International Journal of General Medicine最新文献

{"title":"Serum Transcription Factor EB Levels in Relation to Poor Neurological Prognosis and Mediation Effect of Stroke-Associated Pneumonia in Acute Intracerebral Hemorrhage: Evidence from a Two-Center Prospective Cohort Study.","authors":"Kang Wang, Guoyong Zhan, Qingsong Jiang, Cai Jiang, Guofu Zheng, Zhuxiao Tang","doi":"10.2147/IJGM.S519757","DOIUrl":"10.2147/IJGM.S519757","url":null,"abstract":"<p><strong>Background: </strong>Transcription factor EB (TFEB) is an endogenous protective protein. Serum TFEB levels were measured after acute intracerebral hemorrhage (ICH), in addition to determining their connection to the severity and neurological outcomes of patients.</p><p><strong>Methods: </strong>Serum TFEB levels were measured in a prospective cohort study of 186 ICH patients and 100 controls. Severity was estimated using the National Institutes of Health Stroke Scale (NIHSS) and hematoma volume. Poor neurological status mirrored by the post-ICH six-month modified Rankin Scale (mRS), along with stroke-associated pneumonia (SAP), was considered as the two outcome variables.</p><p><strong>Results: </strong>Patients showed a marked decline in serum TFEB levels compared with controls. Serum TFEB levels were significantly inversely correlated with both NIHSS scores and hematoma volume; had a linear relationship with likelihoods of both SAP and poor prognosis (mRS scores 3-6), were independent of ordinal mRS scores, SAP, and poor prognosis; and were efficiently predictive of SAP and poor prognosis with analogous areas under the receiver operating characteristic curve as NIHSS scores and hematoma volume. The association between serum TFEB levels and poor prognosis is partly mediated by SAP.</p><p><strong>Conclusion: </strong>Reduced serum TFEB levels post-ICH of evident relevance to bleeding intensity are powerfully linked to poor neurological prognosis, wherein there is a partial mediative effect by SAP, thereby reinforcing TFEB as a serological prognostic indicator of good prospect in ICH.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2539-2552"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Visceral Adiposity and Plasma Atherogenicity Indices, Which are Cardiovascular Risk Markers in Hypothyroid Patients and Healthy Controls.","authors":"Selma Pekgör, Mehmet Ali Eryılmaz, Hayriye Şentürk","doi":"10.2147/IJGM.S519429","DOIUrl":"10.2147/IJGM.S519429","url":null,"abstract":"<p><strong>Purpose: </strong>Hypothyroidism increases the risk of cardiovascular disease. In recent years, it has been suggested that the Visceral Adiposity Index (VAI) and the Plasma Atherogenicity Index (PAI) may serve as markers of cardiovascular risk. This study aimed to investigate the potential utility of VAI and PAI as predictors of increased cardiovascular risk in patients with hypothyroidism.</p><p><strong>Patients and methods: </strong>A retrospective analysis was conducted on 134 participants, including 85 hypothyroid patients and 49 individuals with normal thyroid function who visited the Family Medicine Clinic of Konya Training and Research Hospital between March 2016 and June 2017. Sociodemographic characteristics, anthropometric measurements, blood lipid profiles, and thyroid hormone levels were analyzed for all participants. VAI and PAI levels were calculated.</p><p><strong>Results: </strong>Among the participants, 111 (82.8%) were female, and 23 (17.2%) were male. In the hypothyroid group, triglycerides (TG) (p=0.001), Visceral Adiposity Index (VAI) (p<0.001), and Plasma Atherogenic Index (PAI) (p<0.001) were significantly higher, in contrast high-density lipoprotein (HDL) (p<0.001) was substantially lower than in the control group. Patients were divided into three categories based on PAI levels: low, moderate, and high risk. Compared to the moderate-risk group, the high-risk group had higher weight (p=0.007), BMI (p=0.012), WC (p=0.001), TG (p<0.001), VAI (p<0.001), and PAI (p<0.001), but lower HDL (p<0.001). PAI showed a positive correlation with age, weight, BMI, WC, systolic and diastolic blood pressure, thyroid-stimulating hormone (TSH), TG, total cholesterol, and VAI, and a negative correlation with HDL.