International Journal of General Medicine最新文献

{"title":"Clinicopathological Analysis of Patients with Isolated Hematuria and/or Mild Proteinuria.","authors":"Junping Tang, Pingping Luo, Min He, Lin Ning, Zhenqin Tan","doi":"10.2147/IJGM.S504226","DOIUrl":"10.2147/IJGM.S504226","url":null,"abstract":"<p><strong>Objective: </strong>This investigation aimed to explore the clinicopathological features of patients with isolated hematuria and/or mild proteinuria in kidney disease.</p><p><strong>Materials and methods: </strong>We conducted a retrospective review of the clinical and pathological information of patients initially diagnosed with chronic nephritis syndrome in the Nephrology Department of Yuebei People's Hospital.</p><p><strong>Results: </strong>In total, 227 participants were recruited for the study, including 79 patients (34.8%) in the group with isolated hematuria and/or mild proteinuria and 148 patients (65.2%) in the group with medium-large amounts of proteinuria. There were 29 cases (36.7%) of IgA nephropathy, seven cases (8.9%) of focal segmental glomerulosclerosis, six cases (7.6%) of membranous nephropathy, and six cases (7.9%) of acute renal tubular injury in the group with isolated hematuria and/or mild proteinuria. The common pathological types in the medium-large proteinuria group were membranous nephropathy in 68 cases (45.9%), minimal change nephropathy in 25 cases (16.9%), and IgA nephropathy in 20 cases (13.5%).</p><p><strong>Conclusion: </strong>IgA nephropathy is the main pathological type in the group with isolated hematuria and/or mild proteinuria, while membranous nephropathy is the common pathological type in the group with moderate to severe proteinuria. There was a significantly stronger correlation between the level of hematuria/proteinuria and both BMI and MAP.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1623-1628"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram for Predicting the Risk of Twin and Preterm Births After Two Cleavage-Stage Embryo Transfer.","authors":"Yunzhu Lan, Shuang Liu, Emmanuel Osei Nkansah, Fang Wang, Shaowei Chen, Jun Zhang, Lan Yuan, Jian Xu","doi":"10.2147/IJGM.S510014","DOIUrl":"10.2147/IJGM.S510014","url":null,"abstract":"<p><strong>Objective: </strong>To propose a prediction model aimed at increasing the live birth rate of patients undergoing two-cell embryo transfer while eliminating multiple pregnancy complications.</p><p><strong>Methods: </strong>Women who underwent their first In Vitro Fertilization (IVF) cycle with transferred cleavage-stage embryos at the Affiliated Hospital of Southwest Medical University between January 2016 and December 2024 were included. This study recruited women who received the GnRH agonist long protocol (GnRH-a) or antagonist protocol (GnRH-ant) for ovarian stimulation. In addition, the clinical parameters related to the basic protocol and embryo characteristics were recorded.</p><p><strong>Results: </strong>In the multivariate analysis, we found that female age, endometrial thickness on the Human Chorionic Gonadotropin (HCG) days, patients with Body Mass Index (BMI) >30, high-quality embryos with 4 cells between 1 and 4 pieces, high-quality embryos with 8 cells, available embryos between 5 and 15 pieces and high-quality embryos between 1 and 4 pieces were crucial factors in the twin pregnancies prediction model (<i>p</i> < 0.05). On the basis of these characteristics, we constructed a nomogram for twin pregnancies. Additionally, we compared the difference between premature and normal births and found that endometrial thickness on HCG days positively correlated with the model score. In the premature group, the endometrial thickness on HCG days was lower than that found in patients without premature births.</p><p><strong>Conclusion: </strong>Endometrial thickness on the HCG day may influence the outcome of twin pregnancies. The high-quality embryos showed a higher positive correlation with the model score. Patients with preterm birth had less endometrial thickness on the HCG day than patients without premature birth. For patients with high-quality embryos, it is advisable to use single embryo transfer to reduce the rate of twin pregnancies. This nomogram will enhance the counseling of patients with infertility challenges.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1629-1641"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Preoperative Blood Pressure Fluctuations in Patients Undergoing Elective Surgery: A Retrospective Observational Study.","authors":"Zifei Cheng, Lihui Zhang, Minglei Liu, Dali Liang, Yue Li, Xiansong Huang, Li Peng","doi":"10.2147/IJGM.S507706","DOIUrl":"10.2147/IJGM.S507706","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the factors influencing preoperative blood pressure fluctuations in patients undergoing elective surgery.