International Journal of General Medicine最新文献

{"title":"Very-High-Frequency Ultrasonographic Profiling Characteristics of Nodular Hidradenoma: A Retrospective Analysis.","authors":"Bin Dong, Hongsheng Xia, Ying Liu, Su Wang, Zhubiao Ye","doi":"10.2147/IJGM.S534241","DOIUrl":"10.2147/IJGM.S534241","url":null,"abstract":"<p><strong>Background: </strong>Nodular hidradenoma (NH) is a rare benign adnexal tumor originating from sweat glands, often misdiagnosed due to nonspecific clinical manifestations. Ultrasonography (US) plays a critical role in the diagnosis of skin tumors, yet systematic descriptions of its sonographic features remain limited.</p><p><strong>Objective: </strong>This study aims to investigate the very-high-frequency (VHF) characteristics of eccrine nodular hidradenoma (ENH) and establish key imaging criteria to differentiate it from other cutaneous/subcutaneous lesions.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 32 histopathologically confirmed ENH cases between November 2018 and December 2024. The VHF ultrasound evaluated ENH location, size, shape, margin, boundary, echogenicity, calcification, blood supply, and so on.</p><p><strong>Results: </strong>The VHF features of ENH showed that the maximum diameter of the lesions was about 12.42 ± 7.66 mm. Most lesions revealed predominant craniofacial/limb involvement (62.5%) and almost all lesions (96.9%) demonstrated transdermal extension into subcutaneous tissue. Lesion morphology varied from geometric regularity (87.5%) to irregular lobulation (12.5%), reflecting ENH's structural diversity. Echogenicity patterns were classified as: homogeneous solid hypoechoic architecture (6.2%, 2/32), heterogeneous solid-dominant hypoechogenicity (40.6%, 13/32), mixed echogenicity with solid-cystic components (31.3%, 10/32, solid:cystic ≈1:1), mixed cystic-dominant echogenicity (21.9%, 7/32). Notably, the ultrasound features of inner septa, \"snow falling\" or \"fluid-fluid level\" were observed in some lesions. Additionally, 9.4% (3/32) showed intralesional calcifications and all lesions exhibited posterior acoustic enhancement. Doppler analysis highlighted vascular heterogeneity, with 87.5% (28/32) classified as Adler grade 2-3, correlating histopathologically with vascularized stromal septa.</p><p><strong>Conclusion: </strong>The VHF ultrasound demonstrates characteristic diagnostic features of ENH, including its anatomical predilection, the involved skin layers, heterogeneous internal echogenicity, and distinctive blood flow patterns. These features provide critical indicators for differential diagnosis, establishing VHF ultrasound as a pivotal imaging modality to enhance diagnostic precision and optimize clinical decision-making in dermatologic oncology.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5127-5135"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Absent in Melanoma 2 as a Serological Marker in Relation to Complicated Community-Acquired Pneumonia in Children: A Prospective Cohort Study.","authors":"Linjie Hu, Peng Zhou, Shanlin Wang, Yaping Shen, Suli Xing, Yuehan Zhang, Yanyan Zhu","doi":"10.2147/IJGM.S538528","DOIUrl":"10.2147/IJGM.S538528","url":null,"abstract":"<p><strong>Objective: </strong>Absent in melanoma 2 (AIM2) is associated with inflammation. We intended to determine whether serum AIM2 levels are related to severity and complications of community-acquired pneumonia (CAP) in children.</p><p><strong>Methods: </strong>In this prospective cohort study, serum AIM2 levels were measured in 305 children with CAP and in 100 healthy controls at the Hangzhou Children's Hospital between January 2022 and June 2023. CAP severity was assessed using the pediatric critical illness score (PCIS) and clinical pulmonary infection score (CPIS). In-hospital complicated CAP was identified as the outcome variable. Univariate and multivariate analyses were sequentially performed to determine the correlation between severity, outcome and serum AIM2 levels.