International Journal of General Medicine最新文献

{"title":"Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics.","authors":"Xuan Zhang, Hang Yin, Xu Yang, Jie Kang, Nan Sui","doi":"10.2147/IJGM.S509592","DOIUrl":"https://doi.org/10.2147/IJGM.S509592","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the mechanism of Zhuyang Tongbian Decoction (ZTD) in treating functional constipation (FC) by observing its effects on intestinal flora composition, the metabolic function of gut microbiota, fecal short-chain fatty acid (SCFA) levels, and serum concentrations of TLR4, NF-κB, TNF-α, and IL-6 in patients with FC.</p><p><strong>Patients and methods: </strong>40 patients with FC were randomly divided into the control group and the treatment group, 20 cases in each group. And 20 healthy volunteers were recruited during the same period. The control group was administered lactulose, while the treatment group was treated with ZTD. 16s RNA sequencing technology was used to compare the changes in the structure and diversity of the intestinal flora of patients before and after treatment. Changes in the levels of SCFAs in faeces and the levels of TLR4, NF-κB, TNF-α and IL-6 in serum were analysed. Metagenomics sequencing assessed microbiota metabolic functions.</p><p><strong>Results: </strong>The treatment group showed a significant increase in the relative abundance of beneficial bacteria, including Bifidobacterium, Lactobacillus, and Faecalibacterium_prausnitzii (P < 0.05), whereas Desulfobacterota and Ruminococcus were significantly reduced (P < 0.05). Notably, fecal acetic and propionic acid levels were significantly higher in the treatment group (P < 0.05). Serum biomarkers TLR4, NF-κB, TNF-α, and IL-6 decreased significantly (P < 0.05). Metagenomics sequencing showed that Carbohydrate metabolism, Metabolism of cofactors and vitamins, and C5- Branched dibasic acid metabolism were significantly increased in functional abundance (P < 0.05).</p><p><strong>Conclusion: </strong>ZTD notably improves intestinal flora composition and gut microbiota metabolic function, regulates SCFA levels, and reduces inflammation markers in FC patients. The strain Faecalibacterium_prausnitzii shows significant potential in regulation of intestinal inflammation and may play a crucial role in the treatment efficacy of ZTD for FC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1007-1022"},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Peripheral Blood Regulatory T Cells and IL-2 in the Collateral Circulation of Acute Ischemic Stroke.","authors":"Simin Zhang, Chen Rao, Meihai Wen, Xuke Zhang, Zhiwen Zha, Tong Gu, Lei Zhu, Chuanqing Yu","doi":"10.2147/IJGM.S504218","DOIUrl":"https://doi.org/10.2147/IJGM.S504218","url":null,"abstract":"<p><strong>Background: </strong>Inflammation is recognized as a pivotal factor in the pathophysiology of acute ischemic stroke (AIS) and has the potential to influence the collateral circulation of patients. The objective of this investigation was to explore the link between peripheral regulatory T cells (Tregs), interleukin-2 (IL-2), and the status of collateral circulation.</p><p><strong>Methods: </strong>Between September 2023 and May 2024, the study incorporated 117 AIS patients from the neurology department, with 60 identified as having good collateral status (GCS) and 57 with poor collateral status (PCS). Additionally, a control group of 46 healthy individuals was included. Collateral circulation in AIS patients was assessed via computed tomography angiography. The levels of peripheral blood Tregs were quantified through flow cytometry, while IL-2 was measured by ELISA.</p><p><strong>Results: </strong>In this investigation, patients diagnosed with PCS demonstrated reduced Tregs (5.77 ± 1.55%) and IL-2 levels (7.37 ± 2.61 pg/mL) compared to individuals with GCS (7.09 ± 1.32%, 9.95 ± 3.58 pg/mL) and healthy controls (7.17 ± 1.40%,10.33 ± 4.01 pg/mL). Logistic regression analysis identified significant associations between Tregs and IL-2 levels and collateral circulation status (<i>p</i><0.05), with diminished levels of both being independent predictors of PCS when compared to GCS. A nomogram was developed to forecast risk factors for collateral circulation, further highlighting the potential of plasma Tregs and IL-2 levels as biomarkers in predicting collateral circulation among AIS patients. The diagnostic performance of Tregs and IL-2 was assessed utilizing receiver operating characteristic (ROC) analysis. The area under the ROC curve (AUC) for Tregs in differentiating GCS from PCS patients was ascertained to be 0.741 (95% confidence interval [CI]: 0.652-0.830), while for IL-2, it was 0.710 (95% CI: 0.618-0.803). Moreover, the combined measurement of Tregs and IL-2 resulted in an AUC of 0.779 (95% CI: 0.695-0.863).