</p><p><strong>Conclusion: </strong>This study demonstrates that cardiovascular risk is increased in hypothyroid patients, VAI and PAI are reliable markers for assessing cardiovascular disease risk in this population. These findings may aid primary care physicians in early identification and management of cardiovascular risk in hypothyroid patients. Limitations include the retrospective design and limited male representation in the sample.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2581-2588"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Midkine Expression Correlates with Poor Prognosis and Immune Cell Infiltration in Hepatocellular Carcinoma.","authors":"Lili Yan, Ji Lv, Meimei Xu, Hongyu Jia, Shanshan Li","doi":"10.2147/IJGM.S490409","DOIUrl":"10.2147/IJGM.S490409","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the role of MDK (Midkine) in hepatocellular carcinoma (HCC) through bioinformatics analysis and experimental validation, focusing on its relationship with tumor immune microenvironment and patient prognosis.</p><p><strong>Methods: </strong>We employed the GEPIA database to analyze MDK expression patterns across cancer types and specifically in HCC versus normal tissues. MDK expression was validated through immunohistochemistry (IHC) in 100 paired HCC and adjacent tissue samples. Survival analyses were conducted using Kaplan-Meier and Cox regression methods. The relationship between MDK expression and immune cell infiltration was investigated using TIMER 2.0 database and verified through IHC staining of immune cell markers.</p><p><strong>Results: </strong>MDK expression was significantly elevated in HCC tissues compared to adjacent normal tissues. High MDK expression strongly correlated with tumor number, vascular invasion, advanced clinical stage and poor prognosis, serving as an independent prognostic factor. Notably, elevated MDK expression predicted poor outcomes in patients receiving immunotherapy. Database analysis and IHC analysis revealed that MDK expression positively correlated with regulatory T (Treg) cell infiltration while negatively correlating with natural killer (NK) cell presence, suggesting its role in shaping the tumor immune microenvironment.</p><p><strong>Conclusion: </strong>High MDK expression in HCC correlates with unfavorable patient outcomes and impacts immune cell infiltration. MDK may serve as a novel prognostic biomarker and potential therapeutic target in HCC treatment.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2567-2579"},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Trends and Public Health Implications of Dengue Fever in Zhejiang Province, China: A Decadal Analysis from National to Cangnan Perspectives.","authors":"Qi-Lei Hu, Su Ai Fang, Jiao Dong Lin, Zuo Jie Li","doi":"10.2147/IJGM.S519635","DOIUrl":"10.2147/IJGM.S519635","url":null,"abstract":"<p><strong>Objective: </strong>To analyze dengue fever outbreaks in China, Zhejiang Province, and a local region to provide a scientific basis for early warning surveillance and the prevention and control of dengue epidemics.</p><p><strong>Methods: </strong>This retrospective study examines dengue fever data from China and Zhejiang Province over the past decade, including incidence, mortality, seasonal distribution, age characteristics, and regional distribution. Local data from the past decade were also analyzed.</p><p><strong>Results: </strong>Over the last ten years, the average annual incidence rate of dengue fever in China has been 0.7764 per 100,000 individuals, with a mortality rate of 0.000945 per 100,000. In the same period, the incidence rate in Zhejiang Province was 0.4546 per 100,000, with no fatalities reported. Dengue fever cases in both China and Zhejiang Province are primarily seen during the summer and autumn seasons. Between 2014 and 2020, cases were documented across all age groups in China, demonstrating an age-specific pattern in the annual average incidence rate, with rates initially increasing to peak in young adults and subsequently declining with advancing age. The highest rates were noted in the 20-29.9 and 30-39.9 age brackets. With the exception of Tibet, all regions in China have recorded cases, with Guangdong, Yunnan, Fujian and Zhejiang in the southern part of the country being the main high-incidence areas. In Cangnan County, 30 cases of dengue fever were reported over the past decade, predominantly affecting imported cases, males, and young to middle-aged adults.