International Journal of General Medicine最新文献

{"title":"Disease Burden and Associated Factors in Chinese Patients with Tuberous Sclerosis Complex: Results of a Patient and Caregiver Survey.","authors":"Fangping Wang, Luyang Zhang, Jianxiang Liao, Jinzhu Liu, Bixia Yuan, Jinghua Ye","doi":"10.2147/IJGM.S507375","DOIUrl":"10.2147/IJGM.S507375","url":null,"abstract":"<p><strong>Objective: </strong>Tuberous Sclerosis Complex (TSC) is a rare autosomal dominant genetic disorder primarily characterized by neurological symptoms. This study aimed to evaluate the current disease burden in Chinese patients with TSC and to identify the potential influencing factors.</p><p><strong>Methods: </strong>A cross-sectional study design was employed using an online questionnaire survey. The questionnaire covered demographics, diagnosis and treatment status, medication use, and disease burden. Descriptive statistics were used to summarize the data, and multivariate logistic regression analysis was performed to examine factors influencing the disease burden in pediatric and adult patients with TSC.</p><p><strong>Results: </strong>The survey involved a total of 840 patients or their caregivers, comprising 691 pediatric and 149 adult patients, with an average age at diagnosis of 1.77 years for pediatric patients and 15.28 years for adult patients. The most prevalent clinical manifestations were seizures (75.1% in pediatric, 43.6% in adult), brain calcification spots/nodules (87.8% pediatric, 82.5% adult), and hypomelanotic macules (89.5% pediatric, 72.4% adult). Intellectual disability (ID) was reported in 29.6% of pediatric patients and 19.4% of adult patients. Catastrophic health expenditure (CHE) was reported by 29.6% of patients. Factors influencing the disease burden included ID, misdiagnosis, and use of anti-seizure medications (ASMs) and mammalian target of rapamycin (mTOR) inhibitors for pediatric patients or educational attainment, medication use (such as ASMs and mTOR inhibitors), and ID for adult patients.</p><p><strong>Conclusion: </strong>The study demonstrated that Chinese patients with TSC are confronted with a considerable disease burden. Comprehensive care strategies, tailored educational support for pediatric patients, and multidisciplinary approaches for early diagnosis are crucial for managing TSC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1481-1495"},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving Forward Despite Obstacles: A Qualitative Study on Healthy Lifestyle Adjustments Among Patients with Coronary Heart Disease After Their First Percutaneous Coronary Intervention.","authors":"Li Cheng, Wen-Ru Wang, Lotta Wikström, Jan Mårtensson","doi":"10.2147/IJGM.S491082","DOIUrl":"10.2147/IJGM.S491082","url":null,"abstract":"<p><strong>Background: </strong>Lifestyle factors, including diet, physical activity, smoking cessation, and stress management, are crucial for reducing the risk of recurrent cardiac events and promoting overall cardiovascular health. Despite their clinical significance, the experiences of patients with coronary heart disease (CHD) in adjusting to and maintaining these lifestyle changes after their first percutaneous coronary intervention (PCI) remain relatively unexplored, especially in China. This study aims to address this gap by exploring the experiences of patients with CHD in central China as they make adjustments to healthy lifestyles following their first PCI.</p><p><strong>Methods: </strong>A qualitative descriptive study was designed. Eighteen participants from a regional teaching hospital in central China participated in the study conducted from 2022 to 2023. Data were collected through face-to-face interviews guided by semi-structured questions, resulting in five sub-themes and one main theme emerging from the thematic analysis.</p><p><strong>Results: </strong>Adjusting to a healthy lifestyle post-PCI was described as \"moving forward despite obstacles\", reflecting resilience and determination in overcoming challenges to improve health and well-being. The participants initially trusted their doctors' recommendations and became motivated by the positive effects of lifestyle changes and the desire to alleviate the burden of their loved ones. However, they also faced challenges related to Chinese traditional culture and other physical issues.