</p><p><strong>Results: </strong>Children with CAP had higher serum AIM2 levels than controls (median, 1.45 ng/mL versus 0.36 ng/mL; P<0.001). Serum AIM2 levels in diseased children were independently correlated with PCIS (beta=-0.020; P=0.001) and CPIS (beta=0.092; P=0.002), were linearly related to likelihood of complicated CAP (P for nonlinear =0.057), and were independently associated with complicated CAP (odds ratio= 6.162; P=0.005). The outcome association was robust by calculating the E-value at 11.8 and was not moderated by age, sex, weight and more (all P interaction >0.05). Serum AIM2 levels and two independent predictors, PCIS and CPIS, were integrated to construct the model. The model was pictorially represented by the nomogram and exhibited satisfactory discrimination capability, validity, and stability under the receiver operating characteristic (ROC) curve, decision curve, and calibration curve. By computing the net reclassification improvement and integrated discrimination improvement indices and comparing the area under the ROC curve, the model significantly outperformed the combination of the PCIS and CPIS.</p><p><strong>Conclusion: </strong>Markedly enhanced serum AIM2 levels following CAP in children are highly linked to severity and complicated CAP, substantializing serum AIM2 as a biochemical metric for assessing the severity and identifying adverse outcomes of childhood CAP.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5155-5169"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Interaction Between Sjögren's Syndrome and Osteoporosis: Pathophysiological Mechanisms and Management Strategies.","authors":"Zhenghao Shi, Jiaxu Chen, Luan Xue","doi":"10.2147/IJGM.S543209","DOIUrl":"10.2147/IJGM.S543209","url":null,"abstract":"<p><p>Sjögren's syndrome (SS) is a systemic autoimmune disorder predominantly affecting middle-aged and elderly women, characterized by lymphocytic infiltration of exocrine glands-particularly the salivary and lacrimal glands-resulting in xerophthalmia and xerostomia. Osteoporosis (OP), sharing similar age of onset and gender predilection, is a skeletal disorder defined by reduced bone mineral density and heightened fracture risk. The comorbidity of SS and OP represents a prevalent clinical phenomenon, with studies reporting an incidence rate of 33.1% to 51.6% among SS patients, significantly higher than that observed in healthy elderly populations. Vitamin D metabolism, widespread abnormal immune responses, hormonal imbalances, metabolic acidosis, and the RANKL/RANK/OPG axis exert significant contributory roles in the pathogenesis of both conditions. Treatment regimens for SS and OP may present certain overlaps yet potential contradictions. In this narrative review, we summarize the bidirectional relationship between these two diseases, thoroughly discuss the existing challenges in their management, and emphasize that recommending a comprehensive management strategy for SS patients with concurrent OP is crucial for enhancing patients' quality of life.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5137-5153"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the Study of Diagnostic Methods for Central Acute Vestibular Syndrome of a Vascular Cause.","authors":"Jing Zhao, Yuan Xu, Jia Chen, Chong Shi, Xuefang Liu, Guihua Wang, Hongmei Zhang, Shaochen Ma, Paolo Candelaresi, Jilai Li, Peifu Wang, Jichen Du, Zhirong Wan","doi":"10.2147/IJGM.S538594","DOIUrl":"10.2147/IJGM.S538594","url":null,"abstract":"<p><p>Acute vestibular syndrome (AVS) is characterized by the sudden onset of dizziness or vertigo, accompanied by nausea, vomiting, gait instability, and nystagmus, lasting for more than 24 hours and often persisting for several days to weeks. Central AVS primarily involves central vestibular structures, such as the brainstem and cerebellum, and is most commonly caused by ischemic stroke in the posterior circulation. When acute posterior circulation infarction presents solely with isolated dizziness or vertigo, without other symptoms of central nervous system damage, it is often misdiagnosed as a peripheral vestibular disorder, this can lead to serious consequences. Therefore, distinguishing between central AVS and peripheral AVS in clinical practice is crucial, as the treatment strategies and prognosis differ significantly. Early identification of central AVS helps in adopting specific diagnostic and therapeutic measures. With advancements in vestibular and oculomotor theories, as well as neuroimaging, it is now possible to rapidly identify and diagnose central AVS of a vascular cause. This article summarizes recent diagnostic strategies, and discusses the progress in clinical and laboratory examinations for central AVS of a vascular cause presenting as isolated vertigo.