</p><p><strong>Conclusion: </strong>Dengue fever cases are rising in China, particularly in southern regions. 15 to 50 years old people are most affected. There is a pressing need for region-specific strategies to mitigate the impact of dengue fever, particularly in high-incidence areas.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2553-2566"},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Radial Shock Wave Therapy to Control Cerebral Palsy-Related Dysfunctions: A Randomized Controlled Trial [Response to Letter].","authors":"Hisham M Hussein, Ahmed M Gabr, Monira I Aldhahi, Amsha Alhumaidi Alshammari, Hand Zamel Alshammari, Khulood Khleiwi Altamimi, Abdulaziz Mohammed Alqahtani, Ibrahim M Dewir, Shamekh Mohamed El-Shamy, Ahmed Abdelmoniem Ibrahim","doi":"10.2147/IJGM.S538434","DOIUrl":"10.2147/IJGM.S538434","url":null,"abstract":"","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2537-2538"},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Multi-Task Artificial Intelligence-Assisted System for Small Bowel Capsule Endoscopy.","authors":"Jian Chen, Hongwei Wang, Zihao Zhang, Kaijian Xia, Fuli Gao, Xiaodan Xu, Ganhong Wang","doi":"10.2147/IJGM.S522587","DOIUrl":"10.2147/IJGM.S522587","url":null,"abstract":"<p><strong>Objective: </strong>To develop a multi-task artificial intelligence-assisted system for small bowel capsule endoscopy (SBCE) based on various Transformer neural network architectures. The system integrates lesion recognition, cumulative time statistics, and progress bar marking functions to enhance the efficiency and accuracy of endoscopic image interpretation while effectively reducing missed diagnoses.</p><p><strong>Methods: </strong>A dataset comprising 12 annotated categories of images captured by three different brands of capsule endoscopy devices was collected. Transfer learning and fine-tuning were conducted on five pre-trained Transformer models. Performance metrics, including accuracy, sensitivity, specificity, and recognition speed, were evaluated to select the best-performing model. The optimal model was converted from PyTorch to Open Neural Network Exchange (ONNX) format. Using OpenCV and MMCV tools, a multi-task SBCE-assisted reading system was developed.</p><p><strong>Results: </strong>A total of 34,799 images were included in the study. The best-performing model, FocalNet, achieved a weighted average sensitivity of 85.69%, specificity of 98.58%, accuracy of 85.69%, and an AUC of 0.98 across all categories. Its diagnostic accuracy outperformed junior physicians (<i>χ²</i>=17.26, <i>p</i><0.05) and showed no statistical difference compared to senior physicians (<i>χ²</i>=0.0716, <i>p</i>>0.05). The multi-task AI-assisted reading system, \"FocalCE-Master\", developed based on FocalNet, achieved a diagnostic speed of 592.40 frames per second, significantly faster than endoscopists. By integrating cumulative time bar charts with progress bar marking functionality, the system enables rapid localization and review of lesions, effectively streamlining the diagnostic workflow of SBCE.</p><p><strong>Conclusion: </strong>The multi-task SBCE-assisted reading system developed using Transformer networks demonstrated rapid and accurate classification of various small bowel lesions. It holds significant potential in enhancing diagnostic efficiency and image review speed for endoscopists. However, the AI system has not yet been validated in prospective clinical trials, and further real-world studies are needed to confirm its clinical applicability.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2521-2536"},"PeriodicalIF":2.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-Induced Klotho Deficiency: A Possible Key Driver of Chronic Kidney Disease Progression.","authors":"Yan Liang, Qi Zhang, Jing-Rong Qian, Sha-Sha Li, Qi-Feng Liu","doi":"10.2147/IJGM.S513497","DOIUrl":"https://doi.org/10.2147/IJGM.S513497","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is influenced by inflammation, a critical factor in its progression. However, the underlying mechanism through which inflammation contributes to CKD is still obscure. The Klotho protein, which is predominantly found in the kidneys, is known for its protective functions, including anti-inflammatory, anti-aging, antioxidant, and anti-fibrotic effects. A myriad of studies have suggested that inflammation in CKD leads