</p><p><strong>Conclusion: </strong>Adjustment to a healthy lifestyle is essential but challenging. Our findings highlight the influence of external and internal factors on behavioural changes and underscore the need for health professionals to understand and support patients' experiences to inspire and sustain their lifestyle adjustments.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1451-1461"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation.","authors":"Hai Li, Dongnan Sun, Kai Jin, Xudong Wang","doi":"10.2147/IJGM.S502480","DOIUrl":"10.2147/IJGM.S502480","url":null,"abstract":"<p><strong>Background: </strong>Although with a good prognosis of papillary thyroid cancer (PTC), patients with PTC and also experiencing lymph node metastasis (LNM) had higher recurrence and mortality rates. Therefore it was essential to explore novel biomarkers or methods to predict and evaluate the situation in the stages of PTC.</p><p><strong>Methods: </strong>In this study, mRNA sequence datasets from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) were utilized to obtain differentially expressed genes (DEGs) between PTC tumors and normal specimens and DEGs related to lymph node metastasis were identified using weighted gene co-expression network analysis (WGCNA) according to the clinical information. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied to query the biological functions and pathways. Furthermore, a protein-protein interaction (PPI) network was constructed using a STRING database and a prognosis model was established using the least absolute shrinkage and selection operator (LASSO) Cox regression analysis based on the LNM-related DEGs. Finally, six hub genes were identified and verified in vitro experiments.</p><p><strong>Results: </strong>A novel six-gene signature model including COL8A2, MET, FN1, MPZL2, PDLIM4 and CLDN10 was established based on a total of 52 DEGs from the intersection of LNM-related modules identified by WGNCA from TCGA, THCA and GSE60542 to predict the situation of lymph node metastasis in PTC. Those six hub genes were all more highly expressed in PTC tumors and played potential biological functions on the development of PTC in in vitro experiments, which had potential values as diagnostic and therapeutic targets.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1463-1479"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Aggregate Index of Systemic Inflammation and Slow Coronary Flow Phenomenon in Patients with Ischemia and No Obstructive Coronary Arteries.","authors":"Hong-Yang Wang, Jiang Guo, Min-Yan Hong, Jia-Jia Li, Xue-Qiang Jin","doi":"10.2147/IJGM.S515822","DOIUrl":"https://doi.org/10.2147/IJGM.S515822","url":null,"abstract":"<p><strong>Background: </strong>Inflammation has been proposed as a potential pathogenic mechanism underlying the slow coronary flow phenomenon (SCFP). The aggregate index of systemic inflammation (AISI), a novel biomarker for evaluating inflammation, has been linked to various cardiovascular diseases. However, the relationship between AISI and the occurrence of SCFP in patients with ischemia and non - obstructive coronary arteries (INOCA) remains unclear.</p><p><strong>Methods: </strong>In this study, 1328 consecutive patients with INOCA were recruited. Among them, 90 patients had SCFP (SCFP group). A total of 180 age - and sex - matched individuals with INOCA and normal blood flow were selected as controls at a ratio of 1:2. Clinical manifestations, laboratory parameters, and angiographic features were recorded to identify potential predictors of SCFP in INOCA patients.</p><p><strong>Results: </strong>Compared with the control group, patients in the SCFP group had a higher prevalence of current smoking, as well as elevated white blood cell (WBC), neutrophil, monocyte, and platelet counts, and a higher AISI. The AISI value increased with the number of vessels affected by SCFP. Multivariate logistic regression analysis demonstrated that the WBC count and AISI were independent predictors of SCFP in INOCA patients. Additionally, when the AISI was > 264.1, the sensitivity and specificity were 64.4% and 64.4% respectively, and the area under the receiver operating characteristic curve (AUC) was 0.657 (95% CI: 0.590-0.723, P < 0.001). The AISI had a more favorable predictive value for the presence of SCFP than WBC, neutrophils, lymphocytes, monocytes, and platelets alone (P < 0.05).