</p><p><strong>Conclusion: </strong>Plasma levels of peripheral blood Tregs and IL-2 may function as promising biomarkers for the prediction of collateral circulation status, suggesting potential new therapeutic approaches aimed at enhancing cerebral collateral circulation, and providing new therapeutic targets for acute ischemic stroke.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1075-1088"},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Serum Cholinesterase Levels Predict Poor Prognosis in Patients with Ovarian Cancer.","authors":"Hailan Su, Danfeng Liao, Chaolin Huang, Qin Liu, Lingfang Yu","doi":"10.2147/IJGM.S509718","DOIUrl":"https://doi.org/10.2147/IJGM.S509718","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies reported that low cholinesterase (ChE) levels were associated with poor prognosis in various cancers, including bladder, pancreatic, lung, and colorectal cancers. This study aimed to evaluate the clinical significance of serum ChE levels as a prognostic biomarker in ovarian cancer.</p><p><strong>Materials and methods: </strong>A retrospective cohort analysis was conducted on 168 patients diagnosed with epithelial ovarian cancer at the Suzhou Ninth People's Hospital from 2019 to 2020. Serum ChE levels were measured before initiating treatment and stratified into low and high groups based on the median level (7600 U/L). Clinical and pathological data, such as FIGO stage, age, tumor histological type, and survival outcomes, were collected. Kaplan-Meier analysis and Cox proportional hazards regression were used to assess the relationship between ChE levels and overall survival and disease-free survival.</p><p><strong>Results: </strong>ChE levels were significantly correlated with clinicopathological features of epithelial ovarian cancer, including FIGO stage (p < 0.001), surgery completeness (p = 0.001), and platinum-resistant (p = 0.001). Kaplan-Meier analysis demonstrated that patients in the low ChE group had significantly worse overall survival (p = 0.003) and disease-free survival (p = 0.005) than those in the high ChE group. Multivariate Cox regression analysis identified low serum ChE levels as an independent predictor of poor overall survival and disease-free survival.</p><p><strong>Conclusion: </strong>Low serum ChE levels are independently associated with poor prognosis in ovarian cancer patients, reflecting systemic inflammation, malnutrition, and potential hepatic dysfunction. These findings suggest that ChE could serve as a cost-effective and non-invasive biomarker for risk stratification and prognosis in clinical practice.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1023-1033"},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts.","authors":"ChengLing Fan, HongXia Zhou, YuFei Pan, Dan Lu","doi":"10.2147/IJGM.S507410","DOIUrl":"https://doi.org/10.2147/IJGM.S507410","url":null,"abstract":"<p><strong>Background and objective: </strong>Preeclampsia (PE) is a severe gestational disorder characterized by sudden hypertension and proteinuria, with substantial risks to both mother and fetus. This study aims to delineate the role of neprilysin, a metalloprotease known for its role in modulating vasoactive peptides, in the pathophysiology of PE.</p><p><strong>Methods: </strong>We recruited a cohort of 57 participants, comprising 38 patients diagnosed with PE and 19 healthy controls, matched for demographic and clinical characteristics. Neprilysin expression was assessed in serum and placental tissues through quantitative RT-qPCR and Western blot analyses. Functional impacts of neprilysin modulation were explored via siRNA knockdown and overexpression in HTR8/SVneo cells, followed by assessments of oxidative stress, mitochondrial function, apoptosis, and trophoblast invasion using various biochemical assays including CCK-8, DCFH-DA, JC-1 staining, and flow cytometry.</p><p><strong>Results: </strong>Our results demonstrate a marked overexpression of neprilysin in the serum and placental tissues of PE patients compared to healthy controls. Elevated neprilysin levels were positively correlated with increased systolic and diastolic blood pressures. In functional assays, neprilysin knockdown alleviated H₂O₂-induced oxidative stress, restored mitochondrial function, and improved cell invasion and migration in EVT cells. Conversely, the overexpression of IGF2BP1, a regulator of mRNA stability, exacerbated neprilysin expression and intensified cellular damage under oxidative stress conditions. The reciprocal regulation of neprilysin by IGF2BP1 highlights a critical molecular interplay impacting cellular resilience to oxidative stress in PE.</p><p><strong>Conclusion: </strong>These findings establish neprilysin as a critical mediator in the pathogenesis of PE, where its aberrant overexpression is linked to exacerbated hypertensive symptoms and impaired trophoblast function. The interaction between neprilysin and IGF2BP1 provides a potential therapeutic target for mitigating the progression of PE, suggesting avenues for future intervention strategies.