to a decrease in Klotho expression, diminishing Klotho protection capabilities and exacerbating kidney damage, thereby promoting CKD progression. These findings suggest that Klotho deficiency could be a crucial link between inflammation and CKD progression. However, the mechanism regarding their relationship is still unclear. The reduction in Klotho due to inflammation may be attributed to epigenetic mechanisms, such as DNA methylation, histone deacetylation, transcription factor, microRNA (miRNA) regulation and long non-coding RNA (lncRNA) regulation or non-epigenetic factors, such as endoplasmic reticulum (ER) stress and ER-associated degradation (ERAD), which affect Klotho protein metabolism. Through these pathways, inflammation triggers a decrease in Klotho expression, further driving CKD progression. Notably, Klotho also exerts a strong anti-inflammatory effect by inhibiting key inflammatory factors and pathways, suggesting that there is intricate crosstalk between inflammatory factors and Klotho in CKD. This review highlights how inflammation suppresses the expression of Klotho and further contributes to the development and exacerbation of CKD. By focusing on the interplay between inflammation and Klotho, the present review provides novel potential therapeutic strategies such as correcting epigenetic and non-epigenetic abnormalities for treating CKD by targeting this specific axis.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2507-2520"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Lung Cancer Inflammation Index as a Predictor of Coronary Slow Flow Phenomenon in Patients with Angina and Non-Obstructive Coronary Arteries.","authors":"Yu-Ting Jiang, Zhen-Ming Yan, Wei Gu, Hong-Shan Guo, Xiu-Ting Li, Si-Qi Zheng, Xuan Liao, De-Gang Xue","doi":"10.2147/IJGM.S522261","DOIUrl":"https://doi.org/10.2147/IJGM.S522261","url":null,"abstract":"<p><strong>Background: </strong>The advanced lung cancer inflammation index (ALI) is associated with the prognosis of cardiovascular diseases. However, the relationship between ALI and the occurrence of coronary slow flow phenomenon (CSFP) remains unclear.</p><p><strong>Methods: </strong>We consecutively enrolled 1495 patients with angina and non-obstructive coronary arteries (ANOCA). In total, 93 patients were diagnosed with CSFP. A 1:2 age- and sex-matched patient with a normal coronary blood flow was selected as the control group. Demographic characteristics, laboratory parameters, and angiographic findings were compared between groups. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of CSFP in patients with ANOCA.</p><p><strong>Results: </strong>A total of 93 individuals developed CSFP, accounting for 6.4% of the ANOCA patients. Compared with controls, patients with CSFP had a lower body mass index (BMI) and a higher incidence of nitrates before admission (P<0.05). The neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and fasting blood glucose (FBG) level were significantly higher in patients with CSFP, whereas decreased lymphocyte count, albumin level, and ALI were found in patients with CSFP. Multivariable logistic regression analyses revealed that ALI was an independent predictor of CSFP. The receiver operating characteristic (ROC) curve showed that when ALI was ≤389.5, the specificity and sensitivity were 0.624 and 0.652, respectively (AUC, 0.694; 95% CI, 0.633-0.755, P<0.001). Moreover, ALI demonstrated a better predictive value than indicators alone, including albumin level, BMI, and NLR.</p><p><strong>Conclusion: </strong>A lower ALI demonstrated a reliable predictive value for the occurrence of CSFP in patients with ANOCA. As an easily calculated and acquired parameter, ALI can be used for risk stratification and optimal management of patients with ANOCA.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2497-2505"},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of IL-6 and PDGF-AA for 28-Day Mortality Risk in Critical Ill Patients.","authors":"Liyan Wu, Ye Zhang, Li Gu, Junyu Wang, Bing Wei, Yugeng Liu","doi":"10.2147/IJGM.S512295","DOIUrl":"https://doi.org/10.2147/IJGM.S512295","url":null,"abstract":"<p><strong>Background: </strong>Identification of prognostic biomarkers for critical illness are essential to improving mortality in the context of precision medicine. The purpose of this study was to evaluate the prognostic value of interleukin-6 (IL-6) and platelet-derived growth factor AA(PDGF-AA) in predicting 28-day mortality in critically ill patients.