Patients were categorized based on the timing of embryo transfer (on the 6th or 7th day of progesterone administration), and both univariate and multivariate regression analyses were employed to assess the impact of transfer timing on clinical pregnancy outcomes.</p><p><strong>Results: </strong>The results revealed no significant differences in baseline characteristics or treatment cycle parameters between the two groups based on transfer timing. Univariate analysis identified several factors, including the age of both partners, infertility etiology, anti-Müllerian hormone (AMH) levels, antral follicle count (AFC), and the number of prior ART cycles, which may influence clinical pregnancy outcomes. After adjusting for these variables, multivariate regression analysis indicated that the timing of endometrial preparation for D6 single blastocyst transfer did not significantly affect clinical pregnancy rates.</p><p><strong>Conclusion: </strong>In conclusion, our retrospective data suggest that transferring single D6 blastocysts on either the sixth or seventh day of progesterone administration in HRT-FET cycles yields comparable clinical pregnancy outcomes. Until further prospective evidence emerges, our findings do not support routine delay of D6 blastocyst transfers in HRT cycles.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5949-5957"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for the Treatment of Cervical Spondylotic Radiculopathy: An Overview of Systematic Reviews.","authors":"Ruisi Chen, Jixin Chen, Dongdong Cao, Chao Du, Jiwei Zhong, Aifeng Liu","doi":"10.2147/IJGM.S553977","DOIUrl":"10.2147/IJGM.S553977","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture has been extensively applied in the clinical management of cervical spondylotic radiculopathy (CSR). This overview aims to systematically summarize the efficacy and safety of acupuncture for the treatment of CSR, as well as to assess the methodological rigor and quality of evidence of the included studies.</p><p><strong>Methods: </strong>A comprehensive literature search for systematic reviews and meta-analyses was conducted across four Chinese and five international databases (PubMed, Web of Science, Cochrane Library, MEDLINE, Embase, China National Knowledge Infrastructure Database, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP).The literature search was conducted from the inception of each database to May 2025 (1996-2025). The PRISMA 2020 statement, AMSTAR 2, ROBIS, and GRADE tools were used to assess reporting quality, methodological quality, risk of bias, and evidence strength. Qualitative and quantitative evaluations were also performed on the results.</p><p><strong>Results: </strong>Six SR/MA studies were included. One study had relatively complete reporting with a PRISMA score of 24.5, while five showed reporting deficiencies (scores 18-20). All six studies scored very low on methodological quality according to AMSTAR 2. Only one study was rated as low risk of bias by ROBIS, while five were high risk. GRADE assessment of 41 outcomes showed 2.4% moderate quality, 24.3% low quality, and 73.2% very low quality, mainly downgraded due to study design limitations and publication bias.</p><p><strong>Conclusion: </strong>Acupuncture combined with conventional treatment may provide therapeutic benefits for CSR patients compared to conventional treatment alone. However, the safety of acupuncture for CSR has not been systematically evaluated, and the overall evidence quality is low, so conclusions should be interpreted cautiously.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5959-5975"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Nomogram for Predicting Sepsis-Associated Acute Respiratory Distress Syndrome.","authors":"Chen Yan, Yangming Cai, Weiyi Cai, Qin Wang, Wen Li, Qing Geng","doi":"10.2147/IJGM.S542796","DOIUrl":"10.2147/IJGM.S542796","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated acute respiratory distress syndrome (ARDS) is a critical condition with high morbidity and mortality. Early identification of patients at high risk is crucial for timely intervention. This study aimed to develop and validate a nomogram for predicting the risk of ARDS in patients with sepsis.</p><p><strong>Methods: </strong>A total of 308 patients with sepsis were retrospectively enrolled as the development cohort, and 132 patients were enrolled as an external validation cohort. Patients were categorized into ARDS and non-ARDS groups. Univariate and multivariate logistic regression analyses identified independent risk factors for ARDS in the development cohort, which were used to construct a nomogram. The nomogram's performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration curves, decision curve analysis (DCA), and the Hosmer-Lemeshow (H-L) test.</p><p><strong>Results: </strong>In the development cohort, 104 patients (33.77%) developed ARDS. Pulmonary infection (Odds Ratio [OR]=16.82), procalcitonin (PCT) (OR=2.71), tumor necrosis factor-alpha (TNF-α) (OR=1.102), oxygenation index (OR=0.861), and Acute Physiology and Chronic Health Evaluation II (APACHE II) score (OR=1.785) were identified as independent predictors. The nomogram demonstrated excellent discrimination, with an AUC of 0.862 in the development cohort and 0.881 in the validation cohort. Calibration curves showed good agreement between predicted and observed probabilities, supported by non-significant H-L tests (P>0.05). DCA confirmed the nomogram's clinical utility across a wide range of risk thresholds.