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"967-980"},"PeriodicalIF":2.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics-Based Deep Learning Prediction of Prognosis and Therapeutic Response in Patients With Extensive-Stage Small Cell Lung Cancer Receiving Chemoimmunotherapy: A Retrospective Cohort Study.","authors":"Fang Nie, Xiufeng Pei, Jiale Du, Wanting Shi, Jianying Wang, Lu Feng, Yonggang Liu","doi":"10.2147/IJGM.S506485","DOIUrl":"https://doi.org/10.2147/IJGM.S506485","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a clinical early warning prediction model to evaluate the prognosis and response to chemoimmunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), thereby guiding clinical decision-making.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data and radiomics parameters of 309 patients with ES-SCLC hospitalized at Baotou Cancer Hospital from February 2020 to September 2024. Patients were divided into reactive and non-reactive groups based on their response to chemoimmunotherapy.Machine learning algorithms (including random forests, decision trees, artificial neural networks, and generalized linear regression) were used to predict the combined treatment response. The model's predictive ability was evaluated using the receiver operating characteristic (ROC) curve and clinical decision curve analysis(DCA). The prognostic evaluation of patients receiving combination therapy was based on the COX regression model, with predictive performance assessed through nomogram visualization and calibration curves.</p><p><strong>Results: </strong>Out of 309 patients with ES-SCLC, 248 (80.26%) responded to combination therapy. Logistic regression and Least absolute shrinkage and selection operator (LASSO) regression analyses identified Energy, sum of squares(SOS), mean sum(MES), sum variance(SUV), sum entropy(SUE), difference variance(DIV), and pathomics score as independent risk factors for treatment response. The area under the ROC curve for predicting treatment response using machine learning were 0.764 (95% confidence interval [CI]: 0.707~0.821) and 0.901 (95% CI: 0.846~0.956) in the training and validation sets. The C-index of the radiomics and pathomics prognostic nomogram model based on the COX prognostic model was 0.766 and 0.812 in those sets, respectively.</p><p><strong>Conclusion: </strong>We developed prediction model based on multi-omics demonstrated satisfactory performance in predicting chemoimmunotherapy response in patients with ES-SCLC. The random forest prediction model, in particular, provides accurate response and prognostic risk assessments, thereby assisting clinical decision-making.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"981-996"},"PeriodicalIF":2.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Objective Evaluation Model of CTPA Image Quality: A Multi-Center Study.","authors":"Qihang Sun, Zhongxiao Liu, Tao Ding, Changzhou Shi, Nailong Hou, Cunjie Sun","doi":"10.2147/IJGM.S510784","DOIUrl":"https://doi.org/10.2147/IJGM.S510784","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to develop a machine learning-based model for the objective assessment of CT pulmonary angiography (CTPA) image quality.</p><p><strong>Patients and methods: </strong>A retrospective analysis was conducted using data from 99 patients who underwent CTPA between March 2022 and January 2023, alongside two public datasets, FUMPE (21 cases) and CAD-PE (30 cases). In total, 150 cases from multiple centers were included in this analysis. The dataset was randomly split into a training set (105 cases) and a testing set (45 cases) in a 7:3 ratio. CT values and their standard deviations (SD) were measured in 11 specific regions of interest, and two radiologists independently assigned anonymous random scores to the images. The average of their subjective scores was used as the target output for the model, which was the mean opinion score (MOS) for image quality. Feature selection was performed using the Lasso algorithm and Pearson correlation coefficient, and a random forest regression model was constructed. Model performance was evaluated using mean square error (MSE), coefficient of determination (R²), Pearson linear correlation coefficient (PLCC), Spearman rank correlation coefficient (SRCC), and Kendall rank correlation coefficient (KRCC).</p><p><strong>Results: </strong>After feature selection, three key features were retained: main pulmonary artery CT value, ascending aorta CT value, and the difference in noise values between the left and right main pulmonary arteries. The random forest regression model constructed achieved MSE, R2_score, PLCC, SRCC, and KRCC values of 0.2001, 0.6695, 0.8682, 0.8694, 0.7363, respectively, on the testing set.</p><p><strong>Conclusion: </strong>This study successfully developed an interpretable machine learning-based model for the objective assessment of CTPA image quality. The model offers effective support for improving image quality control efficiency and precision. However, the limited sample size may affect the model's generalizability, so it's essential to conduct further research with larger datasets.