</p><p><strong>Conclusion: </strong>Higher AISI scores are associated with an increased risk of SCFP in INOCA patients. As an easily - obtained biomarker for assessing the degree of inflammation, the AISI can serve as a promising tool for risk stratification and appropriate management in INOCA patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1431-1438"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Radial Shock Wave Therapy to Control Cerebral Palsy-Related Dysfunctions: A Randomized Controlled Trial.","authors":"Hisham M Hussein, Ahmed M Gabr, Monira I Aldhahi, Amsha Alhumaidi Alshammari, Hand Zamel Alshammari, Khulood Khleiwi Altamimi, Abdulaziz Mohammed Alqahtani, Ibrahim M Dewir, Shamekh Mohamed El-Shamy, Ahmed Abdelmoniem Ibrahim","doi":"10.2147/IJGM.S510383","DOIUrl":"10.2147/IJGM.S510383","url":null,"abstract":"<p><strong>Background: </strong>Radial Shock wave Therapy (rSWT) is one of the recent promising modalities that can effectively improve muscle tone, ROM, and enhance functional capacity. It can be used to augment the rehabilitation effectiveness in spastic CP children. So, enhance their engagement in community and participation in social activities and decrease economic burden of rehabilitation.</p><p><strong>Purpose: </strong>To investigate the effect of adding rSWT to standard physical therapy on muscular spasticity, ROM, gross motor function, and planter surface in spastic CP patients.</p><p><strong>Methods: </strong>A total of 70 children (48 girls and 22 boys) with spastic CP were randomly assigned into the control group (n= 35 and average age 8.82±0.91) which received standard physical therapy and the rSWT group (n=35 and average age 9.0±1.81) which received the standard physical therapy plus 1500 rSWT shocks with 2 bar pressure and Hz frequency applied over acupuncture points. Passive ankle ROM, calf muscle tone, gross motor function (D and E categories), plantar surface area (PSA), and peak pressure values at midfoot (PPMF), and hindfoot (PPHF) were assessed at baseline, post-treatment, and three-month follow-up.</p><p><strong>Results: </strong>Between-group comparisons demonstrated post-treatment statistically significant differences in ankle plantar flexion (APF), walking category of the GMFM (GMFM-E), PPHF, and PPMF with medium to high effect size values favoring the rSWTG (p=0.011, <i>d</i>=0.858; p=0.003, <i>d</i>=1.02; p=0.035, <i>d</i>=0.577; p=0.049, <i>d</i>= 0.216, respectively). At follow-up, all outcomes were statistically significantly different (p<0.05).</p><p><strong>Conclusion: </strong>rSWT is an effective addition to the standard physical therapy care for spastic CP children in favor of spasticity, ROM, and function.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1439-1450"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the SOX Regimen on Immune Function and Tumor Markers in Advanced Gastric Cancer.","authors":"Yifen Liu, Jian-Gang Zhao, Guang-Yuan Zhao","doi":"10.2147/IJGM.S509902","DOIUrl":"https://doi.org/10.2147/IJGM.S509902","url":null,"abstract":"<p><strong>Background: </strong>Locally advanced gastric cancer presents significant challenges in treatment, often limiting the effectiveness of surgical interventions. Chemotherapy, especially the SOX regimen (combining oxaliplatin and tegafur/gimeracil/oteracil), has been explored as a potential alternative in the management of advanced gastric cancer. While studies on SOX have been conducted in other regions, its impact on immune function and tumor markers remains inadequately evaluated, particularly in China.</p><p><strong>Objective: </strong>This study aimed to assess the toxicological profile, immune function modulation, and tumor marker reduction of the SOX regimen in patients with advanced gastric cancer.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 100 patients diagnosed with advanced gastric cancer, excluding eight ineligible cases. Based on clinical records, patients were grouped into either the oxaliplatin monotherapy group (reference group) or the SOX regimen group (observation group), with 50 patients in each group. The primary endpoint was clinical effectiveness, while secondary endpoints included immune function, tumor marker levels, and chemotherapy-related toxicity.