</p><p><strong>Conclusion: </strong>The developed nomogram, incorporating five accessible variables, is a reliable and practical tool for predicting the risk of ARDS in patients with sepsis. This model can assist clinicians in identifying high-risk individuals for early preventive measures and personalized management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5917-5925"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role and Research Progress of Glycolytic Metabolic Reprogramming in Smooth Muscle Cells in Atherosclerosis.","authors":"Yurong Sun, Bin Zhang, Fengyi Liu, Bo Luan, Yanchun Ding","doi":"10.2147/IJGM.S550081","DOIUrl":"10.2147/IJGM.S550081","url":null,"abstract":"<p><p>Atherosclerosis(AS) is a chronic vascular disease resulting from the combined effects of lipid deposition and inflammatory responses, in which the phenotypic plasticity of vascular smooth muscle cells (VSMCs) plays a central role in disease progression. Under aerobic conditions, VSMCs undergo a metabolic shift reminiscent of the \"Warburg effect\", supporting their proliferation, migration, and phenotypic modulation through enhanced glycolytic flux. Despite its pathophysiological significance, the mechanistic interplay between glycolytic reprogramming in VSMCs and atherosclerotic progression remains inadequately systematized. This review aims to bridge this knowledge gap by synthesizing emerging evidence on how glycolysis orchestrates VSMCs remodeling and contributes to the clinical manifestations of AS. Furthermore, we explore the synergistic coupling between glycolytic metabolism and electrophysiological dynamics in VSMCs-an emerging area with transformative potential. Our methodology integrates multidimensional strategies: first, we delineate the metabolic drivers of VSMCs phenotypic switching in AS; second, we combine in vitro and in vivo models to elucidate the role of VSMCs glycolysis in diabetes-accelerated AS and in-stent restenosis; lastly, we investigate metaboloelectrophysiological crosstalk and ion channel regulation as central mechanisms. This synthesis provides a conceptual and mechanistic foundation for targeting glycolytic pathways in AS and its complications, offering novel avenues for therapeutic intervention.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5803-5810"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Metabolic and Gut Microbiome Differences in Age-Associated Fragile X Syndrome (FXS) Pediatric Patients May Benefit Clinical Therapy Development.","authors":"Xiaqing Han, Jianen Zhu, Wenying Zhao, Ying Han","doi":"10.2147/IJGM.S548349","DOIUrl":"10.2147/IJGM.S548349","url":null,"abstract":"<p><strong>Background: </strong>Fragile X syndrome (FXS) is a rare, genetically based neurodevelopmental disorder characterized by intellectual disability. While previous research has largely focused on its genetic mechanisms, the role of metabolism and the gut microbiome in FXS remains underexplored. This study aimed to investigate age-related metabolic differences in the gut flora and serum metabolites of children with FXS and their associations with clinical behavioral outcomes.</p><p><strong>Methods: </strong>A total of 32 children with FXS under 18 years were enrolled and divided into two age groups: younger (3-8 years) and older (8-18 years). Intestinal microbiota composition was analyzed using 16S rDNA gene sequencing, and serum metabolite profiles were assessed via ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Spearman correlation analysis was used to assess associations among gut flora, serum metabolites, and scores from the Social Responsiveness Scale (SRS) and Child Behavior Checklist (CBCL).</p><p><strong>Results: </strong>Significant differences in gut bacterial genera and 1,352 serum metabolites were observed between the age groups. The older group exhibited higher levels of phospholipids, steroids, and peptides, and enrichment in the steroid hormone biosynthesis pathway. Several metabolites were significantly correlated with SRS and CBCL scores, indicating potential links between metabolic changes and behavioral symptoms.</p><p><strong>Conclusion: </strong>Age-associated metabolic and gut microbiota alterations in FXS may contribute to variations in clinical presentation. These findings suggest a metabolic basis for FXS and provide a foundation for future research into microbiome-targeted interventions in FXS management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5869-5882"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice and Effect Evaluation of Hypertension Homogenization Management Model Under the \"Walking Hospital\" Mode in Primary Medical Institutions.","authors":"Falin Weng, Gang Feng, Wei Lu, Libin Xu, Wenxiang Zhu, Man Tan, Pengjuan Weng, Yating Wang","doi":"10.2147/IJGM.S544119","DOIUrl":"10.2147/IJGM.S544119","url":null,"abstract":"<p><strong>Purpose: </strong>To practice and evaluate the effectiveness of a hypertension homogenization management model under the \"walking hospital\" mode in primary medical institutions.</p><p><strong>Methods: </strong>This study examines the impact of hypertension management under the \"Walking Hospital\" model in Wushan County, encompassing all eligible hypertension patients with established records from various townships and streets. The management approach involves standardized procedures, including unified blood pressure measurement, diagnostic evaluation, treatment follow-up, referral of acute and severe cases, and quality control standards. Data is collected through face-to-face interviews before and after the management initiative. Key indicators of observation include the status of hypertension control (awareness, treatment, and control rates) across different areas. Patient follow-up and data collection span from August 2023 to August 2024. Analysis is conducted using SPSS 22.0, with categorical variable data presented as percentages, and repeated measures ANOVA used for statistical analysis.</p><p><strong>Results: </strong>Prior to the implementation of the aforementioned management strategies, the prevalence of hypertension awareness in Wushan County was 50.35% (±7.09% SD), with a treatment rate of 42.73% (±7.20% SD) and a control rate of 16.25% (±2.49% SD). Following the implementation of these strategies, there was a significant increase in hypertension awareness to 72.85% (±4.99% SD), treatment rate to 60.92% (±3.78% SD), and control rate to 43.32% (±3.41% SD) in Wushan County (p<0.0001).</p><p><strong>Conclusion: </strong>Wushan County's \"walking hospital\" for hypertension management employs standardized procedures, encompassing uniform blood pressure measurement, diagnostic evaluation, treatment monitoring, emergency protocols for acute and severe cases, and stringent quality control standards. This approach effectively enhances the awareness, treatment adherence, and control of hypertension in the region.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5845-5853"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}