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"997-1005"},"PeriodicalIF":2.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Diagnostic Potential of Video-Based Breathing Control Training: A Sonographic Evaluation of Abdominal Organ Measures.","authors":"Mahasin G Hassan, Afnan M AlOtaibi, Raghad H Altuwaym, Reem H Alnuwaysir, Renad B Alharbi, Lama M Alnajashi, Mayer K Alsaber, Hetaf F Aldakan, Halima M Hawesa, Zohida A Abdelgabar, Asma S Aldahes, Mohammed G Yaqob","doi":"10.2147/IJGM.S483995","DOIUrl":"10.2147/IJGM.S483995","url":null,"abstract":"<p><strong>Background: </strong>Breathing control training programs have gained attention due to their potential to influence diagnostic procedures. However, the role of video-based tools to demonstrate breathing maneuvers during sonographic quantification of abdominal organs needs to be studied more. This study explores the impact of a video-based breathing training program on sonographic examination of abdominal organs.</p><p><strong>Methodology: </strong>This quasi-experimental study recruited 49 healthy volunteers at the ultrasound lab of College of Health and Rehabilitation Sciences in Princess Nourah bint Abdul Rahman University. The study employed a video-based breathing control training program that includes diaphragmatic breathing exercises. Sonographic assessments of abdominal organs were conducted before and after the intervention period using standardized protocols. Data was analyzed using SPSS V 28.</p><p><strong>Results: </strong>The right renal length (p-value <0.001), thickness (p-value 0.025), and volume measured (p-value <0.001) were significantly improved following the video training. Similarly, splenic length (p-value 0.015), width (p-value <0.001), and volume (p-value 0.001). Additionally, the operator time demonstrated a notable decrease from 13.14 ± 3.4 to 8.1 ± 3.5 minutes after the video training intervention (p-value <0.001).</p><p><strong>Conclusion: </strong>The study provides evidence for the beneficial effects of a video-based breathing control training program on sonographic quantification of abdominal organs. These findings suggest potential clinical utility for integrating video-based breathing interventions into practice, although study limitations require further validation and generalization. Nonetheless, the study highlights the promising role of breathing control training in enhancing the diagnostic accuracy of abdominal sonography.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"947-953"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between MIC-1, VEGF, and TGF-β1 and Clinicopathologic Stage and Lymph Node Metastasis in Gastric Cancer.","authors":"Jianyun Sheng, Jieshi Wang, Tengda Ma, Peina He","doi":"10.2147/IJGM.S497572","DOIUrl":"10.2147/IJGM.S497572","url":null,"abstract":"<p><strong>Objective: </strong>This research investigated the relationship between serum macrophage inhibitory cytokine-1 (MIC-1), vascular endothelial growth factor (VEGF), and transforming growth factor-β1 (TGF-β1) levels and clinicopathologic features, lymph node metastasis (LNM), and prognosis of gastric cancer (GC) patients.</p><p><strong>Methods: </strong>The GC group (GC patients, 198 cases)) and healthy group (healthy people, 100 cases) were established. The relationship between serum MIC-1, VEGF, TGF-β1, and clinical and pathological features in GC patients was analyzed. GC patients were divided into a metastasis group (77 patients) and a non-metastasis group (121 patients) based on whether they had LNM. The factors influencing LNM in GC patients were identified. The predictive value of serum MIC-1, VEGF, and TGF-β1 for LNM in GC patients and the relationship between serum MIC-1, VEGF, TGF-β1 levels and prognosis were analyzed.</p><p><strong>Results: </strong>MIC-1, VEGF, and TGF-β1 were higher in GC. Serum MIC-1, VEGF, and TGF-β1 levels were higher in GC patients with tumor diameter ≥ 3 cm, T stage of T3 and T4, low/moderate differentiation, and LNM. Multivariate Logistic regression analysis showed that TNM stage, tumor differentiation, and serum MIC-1, VEGF, and TGF-β1 levels were risk factors for LNM in GC patients. The ROC results indicated that the combination of serum MIC-1, VEGF, and TGF-β1 had the highest AUC for predicting LNM in GV patients. The median survival time of patients with low serum MIC-1, VEGF, and TGF-β1 was higher than that of patients with high serum MIC-1, VEGF, and TGF-β1 (26.13 months vs 19.24 months, 27.06 months vs 20.18 months, and 24.20 months vs 20.08 months).