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5105-5113"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MCU-Mediated SIRT3 Inhibition Drives Oxidative Stress-Induced Cytoskeletal Disruption in Pancreatic Ductal Epithelium: A Mechanism of Hypertriglyceridemic Acute Pancreatitis.","authors":"Junbo Hong, Qingzi Fu, Liang Zhu, Zhenzhen Yang, Jianhua Wan, Qiaofeng Chen, Peng Chen, Shiyu Zhang","doi":"10.2147/IJGM.S542782","DOIUrl":"10.2147/IJGM.S542782","url":null,"abstract":"<p><strong>Purpose: </strong>The pathogenesis of hypertriglyceridemia -induced pancreatitis (HTGP) is complex and not fully understood. The purpose of this study was to investigate the molecular mechanism of the mitochondrial Ca²⁺ uniporter (MCU) in HTGP.</p><p><strong>Methods: </strong>We observed the expression levels of MCU and silent information regulator 3 (SIRT3) in both in vivo and in vitro HTGP models, and after intervention with ruthenium red (RR), an active inhibitor of MCU, and 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), an active inhibitor of SIRT3, changes in mitochondrial calcium ions, oxidative stress-related indices, the microfilament cytoskeleton, and monolayer cell permeability were detected.</p><p><strong>Results: </strong>In vivo and in vitro experiments revealed the upregulation of MCU and downregulation of SIRT3 in caerulein-treated HPDE6-C7 cells and mice, along with increased mitochondrial calcium accumulation, increased reactive oxygen species (ROS) and malondialdehyde (MDA) levels, decreased gamma-glutamylcysteine (GSH) levels, destruction of the microfilament cytoskeleton, and increased monolayer permeability. During in vitro experiments, intervention with RR, an active inhibitor of MCU, reversed the above changes, whereas intervention with 3-TYP, an active inhibitor of SIRT3, further exacerbated the above changes.</p><p><strong>Conclusion: </strong>MCU may be involved in the pathogenesis of AP by inhibiting the expression of SIRT3, resulting in increased oxidative stress and destruction of the microfilament cytoskeleton and pancreatic ductal mucosal barrier (PDMB) functions.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5195-5211"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Density Lipoprotein and High-Density Lipoprotein as Biomarkers for Inflammatory Bowel Disease Activity Assessment.","authors":"Xi Zhao, Wei Yan, Li Wang, Qinyu Feng, Yingzhi Pang, Yanping Wang, Meihui Tao, Jingyue Zhang, Yu Fu","doi":"10.2147/IJGM.S529428","DOIUrl":"10.2147/IJGM.S529428","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the correlation of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) with inflammatory bowel disease activity and their value in predicting disease activity.</p><p><strong>Patients and methods: </strong>Clinical data of 490 adult IBD patients diagnosed in two IBD centers were collected, and 200 healthy people were served as controls. To evaluate the correlation of IDL and HDL with clinical and endoscopic activity of inflammatory bowel disease (IBD), and to explore the predictive value of them for disease activity.</p><p><strong>Results: </strong>In CD, there were differences in HDL, CRP and ESR levels (p<0.001) among different disease activity groups. HDL levels were negatively correlated with HBI and CDEIS. In UC, there were differences in LDL, HDL, CRP and ESR levels among groups with different disease activities (p<0.001). Both LDL and HDL levels were negatively correlated with Mayo clinical score and UCEIS (p<0.001). The sensitivity of LDL for predicting moderate-severe UC was slightly higher than CRP (65.65% vs 60.31%). The specificity of HDL in predicting moderate-severe CD (65.85% vs 52.44%) and UC (87.34% vs 79.75%) was higher than CRP.