</p><p><strong>Patients and methods: </strong>This retrospective observational study included 776 patients who underwent elective surgery between January and October 2021. Preoperative blood pressure fluctuations were defined las a systolic or diastolic change exceeding 20% compared to baseline measurements taken one day prior to surgery. Patients were divided into two groups: the elevated blood pressure group (n=328) and the non-fluctuating group (n=448). Multivariate logistic regression analysis was employed to identify independent risk factors associated with blood pressure fluctuations.</p><p><strong>Results: </strong>Among the 776 patients (335 males and 441 females), the average systolic blood pressure increased by 12.98 ± 19.33 mmHg, and diastolic blood pressure increased by 6.67 ± 13.20 mmHg on the day of surgery compared to the previous day. Preoperative blood pressure fluctuations exceeding 20% were observed in 42.27% of patients. Multivariate logistic regression revealed that older age (OR = 1.021; 95% CI: 1.007-1.035; P = 0.003), preoperative hypertension (OR = 1.785; 95% CI: 1.142-2.807; P = 0.011), and shorter sleep duration the night before surgery (OR = 0.835; 95% CI: 0.747-0.932; P = 0.001) were independent risk factors for blood pressure fluctuations.</p><p><strong>Conclusion: </strong>Significant increases in preoperative blood pressure were observed upon patient entry into the operating room. Older age, preoperative hypertension, and inadequate sleep duration were identified as independent risk factors for blood pressure fluctuations. These findings underscore the need for targeted preoperative interventions to minimize blood pressure variability, particularly in elderly and hypertensive patients with inadequate sleep duration.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1615-1622"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic Comorbidities in Patients With Chronic Hepatitis B and Impact on Incidence of Liver Complications. A Danish Nationwide Cohort Study.","authors":"Sofie Jespersen, Signe Bollerup, Sten Madsbad, Rikke Krogh-Madsen, Stine Byberg, Nina Weis","doi":"10.2147/IJGM.S471083","DOIUrl":"10.2147/IJGM.S471083","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate liver complications in patients with chronic hepatitis B, both with and without cardiometabolic comorbidities, and to compare the incidence of cardiometabolic comorbidities in these patients with that of the general population.</p><p><strong>Study population and methods: </strong>This nationwide registry-based cohort study included data from 2002-2020. In the primary analysis, we used multivariate Poisson regression to estimate the incidence rate and incidence rate ratio of liver complications in patients with chronic hepatitis B, stratified by the presence of cardiometabolic comorbidities. In the secondary analysis, we compared the incidence rate of developing cardiometabolic comorbidities in patients with chronic hepatitis B to those of the general population. Both analyses were adjusted for sex, age, and country of origin, while the primary analysis was additionally adjusted for time since cardiometabolic comorbidity diagnosis and calendar year.</p><p><strong>Results: </strong>The primary analysis included 4731 patients with chronic hepatitis B, of whom 532 (11%) had at least one cardiometabolic comorbidity. The unadjusted overall incidence rate of liver complications in patients with cardiometabolic comorbidities was 1.0 per 100 person-years (95% confidence intervals: 0.84-1.30) compared to 0.4 per 100 person-years (95% confidence intervals: 0.30-0.42) in those without. The incidence rate ratio for liver complications was highest in the first year following the diagnosis of cardiometabolic comorbidity. The incidence rate ratio for developing cardiometabolic comorbidities in the chronic hepatitis B cohort compared to the general population, was 1.10 (95% confidence intervals: 1.02-1.19). Sensitivity analyses revealed a higher incidence rate ratio for type 2 diabetes and hypertension but a lower incidence rate ratio for hypercholesterolemia.</p><p><strong>Conclusion: </strong>Patients with chronic hepatitis B and cardiometabolic comorbidities exhibit a higher incidence of liver complications, particularly in the first year following comorbidity diagnosis compared to those without comorbidities. Furthermore, patients with chronic hepatitis B have a higher incidence of cardiometabolic comorbidities than the general population.