</p><p><strong>Results: </strong>The SOX regimen demonstrated significantly higher disease control and objective remission rates compared to oxaliplatin monotherapy (P<0.05). In the SOX group, immune function was enhanced, with increased levels of immunoglobulins (IgA, IgG, IgM) and lymphocyte subsets (CD3+, CD4+, NK cells), and a decrease in CD8+ levels (P<0.05). Additionally, tumor markers such as CA125, CEA, MRP14, SDF-1, FSP-1, and CXCR4 showed a significant reduction (P<0.05). The SOX regimen also exhibited a more favorable safety profile, with lower incidences of chemotherapy-related nausea, vomiting, and leukopenia (P<0.05).</p><p><strong>Conclusion: </strong>The SOX regimen is an effective and promising treatment option for advanced gastric cancer, offering significant improvements in clinical outcomes, immune function, and tumor marker reduction, with fewer chemotherapy-related toxicities. This study provides valuable insights into the application of the SOX regimen in Chinese patients with advanced gastric cancer.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1415-1422"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramyocardial Hemorrhage in Patients with Acute Myocardial Infarction Without Reperfusion Therapy: A Prospective Study.","authors":"Muzheng Li, Zhijian Wu, Ilyas Tudahun, Kun Zhang","doi":"10.2147/IJGM.S501504","DOIUrl":"https://doi.org/10.2147/IJGM.S501504","url":null,"abstract":"<p><strong>Background and aims: </strong>IMH commonly presents in STEMI patients receiving reperfusion therapy and is considered as an ischemic reperfusion injury. However, it is unclear whether IMH occurs in AMI patients without reperfusion therapy.</p><p><strong>Methods and results: </strong>We prospectively enrolled 40 patients with STEMI and 41 patients with NSTEMI admitted to the CCU of the Second Xiangya Hospital of Central South University from April 2020 to November 2021, all of whom did not receive reperfusion therapy. In the STEMI group, 16 patients were detected with IMH by CMR. However, in the NSTEMI group, only 3 patients were detected. The incidence of IMH was significantly higher in patients with STEMI than NSTEMI (16/40 vs 3/41, P < 0.001). Among patients with STEMI, the incidence of IMH was not significantly different between patients who underwent primary percutaneous coronary intervention and those who did not (16/40 vs 27/65, P = 0.876). Patients in the spontaneous reperfusion group had a higher incidence of IMH than patients in the non-spontaneous reperfusion group (11/23 vs 5/17, P = 0.240). Similarly, in patients with STEMI who did not receive reperfusion therapy, the incidence of MACE was higher in the IMH-present group than in the IMH-absent group (5/16 vs 2/24, P = 0.063).</p><p><strong>Conclusion: </strong>The incidence of IMH is comparable in patients with STEMI with or without reperfusion therapy, but considerably higher than that in NSTEMI patients. Patients with STEMI can present with IMH even when infarct-related vessel flow is not restored.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1393-1401"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Value of Serum MCP-1 Combined with OPN Detection for Early Renal Injury in Gout Patients.","authors":"Haiying Chang, Jing Lv, Yinglin Zheng, Dongsheng Li, Yi Li","doi":"10.2147/IJGM.S508220","DOIUrl":"https://doi.org/10.2147/IJGM.S508220","url":null,"abstract":"<p><strong>Objective: </strong>To explore the changes in serum Monocyte chemoattractant protein-1 (MCP-1) and Osteopontin (OPN) in gout patients and their diagnostic value for early renal injury.</p><p><strong>Methods: </strong>In this research, 174 gout patients (January 2022-October 2024) were divided into the early renal injury group (50 cases) and non-early renal injury group (124 cases). Additionally, 169 healthy individuals were included as controls. Clinical indicators such as serum creatinine, cystatin C (CysC), and GFR were recorded. MCP-1 and OPN levels were measured using ELISA. Pearson's correlation was used to analyze relationships; Logit regression was applied to identify influencing factors, and ROC curves assessed diagnostic value, with AUC comparisons via Z-test.</p><p><strong>Results: </strong>Serum MCP-1 and OPN levels were significantly higher in the gout group compared to controls (P<0.05) and further elevated in the early renal injury group (P<0.05). MCP-1 and OPN correlated positively with creatinine and CysC and negatively with GFR (P<0.05). Logit regression identified MCP-1 (OR: 2.765, 95% CI: 1.308-5.846) and OPN (OR: 3.019, 95% CI: 1.468-6.210) as independent risk factors (P<0.05). The AUC for diagnosing early renal injury was 0.775 (MCP-1), 0.827 (OPN), and 0.938 (combined), with the combination significantly outperforming either marker alone (Z=3.075, 2.273, P<0.05).