</p><p><strong>Conclusion: </strong>In patients with IBD, serum levels of both LDL and HDL were significantly lower compared to healthy controls. These levels correlated with disease activity. Furthermore, LDL and HDL levels demonstrated potential utility in distinguishing patients with moderate-severe IBD and show promise as monitoring biomarkers for IBD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5115-5125"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Nomogram for Predicting Hyperuricemia in Perimenopausal Women.","authors":"Yu-Fei Liu, Xiao-Jing Li, Yu-Ting Li, Xue-Han Liu, Hai-Yan Gao, Tian-Ping Zhang, Chun-Mei Yang","doi":"10.2147/IJGM.S538751","DOIUrl":"10.2147/IJGM.S538751","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a nomogram model for predicting the risk of hyperuricemia (HUA) in perimenopausal women.</p><p><strong>Methods: </strong>In this study, physical examination information of perimenopausal women was collected at the First Affiliated Hospital of University of Science and Technology of China. We utilized the Least Absolute Shrinkage and Selection Operator (Lasso) and binary logistic regression to investigate the risk factors of HUA among perimenopausal women.</p><p><strong>Results: </strong>We finally collected 5637 patients in this study. Based on the results of Lasso-logistic regression analysis, we incorporated ten different independent variables into the risk prediction model for HUA. The risk prediction model showed good discrimination ability in both the training set (AUC=0.819; 95% CI=0.801~0.838) and validation set (AUC=0.787; 95% CI=0.756~0.818), the calibration curve demonstrates that the model was well-calibrated. In addition, we constructed HUA risk prediction models for perimenopausal women with BMI < 25.0 and BMI ≥ 25.0, respectively. The AUC of the prediction model in the population with BMI < 25.0 was 0.793, and the AUC of the prediction model in the population with BMI ≥ 25.0 was 0.765.</p><p><strong>Conclusion: </strong>Our study identified several independent risk factors for HUA in perimenopausal women and developed a prediction mode, which might be used to detect the individual conditions and implement the preventive interventions.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5171-5182"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Chinese Visceral Adiposity Index and Obstructive Sleep Apnoea in Hypertensive Patients with Normal-Weight: A Cross-Sectional Study.","authors":"Delian Zhang, Kangxin Cai, Qing Zhu, Aliye Abulaiti, Jing Hong, Yingchun Wang, Nanfang Li","doi":"10.2147/IJGM.S536352","DOIUrl":"10.2147/IJGM.S536352","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have mainly focused on the relationship between the Chinese Visceral Adiposity Index (CVAI) and obstructive sleep apnea (OSA) in general or overweight/obese populations. However, normal-weight hypertensive patients represent a clinically relevant yet understudied group, in whom OSA risk may be underestimated due to the absence of overt obesity. This study aimed to investigate the association between CVAI and OSA in normal-weight patients with hypertension, given the important role of visceral adiposity in the pathogenesis of OSA.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, hypertensive patients admitted between January 1, 2021, and December 31, 2023, were enrolled. Multivariate logistic and linear regression analyses were conducted. Additionally, restricted cubic spline (RCS) analyses were used to examine potential dose-response relationships.</p><p><strong>Results: </strong>A total of 6659 hypertensive patients were included. After adjusting for potential confounders, elevated CVAI levels were significantly associated with an increased risk and severity of OSA. RCS analyses demonstrated a clear linear dose-response relationship between CVAI and both the presence of OSA and apnea-hypopnea index (AHI) levels. These results were robust across both subgroup and sensitivity analyses.</p><p><strong>Conclusion: </strong>Our study results indicate that CVAI is associated with the occurrence and severity of OSA in hypertensive patients with normal body weight. Further research is needed to confirm these findings.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5063-5071"},"PeriodicalIF":2.