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1591-1604"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Visualized Nomogram to Predict the Risk of Acute Ischemic Stroke Among Patients With Cervical Artery Dissection.","authors":"Changyu Li, Jincheng Guan, Qingshi Zhao, Jiahua Li, Yuying Wang, Kui Zhao","doi":"10.2147/IJGM.S507043","DOIUrl":"10.2147/IJGM.S507043","url":null,"abstract":"<p><strong>Background: </strong>Acute ischemic stroke (AIS) is a significant global health concern, with cervical artery dissection (CAD) being a notable yet frequently overlooked cause, particularly in young adults. Despite advancements in imaging technologies, there remains a deficiency in effective methodologies for the prompt identification of AIS attributable to CAD. This research aims to create a predictive model combining clinical, imaging, and laboratory data to improve risk stratification and guide timely interventions.</p><p><strong>Methods: </strong>Between 2019 and 2024, patients diagnosed with CAD were enrolled in the study. Nomogram models were constructed utilizing a two-step methodological approach. Initially, the least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to improve variable selection. Subsequently, logistic regression analysis was conducted to develop an estimation model using the significant indicators identified by the LASSO. The model's accuracy was evaluated using the application of receiver operating characteristic (ROC) curves, calibration curves, decision curve analyses, and clinical impact curves. The model underwent internal validation through bootstrap resampling with 1,000 iterations.</p><p><strong>Results: </strong>In the cohort of 102 patients, 75 individuals with CAD experienced had an acute ischemic stroke. This cohort was characterized by a significantly older median age (42 years vs 51 years, p=0.041) and a comparable proportion of males (78.7% vs 74.1%,p=0.825). The analysis identified hyperlipidemia (aOR=0.19, 95% CI=0.040-0.893, p=0.036), lumen occlusion (aOR=5.41, 95% CI=1.236-23.648, p=0.025), a lower lymphocyte-to-monocyte ratio (LMR) (aOR=0.68, 95% CI=0.476-0.797, p=0.038), and higher systemic immune-inflammation index (SII) (aOR=1.01, 95% CI=1.001-1.016, p=0.026) are independent factors linked to ischemic stroke in CAD patients. The predictive model showed strong performance with an AUC of 0.870 (95% CI=0.789-0.950) under the ROC curve. Decision curve analysis (DCA) indicated that the constructed nomogram was clinically applicable, with a risk threshold ranging from 9% to 95%.</p><p><strong>Conclusion: </strong>This study developed a dynamic and visualized nomogram model for the precise prediction of stroke risk in patients with CAD, exhibiting robust performance, calibration, and clinical utility. Future multi-center studies are anticipated to further substantiate its clinical applicability.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1569-1580"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Predictive Value of Neutrophil Percentage-to-Albumin Ratio and Modified Glasgow Prognostic Score for the Risk of Stroke-Associated Pneumonia Among Stroke Patients.","authors":"Zhu Tian, Yufeng Lin, Yang Song, Chi Zhang, Zhiyun Wang","doi":"10.2147/IJGM.S504231","DOIUrl":"10.2147/IJGM.S504231","url":null,"abstract":"<p><strong>Objective: </strong>To assess the predicting value of neutrophil percentage-to-albumin ratio (NPAR) and modified Glasgow Prognostic Score (mGPS) for Stroke-Associated Pneumonia (SAP) occurrence among stroke patients.</p><p><strong>Methods: </strong>We recruited stroke patients (aged 18 years) hospitalized at Tianjin First Central Hospital from January 2022 to February 2023 for this retrospective cohort study. NPAR was categorized into four groups by considering the quartiles: Q1 (<1.38), Q2 (≥1.38 and <1.62), Q3 (≥1.62 and <1.87), Q4 (≥1.87). SAP incident was the primary outcome in this study. Univariate and multivariate logistic regression models were employed to explore the association between NPAR, mGPS and SAP occurrence among individuals with stroke. Besides, we compared the predicting value of NPAR and mGPS for SAP occurrence by the receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>Our study encompassed 851 patients with stroke. One hundred and forty-seven patients (17.27%) developed SAP. After accounting for confounding factors, we observed significant positive association of high NPAR with SAP occurrence [(for the third quartile: odds ratio (OR)=2.35, 95% confidence interval (CI): 1.01-5.47; for the fourth quartile: OR=3.35, 95% CI: 1.44-7.77)]. Additionally, the results also indicated that mGPS 1 (OR=2.26, 95% CI: 1.25-4.08) and mGPS 2 (OR=7.37, 95% CI: 2.63-20.70) were related to the increased probability of SAP, respectively. ROC analysis demonstrated that both the NPAR [area under the curve (AUC)=0.729, 95% CI: 0.687-0.771] and mGPS (AUC=0.671, 95% CI: 0.627-0.716) exhibited good predictive power for SAP occurrence. Based on the DeLong test, the predictive value of NPAR for SAP may be significantly superior to that of mGPS (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Our findings suggest that both NPAR and mGPS serve as reliable biomarker for assessing SAP risk in stroke patients, with NPAR demonstrating superior predictive value for SAP compared to mGPS.