</p><p><strong>Conclusion: </strong>The combination of serum MCP-1 and OPN in gout patients has a higher diagnostic value for early renal injury, it is obviously higher than the individual diagnosis of each indicator, and demonstrates significant clinical implications.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1423-1429"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review.","authors":"Dan-Dan Wang, Shi-Guang Ren, Rui Hu, Hui-Lan Zhai, Fen Xie, Lu Jiang, Wen-Lei Huang, Xue-Qin Li","doi":"10.2147/IJGM.S502142","DOIUrl":"https://doi.org/10.2147/IJGM.S502142","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the digestive tract, including Crohn's disease and ulcerative colitis. Fatigue is one of the common and important extraintestinal symptoms in IBD patients, which significantly affects the patient's ability to work, daily life, social activities, emotional state, and cognitive function. Although the impact of fatigue on patients' quality of life cannot be ignored, medical professionals still have limited knowledge of its concepts, assessment tools, influencing factors, and non-pharmacological interventions, which may lead to neglect and inadequate management of the symptoms. The purpose of this article is to review the definition and epidemiological characteristics of IBD-related fatigue and to discuss the application of four commonly used fatigue assessment tools in patients with IBD. In addition, we will analyze the multiple factors that affect fatigue in IBD patients from three levels: physiological, psychological, and sociodemographic. Finally, we will assess the effectiveness of different non-pharmacological interventions in alleviating fatigue in people with IBD and make corresponding clinical recommendations.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1403-1413"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Immune-Nutrition Inflammation Index for Predicting Coronary Slow Flow Phenomenon in Patients with Angina and No Obstructive Coronary Arteries.","authors":"Jiang Guo, Zhi-Zhen Xiang, Dan-Dan Ma","doi":"10.2147/IJGM.S516108","DOIUrl":"10.2147/IJGM.S516108","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammatory responses are involved in the initiation and development of the coronary slow flow phenomenon (CSFP). However, as a newly developed immuno-nutritional inflammation indicator, the global immune-nutrition inflammation index (GINI) has not been well elaborated for predicting CSFP in patients with angina and no obstructive coronary arteries (ANOCA).</p><p><strong>Methods: </strong>A total of 1422 individuals with ANOCA were consecutively included in this study, of whom 93 developed CSFP (CSFP group). We selected 186 (1:2 matched) age- and sex-matched patients with ANOCA and angiographically proven normal coronary blood flow as the controls (the control group). Multivariate logistic regression analysis was used to investigate predictors of CSFP in patients with ANOCA. The optimal cutoff values for GINI were calculated.</p><p><strong>Results: </strong>In total, 93 patients developed CSFP, including 29% (27) in one vessel, 28% (26) in two vessels, and 43% (40) in three vessels. Patients with CSFP had an elevated CRP level, white blood cell (WBC) count, neutrophil count, GINI, fasting blood glucose (FBG) level, and a lower lymphocyte count (P<0.05). Multivariate logistic analysis showed that the GINI and FBG levels were independent predictors of CSFP in patients with ANOCA. Moreover, we found that the more vessels affected by CSFP, the higher the GINI level. The receiver operating characteristic (ROC) showed that GINI had a better predictive value than indicators alone. When the GINI AISI was >84.1, the sensitivity and specificity were 88.2% and 58.7%, respectively [The Area Under the ROC curve (AUC): 0.774; 95% CI: 0.721-0.827; P < 0.001].</p><p><strong>Conclusion: </strong>Elevated GINI is a reliable predictor of CSFP in patients with ANOCA. Moreover, GINI had a superior predictive value compared to the indicators alone. As a newly developed inflammatory indicator, GINI can be used for further risk stratification of patients with ANOCA.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1325-1332"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}