</p><p><strong>Conclusion: </strong>The changes of serum MIC-1, VEGF and TGF-β1 levels are related to the clinicopathological characteristics of GC patients, and the elevated levels of these indices are independent risk factors affecting LNM and prognosis of GC patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"955-965"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Skeletal Muscle Mass and Different Pathological Types of Colorectal Polyp in Chinese Asymptomatic Population.","authors":"Wenya Li, Na Wang, Huajun Ye, Mengjun Chen","doi":"10.2147/IJGM.S503137","DOIUrl":"10.2147/IJGM.S503137","url":null,"abstract":"<p><strong>Background: </strong>Low relative muscle mass was identified to be related to ascending risk of pre-cancerous polyps (adenoma) in recent cohort study. Our study aimed to dig out the correlation between muscle mass and different pathological types of colorectal polyps in Chinese asymptomatic population.</p><p><strong>Methods: </strong>In all, 5923 adults were included. The effects of low skeletal muscle mass index (SMI) on colorectal polyp occurrence, including different pathological types, and the effects modification of age and BMI were analyzed using univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Lower SMI was connected with the lower occurrence of colorectal polyp (OR: 0.810, 95% CI: 0.683~0.960, p=0.015). Considering different pathological types of colorectal polyps, lower SMI was associated with lower occurrence of inflammatory polyp (OR: 0.633, 95% CI: 0.434~0.898, p=0.013), rather than conventional adenoma and serrated polyp (all p>0.05). Besides, SMI was positively related to the occurrence of 2 pathological types of colorectal polyp in males: inflammatory polyp (OR: 1.237, 95% CI: 1.058~1.444, p=0.007) and serrated polyp (OR: 1.288, 95% CI: 1.143~1.456, p<0.001). The interaction effect of BMI and SMI on occurrence of inflammatory polyp after adjusting age and smoking status was significant (p=0.015). For individuals with low SMI (compared with the normal SMI group), the incidence of inflammatory polyp was reduced from 8.95% to 3.50% in the low BMI quartile (Q1) in the adjusted model (OR of 0.332, 95% CI: 0.005-0.061, p<0.001). It was noticeable for males rather than females that individuals with colorectal polyps had higher levels of SMI (p=0.003). In addition, individuals with inflammatory polyps as well as serrated polyps possessed higher levels of SMI in males (all p<0.05).</p><p><strong>Conclusion: </strong>Generally, especially in Chinese asymptomatic males, low SMI kept independent effect on the presence of inflammatory polyp and serrated polyp, rather than conventional adenoma.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"927-938"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Myocardial Injury/Infarction in Patients with Stable or Unstable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention: The Effects of Preoperative Lipid Management.","authors":"Xuefeng Chen, Wenlou Bai, Peng Qi, Yantao Zhang, Wenjing Yao, Yi Dang","doi":"10.2147/IJGM.S508529","DOIUrl":"10.2147/IJGM.S508529","url":null,"abstract":"<p><strong>Background: </strong>Identifying the risk factors for perioperative myocardial injury/infarction (PMI) is critical to prevent postoperative adverse cardiovascular events. However, whether reducing the preoperative LDL-C can mitigate the risk of PMI remains unclear. We therefore investigated the effect of the preoperative LDL-C level in patients with stable angina pectoris (SAP) or unstable angina pectoris (UAP) on perioperative myocardial injury/infarction (PMI) after elective percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>Patients with SAP or UAP who received PCI from January 2021 to June 2023 at one of the two institutions (Hebei Provincial People's Hospital, Handan Central Hospital) were reviewed. The occurrence of PMI was determined based on the elevation of cardiac troponin I (cTnI) after the operation. The preoperative low density lipoprotein cholesterol (LDL-C) level was divided into three grades: low, <1.4 mmol/L; medium, 1.4-1.8 mmol/L; high, >1.8 mmol/L. The relationship between PMI and preoperative LDL-C was analyzed.</p><p><strong>Results: </strong>Of all 308 included patients, 226 did not have PMI and 82 experienced PMI. Positive correlation was found both between PMI and preoperative LDL-C level (r = 0.322, <i>P</i> < 0.05) and between PMI and preoperative LDL-C grade (r = 0.189, <i>P</i> < 0.05). According to the multivariate logistic regression analysis, the preoperative LDL-C grade (Medium vs Low, <i>OR</i>=3.994, <i>P</i> < 0.05; High vs Medium, <i>OR</i>=6.140, <i>P</i> < 0.05) and the number of stents implanted during PCI were independent risk factors for PMI (<i>OR</i>=1.940; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>For SAP and UAP patients, decreasing LDL-C to <1.4 mmol/L before elective PCI can reduce the incidence of PMI after the operation. We strongly recommend the practice of sufficiently reducing LDL-C level below 1.4 for patients with SAP or UAP who receive elective PCI.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"939-945"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}