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1605-1614"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Postpartum Women With Hypoxia: A Retrospective Analysis of 92 Cases.","authors":"Ting Wang, Rui Liu, Yuanpeng Li, Wei Qian, Man Niu","doi":"10.2147/IJGM.S508028","DOIUrl":"10.2147/IJGM.S508028","url":null,"abstract":"<p><strong>Purpose: </strong>Postpartum hypoxia is a significant concern among clinicians due to its association with fatal diseases such as amniotic fluid embolism. This study analyzed the clinical characteristics of patients with different etiologies of postpartum hypoxia.</p><p><strong>Patients and methods: </strong>Ninety-two postpartum cases with hypoxia, defined as oxygen saturation (SpO₂) < 95% within 48 h postpartum without supplemental oxygen inhalation, and 100 normal gravidas were enrolled. All patients with postpartum hypoxia underwent 24 h vital sign monitoring and relevant examinations, including hematological tests, chest computed tomography (CT) scans, or CT pulmonary angiography, to determine the cause of hypoxia and received appropriate treatments. All patients were followed up for 1 month.</p><p><strong>Results: </strong>Compared with normal gravidas, the patients with postpartum hypoxia had a higher occurrence rate of complications, including gestational hypertension (26.09% vs 8.00%), eclampsia (20.65% vs 4.00%), and a lower level of albumin (29.09 ± 0.57 vs 32.74 ± 0.94), thus tended to have longer hospitalization days (7.98 ± 0.40 vs 4.90 ± 0.16), with all <i>P</i> < 0.05. In all 92 cases, the most common cause of postpartum hypoxia was partial atelectasis with pleural effusion (65/92), followed by pulmonary edema (18/92), pneumonia (9/92), pulmonary embolism (6/92), and asthma (4/92). Among the five groups, patients with pneumonia had the longest hospital stay, whereas most patients with partial atelectasis accompanied by pleural effusion were asymptomatic. From the 1-month follow-up, all patients had a favorable prognosis with no apparent symptoms. Among those who underwent re-examination (27/92), no apparent imaging abnormalities were detected.</p><p><strong>Conclusion: </strong>Postpartum hypoxia, which occurs more commonly in patients with gestational hypertension, is often caused by partial atelectasis with pleural effusion or pulmonary edema. The patient's prognosis was generally satisfactory after treatment.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1581-1590"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of CXCR4 in the Primary Lesion of Recurrent Metastatic Breast Cancer and Its Association With Prognosis.","authors":"DanChan Huang, DanXia Lin, SiXian Liang, Jing Lin","doi":"10.2147/IJGM.S511426","DOIUrl":"10.2147/IJGM.S511426","url":null,"abstract":"<p><strong>Objective: </strong>This study examined CXCR4 expression in primary lesions of recurrent metastatic breast cancer patients, analyzing its association with clinicopathological features, chemotherapy efficacy, and prognosis.</p><p><strong>Methods: </strong>Eighty-five early surgical specimens of advanced BCa were examined for CXCR4 expression using immunohistochemical staining. The relationships between CXCR4 expression and clinical pathological factors, such as tumor size, lymph node metastasis, tumor stage, and metastatic site, were statistically analyzed, along with their effect on the efficacy of platinum-based chemotherapy and prognosis in patients with advanced BCa.</p><p><strong>Results: </strong>Significant associations were found between high CXCR4 levels in primary lesions of recurrent metastatic BCa and more frequent visceral metastases (<i>p</i> = 0.010), along with a higher rate of lymph node metastases (<i>p</i> = 0.022). Patients with advanced BCa showing high CXCR4 expression had lower efficacy with platinum-based chemotherapy (<i>p</i> = 0.002). Patients with high CXCR4 expression exhibited shorter disease-free survival (DFS) and overall survival (OS) compared to those with low expression, though the differences lacked statistical significance.</p><p><strong>Conclusion: </strong>Patients with recurrent metastatic BCa with high expression of CXCR4 in primary lesions have poor efficacy with platinum-based chemotherapy, shorter DFS and OS, and poor prognosis. CXCR4 may be an important biomarker in metastatic BCa. It can be used not only as a predictor of metastasis and prognosis, but also as a therapeutic target and a tool to monitor treatment efficacy.