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics and Clinical Validation Identify Key Glycolysis- and Immune-Related Genes in Sepsis.","authors":"Hengjian Du, Xin Dai, Ting Zhang, Zhao Zhang, XiaoTao Xu, YaoXia Liu, Zhen Fan","doi":"10.2147/IJGM.S539158","DOIUrl":"10.2147/IJGM.S539158","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is characterized by profound immune and metabolic perturbations, with glycolysis serving as a pivotal modulator of immune responses. However, the molecular mechanisms linking glycolytic reprogramming to immune dysfunction remain poorly defined.</p><p><strong>Methods: </strong>Transcriptomic profiles of sepsis were obtained from the Gene Expression Omnibus. Differentially expressed genes (DEGs) related to glycolysis were identified through a combination of ssGSEA, WGCNA and differential expression analysis. Hub genes were prioritized using Mendelian randomization and machine learning algorithms (LASSO, SVM-RFE, and Boruta), and validated in an independent dataset and by RT-qPCR in a clinical sepsis cohort. Immune cell infiltration was assessed using CIBERSORT to profile the immune landscape, and single-cell RNA sequencing (scRNA-seq) was employed to delineate the cell type-specific transcriptional profiles.</p><p><strong>Results: </strong>The ssGSEA scores derived from the glycolysis signature indicated a marked reduction in glycolytic activity associated with sepsis. By employing an integrative framework that includes WGCNA, differential expression analysis, Mendelian randomization, and machine learning algorithms, this study successfully identified five pivotal genes associated with glycolysis: DDX18, EIF3L, MAK16, THUMPD1, and ZNF260. The diminished expression of these genes was significantly correlated with immune remodeling, characterized by an increase in neutrophils and a decrease in lymphocytes. In a clinical sepsis cohort, RT-qPCR of peripheral blood, in conjunction with routine hematological profiling, validated their expression pattern and immune associations. Moreover, scRNA-seq facilitated a comprehensive characterization of these transcriptional alterations within distinct subsets of immune cells.</p><p><strong>Conclusion: </strong>This study identifies five glycolysis-related genes linked to immune remodeling in sepsis, revealing a metabolic-immune axis that may drives disease pathogenesis and offers promising targets for therapeutic intervention.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5085-5103"},"PeriodicalIF":2.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Qingke Mixture in Treating Mycoplasma Pneumonia in Children: A Randomized Controlled Trial.","authors":"Xiaofei Xie, Wei Wang, ShengTao Cui, Tianlong Xie, Yongfu Song, Na Wang, Zhuang Wang, Yongji Wang","doi":"10.2147/IJGM.S531095","DOIUrl":"10.2147/IJGM.S531095","url":null,"abstract":"<p><strong>Background: </strong>Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, current treatments are limited by resistance and side effects. This study aims to evaluate the clinical efficacy and safety of combining Qingke Mixture with azithromycin for treating MPP in children.</p><p><strong>Methods: </strong>This prospective, randomized, double-blind, controlled trial included 92 children diagnosed with MPP. The treatment group received Qingke Mixture and azithromycin, while the control group received azithromycin alone. Outcomes assessed included clinical symptoms, inflammatory markers, immune response, pulmonary function, and adverse events.</p><p><strong>Results: </strong>The treatment group showed significantly higher clinical efficacy (95.65% vs 80.43%, P < 0.05). The treatment group showed faster resolution of pulmonary symptoms, shorter hospital stays, and greater improvements in pulmonary function and TCM symptom scores (P < 0.05). Inflammatory markers (WBC, CRP, IL-6, IL-8) were significantly lower, while immunoglobulin levels (IgA, IgG, IgM) and T lymphocyte subsets (CD3+, CD4+/CD8+ ratio) were higher in the treatment group compared to the control group (P < 0.05). The incidence of adverse events was low in both groups, with no statistically significant difference.</p><p><strong>Conclusion: </strong>Qingke Mixture combined with azithromycin significantly improves clinical outcomes in children with MPP, enhancing efficacy while maintaining safety.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5073-5083"},"PeriodicalIF":2.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}