</p><p><strong>Methods: </strong>199 critically ill patients were recruited from the emergency department of the Beijing Chaoyang Hospital, Capital Medical University, between October 2020 and April 2021. IL-6, PDGF-AA and other markers were tested immediately, and the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were calculated within 24h of admission to the emergency department. Patients were divided into survival and non-survival groups according to clinical outcomes for 28 days. The quantitative detections of IL-6 and PDGF-AA were performed using the Luminex assay. Spearman correlation, logistic regression, and receiver operating characteristic curve (ROC) analyses were conducted for comparison.</p><p><strong>Results: </strong>Among 199 patients, 139 died and 60 survived within 28 days, IL-6 and PDGF-AA levels were higher in the non-survival group (P<0.05). IL-6 levels correlated with PDGF-AA levels in the non-survival group (P<0.001). IL-6 and PDGF-AA were independent predictors off 28-day mortality in critically ill patients (OR=1.003, 1.002). Combination of IL-6 and SOFA can make an AUROC of 0.892 with a specificity of 91.4%. Combination of IL-6, PDGF-AA and SOFA can make an AUROC of 0.905 with a specificity of 91.5%.</p><p><strong>Conclusion: </strong>This study highlights the importance of monitoring serum levels of IL-6 and PDGF-AA in critically ill patients. Compared with the marker alone, combinations with other conventional risk factors have better predictive values.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2477-2486"},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Independent Risk Factors of second-Degree Atrioventricular Block in Patients with Atrial Fibrillation and the Diagnostic Efficacy of Dynamic Electrocardiogram.","authors":"Ping Lu, Xingchun Mo, Xiaojing Yang, Yaoyao Lin","doi":"10.2147/IJGM.S515113","DOIUrl":"https://doi.org/10.2147/IJGM.S515113","url":null,"abstract":"<p><strong>Objective: </strong>Exploring the independent risk factors of second-degree atrioventricular block (II AVB) in patients with atrial fibrillation (AF), and to evaluate the clinical value of 24-hour dynamic electrocardiogram (DCG) in its diagnosis.</p><p><strong>Methods: </strong>A prospective cohort study was conducted on 947 patients with AF diagnosed and treated in our hospital from January 1, 2021 to December 31, 2021. These patients were divided into combined group (98 cases) and uncombined group (849 cases) according to whether they were accompanied by. The clinicopathological data of the patients were collected, and Multivariate logistic regression analysis was used to analyze the independent risk factors. Patients in combined group were further evenly divided into the study group (underwent 24-hour DCG) and the control group (underwent routine ECG) based on the detection methods. The diagnostic value was valued and the positive detection rate was calculated by ROC curve.</p><p><strong>Results: </strong>The smoking history, left atrial internal diameter (LAD), R-R interval and ventricular rate of patients in two groups had significant differences (<i>P</i><0.001). Smoking history (HR=1.531, 95% CI 1.150-2.038, <i>P</i><0.001), LAD>35.88 mm (HR=1.941, 95% CI 1.301-2.895, <i>P</i><0.001), R-R interval>2.50 s (HR=2.282, 95% CI 1.231-4.229, <i>P</i>=0.014) were independent risk factors for AF combined with II AVB, while ventricular rate≤70 beats/min (HR=0.506, 95% CI 0.293-0.873, <i>P</i>=0.014) were independent protective factors for AF combined with II AVB. The mean ventricular rate (70.03±5.40 beats/min vs 83.11±8.05 beats/min, <i>P</i><0.001) and R-R interval (2.82±0.26s vs 2.37±0.14s, <i>P</i><0.001) in the study group were longer than the control group. The diagnostic positive rate of DCG (97.96% vs 85.71%, <i>χ</i>²=4.900, <i>P</i>=0.027) was higher than that of conventional ECG.</p><p><strong>Conclusion: </strong>Smoking history, LAD, R-R interval and ventricular rate were influential factors for AF combined with II AVB. 24-h DCG had potential diagnostic value in the occurrence of AF combined with II AVB.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2487-2495"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}