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1543-1553"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Practices Regarding Swallowing Disorders Among General Practitioners.","authors":"Min Zou, Xingzhi Zhu, Juan Li, Huan Yu, Peipei Guo","doi":"10.2147/IJGM.S506819","DOIUrl":"10.2147/IJGM.S506819","url":null,"abstract":"<p><strong>Background: </strong>Swallowing disorders constitute a significant clinical concern, necessitating effective management and early detection. General practitioners (GPs) play a pivotal role in identifying and referring patients with swallowing disorders, emphasizing the importance of assessing their Knowledge, Attitudes, and Practices (KAP) in this domain.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between July and October 2023, involving general practitioners who completed a self-administered questionnaire containing demographic information and KAP assessment.</p><p><strong>Results: </strong>The final analysis included 365 participates, with 242 (66.3%) completed by female participants and 106 (29.04%) by individuals with 5-10 years of professional working experience. The mean scores for knowledge, attitude, and practice were 12.41 ± 4.202 (possible range: 0-18), 22.25 ± 2.06 (possible range: 6-30), and 32.81 ± 9.48 (possible range: 10-50), respectively. Knowledge was demonstrated a positive correlation with attitude <i>(r</i> = 0.329, P < 0.001) and practice (r = 0.375, P < 0.001), while attitude also showed a positive correlation with practice (r = 0.309, P < 0.001). According to multivariate analysis, knowledge (OR = 1.13, 95% CI: [1.07-1.20], P < 0.001) and attitude (OR = 1.19, 95% CI: [1.05-1.36], P = 0.005) were independently associated with proactive practice.</p><p><strong>Conclusion: </strong>General practitioners demonstrated moderate knowledge, attitudes, and practices regarding swallowing disorders. Targeted educational interventions are essential to enhance general practitioners' knowledge regarding swallowing disorders.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1555-1567"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics of Foodborne Disease Outbreaks in a Hospital: A 5-Year Retrospective Study.","authors":"Yang Yang, Fang-Rong Xu, Yi-Bo Zhou, Li-Qing Hu, Wei Lu, Su-Hua Zhang, Han Hu, Xin-Er Huang","doi":"10.2147/IJGM.S496799","DOIUrl":"10.2147/IJGM.S496799","url":null,"abstract":"<p><strong>Introduction: </strong>Foodborne disease outbreaks (FBDOs) pose a significant threat to public health globally, leading to substantial morbidity, mortality, and economic losses. However, the underlying causes and impacts of FBDOs often remain underexplored in specific regions, limiting the effectiveness of targeted prevention strategies.</p><p><strong>Methods: </strong>This study aimed to investigate the epidemiological characteristics, causes, and economic burden of FBDOs in Jinhua city, Zhejiang province, China, between 2018 and 2022. Data were collected from the national surveillance system, encompassing 63 FBDOs with 305 cases. FBD cases were defined as patients with diarrhea, vomiting, or toxic symptoms suspected to be caused by food consumption, with outbreaks referring to incidents where two or more individuals presented similar symptoms after consuming the same food. Descriptive statistics were used to analyze numerical and categorical variables, focusing on outbreak sources, pathogenic factors, and economic consequences.</p><p><strong>Results: </strong>Data analysis revealed that catering services were the most common source of FBDOs, likely due to the widespread consumption of prepared meals and potential lapses in hygiene. Approximately 50% of the outbreaks were linked to unidentified pathogens. The reported microorganisms, including <i>Norovirus, Nontyphoidal Salmonella</i>, and <i>Vibrio parahaemolyticus</i>, were among the target pathogens of the national surveillance system and are also recognized as common causes of FBDOs globally. Among the identified causes, <i>Mushroom toxin</i> (19.05%) was the leading factor, followed by <i>Norovirus</i> (12.70%) and <i>Nontyphoidal Salmonella</i> (6.35%). <i>Norovirus</i> caused the highest number of cases (52). The total economic burden of FBDOs was estimated at 228,078.74 yuan, with a median cost of 648.29 yuan per case. Two fatalities were attributed to wood ear and nitrite consumption.</p><p><strong>Discussion: </strong>The findings highlight high-risk foods and vulnerable populations, underscoring the significant public health and economic impacts of FBDOs. To address these challenges, enhanced surveillance systems, the establishment of regional laboratory centers, and the application of new diagnostic technologies are crucial. Collaborative efforts among governments, the food industry, and consumers are essential to strengthening food safety and reducing the burden of foodborne diseases.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1529-1542"},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}